2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

거주 형태에 따른 에너지 섭취량과 소비량의 균형도 조사

박순목,고성경,남인수,윤재만,임승현,전중기,이종삼 대구대학교 인문과학연구소 2008 人文科學硏究 Vol.31 No.-

We investigated that the effects of residential type on energy balance in college students. Total sixteen college students were participated in this study, all subjects were assigned one of three groups: either school attendee students group, self-governed living students group, dormitory students group. Routine physical activity level (for 5 days including three weekday and two weekend) and food intake were surveyed. For investigation of degree of physical activity, all subjects were requested to record on their physical movements as possible as detail should be obtained. To all subjects, five-day dietary log form was given, and used for examining of calorie intake from their routine diet. There was no statistical difference in energy intake and consumption in each. However energy consumption was significantly higher than energy uptake in school attendee students group. All other groups were shown a similar energy values between energy uptake and consumption. There were no significant differences in energy intake and consumption in any of experimental groups when comparisons were made between weekdays and weekend. As far as energy uptake was concerned it was no statistical difference in any of major nutrients among groups. In conclusion, partial imbalance was found between energy intake and uptake in school attendee groups. This may be due to their more active life style than other groups'. In future studies, better controlled study should be performed not only more subjects are recruited but also minor nutrients are included for examining of energy balance.

남자 고등학교 세팍타크로 경기의 공격기술에 관한 분석 연구

김영호,고문석,제임스전,이영익,차정훈,현종건,김범수,임종만,이석인 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This research aims at analysis of attack technique in sepaktakraw games. For this purpose, 3 high school coaches observed and recorded each game Five times in videos of high school male players' thirty games in 2003. The conclusion from the analysis of the recorded data are as follows. 1. Scissors spike was the most popular (favorite) attack technique. Rolling spike, tapping spike and heading spike was popular in order. 2. Heading spike showed the highest success rate (73.5%) in attack technique. And tapping spike (69.5%), scissors spike (57.8%) and rolling spike (67.11) showed a lower success rate in order. In failure rate, heading spike (5.5%), tapping spike (36.5%), scissors spike (32.2%) and rolling spike (32.9%) had a higher percentage in order. 3. When receive was stable, the success rate in attach technique was 47.1%, the failure rate was 20.1%. On the other hand, when receive was unstable, the success rate in attach technique was 16.5%, the failure rate was 14.3%.

형광직접접합법에 의한 인간정자의 연령별 염색체이상에 관한 연구

이숙환(Sook Hwan Lee),윤태기(Tae Ki Yoon),차광열(Kwang Yul Cha),곽인평(In Pyung Kwak),이재호(Jae Ho Lee),엄기봉(Ki Boong Oum),손지은(Jie Ohn Shon),고정재(Jung Jae Ko) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2

Determmation of the chomosomal constitution of human spermatozoa has been camed out though the human-hamster interspecific in vitro fertilization(IVF) system. In recent years, the introduction of fluorescence in-situ hybridization(FISH) technique has provided an alternative approach to evaluate the cbmmosomal constitution of human spermatozoa. The nuclei of mature spermatozoa are highly condensed with interpmtamine disulphide bridges, therefore the success of FISH on interphase human spermatozoa relies on partial decondensation of the sperm chromatin. In early studies, dithioothreitol(DTT) has been known as an efficient decondensation agent. Since then, several different decondensation methods using D1T have been establisdhed, and in terms of decondensation, we were tried to fix the optimal decondensation protocol using DlT. In our study, the optimal concentration and treatment time were 1-mM and 30 min, respectively. We examined chromosome complements of human sperm to investigate the effect of paternal age on the hequency of nondisjunction in human sperm. We investgated sperm karyotypes ftom two diffaent age groups)28+-0.5, 46+-6), A minimum of 1000 spermatozoa for one patient were analyzed. The mean frequencies of YY, XX, XY, 21-disamy spermatozoa ware 0.04%, 0.45%, 0.40%, 0.45% respectively in young age group and 1.06%, 0.62%, 1.06%, 0.76% in old ages. The mean frequency of disomy spermatozoa was higher in old age poup compare with those of young age group.

The Identification of Binding Mode for Arabidopsis thaliana 7-Keto-8-aminopelargonic Acid Synthase (AtKAPAS) Inhibitors

Cho, Jae-Eun,Kang, Sun-Young,Choi, Jung-Sup,Ko, Young-Kwan,Hwang, In-Taek,Kang, Nam-Sook Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5

In this study, we determined the 3D-structure of Arabidopsis thaliana KAPAS by homology modeling. We then investigated the binding mode of compounds obtained from in-house library using computational docking methods. From the flexible docking study, we achieved high dock scores for the active compounds denoted in this study as compound $\mathbf{3}$ and compound $\mathbf{4}$. Thus, we highlight the flexibility of specific residues, Lys 312 and Phe 172, when used in active sites.

