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Anti-N-Methyl-D-Aspartate Receptor Encephalitis Presenting Progressive Dyslexia: A Case Report
Kwang Hyun Pan,Jin Hee Kim,Byung-Jo Kim,이찬녕 대한치매학회 2015 Dementia and Neurocognitive Disorders Vol.14 No.4
Background Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis was discovered less than 10 years ago. Its symptoms andcharacteristics are not well-defined yet. We experienced a case of anti-NMDA receptor encephalitis with phonemic paraphasia and acalculiathat were not classical characteristics. Case Report A 44-year-old woman started to show dyslexia, phonemic paraphasia, and dyscalculia. These symptoms were gradually worseningfor over 30 days. Various brain images were not helpful for primary diagnosis. Anti-NMDA receptor encephalitis was confirmed in twodifferent laboratories. The patient started to recover with various immunosuppressive therapies. Conclusions Anti-NMDA receptor encephalitis can have various symptoms, including phonemic paraphasia and acalculia.
Cha, Kwang Hyun,Lee, Joo Young,Song, Dae-Geun,Kim, Sang Min,Lee, Dong-Un,Jeon, Jin-Young,Pan, Cheol-Ho American Chemical Society 2011 Journal of agricultural and food chemistry Vol.59 No.16
<P><I>Chlorella</I> is a nutrient-rich microalga that contains protein, lipid, minerals, vitamins, and high levels of lutein. This study evaluated the bioavailability of lutein from <I>Chlorella vulgaris</I> using a coupled in vitro digestion and human intestinal Caco-2 cell model. Lutein bioaccessibility was low, and approximately 75% of total <I>C. vulgaris</I> lutein was not micellized during the digestion process but remained in the insoluble digestate. Microfluidization improved lutein micellization efficiency during <I>C. vulgaris</I> digestion. <I>C. vulgaris</I> was microfluidized at a pressure exceeding 10000 psi, and the cell surface disruption was visualized by scanning electron microscopy. The mean <I>C. vulgaris</I> particle size was reduced from 3.56 to 0.35 μm with the microfluidization treatment. <I>C. vulgaris</I> microfluidization at 20000 psi was three times more efficient for aqueous lutein micelles production as compared with untreated <I>C. vulgaris</I>, and the final lutein content accumulated by intestinal Caco-2 cells was also higher with microfluidization. <I>C. vulgaris</I> lutein stability was not affected by microfluidization. These results indicate that microfluidization may be useful for improving lutein bioaccessibility from <I>C. vulgaris</I> during food processing.</P>
진광윤 ( Kwang Youn Jin ),최신형 ( Shin Hyeong Choi ),남기현 ( Ki Hyun Nam ),한판암 ( Pan Am Han ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.1
분석 및 설계단계의 산출물을 작성할 때는 대부분 정형화와 표준화를 따른다. 그러나 실제 시스템 개발현장에서는 단계별 산출물들의 개별적인 특성으로 인하여 모든 산출물간에는 연속적이며 자동화된 과정을 통해 산출물들이 작성될 수는 없다. 그 결과 작성된 개발 산출물간의 일관성이 유지되지 못하는 관계로 최종 산출물에서 여러 가지 문제가 야기됨을 알 수 있다. 그러므로 본 논문에서는 객체지향 방법론에 따라 개발되는 시스템에 대해 분석 및 설계단계의 산출물간 일관성을 유지하기 위한 방안을 제시하고, 이를 지원하기 위한 도구를 개발한다.
Yong-Hyun Lee,Mi-Kyung Son,Young-Mi Jung,Tae-Kwon Kim,Dong-Chan Park,Hyeung-Sik Lee,Pan-Soo Kim,Sae-Kwang Ku 한국독성학회 2007 Toxicological Research Vol.23 No.2
This study was conducted to obtain acute information of the oral dose toxicity of PGB-1, a novel polyglucosamine polymer produced from a new strain Enterobacter sp. BL-2 in male and female mice. In order to calculated 50% lethal dose (LD??) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250, 125 and 0 (vehicle control) ㎖/㎏ (body wt.). The mortality and changes on body weight, clinical signs, gross observation and organ weight and histopathology of principle organs were monitored 14 days after dosing with PGB-1. We could not find any mortalities, clinical signs, body weight changes and gross findings. In addition, significant changes in the organ weight and histopathology of principal organs were not observed except for some sporadic findings. The results obtained in this study suggest that PGB-1 may not be toxic in mice and may be therefore safe for clinical use. The LD?? and approximate LD in mice after single oral dose of PGB-1 were considered over 2000 ㎎/㎏ in both female and male mice.
