상염색체우성 다낭신의 임상경과 및 합병증

이상주,이영모,이한규,최대은,박기현,이강욱,신영태 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Autosomal dominant polycystic kidney disease(ADPKD) is one of most common hereditary disorder. It is potentially fatal and the major mobilities are hypertension and renal failure. To elucidate clinical characteristics and outcomes of ADPKD, 67 ADPKD patients were analyzed retrospectively. The male to female ratio was 48 years for males and 42 years for females. The factors leading to the dignosis of ADPKD were flank or abdominal pain (46%), palpable abdominal mass (24%), incidental findings (18%), gross hematuria and headache. Urinalysis result showed hematuria (31%), proteinuria (19%), pyuria (18%). Among renal complications hypertension (67%) was the most common. Other complications were urolithiasis (16%) upper urinary tract infection (9%), cyst infection (7%). Azotemia was observed in 24% of cases. Echocardiography showed left ventricular hypertrophy in 24% and valvular regurgitation in 18% of cases, but there was no mital valve prolapse. Cerebrovascular events occurred in 6 cases (2 cases of intervertebral hemorrhage and 4 cases of cerebral infarction). Hipatic cyst were observed in 64% of cases. Eighteen cases culminated in end stage renal failure (ESRF) at an of 47. According to this study, the most common complications of ADPKD was hypertension (67%), ESRF (27%), and cerebrovascular event (9%). Hypertension was more frequently observed in increased creatinine group than normal.

야생 설치류의 한타바이러스 감염에 대한 연구

백락주,송진원,송기준,박광숙,최영주,강주일,이용주 대한감염학회 1997 감염 Vol.29 No.6

목적:국내 야서중에 한타바이러스의 숙주는 등줄쥐와 집쥐로 알려져 있으나, 한국에 서식하고 있는 다양한 야생 설치류를 채집하여 한타바이러스에 대한 항체검사를 실시하여 새로운 혈청형의 한타바이러스가 있는지를 혈청학적으로 규명하고자 하였다. 방법:국내에 서식하고 있는 야생 설치류를 1995년 10월부터 1996년 10월까지 7종 551수의 야시와 4종 97수의 소형동물을 채집하여 한타바이러스에 대한 항체검사를 간접형광항체법으로 실시하였다. 결과: 1) 야서 7종 551수와 소형동물 4종 97수를 대상으로 한탄바이러스의 감염율은 등줄쥐 17.2%(29/162), 흰넓적다리붉은쥐 8.7%(2/23), 대륙밭쥐는 25%(2/8), 그리고 땃쥐는 7.1%(1/14)이었다. 그리고 야생토끼는 8.8%(7/80)가 서울바이러스에 대한 항체를 가지고 있었다. 등줄쥐의 양성혈청중 대부분은 서울바이러스와 일부는 푸말라바이러스, 프로스펙트힐바이러스, 뉴욕바이러스와도 교차반응이 있었다. 흰넓적다리붉은쥐 2수와 대륙밭쥐 2수는 5가지 한타바이러스 모두에 교차 반응이 있었다. 2) 다람쥐는 9.5%(28/283)가 채집지역에 관계없이 한탄바이러스에 대한 항체를 가지고 있었고 항체기는 1:16 내지 1:256으로 비교적 낮았으며 서울바이러스, 푸말라바이러스, 프로스켁트힐바이러스와 뉴욕바이러스에 각각 반응하는 것도 일부는 교차반응을 보이는것도 있다. 청설모는 10.3%(7/68)가 한탄바이서르에 대한 항체를 가지고 있었으며 항체가는 1:16 내지 1:1,024이었으며 일부는 교차반응이 있었다. 3) 야생토끼의 서울바이러스에대한 항체양성율은 8.8%(7/80)이었으며 이중에 2수는 한탄바이러스와 교차반응이 있었고, 푸말라바이러스, 프로스켁트힐바이러스, 뉴욕바이러스와는 교차반응이 없었다. 항체가는 1:16 내지 1:64로 비교적 낮았다. 결론:등줄쥐는 한탄바이러스에 의한 감염이지만 흰넓적다리붉은쥐, 대륙밭쥐, 다람쥐 그리고 청설모의 일부는 한탄바이러스가 보다 다른 한타바이러스에 대한 항체가가 높았고 특히 일부 다람쥐 혈청은 푸말라바이러스 혹은 프로스켁트힐바이러스에만 반응하였다. 그리고 야생토끼는 서울바이러스에 대한 감염율이 높은 것으로 보아 국내에 한탄바이러스와 서울 바이러스 이외에 새로운 혈청형의 한타바이러스가 있는 것을 사료된다. Background: Hantavirus are widley distributed in rodents populations even in geographical areas where hemorrhagic fever with renal syndrome(HFRS) has not been reported. Multiple species of Murid and Arvicolid rodents serve as the natural reserviors of hantaviruses. Serologic diagnosis using hantaviral antigens indicates that hantaviruses are widley distibuted in wild rodents. This study were designed to find the distribution of hantaviruses among wild rodents and small mammals in Korea, 1995-1996. Methods: Rodents were trapped alive in selected areas. A total of 551 wild rodents from 7 species and 97 small mammals from 4 species were captured in Korea. Serologic evidence for hantavirus infection were tested using five hantavirus antigens by indirect immunofluorescent antibody technique(IFA). Among 162 Apodemus agrarius, 23 Apodemus peninsulae, 8 Clethrionomys regulus, 6 Microtus fortis, 1 Mus musculus, 283 Tamias sibiricus, 68 Sciurus vulgaris, 14 Crocidura laciura, 80 Lepus sinensis, 2 Capereolus capereolus and 1 Nyctereutes procyonoides. Results: 29 A. agrarius, 2 A. peninsulae, 1 C. laciura, 2 C. regulus, 27 T. sibiricus and 7 S. vulgaris were sero positive agaist hantaan virus and 7 L. sinensis were IF antibody positive against Seoul virus. Some of Tamias sibiricus were only seropositive against puumala virus or prospect hill virus. Conclusion: This data suggests that new serotypes of hantavirus might distribute among rodents in Korea.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

