정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

골다공증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이남수,이상건,이상범,이상우,이선정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : As the average lifespan of human increases, osteoporosis and osteoporosis-related fractures have become major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis in general adults. This study examined the recognition of osteoporosis and analyzed the relating factors. Method : A population-based sample of 1086 adults in Asan-city, Korea was investigated with questionnaires and height, weight, Information regarding the general characteristics(gender, age, economic state), lifestylef exercise, smoking, alcohol),medical history(progestin, GH, steroid, calcitonin, PTH), demographic parameter, obesity, stress, and family history was collected through an interview using a structural questionnaire. The level of obesity was measured by the body mass index(BMI). BMD(Bone mineral density) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry. Osteoporosis was considered to be T-score below -2.5. Results : The prevalence of osteoporosis increased progressively with age, decreased with BMI and predominant in women by the result of x^(2) -test, T-test. Age, weight, BMI were significantly correlated with osteoporosis by the result of Pearson correlation ana1ysis(P<0.05). And age, gender, BMI, family history of osteoporosis were proved to be significant risk factors of osteoporosis by the result of multiple logistic regression(P<0.05). Conclusion : These results suggest that age, gender, BMI might be the most important risk factors of osteoporosis. And the history taking about family history of osteoporosis is helpful for diagnosing osteoporosis.

胸腹部癒合重複畸型兒의 1例

李起煥,柳友國,權善鎬,盧興泰 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

Conjoined twins are known to be very rare. A case of thoracoventropagus, aborted on the 20^th weeks gestation, is reported with brief review of the related literatures

알쯔하이머병 환자의 혈소판 아밀로이드 전구단백질 이상

이애영,조은경,김건익,김선국,손은희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Background:Although Alzheimer's disease (AD) is a progressive neurodegenerative disorder without any truly effective pharmacological treatment at present, early accurate diagnosis is important for the delaying of disease progression and proper management It would be desirable to have a peripheral biological marker to identify patients affected by AD Amyloid β-peptide originates from a larger precursor, the amyloid precursor protein (APP). which can be seen in the platelet of its equivalent to those found in brain. To investigate if there is a correlation between level of platelet APP isoform and AD, we evaluate a cohort of subjects including patients affected by sporadic AD, vascular dementia, and controls Subjects & Methods :Thirty-five patients with sporadic AD diagnosed according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Relatec Disorders criteria (NINCDS-ADRDA) and 26 vascular dementia patients diagnosed by the Diagnosis and Statistical Manual of Mental Disorders, Fouth Edition (DSM-Ⅳ) criteria and 12 controls were included Blood sample were drawn from fasting state and collected into 3 mL of 3.8% sodium citrate. Platelets were collected by centrifugation at 500 g for 20 minutes and washed. and the platelet pellet was stored at -80℃ until used APP was assessed by western blot analysis and quantified by densitometry using Image Analyzer Results:In platelets densitometer as well as the result of Western blot was higher compared with those of patients with non-Alzheimer dementia and controls We observed statistically significant reductions in the ratio of 120 kDa to 130 kDa APP to 110 kDa APP (APPr) for patients with probable AD compared with control subjects and patients with vascular dementia APPr levels in AD correlated with the severity of dementia measured by CDR. Accuracy levels measured by Receiver Operating Curve analysis showed that a cut-off level of 0.45 resulted in a sensitivity of 71% and a specificity of 74%, with an area under the curve of 0 793 Conclusion:Platelet APPr allowed to differentiate AD from normal aging and vascular dementia with high sensitivity and specificity These findings suggest that platelet APPr may be a helpful peripheral marker for diagnosis and clinical progression of Alzheimer disease.

