Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

Listeria spp.의 분리와 특성에 관한 연구

배현주,이상명,이호원,황순호 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-

냉동상태로 유통되고 있는 식육점 우육과 수입육전문점 우육 및 도축장 유래 생우육에서 Listeriosis spp.를 분리하여 시료에 따른 균종별 검출율과 생화학적 성상을 확인하고 특히 listeriosis를 유발하는 L. monocytogenes에 대해서는 serotype과 항생제 감수성 시험을 실시하여 아래와 같은 결과를 얻었다. 1. 분리된 46주의 Listeria spp.는 모두 Catalase, Motility 양성이었다. 그리고, β -Hemolysis, CAMP test, 생화학시험 결과, 4균주는 L. monocytogenes, 40균주는 L. innocua로, 그리고 2균주는 L. welshimeri였으며, 시료 60건 中 46시료에서 Listeria spp.가 분리되어 68.3%의 검출율을 나타내었다. 2. Listeria spp.의 균종별 분리율은 L. innocua(8.7%), L. monocytogenes(86.95%), L. welishmeri(4.3%)의 순으로 나타났다. 시료에 따른 Listeria spp.의 균종별 분포는 수입 우육 25건 중 L. monocytogenes가 1주(4%), L. innocua가 13주(52%)로 분리되었고, 시판되고 있는 한우 25건 중 L. monocytogenes가 3주(12%), L. innocua가 20주(80%)분리되었고, 도축장 한우 10건 중 L. innocua가 7주(70%), L. welishmeri가 2주(20%)분리되었다. 3. 분리된 L. monocytogenes 4균주 모두 Stapylococcus aureus ATCC 25923와 Rhodococcus equi KCTC 9082에 양성반응을 나타내었고, L. monocytogenes 로 분리된 4균주의 혈청형은 serotype 1이 1주, Serotype 4가 3주로 나타났으나, 정확한 serovars는 알 수 없었다. 4. 분리된 L. monocytogenes 4주에 대한 항생제 감수성 시험에서 전 균주가 Ampicillin(AM), Cephalothin(CF), Chloramphenicol(C), Erythromycin(E), Gentamycin(GM), Kanamycin(K), Methicillin(Dp), Vancomycin(VA)에 감수성을 나타냈고, Clindamycin(CC) Polymycin(PB)에 대해서는 내성을 나타냈으며, Streptomycin(S)은 L. monocytogenes ATCC 19111 균주와 L. monocytogenes serotype 1에는 감수성을, 4에는 중정도감수성을 나타내었으며, Tetracycline(Te)는 L. monocytogenes ATCC 19111 균주에는 중정도감수성을, L. monocytogenes serotype 1과 4에는 감수성을 나타내었다. Listeria species isolated from specimens are 46 strains which positive to catalase and molility. After β-Hemolysis, CAMP test and boichemical tests, 4 strains are L.monocytogenes, 40 strains are L. innocua and 2 strains are L. welshimeri. Isolation rate of Listeria spp. was 68.3%. Isolation rate of Listeria spp. on samples are L. monocytogenes, 40 strains are L. monocytogenes(86.95%), L. innocua(8.7%) and L. welshimeri(4.3%). 4 L. monocytogenes strains isolated are positive on Stapylococcus aureus ATCC 25923 and Rhodococcus equi KCTC 9082. Serotype of isolated strains were serotype 1 and serotype 4. Antibiotics sensitivity of all L. monocytogenes isolated are sensitivity to Ampicillin(AM), Cephalothin(CF), Chloramphenicol(C), Erythromycin(E). Gentamycin(GM), Kanamycin(K), Methicillin(Dp), Vancomycin(VA) and of those are resistant to Clindamycin(CC) and Polymycin(PB). Streptomycin(S) is sensitivity to L. monocytogenes ATCC 19111, L. monocytogenes serotype 1 and is intermediate sensitive to L. monocytogenes serotype 4. Tetracycline(Te) is intermediate sensitive to L. monocytogenes ATCC 19111 and is sensitivity to L. monocytogenes serotype 1 and 4.

