3경간 중로식 아치교량의 풍하중에 대한 동적안전성

강성후,박선준,정철호 東新大學校 工業技術硏究所 2003 工業技術硏究 Vol.9 No.-

Recently, bridges have been momentous as not only regarding function but also concerning aesthetics. However, when beauty is considered in the design, it is also essential that stability and economics be considered. Moreover, when considering stability, an arch bridge is one of the most stable structures. The most important element is a rise ratio when regarding beauty and economics of arch bridges. Only the effect of dead load has been considered to decide the rise ratio. Therefore, in this study, when going over the rise ratio of 3-Span half through type arch bridges, I examined the problems, that the determination of the rise ratio by the dead load has, by adding the factor of a determination of optimum rise ratio, which is not only the effect of the dead load that has been currently considered but also the problem with respect to wind-resistant dynamic stability that is now taken seriously.

Use of a Balloon Catheter for Occlusion of Iatrogenic Direct Carotid-Cavernous Fistula Occurring during a Neurointerventional Procedure

Chul-Hoo Kang,Hong Jun Kim,Jay Chol Choi,Joong-Goo Kim 대한신경초음파학회 2022 대한신경초음파학회지 (JNN) Vol.14 No.1

Neurointerventional procedures involving the anterior circulation, including aneurysm coiling, mechanical thrombectomy (MT), and intracranial angioplasty, can result in rare life-threatening complications such as iatrogenic carotid-cavernous fistulas (CCFs). Here, we describe the successful use of a balloon catheter for the occlusion of an iatrogenic CCF during neurointerventional procedures in a 78-year-old woman. The patient underwent successful MT for right middle cerebral artery occlusion; however, her symptoms worsened the day after the procedure; therefore, intracranial stenting was planned. An iatrogenic CCF that occurred during the neurointerventional procedure was successfully occluded using a balloon catheter. Neurointerventionalists should be aware of iatrogenic CCFs and be prepared to treat this rare complication. The double-lumen balloon catheter may be a useful tool for the transarterial treatment of iatrogenic CCFs.