피부 악성종양의 통계적 고찰 ( 1996 - 2000 )
서판교(Pan Gyo Seo),문상은(Sang Eun Moon),조광현(Kwang Hyun Cho) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.2
N/A Background : The incidence and clinical characteristics of cutaneous premalignant lesions and malignant tumors in Korea varied according to different authors probably due to social and environmental influences, and the reported time. Objective : The purpose of our study was to analyze the recent changes in cutaneous premalignant lesions and malignant tumors, and to compare them with other data previously reported. Methods : Clinical data and histopathological reports of 93 cases of cutaneous premalignant lesions and 238 cases of cutaneous malignant tumors out of new outpatients that visited the Department of Dermatology at the Seoul National University Hospital during a 5 year period(1996-2000). Results : 1. The average annual incidence of cutaneous premalignant lesions was 0.40% and that of cutaneous malignant tumors was 1.02%. 2. Among the premalignant lesions, actinic keratosis(67.7%) was the most common, and then Bowen`s disease(31.2%). The incidence of Bowen`s disease tended to increase compared to previous reports. 3. The most common malignant tumor was basal cell carcinoma(22.2%), followed by malignant melanoma(19.7%), lymphoma(18.1%), squamous cell carcinoma(12.6%), metastatic cancer(12.6%). The incidence of malignant melanoma was increased compared to previous reports. 4. Among the 53 cases of basal cell carcinoma, 49 cases(92.5%) were ulceronodular type. The most common predirection site was the nose(30.2 %). 5. Among the 43 cases of lymphoma, 38 cases(88.4%) were peripheral T-cell and NK-cell lymphoma, 4 cases(9.3%) were B-cell lymphoma. Among the peripheral T-cell and NK-cell lymphoma, mycosis fungoides was the most common(30.2%).
Cha, Kwang Hyun,Lee, Eun Ha,Yoon, Hyo Shin,Lee, Jae Ho,Kim, Joo Yun,Kang, Kyungsu,Park, Jin-Soo,Jin, Jong Beom,Ko, GwangPyo,Pan, Cheol-Ho Elsevier 2018 Food chemistry Vol.263 No.-
<P><B>Abstract</B></P> <P>We investigated the impact of a fermented milk product on gut microbiota and their metabolism in 3 different conditions of the colon with a systemic viewpoint. An <I>in vitro</I> semi-continuous anaerobic cultivation was used to assess the colon compartment-specific influence of fermented milk, followed by a multiomics approach combining 16S rDNA amplicon sequencing and nuclear magnetic resonance (NMR) spectroscopy. The microbiome profiling and metabolomic features were significantly different across three colon compartments and after fermented milk treatment. Integrative correlation analysis indicated that the alteration of butyrate-producing microbiota (<I>Veillonella, Roseburia, Lachnospira,</I> and <I>Coprococcus</I>) and some primary metabolites (butyrate, ethanol, lactate, and isobutyrate) in the treatment group had a strong association with the fermented milk microorganisms. Our findings suggested that fermented milk treatment significantly affected microbial population in an <I>in vitro</I> cultivation system as well as the colonic metabolome in different ways in each of colon compartment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A fermented milk product was treated using an <I>in vitro</I> colonic fermentation. </LI> <LI> Three colon compartments showed an apparent microbial and metabolomic distinction. </LI> <LI> Fermented milk treatment induced an increase in butyrate-producing bacteria. </LI> <LI> There were clear changes in colonic primary metabolome after fermented milk treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Paik, Hyun Dong,Lee, Na KYoung,Lee, Kwang Ho,Hwang, Yong Il,Pan, Jae Gu 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.2
Bacillus cereus BS229 was identified as a bacteriocin producer with a bactericidal activity against Bacillus thuringiensis subsp. thomsoni BR40. Bacillus cereus BS229 and cerein BS229, named tentatively as the bacteriocin produced by Bacillus cereus BS229, showed a narrow spectrum of activity against Gram-positive and Gram-negative bacteria, along with yeast and molds. Production of cerein BS229 in a 5-1 fermenter followed typical kinetics of primary metabolite synthesis. The antibacterial activity of cerein BS229 on sensitive indicator cells disappeared completely by α-chymotrypsin or proteinase K, which indicates its proteinaceous nature. Cerein BS229 seemed to be very stable throughout the pH range of 2.0 to 9.0 and it was relatively heat labile, despite the fact that bacteriocin activity was still detected after being boiled for 30 min. Cerein BS229 activity has been changed with some of the organic solvents such as toluene, ethanol, and chloroform. Direct detection of cerein BS229 activity on SDS-PAGE suggested that it had an apparent molecular mass of about 8.2kDa.