수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)

조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

취업 및 국가기술자격 취득 증진 방안 연구

이완영,백기영,김영환,장세봉 永同大學校 1997 硏究論叢 Vol.3 No.1

본 연구는 도시공학 전공 학생의 국가기술자격 취득 및 취업, 진학 등에 필수적으로 요구되는 도시공학 관련 기초지식을 연마하고 전공지식을 심화 교육함으로서 산·학·연 연계체계에 기초하여 도시공학 전공 학생의 취업증진을 도모하기 위한 종합적이고 구체적인 방안을 모색하고자 하는 것이다. 이를 위하여 본 연구에서는 사회수요에 부응하기 위한 기술교육의 강화, 국가기술자격 취득 제고, 현장실습제도 등 3가지 측면에서 취업증진을 위한 추진실적 및 문제점을 점검하고 이에 대한 향후 개선방안을 모색하고자 하였다. The purpose of this study is to search for the comprehensive and concrete methods of increasing the graduates' employment based on both fundamental and advanced knowledge concerned urban engineering major. For this , existing condition, problems and improvement of students employment are searched in 3 view points such as strengthening of technical education to follow the social demands, enhancement of acquisition of the national qualifying examination and making the best of the field training system.

이차원 LMS 알고리즘의 Systolic Array 구현

박완수,최훈,홍기섭,박봉수,배현덕 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

적응알고리듬의 VLSI 구현에 있어서 파이프라이닝이나 시스토릭과 같은 구조적 설계기법을 이용하여 알고리듬을 변환하는 것은 효과적이다. 알고리듬 변환은 z-변환 영역에서 연산의 규칙성과 반복성을 찾아 이루어 진다. 본 논문에서는 이차원 필터와 계수갱신 시스템을 시스토릭 구조로 설계하여 LMS의 확장 형태인 TDLMS을 STDLMS로 변환한다. 변화된 STDLMS를 이용 이차원 ALE를 Altera사의 Max-PlusII 상에서 구현하여 시뮬레이션을 통해 성능을 평가한다. 시뮬레이션 결과 salt-pepper 잡음과 가우시안 잡음에 오염된 화상을 ALE가 개선할 수 있음을 보였다. In VLSI realization of adaptive algorithm. it is necessary and efficient that the algorithm is transformed to structural one suitably using architectural design techniques such as pipelining or systolic array. These transform method use regular and recursive of operation of the algorithm on z-transform domain. In this paper, the TDLMS which is a extended version of LMS is transformed to STDLMS which has systolic array architecture in two dimensional filter and coefficients update system. The transformed STDLMS is applied for realization of two dimensional ALE. And the ALE performances are evaluated by Max-PlusII of Altera Co.. The simulation results show that the ALE enhances image data which were corrupted by salt-pepper noise and Gaussian noise.

도시공학 핵심과목의 심화교육 프로그램 개발에 관한 연구

이완영,백기영,김영환,장세봉 永同工科大學校 1996 硏究論叢 Vol.2 No.1

본 연구는 핵심과목 요목의 작성과 난이도별 문제은행의 지도과정, 핵심과목에 대한 자율학습 문제은행을 데이타베이스화하여 상시 활용화 추구, 교수와 학생의 상호 협동시스템에 의한 학습방법론 도출을 시도하였다. 시론적 성격에 한정되어 있긴 하나 본 연구는 협동시스템을 기반으로한 자율학습모형을 구축함으로써 학습과 교육효과 제고, 협동심과 선의의 경쟁을 매개로 하는 생활구현, 취업대비 등의 목표에 기여하는데 의의가 있다. This paper examines that drawing up a syllabus of core courses and an item pool classified by the degree of difficulty, and that inquiring practical use an databased item pool, and that proposing study method by cooperative system between students and professors. The result of this study is expected to contribute to studying, life, and taking up an occupation by constructing autonomous study model founded the cooperative system.

흰쥐 젖샘신경으로 투사하는 중추신경내 Oxytocin 신경로에 관한 연구

백상호,강기동,김은아,조경제,최완성,이봉희 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

재조합 Saccharomyces cerevisiae로부터 인체 리포코틴-Ⅰ의 분비 생산 및 정제

김병문,정봉현,이상기,박영훈,남수완 동의대학교 기초과학연구소 1996 基礎科學硏究論文集 Vol.6 No.1

Human lipocortin-I (LCI) is a calcium ion-dependent and phospholipid-binding protein which exhibits an anti-inflammatory activity by inhibiting phospholipase A₂ activity. In this study, the LCI gene containing its own terminator region was joined to GAL10 promoter-ppL (prepro-leader sequence of mating factor a). An ATG start codon of LCI gene was placed at downstream with KR endoprotease recognition site (Lys-Arg) of ppL. Recombinant S. cerevisiae harboring the LCI expression/secretion vector, pYGLPT5, was aerobically grown on a liquid YPDG medium at 30℃ for 72hrs. The whole cell and culture supernatant were separated after centrifugation, and the expressed LCI was analyzed by SDS-PAGE and western blotting methods. A majority fraction of the expressed LCI was found to be accumulated in the intracellular fraction, resulting in very low secretion efficiency of about 7.4%. About 500mg/ℓof LCI was extracellularly produced by the fed-batch culture employing the controlled-feeding of glucose and galactose. The secreted LCI was purified by ultrafiltration and hydroxylapatite column chromatography, and a purity of more than 99% was obtained.