재발성 일과성 허혈 발작을 주소로 내원한 비-안와-대뇌 모균증 1예

강우열,이주헌,성영희,최일수,송홍기,이병철 대한노인병학회 2002 대한노인병학회지 Vol.6 No.3

일부농촌지역의 농약사용실태 및 농약중독 요인 조사

이경민,송주희,장재혁,심수정,강양화,안재경,이숭호,박미영,정문호 대한보건협회 2002 대한보건연구 Vol.28 No.4

Object The usage of agricultural chemical is on the increasing. Use of pesticides has increased agricultural production. However, negative externalities from such use have increased too. Pesticide poisoning is a major public problem. The purpose if this study is to find out the relationship between keeping the safety rules or protective equipments or attending safety education or dose of pesticides use , and poisoning experience. Methods For Gu, H.M. and Pack, S.G. study , we obtained questionnaire data concerning pesticides poisoming. A person interviews on 203 were conducted in two villages in Sinmeari and woulbonri Chunchun , Kangwon province, July 2002. Result 1. 144 people(70.9%) have sprayed pesticides and the rata of experiences of pesticide poisoning was 26% among 144. Spraying time of pesticides was 1-2 hours in 63.9% of farmers. Rate of using the protective equipment was 25.7% (protective clothes), 49.3% (Mask), 48.6 (Gloves), 7.0 (Protective glasses), 64.6% (boots) respectively. 2. Chi-square and multiple logistic regression analysis showed that Duration of spraying per day (<2hr) and using of mask(protective equipment)are significantly association with poisoning experience.(x^2=5.2684 p=0.0217, CI=0.140-0.5853 OR=0.346 p=0.0211 respectively). But no association between poisoning experience and keeping safety rule, attending of safety education. 3. Spraying pesticides. Duration of spraying pesticides, reading manuals and no spraying at fatigue (keeping safety rule) are significantly association with symptom experience(x^2=14.0621 p=0.0002, x^2=7.0639 p=0.0079, CI01.395-10.950 OR=3.908 p=0.0095, CI=0.101-0.726 OR=0.271 0.0094 respectively). But no association between symptom experience and protective equipments, attending of safety education.

