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Lee, Kyung Sun,Kim, So Ri,Park, Seoung Ju,Park, Hee Sun,Min, Kyung Hoon,Jin, Sun Mi,Lee, Moon Kyu,Kim, Uh Hyun,Lee, Yong Chul Elsevier 2006 The journal of allergy and clinical immunology Vol.118 No.1
<P><B>Background</B></P><P>Reactive oxygen species (ROSs) play a crucial role in the pathogenesis of airway inflammation. Peroxisome proliferator activated receptor (PPAR)-γ is also involved in airway inflammation. We have demonstrated that the administration of PPARγ agonists or adenovirus carrying PPARγ cDNA (AdPPARγ) reduced bronchial inflammation and airway hyperresponsiveness. However, the effects of PPARγ on ROS generation in conditions associated with airway inflammation have not been clarified.</P><P><B>Objective</B></P><P>This study aimed to investigate the effects of the PPARγ on ROS generation in allergic airway disease of mice.</P><P><B>Methods</B></P><P>We have used a female C57BL/6 mouse model for allergic airway disease to determine the role of PPARγ.</P><P><B>Results</B></P><P>In this study with an ovalbumin-induced murine model of allergic airway disease, the increased ROS generation and the increased expression of T<SUB>H</SUB>2 cell cytokines, adhesion molecules, chemokines, and vascular endothelial growth factor in lungs after ovalbumin inhalation were significantly reduced by the administration of PPARγ agonists or AdPPARγ. We also showed that the increased nuclear factor-κB and hypoxia-inducible factor 1α levels in nuclear protein extracts of lung tissues after ovalbumin inhalation were decreased by the administration of PPARγ agonists or AdPPARγ.</P><P><B>Conclusion</B></P><P>These results indicate that the effects of PPARγ are mediated by the modulation of ROS generation and activation of redox-sensitive transcription factor nuclear factor-κB and HIF-1α in allergic airway disease of mice.</P><P><B>Clinical implications</B></P><P>Thus, these findings provide a pivotal molecular mechanism for the use of PPARγ agonists to prevent and/or treat asthma and other airway inflammatory disorders.</P>
( Ju-ri Jeong ),( Su-jin Lee ),( Wan-hee Lee ) 물리치료재활과학회 2017 Physical therapy rehabilitation science Vol.6 No.1
Objective: The aim of this study was to investigate the inter-rater and intra-rater reliability of rehabilitative ultrasound imaging (RUSI) for measurement of muscle thickness with changes in angles of the gluteus maximus (GM) at rest and during contraction. Design: Cross-sectional study. Methods: Twenty-two healthy men volunteered for this study. GM muscle images were obtained in the resting position and during prone hip extension with knee flexion at hip abduction angles of 0° and 30°, respectively. Two examiners randomly measured the thickness of the GM twice in three different positions. The first position was a comfortable prone position. The second position was prone hip extension with knee flexion (PHEKF) to 90°. The third position was achieved by hanging a 1-kg weight on the ankle of the lifted leg during PHEKF with the angle of the lifted leg the same as the second position. Intra-class correlation coefficients (ICCs), standard error measurements, and minimal detectable changes were used to estimate reliability. Results: The intra-rater reliability ICCs (95% confidence interval) of the GM were >0.870, indicating good reliability. Inter-rater reliability ICCs ranged from 0.668 to 0.913. The reliability of measurements of muscle thickness at each position was similar to the reliability of the angle change. Differences in muscle thickness and ratios for each position with 0° and 30° of hip abduction were not statistically significant. Conclusions: In the present study, the intra-rater reliability of muscle thickness measurements of the GM was good, and the inter-rater reliability was moderate to good. Reliable RUSI measurements of wide and large muscles, such as the GM muscle at rest and during contraction, are feasible. Further investigation is required to establish the reproducibility of the protocols presented in this study.