偏心荷重을 받는 基礎構造物의 安定性에 關한 信賴度 解析

裵主星,吳秉炫 全北大學校 1994 論文集 Vol.38 No.-

In the stability analysis of eccentrically loaded foundation, soil properties and loads involve many uncertainties so it is necessary to do stability analysis of foundation that considers the probabilistic properties of each variable. This study is performed to reliability analysis for bearing capacity and settlement of eccentrically loaded foundation by using Monte Carlo Simulation Method. To consider the uncertainty of variables, the soil properties and loads and eccentric length are assumed to be normal distribution random variables. Then it is performed to do sensitivity analysis which is involved to failure probability of bearing capacity and excess probability of allowable criteria of settlement according to varity of each variable. It is thought to be proper that the stability analysis of eccentrically loaded shallow foundation should be analyzed considering uncertainty of variables.

팽이 톱밥 人工栽培時 培地微生物相의 經時的인 密度變化

배태웅,文炳周,辛元敎,宋模烈,李鉉旭,曺東進 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

팽이 재배에 있어 가장 큰 문제 중의 하나는 雜菌에 대한 汚染, 특히 細菌에 의한 피해가 극심하므로 作業段階와 栽培過程 전반에 걸쳐 培地徵生物相의 經時的인 密度變化에 따른 雜菌의 培地內 流入時期를 조사하여 汚染菌의 發生消長을 알아보기 위해 現地農家에서 시험해 본 결과 接種후 培養室에서 菌絲培養을 시작한 5일후부터 細菌이 檢出되기 시작하여 菌긁기전까지 약 25일간 0.5∼3.1×10⁴cfu/g의 密度를 보였으나 經時的인 密度增加는 없었고, 菌絲培養이 끝난 뒤 菌긁기직후부터 細菌의 密度는 118.3×10⁴cfu/g으로 급격히 높아졌으며 子實體生育 기간동안에 시간이 경과함에 따라 密度가 현저하게 증가되는 경향을 나타냈다. 이는 培養室 안으로 흐르는 空氣를 통하여 甁內로 細菌이 流入되고 또한 菌긁기 직후 培地表面에 灌注하는 물과 加濕機에서 噴霧되는 물粒子가 細菌의 密度增加에 절대적으로 영향을 미치는 것으로 판단되므로 이때가 細菌性褐斑病菌에 感染되기 가장 용이한 시기로 생각된다. 眞菌은 菌긁기후 子實體生育 기간동안 1.17∼7.87×10⁴/g의 密度로서 菌絲培養 기간동안의 密度보다 다소 높게 檢出되었으나 대체로 經時的인 密度增加는 보이지 않았으며, 放線菌은 거의 검출되지 않거나 菌絲培養 후 5일째부터 다소 검출되기 시작했으나 밀도가 매우 낮았고 經時的으로도 증가되지 않았다. One of the most serious problem on the Enoki mushroom cultivation is the infection by pathogenicitic microorganisns, especially bacterial diseases causing serious economical losses in the mushroom production. It was carried out to find the tendency of the development of mushroom diseases by temporal changes and variation of the densities of media microflora through the cultivation periods and working stages in a mushroom farm. According to the results, several bacteria were detected from the fifth day after the inoculation and incubation of mycelium in the incubation room, and the density of bacterium was 0.5∼3.1×10⁴cfu/g media for 25 days before the inoculum-removing, although there was no increment of the density. Since the inoculum-removing after the spawn run, the density of bacterium was rapidly increased as 118.3×10⁴cfu/g media, and was significantly increased by time during the growth period of fruitbodies. It was hypothesized that it is the most suitable period for the pathogen infection because the bacterium might be introduced by the air in the incubation-room, and the increment of bacterium density might be affected by moisture supplied through watering or humidifier in the growing room after the inoculum-removing. Fungi were detected as the density as 1.17∼7.87×10⁴/g media and the density was slightly higher than that during the incubation period of hyphae, although there was no significant increment. Generally, the density of Actinomycetes was disregardfully low, or Actinomycetes were hardly ever found, although there was found some 5 days after incubation hyphae in few cases.

