정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

고등학교 야영활동 참여가 인성발달에 미치는 영향

노형철(Hyung Chul Roh),정명수(Myeong Soo Jung),정순승(Soon Seung Jung),이광호(Kwang Ho Lee) 한국사회체육학회 2000 한국사회체육학회지 Vol.13 No.-

Camping activities were thought as one of educational methods. This study analyzed effects of participation in camping activities on high school students` humanity development variables, which affect humanity development were used for this study and data were collected at high schools in Kwang-ju city. At this site 600 surveys were distributed to a random sample of 300 participant and 30 non participant in camping activities. The results were as follows. 1. Participation in camping activities more positively affected humanity developments of male students` than that of female students`. 2. There was significant relationship between camping activities and sociality, leadership, activity and responsibility development. 3. There is no relationship between frequency of participation in camping activities and humanity development. Since the data were collected only at high schools in Kwang-ju city, further studies on high schools in countrysides would be required.

수용성 절삭유제 내에서 Saccharomyces cerevisiae와 Escherichia coli의 성장에 관한 연구

정광진,최희영,김장규,원성호,김남기 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

The water-soluble cutting oil was used in the type of the mixture of additive lubricant, surfactant, etc., as the organic nutrients, with water. Therefore it was easy to be affected by microbials ; they brought the bad odor by putridity, decreased the cutting property, and destroyed the emulsion phase. In the study using cells, Saccharomyces cerevisiae and Escherichia coli, we studied the effect of concentration and dilution ratio on the growth of cells and the cell growth rate, the pH variance and the change of oil's concentration. The results obtained in this experiment were as follows : 1) The result of test dilution ratio (water:oil) vs. cell growth was that by using E. coli, the growth was better in this order in emulsion type (sample 1) 50:1 > 30:1 > 100:1, and in the soluble type (sample 2) the order was 100:1 > 50:1 > 30:1. The effect of the cutting oil's concentration on the Saccaromyces cerevisiae's was less in this order 100:1 < 50:1 < 30:1 ; the maximum growth was occurred at 100:1. 2) In sample 1 by using E, coli, pH range was changed from 9.5 to 8.0 and refractive index(the cutting oil's concentration) was changed from 1.3327 to 1.3318. And in the test using S. cerevisiae, pH range was varied from 9.5 to 6.2 and refractive index was changed from 1.3330 to 1.3310. In sample 2 by using E. coil, pH was changed to 8.9 and refractive index was changed from 1. 3315 to 1.3313 and in that of using S cerevisiae, pH was changed to 8.1 and refractive index was decreased from 1.3355 to 1.3340.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

경동맥 내막 절제술 후 발생한 과관류 증후군 1예

송희정,박광열,정진상,조수진,이순정,허승,김동익,이광호,이병붕 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

후막 전계발광소자(Electroluminescence)의 제조와 발광특성

정영호,김병권,박조용,명광식,Khatkar, S.P.,Liang, Yujun,한상도 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

자발적 운동이 고령자의 혈액성분에 미치는 영향

정일호,이광욱,조명곤 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study was to compared the blood variance following spontaneously exercise for 10weeks in healthy the elderly. When spontaneously exercise, for 10 weeks in exercise intensities between low and middle exercise intensities was participated, the HDL-C in factors of anti-atherosclerosis increased highly. Also, HDL-C/Total-C and HDL-C/LDL-C ratio in atherosclerosis index was improved. The results suggest that, in general, in participation aerobic exercise spontaneously was prevented on disease of lifestyle in the elderly.

