크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

The Effects of Electronic Commerce on the Freight Transport Industry

Yang,Jung Ho 한국무역상무학회 2008 貿易商務硏究 Vol.40 No.-

This paper investigates changing business transaction under the e-commerce environment and their implications on freight transport industry with some case studies. It shows that an efficient and reliable delivery system is essential for e-commerce as business industries are faced with the stricter and more diversified demands of customer, In addition, many aspects of business practices such as small batch. customized production and just-in-time distribution in the e-commerce environment, in turn, bring about a number of changes in the volume and service patterns of freight transport. E-commerce requires longer transport distances and often higher delivery frequencies. It also entails to a certain extent a modal shift towards truck and air freight transport modes. On the on hand. the logistical requirements of e-commerce goods may stimulate greater complexity in existing supply chain management, causing higher costs. However it is true that the increased visibility of goods through more efficient information flow allows more efficient and effective transport management in the logistics system.

정상교하 아동의 두개안면부 성장에 관한 종적 연구

양규호,박창헌,손정수,김낙현,최남기,김선미,김기백,신혜성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

혼합치열기 정상교합 아동 24명(남:14명 여:10명 초진 시 평균 나이 9±1.3세, 평균 관찰 기간: 13±1.3개월)에 대한 성장량을 측정하여 기능적 교정장치의 순수 치료효과를 평가하는데 도움이 되기 위해 3회(5~8개월 간격) 촬영한 측모 두부 방사선 규격 사진에 대한 분석 결과 다음과 같은 결론을 얻었다. 1. 남아는 상악골은 전하방, 하악골은 전방성장하였고, 여아는 상하악골이 전하방 성장하였다(p<0.05). 2. 상하악골의 남녀간 차이에서 수평적 성장상태는 여아가 컸고(A point 여아: 2.39mm, 남아: 1.26mm, p<0.05), 수직적 성장상태는 유의한 차이가 없었다. 3. 상악 전치의 치축은 두개저에 대해서 순측 경사하였고(p<0.01) 하악 전치의 치축은 큰 변화가 없었다. The purpose of this study was to provide the reference data evaluating the treatment effect of orthopedic appliances. The skeletal and dental growth increments were measured in 24 normal mixed dentition children(boys: 14, girls: 10) by three serial lateral cephalograms: initial mean age: 9±1.3 years, mean observation period: 13±1.3 months, Cephalometric changes were analysed. The results were as follows: 1. In boys, the maxilla showed forward and downward growth pattern and the mandible showed forward growth pattern(p<0.05). In girls, the maxilla and mandible showed forward and downward growth pattern(p<0.05). 2. Horizontal growth of both maxilla and mandible in girls was superior to those in boys(A point: girls: 2.39mm, boys: 1.26mm, with p<0.05), whereas vertical growth of both maxilla and mandible in boys was similar to those in girls. 3. The change in tooth axis showed labioversion of upper incisor(p<0.01) and comparatively stable lower incisor position.

수종 치과용 복합레진의 가수분해

양규호,김정란 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.2

심미성 수복재로서 임상에서 널리 사용되는 복합레진은 구강내에서 장기간 유지되도록 하기 위하여 그 물성을 향상시킬 필요가 있다. 복합레진의 단점 중 하나로 낮은 마모 저항성을 들수 있으며, 이와 관련된 하나의 인자로 수복물의 표면하 분해(subsurface degradation)가 고려되고 있다. 본 연구에서는 알카리성 용액(0.1N NaOH)에 현재 임상에서 많이 이용되는 Clearfil APX (CL, Kuraray), Heliomolar (H, Vivadent), Surefil (S, Dentsply), Tetric Ceram (TC, Vivadent), TPH (Dentsply), Z100 (3M)의 6종의 복합레진을 보관하였을 때 각 제품의 분해저항성을 평가하고자 하였다. 각 제품당 3개의 시편을 제작하여 무게측정을 한 후 0.1N NaOH 용액에 저장하여 60℃에서 보관하였다. 2주후 제거하여 HCl로 중화, 세척 후 60℃에서 건조하였다. 무게손실, 분해층 깊이, Si 농도등을 기준으로 분해저항성을 평가하여 다음과 같은 결과를 얻었다. 1.각 제품의 무게손실량은 0.45~3.64% 까지 다양하며 Z100, TC, H, S, CL, TPH 순으로 많았다. 2.각 제품의 표면하 분해층 깊이는 제품마다 다양하며, 10.85~73.38㎛의 범위였고, H, Z100, S, TC, TPH, CL 순으로 깊었다. 3.각 제품으로부터 용출된 Si 양은 Z100군 2060ppm으로 가장 많고, H, TPH, CL, TC, S순으로 많았다. 4.무게손실량과 표면하 분해층 깊이사이에 높은 상관관계를 보였다.(r=0.81, p,0.05) 5.주사전자현미경하 관찰시 NaOH용액에 보관한 후 레진기질과 필러사이의 결합의 파괴를 관찰할 수 있었다. 주요어 : 복합레진, 표면하 분해, 알카리성 용액