한국인 간세포암종 환자에서 간동맥화학색전술후 6개월 미만 조기사망군 과 24개월 이상 장기생존군 간의 비교

강인구,김성우,한성희,조승철,감창우,이동후 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2

목적 : 과거 15년간 간동맥화학색전술을 시행한 환자들을 대상으로 간동맥화학색전술 후 6개월 미만 생존의 조기 사망군, 6개월 이상 23개월 생존군, 24개월 이상 장기 생존 군간에 임상적 특징을 비교하여 그 결과로 추출된 임상지표 인자들의 생존 기간에 미치는 상호 상승적 영향력을 추구하였다. 대상과 방법 : 간세포암종으로 진단받고 간동맥화학색전술을 시행받은 뒤 생사 여부가 확인된 241명을 대상으로 후향적 분석을 실시하였다. 이들을 간동맥화학색전술 치료 후 6개월 미만 생존군, 6개월 이상 23개월 이하 생존군, 24개월 이상 생존군으로 분류하였다. 종양의 유형은 복부 초음파, 복부 전산화 단층촬영과 혈관조영술을 이용하여 결절형(nodular), 괴상형(massive), 미만형(diffuse)으로 나누고, 결절형은 단결절형과 다결절형으로 세분하였다. 간세포암종의 진단 기준은 간 조직검사에서 확진되었거나, 임상 검사에서 전이성 악성간종양을 배제할 수 있고 AFP의 증가 또는 복부 초음파상, 복부 전산화 단층촬영상, 간동맥 조영술에서 전형적인 양상을 보인 경우로 하였다. 간경변증의 진단은 임상소견과 영상진단 소견만으로 진단하였다. 결과 : 간세포암종 자체의 병기, 형태학적유형, 크기 그리고 Child-Pugh 등급 모두 간동맥화학색전술 후 생존 기간과 역상관성을 보였다. 연속 변수들인 간기능 수치 중 알부민 농도만이 장기 생존에 순기능을 보일 뿐 alkaline phosphatase, LDH, GGT, AST/ALT 비, AST와 종양의 크기와 병기진행도와 관련 깊은 AFP 농도 등도 역기능으로 작용하였다. 로짓 회귀분석에서도 남자, 흡연력, 음주벽, 복수 등이 조기 사망에 어느 정도 영향력이 있는 반면에, 다변량 분석 결과에서 나타난 것과 같이 TNM 분류에 따른 종양의 병기는 유의한 의미가 없고 오로지 종양 자체의 유형과 문정맥 혈전의 유무, 그리고 Child-Pugh 등급만이 간세포암종 환자들의 생존에 관한 상대위험도를 제시할 수 있었다. 혈중 알부민 농도가 높을수록 그리고 연령이 높을수록 생존기간이 상승적으로 길어졌다. 하지만 연령이 높더라도 혈중 알부민 농도가 낮으면 생존기간이 짧았다. 한편 알부민 농도는 낮을수록 AFP은 높을수록 생존기간이 짧아지는 경향을 보였다. 또한 혈중 알부민 농도는 높을수록 그리고 alkaline phosphatase가 낮을수록 생존기간이 길어졌다. 그리고 간세포암종의 병기가 초기일수록, 종괴의 크기가 작을수록 혈중 알부민 농도가 높아지면 생존기간이 길었다. 그러나 생존기간은 혈소판수가 높을수록 프로스롬빈 시간이 정상에 가까울수록 혈중 알부민 농도가 높아지면 생존기간이 길어졌다. 그렇지만 혈소판 수가 높거나 프로스롬빈 시간이 정상에 가깝더라도, 혈중 알부민 농도가 낮으면 생존기간이 짧았다. 결론 : 간세포암종 환자들에 대한 간동맥화학색전술 후 조기 사망이냐 장기 생존이냐를 가늠하는 잣대로서 종양 자체의 유형과 문정맥 혈전의 유무, 그리고 환자의 잔여 간기능지표들을 상호 상승적으로 반영하는 Child-Pugh 등급 등이 중요하다. Background/Aim: Although hepatocellular carcinoma(HCC) shows poor prognosis, transcatheter hepatic arterial chemoembolization(TACE) can improve survival rate in some patient groups. This study investigated the synergy effect of the different clinical indices on the survival time in patients with HCC underwent TACE. Materials and Methods: A retrospective study of 241 patients with HCC who underwent TACE with a mixture of lipiodol, mitomycin-C and driamycin, alone or followed by gelfoam was conducted. Three different survival groups (A, less than 6 months; B, between between 6 and 23 months; and C, over 24 months) were compared. Results: Alkaline phosphatase was lowest in group C(p=0.0001). The longer the survival, the lower (p=0.027, p=0.007) the AST and AST/ALT ratio were. Albumin was higher (p=0.032), GGT and LDH were lower (p=0.003, p=0.002) in the long-term survival group. The long-term survival group revealed an absence of both ascites(p<0.002) and portal vein thrombosis(p<0.001), and lower TNM stage (P<0.0001). The single nodular type of HCC was more frequent (P<0.0001) and the size of tumor was smaller in the long-term survival group (P<0.0001). Child-Pugh class was lower in the long-term survival group (p=0.017). The higher serum albumin and elder age, the higher albumin and the lower alkaline phosphatase or alpha-fetoprotein, represented synergic effects on a long term survival. The higher albumin and the smaller size or the lower tumor stage, the higher albumin and platelet revealed similar synergy effects. Although the age or platelet is high, low albumin showed poor prognosis. Conclusion: Patients with small-sized single, nodular HCC in a low Child-Pugh class without evidence of ascites and portal vein thrombosis, and the higher level of serum albumin but lower levels of alpha-fetoprotein, alkaline phosphatase, GGT, and LDH, can expect a long-term survival over 24 months by the treatment of TACE. There are meaningful synergies of the different clinical variables affecting the survival times in the patients with HCC undergoing TACE.(Korean J Hepatol 2002;8:189-200)

A Functional Polymorphism in CSF1R Gene Is a Novel Susceptibility Marker for Lung Cancer among Never-Smoking Females