An unusual abscess formation in the masticator space after acupressure massage: a case report

In-Chan Ko,Kyu-Ho Yoon,Kwan-Soo Park,Jeong-Kwon Cheong,Jung-Ho Bae,Kwon-Woo Lee,Young-Jai Chin 대한구강악안면외과학회 2015 대한구강악안면외과학회지 Vol.41 No.1

Clinical features of masticator-space abscess (MSA) are very similar to those of parotitis or temporomandibular disorder (TMD), making early differ- ential diagnosis difficult. Local causes of MSA include nerve block anesthesia, infection after tooth extraction, and trauma to the temporomandibular joint (TMJ); the systemic cause is immunodeficiency. Odontogenic causes account for most etiologies, but there are also unusual causes of MSA. A 66-year-old male patient visited the emergency room (ER) presenting with left-side TMJ pain three days after receiving an acupressure massage. He was tentatively diagnosed with conventional post-trauma TMD and discharged with medication. However, the patient returned to the ER with in- creased pain. At this time, his TMD diagnosis was confirmed. He made a third visit to the ER during which facial computed tomographic (CT) images were taken. CT readings identified an abscess or hematoma in the left masticator space. After hospitalizing the patient, needle aspiration confirmed pus in the infratemporal and temporal fossa. Antibiotics were administered, and the abscess was drained through an incision made by the attending physician. The patient’s symptoms decreased, and he was discharged.

In-situ fabrication of TiC-Fe₃Al cermet

Kim, Yong-In,Seok An, Gye,Lee, Wonsik,Man Jang, Jin,Park, Bong-Geun,Jung, Yeon-Gil,Choi, Sung-Churl,Ko, Se-Hyun Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.8

<P><B>Abstract</B></P> <P>Titanium carbide has high hardness, resistance to oxidation and abrasion while iron aluminide has proper ductility as well as good strength and excellent oxidation resistance up to high temperatures. Therefore, it can be expected TiC-iron aluminide cermet to have excellent mechanical properties as a cutting tool and a wear-resistance material. In this study, mechanical milling and hot press sintering processes were used to manufacture in-situ TiC-Fe<SUB>3</SUB>Al cermet, whose microstructure and mechanical properties were examined according to the changes in volume fraction of TiC and milling time. After 48h of milling each mechanically alloyed powder crystallized in a TiC and Fe<SUB>3</SUB>Al biphasic material. The milled powder was hot-pressed at 1250℃ and 50MPa for 30min to obtain sintered bodies also consisting of only TiC and Fe<SUB>3</SUB>Al phases. The hard phase, TiC, had a size of 100–300nm with overall uniform distribution decreasing as the volume fraction of TiC increased. The hardness of each sintered body showed a linearly increasing tendency according to the increase in TiC content, the hardness for 90vol% TiC cermet being as high as 1813Hv. On the other hand, the bending strength was 1800MPa and 1780MPa when TiC volume fraction was 50% and 70%, respectively, while it showed an abrupt decrease up to 580MPa at 90% TiC volume fraction. Fe<SUB>3</SUB>Al phase is effective to toughening of TiC-Fe<SUB>3</SUB>Al cermet and the volume fraction of Fe<SUB>3</SUB>Al phase significantly influences the bending strength of the cermet.</P>

임신부 뇨로부터 정제된 인간 상피세포 증식 인자 유사체의 in vitro bioassay 및 특성

박세철,전재현,남정현,권태종,고인영,유광현 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.4

벤조산흡착, 음이온 교환수지, 단일클론항체을 이용한 immunoaffinity chromatography를 통하여 임신부 뇨로부터 천연의 hEGF를 정제하였다. 정제된 hEGF는 μ Bonda C_18 column을 사용한 HPLC 분석을 통하여 4개의 fraction으로 분리가 가능하였으며 western blot과 double immunodiffusion 실험 결과, 각각의 fraction이 hEGF의 특성을 가진 유사체인 것을 알 수 있었다. 또한 hEGF 표준 물질과의 spiking 및 아미노산 분석 등을 통하여 두 번째 fraction이 nhEGF와 동일한 것으로 확인하였다. nhEGF 및 그 유사체의 생물학적 활성 비교를 위하여 NIH 3T3 세포주에서 5'-Brdu incorporation 측정을 위한 labelling 시간, 혈청 농도의 최적 조건을 결정하였다. NIH 3T3 세포주의 DNA 합성능은 0.2% FCS가 포함된 저혈청 배지에서 hEGF가 0.1~10 ng/ml 농도로 첨가하였을 때 증가하는 경향을 나타냈다. HPLC를 통하여 분리된 두번째 hEGF 유사체가 다른 유사체보다도 생물학적인 활성이 우수하였으며, rhEGF 표준물질과의 spiking 및 아미노산 서열 분석등을 통하여 nhEGF로 밝혀졌다. 임신부의 뇨의 hEGF 유사체 함량중 natural hEGF는 46%이었다. Natural human epidermal growth facto (nhEGF) was purified from pregnant human urine by benzoic acid adsorption, DEAE-Sepharose ion exchange, and immunoaffinity chromatography. The purified nhEGF was further separated into four fractions using Bondapak C_18 HPLC system. Following characterization by Western blot and double immunodiffusion, we found that each fraction corresponds to four derivatives of the nhEGF. For biological analysis of nhEGF, we optimized the labeling time and serum concentration for the incorporation of 5-bromo-2'-deoxy-uridine (BrdU), a non-radioactive alternative for [^3H]-thymidine uptake, into NIH 3T3 cells. The DNA synthesis of NIH 3T3 cells was gradually increased at the nhEGF concentrations between 0.1~10 ng/ml in the Dulbecco's Modified Eagles Medium (DMEM) containing 0.2% Fetal calf serum (FCS). When we assayed the biological activity of four fractions, the activity of the second fraction was superior to that of the others.

