C형 간염바이러스항체 검출을 위한3세대 효소면역측정 시약의 비교

이장혁,서순팔,기승정,송정원,신명근,신종희,양동욱,김세종 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.4

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

苦汁으로 부터 炭酸마그네슘과 酸化마그네슘의 最適合成條件에 關한 硏究

鄭東燻,辛宗根,申和雨 圓光大學校 1989 論文集 Vol.23 No.2

고즙과 탄산나트륨을 원료로 1)반응액의 온도, 2)반응액의 농도, 3)혼합비율(〔Bittern〕/〔Na₂CO₃〕), 4)작용시간 및 5)건조온도를 합성요인으로 하여 Box-Wilson 실험계획법에 의해 탄산마그네슘의 최적합성조건을 추구하고 그 중 우수제품에 대해 D.S.C.를 측정하여 이를 기준으로 하소시켜 산화마그네슘을 제조하여 용적시험, 제산도시험 및 광학현미경사진을 관찰한 결과 1. 탄산마그네슘의 최적합성조건의 범위는 ①반응액의 온도범위는 50∼70℃ ②반응액의 농도범위는 고즙은 37.3∼38.1%, 탄산나트륨은 9.9∼10.3%, ③혼합비율(〔Bittern〕/〔Na₂CO₃〕)의 범위는 1.485∼1.503, ④작용시간의 범위는 10∼12분, ⑤건조온도의 범위는 73∼83℃이다. 2. 시료탄산마그네슘의 D.S.C.측정결과 75℃정도에서 결정수의 이탈로 보이는 흡열Peak를 나타냈고, 290℃정도에서 구조수의 이탈로 생각되는 흡열Peak를 나타냈으며, 408℃정도에서 탄산깨스의 이탈로 생각되는 흡열Peak를 나타냈다. 3. 탄산마그네슘의 하소온도는 500∼600℃가 적당하겠으며, 용적시험결과는 모두 경질품이었고, 시판품보다 모두 용적시험치가 큰 결과를 나타냈다. 4. 제산도시험의 결과는 시판품의 제산능보다 모두 크며 광학현미경사진에 의한 관찰을 하였다. Optimal Synthesis Condition of Magnesium Carbonate were investigated from the viewpoint of bulkiness according to a randomized complete block design proposed by G.E.P. Box and K.B. Wilson. Bittern and Sodium Carbonate were utilized as reactants in order to prepare Magnesium Carbonate. It was found that optimum temperature range of reactant solutions was 50∼70℃ and the optimum concentration range of the reactant solutions was 37.3∼38.1%(Bittern), 9.9∼10.3%(Sodium Carbonate), on the viewpoint of bulkiness. The optimum mole ratio of Bittern to Sodium Carbonate was in the range of 1.485∼1.503and the optimum reacting time range was 10∼12minutes. The optimum drying temperature range was 73∼83℃. Magnesium Oxide comes two types of granules when prepared by calcination of Magnesium Carbonate. The outcome of D.S.C. indicated a desolvation of Magnesium Carbonate occurred at about 75℃. The dehydration of the compound ceased at about 290℃ and the decarboxylation ceased at about 408℃. The physical and chemical properties of Magnesium Oxide as medicine were studied by use of Volume Test, Optical microscopic photographs and Acid Consuming Capacity measurments.

전문가 시스템과 유한요소법에 의한 열간단조의 공정설계

정영철,이동근,박종진 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1

In general, a forging product is produced through buster, blocker and finisher processes. The blocker, a transient shape between the buster and the finisher, is to ease the metal flow in the finisher dies. In general, as the finisher shape becomes complicated, the blocker design becomes quite difficult. In the present study, an expert system is developed for the blocker die design of axisymmetric hot steel forging. It is a rule based system written in Fortran and AutoLISP, operating on a personal computer. In this paper, the major rules considered in the system are summarized and several blockers designed by the system are discussed with results of rigid viscoplastic finite element analysis.