Kang, Hyo-Gyoung,Lee, Shin Yup,Jeon, Hyo-Sung,Choi, Yi Young,Kim, Soyoun,Lee, Won Kee,Lee, Hyun Chul,Choi, Jin Eun,Bae, Eun Young,Yoo, Seung Soo,Lee, Jaehee,Cha, Seung Ick,Kim, Chang Ho,Lee, Myung Hoo LIPPINCOTT WILLIAMS WILKINS 2014 JOURNAL OF THORACIC ONCOLOGY Vol.9 No.11

동적하중을 받는 콘크리트보의 파괴에너지 해석

姜聲厚,柳井善,孫官哲 東新大學校 工業技術硏究所 1994 工業技術硏究 Vol.1 No.-

In this study, after concrete cylinders were made on the condition of varying water-to-cement ratio, and cured 80 days compressive strength and splitting tensile strength were performed and modulus of elasticity is obtained. The fracture energy was obtained by acting three point bending on the 80cm in length. This test involved static loading test and dynamic loading test. In this work, the new interrelation of the material constants was obtained clearly and the property of the mixture was inspected, including the relation between the fracture energy and all kind of the material constants.

The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease

Lee, Kang Uk,Lee, Jung Hie,Lee, Dong Young,Youn, Jong Chul,Kim, Jeong Lan,Moon, Seok Woo,Kim, Bong-Jo,Ryu, Seung-Ho,Kim, Moon Doo,Lee, Chang-Uk,Lee, Nam-Jin,Chang, Sung Man,Kim, Young Hoon,Kim, Do Hoo Korean College of Neuropsychopharmacology 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2

<P><B>Objective</B></P><P>We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.</P><P><B>Methods</B></P><P>Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s <I>t</I>-test.</P><P><B>Results</B></P><P>At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (<I>p</I>=0.02 for MMSE-KC and <I>p</I>=0.03 for CERAD-K(N) WSS respectively).</P><P><B>Conclusion</B></P><P>Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.</P>

Magnesium sulfate 와 Ritodrine hydrochloride의 조기진통 억제효과 및 안정성에 대한 비교연구

박후철(Hoo Chul Park),왕중서(Joong Seo Wang),최은주(Eun Ju Choi),정지영(Ji Young Jeong),이동규(Dong Gyu Lee),박정석(Jeong Seok Park),강상대(Sang Dae Kang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10