진행성 위암에 동반된 위 칸디다증 1예

이두영,김성호,선제형,박진석,손존광,선홍주,이승,박찬국 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Gastric candidiasis is an uncommon disorder. It is an opportunistic pathogen in immune compromised individuals, alcoholics, persons treated with broad-spectrum antibiotics, immunosuppressive and chemotherapeutic agents. Besides, the use of drugs that reduce the gastric acid production may be a cause of gastric candidiasis. We experienced a case of gastric candidiasis following advanced gastric adenocarcinoma. A 85-year-old woman was admitted to our hospital because of epigastric soreness. Endoscopic findings revealed a large ulcero-infiltrating mass with yellow exudate at cardia of the stomach, which suggested an advanced gastric cancer. Endoscopic biopsy revealed spores and pseudohyphae infiltrating through the ulcerated stomach wall, diffuse infiltration of tumor cells and abortive tumor glands. After treatment with fluconazole 100 mg daily for 21 days, no evidence of the gastric candidiasis was seen on endoscopic biopsy and pathologic findings. The case is herein reported of gastric candidiasis following advanced gastric adenocarcinoma along with a review of corresponding literature.

쇼트피닝가공한 평기어의 최적 피닝강도 탐색에 관한 연구

이동선,이국진,김태형,정성균 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The shot peening process is often used to improve fatigue properties of metal parts. Among them, It is the most use in an auto-component. In order to achieve optimum, repeatable and reliable fatigue enhancement from the shot peening process, the important shot peening parameters must be controlled. In this paper, the optimum peening intensity (Almen intensity) condition is investigated by experiment..The Spur Gear steel was used to investigate shot peening effects. The fatigue life at σ_(a)=1,050 and σ_(a)=1,250MPa first gently increases, then drops gently as peening intensity increases compared with unpeened specimen. Experimental results show that the optimum peening intensity range is 0.391~0.434mmA..So the fatigue strength and fatigue life have been tremendously increased by optimum-peening treatment. However, the fatigue strength and fatigue life have been decreased by over peeing.

쇼트피닝 가공에 의한 자동차용 Drive Plate의 내구성 향상

이국진,이동선,이재헌,정성균 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The effects of shot peening on the fatigue strength of SK-5M steel is investigated by experiment. The shot peening process is investigated optimum peening condition by changing impeller speed and exposure time. Bending fatigue test is accomplished to investigate the effect of optimum peening condition on the fatigue characteristics. As exposure time is increased, fatigue life in high stress is increased in early stage, become the maximum from 60 to 100 seconds, and then is decreased. Observing fracture surface through SEM after fatigue test, we can see clear configuration of cracks and peening layer.

PQ 처리된 다운증후군 세포에서의 산소대사이상에 대한 항산하적반응의 증가

김선미,문영준,정성국,강윤성,이광호 中央大學校 基礎科學硏究所 1999 基礎科學硏究所 論文集 Vol.13 No.-

To assess an involvement of oxygen free radicals, especially O₂, in the genesis and the increased chromosome damage of the cell lines with Down's syndrome(DS), the level of superoxide dismutase(SOD) activity and chromosome aberration(CA) and sister chromatid exchange(SCE) frequencies were examined in lymphoblastoid cell lines(LCLs) derived from DS, which exposed to paraquat(PQ), an intracellular O₂generator. DS cells, which have been known to have the elevated level of enzymes such as SOD and glutathione peroxidase(GPX) capable of scavenging oxygen free radicals, were found to show a somewhat different mode from control cells in preventing themselves from genotoxicity by PQ-induced perturbation of oxygen metabolism. PQ induced a dose-dependent increase of CA and SCE frequencies in both control and DS LCLs, but PQ at a very high concentration induced a decrease rather than a increase of CuZnSOD activity in control LCLs whereas DS LCLs showed a marked increase of CuZnSOD activity in the same concentration, and the level of CA and SCE induction by PQ was lower in DS LCLs than in controls. Also, SOD induced by external not by the enzymatic response of cells to the increased level of O₂served as a substrate showed a severe inhibitory action to growth kinetics of PQ-exposed control LCLs, but little PQ-induced inhibition of the growth kinetics in DS LCLs. Considering that 3-amino-1H-1,2,4-triazole(AT) capable of inhibiting the activity of catalase(CAT) was effective in CA induction in DS LCLs but not in control and diethyl maleate(DM) assigned to inhibit the activity of GPX induced the marked increase of CA frequency in both control and DS LCLs, we suggest that DS cells could play a protective role against genotoxicity by H₂O₂using both CAT and GPX whereas control cells could do such an action only with GPX. In addition, DM and diethyldithiocarbamate(DC), an SOD inhibitor, appeared to be closely associated with the induction of SCE and CA, respectively. H₂O₂and O₂might, therefore, be causative factors responsible for the formation of SCE and CA, respectively. These findings imply that an excess of O₂due to an altered oxygen metabolism in DS cells may lead to the enhanced chromosome damages in these cells with genetic disorders and may be at least partly responsible for the genesis of DS.