공공부문 조직과 민간기업 조직의 직무만족도 비교분석 : 한국노동패널연구(KLIPS)자료를 중심으로

정광호,김태일 한국정책학회 2003 韓國政策學會報 Vol.12 No.3

그동안 국내에서 직무만족도에 관한 연구는 사회과학 여러 분야에서 이루어져 왔지만 공공부문과 민간부문사이의 직무만족도가 다를 것이라는 가설은 체계적으로 연구되지 못했다. 특히 대부분의 연구들은 횡단면 자료(cross-sectional data)를 가지고 분석했기 때문에 지난 1997년 경제위기 이후 직무만족도의 종단면적 추이를 분석하는데 한계가 있었다. 이에 본 연구는 기존의 연구와 달리 지난 1998년 이후 매년 조사되고 있는 한국노동패털자료(Korea Labor and Income Panel Study)를 이용하여 공공 및 민간부문간의 직무만족도의 차이에 대한 패널분석을 시도하고 있다. 본 연구의 분석결과 지난 1998년부터 2001년까지 정부기관에 종사자들의 직무만족도가 민간기업종사다들보다 높음을 보여준다. 특히 취업안정성 만족도에서 가장 큰 차이가 발견되었다. 한편 보수만족도의 경우 지난 1998년부터 2000년까지는 양 부문에서 유의미한 차이가 없었지만 2001년의 경우 민간부문에 비하여 공공부문의 보수만족도가 높아지고 있다. 추가로 본 연구는 교육변수와 성별변수에 따라 양 부문간의 직무만족도의 차이를 분석하고 있다. 특히 보수만족도와 복지후생만족도의 경우 공공부문의 고졸집단 만족도가 공공부문 및 민간부문의 대졸집단 만족도보다 높았다. 또한 직업 안정성, 직무내용, 그리고 복지후생 만족도의 경우 공공부문의 남성집단 만족도가 민간부문 여성집단의 만족도보다 높았다. 이 연구결과는 일반적으로 대졸집단이 고졸집단보다 그리고 여성이 남성보다 높은 직무만족도를 보인다는 사실과 상반된 것이다. 이것은 아마도 민간조직과 달리 공공조직이 가진 독특한 특성과 관련이 있어 보인다. Pervious studies have tended to neglect a hypothesis of differences in job satisfaction between public and private organization. Because they examined the hypothesis with a cross-sectional data, they have not showed a trend of job satisfaction since the 1997 economic crisis in South Korea. Unlike prior research, this study explores the longitudinal differences in job satisfaction between these two types of organizations with the Korean Labor & Income Study dat. This study shows that the level of job satisfaction in public organizations was higher difference in the level of satisfaction of job stability in the same period. While there was little difference of wage satisfaction between them between 1998 and 2000, the level of wage satisfaction in public organizations was higher than that in private organizations in 2001. In addition, this study examines differences in job satisfaction in terms of education and gender. In public organization, those with high school degree have a higher level of satisfaction in wage and welfare than those with college degree. In the case of job stability, job contents and occupational welfare, male group in public organizations has a higher level of satisfaction than female group in private organizations These results contrast with the following two facts: (1) in general, the level of job satisfaction for those with college degree is higher than that for those with high school degree or no high school degree; and (2) the level of job satisfaction for female group is higher than that for male group. It appears to be related to the unique characteristics of public organizations.

편심하중을 받는 상자형의 단면변형에 관한 연구

鄭熺孝,安光列,金鎬洙,黃俊碩 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

Eccentric load acts on box girder is divided into bending and torsional load and deforms cross section. Distortion that is resulted from torsional load is largely different according to tickness of each plate or stiffener. According to with and without regard of distorsion effect, it is possible to divide analysis of box gilder into two. First, analysis of box gilder can be able to calcurate with rigid box girder in assumption that there is no distorsion when the girder is well stiffened with diaphragms or cross bracing and plate thickness of box section is thick. Second is the analysis that must be considered effect of distorsion when the girder has not sufficient stiffener or plate thickness of box section is not well thick. In numerical example of this study, normal stress of rigid cross section analysis is compared with that of deformable cross section analysis without interior diaphragms. Then, it was studied that stresses of the deformable cross section analysis can be near rigid analysis when box girder was stiffened with interior diaphragms.