직장인들의 생활체육 참여와 스트레스

양정옥,정지호 신라대학교 자연과학연구소 2002 自然科學論文集 Vol.10 No.-

This study is a comparative analysis of the stress differences between different age groups, and between exercise-participating and non-participating groups. The survey was done against 462 businessmen (male: 242, female: 220) in Busan. The results are as follows: 1.In comparison of the stress differences according to age in the psychological aspect, the highest stress score of 1.81 points was in the twenties, the second about 1.72~ 1.74 points in the thirties and forties, and the third about 1.67 points in the fifties. It was concluded that the intensity of stress increases as age decreases but there was no statistically significant difference(P>.01). In the physical aspect, the highest stress score of 1.78 points was in the twenties, and about 1.6 points in the thirties, forties and fifties. There was a statistically significant difference among these groups (P<.01). In the aspect of stress from job, the highest stress score of 1.85 points was in the twenties. The intensity of stress decreased as age increased but there was no statistically significant difference(p>.01). 2.In comparison of the stress difference between athletes and non-athletes, the athletes showed a statistically significant lower score of 1.55 compared to the non-athletes(1.88) in the psychological aspect (p<.001). In the physical aspect, the athletes showed a statistically significant lower score of 1.51 compared to the non-athletes(1.81) (p<.001). Also, in the aspect of stress from job, the athletes showed a statistically significant lower score of 1.66 compared to the non-athletes(1.98) (P<.001). In consideration of the results and discussion from above, in can be concluded that exercise is theoretically and empirically an appropriate means for stress-relief as exercise for more than 3 days a week requires spontaneous inner motive.

제올라이트(NaA형, NaX형)의 이온교환성에 관한 연구

정순희,김복련,금경호,서양곤,안주현 경상대학교 환경보전연구소 2001 環境保全硏究所報 Vol.9 No.-

A study has been made of the exchange of Ag^+, Li^+, and Ba^++, Ca^++, Sr^++ ion by using synthetic zeolite-13X and zeolite-NaA. The zeolite used in this work was supplied as beads by Aldrich Chemical Company, Inc., and the formula of unit cell is M_x/n[AlO₂)_x(SiO₂)_y]zH₂O. X-ray diffraction analysis and Fourier transform infrared spectroscopy indicated that the crystallinity of zeolites was retained though sodium ion in zeolite exchanged with the cation. The amount of ion exchanged was measured by the determining of the amount of cation remained in solution by Inductively coupled plasma, and surface area, adsorption isotherm, Ion exchange kinetics. The selectivity of ions was in the order Ag^+>Li^+>Sr^++>Ca^++>Ba^++.

유전자 알고리듬을 이용한 유한상태기 상태할당

양세양,김호중,백승수 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-

This paper presents an efficient search method for optimal state assignment of FSM's by Genetic Algorithm(GA). The GA operators, reproduction, crossover, and mutation, are effectively used to find the optimal binary codes with which the corresponding FSM could be implemented in minimal area. The effectiveness of the algorithm is demonstrated by extensive experimental results for a set of benchmark circuits. SAGA, our implementation of the algorithm, can be used to get optimal binary codes of FSM's realized in either multi-level or two-level. 본 논문에서는 유전자알고리듬에 의한 유한상태기의 최적 상태할당을 위한 효과적인 탐색 기법을 제안한다. 유전자알고리듬 연산자들, 재생산, 교환, 및 돌연변이를 적절히 사용하여 유한상태기가 최소한의 면적으로 구현 가능하도록 하는 최적 이진 코드를 찾을 수 있었다. 제안된 알고리듬의 효능은 벤치마크 회로를 이용한 심도있는 실험을 통하여 확인하였다. SAGA라고 명명된 본 논문에서 개발된 상태할당기는 다단회로나 이단회로로 유한상태기를 구현시에 최적의 이진 코드를 찾기 위하여 사용되어 질 수 있다.