밴드 불연속이 p^+ -Al_0.36Ga_0.64As/n^+ -Ga_0.51In_0.49P 이종접합 터널 다이오드의 터널 전류 밀도에 미치는 영향

정동근 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

The effect of the conduction band discontinuity of P^+-Al_0.36Ga_0.64As/n^+=Ga_0.51In_0.49P heterojunction on the tunnel current density is studies by the calculation of the tunnel current density across P^+-Al_0.36Ga_0.64As /n^+=Ga_0.51In_0.49P homojunctions and P^+-Al_0.36Ga_0.64As /n^+=Ga_0.51In_0.49P heterojunctions with and without the conduction band discontinuity ΔE_c. The calculation showed that the peak tunnel current density across the P^+-Al_0.36Ga_0.64As /n^+=Ga_0.51In_0.49P heterojunction with ΔE_c = 0.150 eV was 35% increased, at room temperature, compared with that of the P^+-Al_0.36Ga_0.64As /n^+-Ga_0.51In_0.49P heterojunction with ΔE_c =0.0 eV. The result of the calculation implies that, in addition to high doping levels on p- and n- sides of tunnel junctions, the condition band discontinuity also contributes to high tunnel currents across tunnel junctions.

수입각증후군에 의한 급성 복증 1례

정은욱,지삼룡,이영태,박지훈,김동기,제인수,채두근,박성재,박은택,이연재,이상혁,설상영,정정명 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Afferent loop syndrome is an uncommon complication of a gastrectomy and Billroth Ⅱ reconstruction. It may cause symtoms at any time from the first postoperative day to many years after the gastrectomy. Afferent loop syndrome is characterized by abdominal pain, vomiting and elevation of serum amylase. Thus, it is difficult to differentiate afferent loop syndrome from other cause of acute pancreatitis. However, the history of gastrectomy can be an important clue for diagnosing afferent loop syndrome. We experienced one case of chronic afferent loop syndrome with acute pancreatitis. After appropriate management, the abdominal pain disappeared and serum amylase level decreased. We report this case with a review of relevant literatures.

Carbachol에 의한 닭 췌조직내 nitric oxide synthase 활성 및 methylated arginine 함량변화

유세근,남석우,박승희,남태균,서동완,한정환,홍성렬,이향우 성균관대학교 약학연구소 1994 成均藥硏論文集 Vol.6 No.1

The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in chicken pancreatic tissues. Nitric oxide synthase (NOS) in the pancreatic tissues were Ca^2+-dependent form. Treatment of tissue with L-arginine (10 mM) or carbachol (10^-5 M) showed the increase of pancreatic exocrine secretion, but that of D-arginine (10 mM) did not. ^3H-citrulline formation, cyclic GMP level and methyl arginine contents in the homogenates of pancreatic tissues treated with carbachol were not affected. Although the action mechanism of NO in the pancreatic tissues remains unknown, NO apparently participates significantly in the overall control of pancreatic secretory function.

박판주조법으로 제조된 Zr계 벌크 비정질 합금의 미세파괴기구

이정구,이동근,이성학,김낙준,조경목,박익민 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.2

The mechanical property improvement of a strip-cast Zr-base bulk amorphous alloy was explained by clarifying fracture mechanisms. Effects of crystalline phase particles formed in the amorphous matrix during strip casting on strength, ductility, and fracture toughness were explored in detail by directly observing microfracture processes using an in situ loading stage installed inside a scanning electron microscope (SEM) chamber. The compressive and fracture toughness test results indicated that ductility, strength, and fracture toughness of the atrip-cast amorphous alloy were higher than those of the as-cast monolithic amorphous alloy, although the strip-cast alloy contained a considerable amount (4.5 vol. %) of hard, brittle crystalline particles. This improvement of mechanical properties in the strip-cast alloy could be plausibly explained by mechanisms of (1) blocking of crack propagation, (2) formation of multiple shear bands, and (3) crack deflection by crystalline particles. Such property improvement presents new applicability of the strip-cast amorphous alloy containing crystalline particles to structures and components requiring excellent fracture toughness.

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

하악골에 발생한 다발성 중심성 골종 : 증례보고 REPORT OF A CASE

전효상,이문희,정해송,이동근,김성곤,조병욱 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Osteomas are benign tumor composed of mature compact or cancellous bone. Generally, they are classified as peripheral(periosteal) osteoma and central(endosteal) osteoma by origin. Osteomas are essentially restricted to the craniofacial skeleton and are rarely diagnosed in other bones. Most jaw osteomas are detected in young adults and are generally asymptomatic, solitary lesion. The authors present a case of a endosteal osteoma of the mandible. The lesion was located beneath both the mandibular first premolars, about 2.5㎝×1.5㎝ size. Surgical excision of the lesion was performed and we obtained good result after operation.