카드뮴의 중추신경계 독성유발 기전

이종화,장봉기,박종안,박종영,김완종,우기민 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3

Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system the mechanism of toxicity is not well understood The present study has investigated the effect of cadmium on oxidative stress, Na+/K- ATPase activity and the aggregation of amyloid beta peptide(β-amylotd) in neuronal cell Ime, HT22 cell LC_(5) and LC_(50) of cadmium for HT22 cell resulted from MTT assay was 4 1 μM and 9 5 μM, respectively Cadmium(2 to 8 μM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione Cadmium 4 μM showed a significant decrease in Na^(-)/K^(+) ATPase activity as compared with control group The aggregation of P-amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 μM cadmium These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na^(-)/K^(+) ATPase activity.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

하계 실내 및 실외환경의 공기 중 휘발성 유기화합물 농도 및 개인노출

양원호,손부순,박종안,장봉기,박완모,김윤신,어수미,윤중섭,류인철 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9

Volatile organic compounds (VOCs) are present in essentially all natural and synthetic materials from petrol to flowers. In this study, indoor and outdoor VOCs concentrations of houses, offices and internet-cafes were measured and compared simultaneously with personal exposures of each 50 participants in Asan and Seoul, respectively. Also, factors that influence personal VOCs exposure were statistically analyzed using questionnaires in relation to house characteristics, time activities, and health effects. All VOCs concentrations were measured by OVM passive samplers (3M) and analyzed with GC/MS. Target pollutants among VOCs were Toluene, o-Xylene, m/p-Xylene, Ethylbenzene, MIBK, n-Octane, Styrene, Trichloroethylene, and 1,2-Dichlorobenzene. Indoor and outdoor VOCs concentrations measured in Seoul were significantly higher than those in Asan except Ethylbenzene. Residential indoor/outdoor (I/O) ratios for all target compounds ranged from 0.94 to 1.51 and I/O ratios of Asan were a little higher than those of Seoul. Relationship between personal VOCs exposure, and indoor and outdoor VOCs concentrations suggested that time-activity pattern could affect the high exposure to air pollutant. Factors that influence indoor VOCs level and personal exposure with regard to house characteristics in houses were building age, inside smoking and house type. In addition insecticide and cosmetics interestingly affected the VOCs personal exposure. Higher exposure to VOCs might be caused to be exciting increase and memory reduction, considering the relationship between measured VOCs concentrations and questionnaire (p<0.05).

TFSCAN 검색 프로그램 TFSCAN의 개발

이병욱,박기정,김기봉,박완,박용하 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

TFD는 기능이 알려진 짧은 DNA sequence(signal)들과 그와 연관된 저널 자료로 구성된 데이타베이스이다. 임의의 DNA에서 이 데이타베이스의 sequence들을 검색하여 signal을 찾는 프로그램으로 Dan S. Prestridge가 개발한 SIGNAL SCAN이라는 프로그램이 사용되고 있는데, 이는 간단한 문자열 비교 알고리즘을 사용한다. 본 연구에서는 계산상 보다 효율적인 검색을 위해서, TFD의 sequence를 검색하기 위한 automata를 구성하는 프로그램과, 이 automata에 따라 signal을 검색하도록 하는 TFSCAN이라는 프로그램을 개발하였다. 검색된 signal에 대한 관련 문헌의 검색에서도 인덱싱 방법을 이용하여 계산 속도를 향상시켰다. 프로그램의 사용을 단순화시켰고, 결과 내용을 signal과 관련된 모든 정보를 일목요연하게 보여줄 수 있도록 구성하였다. 이 프로그램을 Web을 통해서도 사용할 수 있도록, GINet Web 서버에 TFSCAN 입력용 form과 CGI 프로그램을 개발·설치하였다. 본 연구의 특정 Motif 패턴으로 구성된 데이타베이스 검색에서, automata를 응용한 알고리즘을 이용하여 계산상 급격히 향상된 결과를 얻을 수 있음을 알 수 있었는데, 이는 생물학의 여러 패턴 검색에 응용될 수 있을 것이다. 더욱 민감한(sensitive) signal 검색을 위해서, 이와 같이 automata를 활용하고, 이 automata를 최적화하는 알고리즘 연구를 계속하고 있다. TFD is a transcription factor database which consists of short functional DNA sequences called as signals and their references. SIGNAL SCAN, developed by Dan S. Prestridge, is used to determine what signals of TFD may exist in a DNA sequence. This program searches TFD database by using a simple algorithm for character string comparison. We developed TFSCAN that aims at searching for signals in an input DNA sequence more efficently than SIGNAL SCAN. Our algorithms consist of two parts, one constructs an automata by scanning sequences of TFD, the other searches for signals through this automata. Searching for signal-related references is radically improved in time by using an indexing method. Usage of TFSCAN is very simple and its output is obvious. We developed and installed a TFSCAN input form and a CGI program in GINet Web server, to use TFSCAN. The algorithm applying automata showed drastical results in improvement of computing time. This approach may apply to recognizing several biological patterns. We have been developing our algorithm to optimize the automata and to search more sensitively for signals.