양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향

강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1

본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.

일제식민지 치하 경성부민의 도시적 감수성 형성과정 연구 : 1930년대 한국소설에 나타난 도시적 소비문화의 성립을 중심으로 Focusing on the Establishment of Urban Consuming Culture in the 1930's Korean novels

강심호,전우형,배주영,이정엽 서울시립대학교 부설 서울학연구소 2003 서울학연구 Vol.- No.21

In 1930's, capitalism gradually became established in Chosun. As Chosun's economy was incorporated into the global capitalistic system, the domestic economy became dependent on the international market. During this time, Kyeong-Seong was transformed into a capitalistic city. Various forms of modern facilities appeared, while urban consumerism constituted the city life. Thus, the everyday life in Kyeong-Seong demanded the acceptance of modern culture in order to adapt to the changing environment. Inside the city, people experienced modern civilization and urban consuming life, and came to adjust their form of living and their viewpoint of the world. This thesis examines the advertisement and text that appears in the newspapers, magazines, and other journalistic material of the thirties in order to determine how the commercials, romance, hobby or entertainment, and the newly discovered "pastoral" influenced the contemporary life and mind. Also, we intend to reveal how these factors took form in the contemporary literature. The contemporary Korean writers were inevitably surrounded by the popular and urban sensibility mentioned above. Even though unconsciously, or sometimes through negative criticism, this sensibility was included in their text. Even the nature that was considered to be a replacement of the desolate and inhuman city life was in fact a filtered form of nature - an image constructed by the popular culture and advertisements. Also, the romance described by the sensitive authors often took the form of a consumer love. Meanwhile, judging from the penetration of commercial statements which appears in several works, there was a growing desire to consume the image. Along with the newly adapted hobbies and leisure culture, the Korean life style went through a significant change, and so did the content of the contemporary novels. The urban sensibility formed in Kyeong-seong during the nineteen thirties can be defined as the common popular sensibility attained by people living in a capitalistic consuming culture. It is attitude of setting the commercial image as a model of life, and is the search of individual life in the standardized and uniform life style of the popular culture. Whether they chose to criticize it or saturate themselves in it, the contemporary writers were unavoidably related to this sensibility and life style.

구개편도에 발생한 결핵

이병돈,강주원,장혁순,박철규,김장묵 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Tonsillar tuberculosis, almost always secondary to pulmonary tuberculosis is very rare disease in otolaryngologic fields. Authors have experienced a case of tonsillar tuberculosis associated with miliary pulmonary tuberculosis. The patient had cough, sputum and sore throat for 1 month. On physical examinations, palatine tonsils were slightly hypertrophied, smoothly surfaced, but crypt ulceration or patches were not seen. Diffuse discrete nodules were seen in both lung fields by simple chest X-ray. In high resolution computed tomography, miliary tuberculosis was suspected and in pleural needle biopsy, granulomatous inflammaiton was diagnosed as tuberculosis. AFB smear of sputum was two positive. Histopatholoigic finding of right tonsil was consistent with tuberculosis. He was cured of it with antituberculosis medications for one year. We report the case with review of the literatures.

지상파 디지털 멀티미디어 방송 시스템을 위한 파이프라인 구조의 IFFT/FFT 모듈

이창훈,하주영,강봉순 東亞大學校附設 情報技術硏究所 2004 情報技術硏究所論文誌 Vol.12 No.1

In this paper, we propose an implementation result for Multi complex point pipelined IFFT/FFT(Inverse Fast Fourier Transform/Fast Fourier Transform) in terms of sequential data processing. We compared four types of IFFT/FFT modules for the hardware complexity and operation for IEEE 802.11a-1999. In order to minimize the error, we design the IFFT/FFT module to operate with additional decimal parts after butterfly operation. In case of the R22SDF(Radix-2 Single-path Delay Feedback), the IFFT/FFT module has low gate counts excluding RAMs and the minimized error rate as compared with other types. Therefore we choose the pipelined R22SDF architecture IFFT/FFT for DAB(Digital Audio Broadcasting) System.