SHIELDING ANALYSIS OF DUAL PURPOSE CASKS FOR SPENT NUCLEAR FUEL UNDER NORMAL STORAGE CONDITIONS

Ko, Jae-Hun,Park, Jea-Ho,Jung, In-Soo,Lee, Gang-Uk,Baeg, Chang-Yeal,Kim, Tae-Man Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.4

Korea expects a shortage in storage capacity for spent fuels at reactor sites. Therefore, a need for more metal and/or concrete casks for storage systems is anticipated for either the reactor site or away from the reactor for interim storage. For the purpose of interim storage and transportation, a dual purpose metal cask that can load 21 spent fuel assemblies is being developed by Korea Radioactive Waste Management Corporation (KRMC) in Korea. At first the gamma and neutron flux for the design basis fuel were determined assuming in-core environment (the temperature, pressure, etc. of the moderator, boron, cladding, $UO_2$ pellets) in which the design basis fuel is loaded, as input data. The evaluation simulated burnup up to 45,000 MWD/MTU and decay during ten years of cooling using the SAS2H/OGIGEN-S module of the SCALE5.1 system. The results from the source term evaluation were used as input data for the final shielding evaluation utilizing the MCNP Code, which yielded the effective dose rate. The design of the cask is based on the safety requirements for normal storage conditions under 10 CFR Part 72. A radiation shielding analysis of the metal storage cask optimized for loading 21 design basis fuels was performed for two cases; one for a single cask and the other for a $2{\times}10$ cask array. For the single cask, dose rates at the external surface of the metal cask, 1m and 2m away from the cask surface, were evaluated. For the $2{\times}10$ cask array, dose rates at the center point of the array and at the center of the casks' height were evaluated. The results of the shielding analysis for the single cask show that dose rates were considerably higher at the lower side (from the bottom of the cask to the bottom of the neutron shielding) of the cask, at over 2mSv/hr at the external surface of the cask. However, this is not considered to be a significant issue since additional shielding will be installed at the storage facility. The shielding analysis results for the $2{\times}10$ cask array showed exponential decrease with distance off the sources. The controlled area boundary was calculated to be approximately 280m from the array, with a dose rate of 25mrem/yr. Actual dose rates within the controlled area boundary will be lower than 25mrem/yr, due to the decay of radioactivity of spent fuel in storage.

무릎관절의 등속성 근력에 관한 연구 : 단축성ㆍ신장성 수축을 중심으로

김정주,박진영,고인태 경희대학교 체육과학연구소 2000 體育學論文集 Vol.28 No.-

Seoul, Korea In compensation for the number of 14 male students in physical education major, the study abtained the fellowing conclusion that the result of measuring Isokinetic Strength was showed by the muscle measurement of muscle strength fellowing muscle contraction of knee joints eccentric and concentric contraction though Cybex NormTM. 1. Peak torque and % peak torque decreased in according to the increase from 60˚/sec to 180˚/sec at the angle of flexion and extension when having the eccentric and concentric contraction, and have also higher eccentric contraction than the concentric contraction when having the flexion and extension and have higher extension and the flexion. 2. In H/Q ratio, the angle's velocity increased in according to the addition from 60˚/sec to 180˚/sec when having the concentric contraction and had the similar tendency when having the eccentric cotraction. In H/Q ratio has a higher average eccentric contraction at the 60˚/sec of the angle's velocity and have also higher concentric contraction at the 180˚/sec of the angle's velocity 3. The average power and % average power increased in according to the addition from 60˚/sec to 180˚/sec at the angle's velocity of flexion and extension when having the concentric and eccentric contraction. and have also higher extension than flexion. In 60˚/sec of the angle's velocity, the average power and % average power have higher eccentric contraction than the concentric contraction. when having the flexion and have also higher concentric contraction when having the extension. In 180˚/sec of the angle's velocity, the average power and % average power have higher eccentric contraction than the concentric contraction and have also higher eccentric contraction when having the extension, 4. The total work and % total work decreased in according to the increase from 60˚/sec to 180˚/sec at the angle's velocity and concentric contraction. and have higher extension than the flexion. In 60˚/sec of the angle's velocity, total work and % total work have higher eccentric contraction than the concentric contraction when having the flexion, and have also higher eccentric contraction when having the flexion. In 180˚/sec of the angle's velocity, total work and %total work have higher eccentric contraction than the concentric contraction when having the flexion. and have also higher eccentric contraction when having the extension.