소방보호복과 119 구조복의 착의실태 분석

배현숙,김채련,이주영 창원대학교 생활과학연구소 1999 생활과학연구 Vol.3 No.-

The purpose of this study was to analysis on the clothing practice of fire fighter's protective clothing and 119 rescue clothing surveys of user's opinion and experiment on the physical properties of material. Firefighter's protective clothing should be required more flame-resistance, water-resistance, air permeability and reflectivity, 119 rescue clothing should be required more water-resistance, toughness and air permeability . Firefighter's protective clothing should be improved color, size, clothing weight, washability and clothing comfort.

웹을 이용한 회계정보의 공시와 과제

박무현,배주한 계명대학교 산업경영연구소 2000 經營經濟 Vol.33 No.2

Recent trends to disclose accounting information on the web require information systems that integrate accounting information and information technology. Korean companies do not provide material accounting and related information on a real-time basis while those in advanced countries do. This study reviews changes in information technology, and the web as an alternative means of disclosing financial information. First, effects of changes in information environments on the information network and on the discipline of accounting are reviewed. Second, a new system under developments in U.S.A. and in Korea, i.e., disclosure of accounting information on an intranet-web basis, are compared. Also discussed are limitations of the new system and solutions. In summary, disclosure of accounting information on the cyber space will become a part of accounting systems in the near future and active discussions about related issues are in order.