활성탄의 급여가 젖소 송아지의 성장 및 배설물의 Ammonia 함량에 미치는 영향

유선일,박덕섭,명윤아,이인덕,남명수,김용국 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

This study was carried out to investigate the influences of feed containing activated charcoal on the performances of calves The daily weight gain, feed intake, feed requirement and the content of ammonia in the excreta were measured. The experiment was conducted with 10 male calves for 30 days. Each were equally divided with treatment group and control group and for the treatment group's animal fed diets containing 1.0% activated charcoal. The daily weight gain of calves were decreased by 1.92% when they were fed activated charcoal(1.02㎏/day) compared to that of control calves(1.04㎏/day) and the daily feed intake of treatment group(2.86㎏/day) was 10.06% lower comparing to the control group(3.18㎏/day). In case of feed requirement, the result showed 8.2% lower in the treatment group(2.80㎏) than control group(3.06㎏). The content of ammonia in excreta was significantly lower for treatment group(0.33ppm) than control group (2.67ppm)(p<0.05), which showed more improvement for reducing ammonia content in the treatment group with 87.6%(p<0.05). 본 연구는 사료에 활성탄을 첨가했을 때 송아지의 일당 증체량, 사료 섭취량, 사료 요구율 및 배설물의 ammonia 함량에 미치는 영향을 규명하기위해 실시하였다. 홀스타인 수송아지 10두를 30일 동안 대조구, 시험구(활성탄 1%첨가)로 각5두 공시하여 시험하였으며, 실험 결과를 요약하면 다음과 같다. 송아지의 일당 증체량은 대조구(1.04kg/일)에 비하여 활성탄을 급여했을 때(l.02kg/일) 1.92% 감소하였고, 일당 사료 섭취량은 시험구(2.86kg/일)가 대조구(3.18kg/일)에 비해서 10.06% 낮았으나, 사료 요구율은 대조구(3.06kg/kg증체)에 비해 시험구(2.80kg/kg증체)에서 8.2% 낮은 결과를 나타내었다. 송아지 배설물의 ammonia 함량은 대조구의 2.67ppm에 비하여 시험구가 0.33ppm으로 87.6% 감소되는 개선효과를 보였다(p<0.05).

乳酸菌에 의한 돼지설사 원인균의 生育沮害

姜國熙,成文喜,李仁善,申鉉靖 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

E. coli A_2 and G_7 occurring bacterial diarrhea of pigs were inoculated with 10^5/ml into thioglycollate medium without indicator-135C, and then Str. faecium and Str. faecalis var. liquefaciens were inoculated with 10^5/ml and 10^7/ml into previous inoculated samples of E. coli A_2 and G_7. Inoculated samples cultured at 37℃, were tested to determine changes in viable numbers of organisms and pH. The experimental results are summerized as follows: 1. In the mixed culture medium of 10^5/ml E. coli and 10^5/ml Streptococci, E. coli decreased after 8 hours from incubation, and finally decreased to 10^1/ml after 48 hours. 2. In the mixed culture medium of 10^5/ml E. coli and 10^7/ml Streptococci, E. coli drastically decreased, were not disappeared after 36 hours. 3. The pH value of the pure culture of E. coli was 5.30 and in the mixed culture of E. coli and Streptococci the pH value was 4.49-4.80 after 8 hours from incubation.