목적: 조기진통 치료에 있어서 magnesium sulfate 와 ritodrine hydrochloride의 효과 및 안전성에 대하여 연구하였다. 방법: 1996년 7월 1일부터 1998년 12월 31일까지 만 2년 6개월 동안 마산 파티마병원 산부인과에 입원 가료한 120례의 조기진통 환자 중 magnesium sulfate를 투여했던 40례와 ritodrine hydrochloride를 투여했던 40례를 연구군으로 절대안정요법 및 수액요법만으로 치료했던 40례를 대조군으로 선정하여 효과 및 안전성에 대하여 비교 분석하였다. 결과: 1. 조기진통의 빈도는 6.0∼7.7%를 보였다. 2. 조기진통의 위험인자로는 조기양막파수, 중증 전자간증, 조산의 기왕력, 쌍태아임신, 전치태반, 태아기형, 자궁경관무력증, 태반조기박리, 자궁근종 순 이었으며, 뚜렷한 원인인자가 없는 경우가 28.6%를 차지하였다. 3. 임신지연기간은 magnesium sulfate로 치료했던 군은 14.95±11.98일, ritodrine으로 치료했던 군은 17.48±13.41일로 두 군간에 유의한 (p<0.05) 차이가 없었으나 대조군의 11.60±14.74일에 비해 두 군 모두에서 증가하였으며, 분만시기도 magnesium sulfate군은 35.10±2.81주, ritodrine군은 35.00±2.49주로 역시 두 군간의 유의한 (p<0.01) 차이는 없었으나, 대조군의 34.95±2.71주에 비해 두 군 모두에서 증가하였다. 4. 치료성적은 magnesium sulfate로 치료했던 군은 완전성공률 12.5%, 불완전성공률 35.0%로 총 성공률 47.5%였으며, ritodrine으로 치료했던 군은 완전성공률 7.5%, 불완전성공률 45.0%, 총 성공률 52.5%로 두 군간에는 유사하였으나 대조군에서는 완전성공률 2.5%, 불완전성공률 27.5%, 총 성공률 30%만을 보였다. 5. 부작용으로는 magnesium sulfate 투여군에서 홍조, 태아곤란증, 흉부 불편감, 태반조기박리 순이었으나, ritodrine 투여군에서는 산모의 빈맥, 현기증, 두통 순 이었으며, 전혀 부작용이 없는 경우는 magnesium sulfate군에서 75.0%로 ritodrine군의 7.5% 보다 현저히 많았다. 2차 약제 추가투여가 필요한 경우는 magnesium sulfate군과 ritodrine군이 각각 15.0%, 12.5%로 유사하였으나, 그 주원인은 magnesium sulfate군은 자궁수축이 조절되지 않는 경우가 대부분 이었지만, ritodrine군은 부작용이 심한 경우가 더 많았다. 6. Magnesium sulfate와 ritodrine 투여군 모두에서 혈압에는 별 영향을 미치질 않았는데 반해 (p<0.01), 맥박수에서는 magnesium sulfate 투여군에선 유의한 (p<0.05) 차이가 없었으나 ritodrine 투여 군에선 현저하게 (p<0.05) 증가하였다. 진통억제 후에, 혈당치는 두 군 모두에서 유의한 (p<0.01) 차이를 보이질 않았으나 혈액내 칼륨치와 칼슘이온은 각각 유의하게 (p<0.05, p<0.01) 감소하였다. 결론: magnesium sulfate 와 ritodrine hydrochloride의 안전성과 효과면에서 유의한 차이가 없었다. Objectives: The purpose of this study was to evaluate the efficacy and safety of magnesium sulfate and ritodrine hydrochloride in the management of preterm labor. Methods: This study was undertaken to assess the clinical efficacy & safety of magnesium sulfate and ritodrine hydrochloride on 120 patients admitted with preterm labor from Jul. 1, 1996 to Dec. 31, 1998. Results: 1. The incidence of preterm labor was showed 6.0∼7.7% of total number of delivery. 2. The risk factors of the preterm labor were premature rupture of membrane, severe preeclampsia, previous preterm delivery, twin pregnancy, placenta previa, fetal anomaly, incompetent cervix, placental abruption, and uterine myoma in order, but 28.6% of preterm labor had no apparent risk factors. 3. The days gained in uterus was not statistically different between the magnesium sulfate group and the ritodrine group (p<0.05) but longer in the two groups than the control group. And the delivery time was also not statistically different between the magnesium sulfate group and the ritodrine group (p<0.01) but significantly increased in the two groups than the control group. 4. The rate of complete and incomplete success was similar as 12.5% and 35% (total success rate 47.5%) in the magnesium sulfate group, 7.5% and 45% (total success rate 52.5%) in the ritodrine group but only 2.5% and 27.5% (total success rate 30%) was showed in the control group. 5. The side effects were much more in the ritodrine group than the magnesium sulfate group. The patients requiring second-line therapy were similar in the both groups but the main cause was uncontrolled uterine contraction in the magnesium sulfate group, and intolerable side effects in the ritodrine group. 6. The pulse rate was not statistically different in magnesium sulfate group but markedly increased in ritodrine group (p<0.05). After managements of preterm labor, the serum potassium and ionized calcium level was significantly decreased in the two groups (p<0.05, p<0.01). Conclusion: There was not significantly different efficacy and safety of magnesium sulfate and ritodrine hydrochloride in the management of preterm labor.

아치교량의 라이즈비에 따른 동적안정성

강성후(Kang Sung Hoo),박선준(Park Sun Joon),정철호(Jeong Chul Ho) 대한토목학회 2003 대한토목학회 학술대회 Vol.2003 No.10

서비스의 개념과 척도에 관한 연구

조현철,강석후 漢陽大學校 産業經營硏究所 1992 産業經營硏究 Vol.4 No.-

Doxorubicin plus Docetaxel as Neoadjuvant Treatment in Patients with Locally Advanced Carcinoma of the Breast

( Se Hoo Lee ),( Young Hyuck Im ),( Soon Il Lee ),( Jinny Park ),( Ho Young Kim ),( Jung Han Kim ),( Joon Oh Park ),( Ki Hyun Kim ),( Chul Won Jung ),( Young Suk Park ),( Won Ki Kang ),( Mark H. Lee ) 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10