용접봉 제조 공장 근로자의 작업과 연관된 요통의 원인에 대한 조사

박주태,임현술,배성한 東國大學校醫學硏究所 1997 東國醫學 Vol.4 No.-

작업과 관련된 요통의 원인과 예방대책에 대하여 조사하고자, 포항시에 위치한 용접봉 제조 업체에 근무하는 297명의 남자 근로자를 대상으로 1993년 10월 15일, 10월 22일 2일간 설문조사를 실시하고, 악력 및 복근력을 측정하였다. 이들 중 과거에 요통을 경험하였거나 현재 요통이 있는 157명 중에서 작업과 관련된 요통이라고 의사가 판단한 104명을 환자군으로 요통을 경험한 적이 전혀 없다고 응답한 140명을 대조군으로 선정하여 다음과 같은 결과를 얻엇다. 1. 조사 대상 남자 근로자들의 작업과 관련된 요통의 유병률은 35.0%였다. 조사 대상 근로자들의 연령별 분포는 양 군간에 유의한 차이가 없었다. 결혼 상태는 환자군에서 기혼이 많앗다.(P<0.05). 교육 수준별 분포는 환자군에서 대조군에 비하여 유의하게 교육수준이 낮았다(P<0.01). 규칙적인 운동의 유무에 따른 비교에서는 양 군간에 유의한 차이가 없었다. 2. 조사 대상 근로자들의 신체적 특성을 살펴보면, 평균 신장, 평균 체중, 체질량지수, 좌우 악력은 양 군간에 유의하지 않았다. 복근력은 환자군에서 유의하게 약했다(P<0.05). 3. 조사 대상 근로자들을 고용 상태별로 비교해 보면, 근무 기간은 환자군에서 유의하게 길었다(P<0.01). 직종별 분포는 생산직이 환자군에서 유의하게 많았다(P<0.01). 부서별 분포는 환자군이 피복 용접봉, 플럭스 코어 와이어에서 대조군보다 유의하게 많았다(P<0.01). 직업 만족도에서는 자신의 직업에 만족하는 경우가 환자군엣6ㅓ 유의하게 만족하는 경우가 적었다(P<0.05). 4. 조사 대상 근로자들을 노동 행태 및 작업 환경별로 비교해 보면, 작업시 허리를 앞으로 구부리는 경우는 양 군에서 통계적으로 유의하지 않았다. 서서 일하는 경우, 무거운 물건을 들어올리거나 운반하는 동작을 하는 경우와 작업대와 의자가 자신의 신체 조건에 비하여 부적합하다고 응답한 경우가 환자군에서 대조군에 비하여 유의하게 많았다(P<0.01). 5. 작업과 관련된 요통의 원인으로 간주되는 위험요인에 대하여 이분변수화하여 로지스틱 회귀분석을 한 결과 근무기간과 무거운 물건을 들어올리거나 운반하는 동작을 하는 경우가 작업과 관련된 요통에 독립적으로 영향을 미치는 변수였다. 결론적으로 무거운 물건을 드는 작업 환경이 요통과 관련성이 높아 근로자의 요통을 예방하기 위하여 무거운 물건을 들어올리거나 운반하는 업무를 자동화하여야 하며, 무거운 물건을 운반할 때는 안전 수칙을 지키도록 교육이 강화되어야 한다. Work-related low back pain is one of the major cause of morbidity, disability, limitation of activity and economic loss. Therefore controlling the work-related low back pain is one of the major issue in the field of industrial safety and health. This study was performed for detecting the risk factors and proposing the effective control programs of work-related low back pain. The subjects were male workers employed at the welding and metal factory. The data was collected by self-reported questionnaire, interview and checking abdomen muscular and grasping power for two days on Octorber, 1993. The contents of questionnaire were as folows: the experience of low back pain, general characteristics, physical characteristics, employment status, type of work and working environment. The number of cases was 104 with a history of work-related low back pain, so the prevalence of work-related low back pain was 35.0%, and the number of controls was 140 without any history of low back pain. As a result, marital status, educational level, abdomen muscular power, tenures, category of job, satisfaction of job, working posture, satisfaction for table and chair and lifting materials showed a statistical significance between the case and control groups. And for the multivariate logistic regression analysis conformed that tenures and lifting heavy materials were independent risk factors for work-related low back pain. Therefore work-related low back pain should be prevented by the ergonomic and working environmental control.

대학급식의 미생물적 품질보증을 위한 HACCP의 적용 : 참치샐러드 Tuna Salad

김운주,최은희,최현미,배주희,채현숙 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.1

The purpose of this study was to evaluate the microbiological quality, and to assure the safety of the food production process in the university foodservice facilities in accordance with the Hazard Analysis Critical Control Point(HACCP) concepts. The kitchen layout and time-temperature relationship, miciobiological quality(total plate count, coliform) were assessed to identify the critical point during each of the production phases. The results were as follows: 1) The kitchen layout had to be improved because contamination area was not separated from non-contamination area, and work table was in contact with washing sink. 2) Some employee did not follow personal hygiene standards(hand washing), and did not wear proper working uniforms(hair restraints). 3) The production time of tuna salad was 120 min, and environment temperature was 20.1~26.0℃. Improper receiving temperature, inproper holding practices(without cover at room temperature) were observed. 4) In the purchasing phase of the raw materials, the microbiological quality of green pepper was not at acceptable level based on the TPC(2.3×10^6CFU/g)and coliform(>14,000 MPN/g). During washing phase TPC was decreased about 3 log cycle. After cutting and holding phase the level of TPC and coliform were increased rapidly. At serving phase the microbiological quality of tuna salad were not at acceptable level(TPC 3.3×10^6 CFU/g, coliform 11,000 MPN/g) according to the standard set(TPC <10^5 CFU/g, coliform <100 MPN/g) by Sorberg et al. 5) For tuna salad, critical control points were purchasing and receiving of fresh vegetables, washing, cutting, holding, mixing and serving phase.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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대전광역 시민의 골다공증 검진에 관한 고찰

유은주,이관우,박현모,이수배,김광현,강희구,박성오 한국건강관리협회 1999 건협 Report Vol.2 No.-