Ju Ri Lee,Seung Wan Suh,Ji Won Han,Seonjeong Byun,Soon Jai Kwon,Kyoung Hwan Lee,Kyung Phil Kwak,Bong Jo Kim,김신겸,김정란,Tae Hui Kim,Seung-Ho Ryu,Seok Woo Moon,Joon Hyuk Park,Dong Woo Lee,Jong Chul Youn,D 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.8
Objective We investigated the impact of depressed mood (dysphoria) and loss of interest or pleasure (anhedonia)on the risk of dementia in cognitively-normal elderly individuals. Methods This study included 2,685 cognitively-normal elderly individuals who completed the baseline and 4-year follow-up assessments of the Korean Longitudinal Study on Cognitive Aging and Dementia. We ascertained the presence of dysphoria and anhedonia using the Mini International Neuropsychiatric Inventory. We defined subjective cognitive decline as the presence of subjective cognitive complaints without objective cognitive impairments. We analyzed the association of dysphoria and anhedonia with the risk of cognitive disorders using multinomial logistic regression analysis adjusted for age, sex, education, Cumulative Illness Rating Scale score, Apolipoprotein E genotype, and neuropsychological test performance. Results During the 4-year follow-up period, anhedonia was associated with an approximately twofold higher risk of mild cognitive impairment (OR=2.09, 95% CI=1.20–3.64, p=0.008) and fivefold higher risk of dementia (OR=5.07, 95% CI=1.44–17.92, p=0.012) but was not associated with the risk of subjective cognitive decline. In contrast, dysphoria was associated with an approximately twofold higher risk of subjective cognitive decline (OR=2.06, 95% CI=1.33–3.19, p=0.001) and 1.7-fold higher risk of mild cognitive impairment (OR=1.75, 95% CI=1.00–3.05, p=0.048) but was not associated with the risk of dementia. Conclusion Anhedonia, but not dysphoria, is a risk factor of dementia in cognitively-normal elderly individuals.
Lee, Yu-Ri,Song, Min-Sun,Lee, Kyung-Min,Kim, In-Young,Hwang, Seong-Ju The Korean Electrochemical Society 2011 Journal of electrochemical science and technology Vol.2 No.1
Nanocomposites of reduced graphene oxide and manganese (II,III) oxide can be synthesized by the freeze-drying process of the mixed colloidal suspension of graphene oxide and manganese oxide, and the subsequent heat-treatment. The calcined reduced graphene oxide-manganese (II,III) oxide nanocomposites are X-ray amorphous, suggesting the formation of homogeneous and disordered mixture without any phase separation. The reduction of graphene oxide to reduced graphene oxide upon the heat-treatment is evidenced by Fourier-transformed infrared spectroscopy. Field emission-scanning electronic microscopy and energy dispersive spectrometry clearly demonstrate the formation of porous structure by the house-of-cards type stacking of reduced graphene oxide nanosheets and the homogeneous distribution of manganese ions in the nanocomposites. According to Mn K-edge X-ray absorption spectroscopy, manganese ions in the calcined nanocomposites are stabilized in octahedral symmetry with mixed Mn oxidation state of Mn(II)/Mn(III). The present reduced graphene oxide-manganese oxide nanocomposites show characteristic pseudocapacitance behavior superior to the pristine manganese oxide, suggesting their applicability as electrode material for supercapacitors.
Ju-Ri Woo,Doo-Ho Choi,Muhammed Taofiq Hamza,Kyung-Oh Doh,Chang-Yoon Lee,Yeon-Sik Choo,Sangman Lee,Jong-Guk Kim,Heeyoun Bunch,Young-Bae Seu 한국균학회 2022 Mycobiology Vol.50 No.5
Regulation of proper gene expression is important for cellular and organismal survival, main- tenance, and growth. Abnormal gene expression, even for a single critical gene, can thwart cellular integrity and normal physiology to cause diseases, aging, and death. Therefore, gene expression profiling serves as a powerful tool to understand the pathology of diseases and to cure them. In this study, the difference in gene expression in Flammulina velutipes was compared between the wild type (WT) mushroom and the mutant one with clogging phe- nomenon. Differentially expressed transcripts were screened to identify the candidate genes responsible for the mutant phenotype using the DNA microarray analysis. A total of 88 genes including 60 upregulated and 28 downregulated genes were validated using the real- time quantitative PCR analysis. In addition, proteomic differences between the WT and mutant mushroom were analyzed using two–dimensional gel electrophoresis and matrix- assisted laser desorption/ionization-time of flight (MALDI-TOF). Interestingly, the genes iden- tified by these genomic and proteomic analyses were involved in stress response, transla- tion, and energy/sugar metabolism, including HSP70, elongation factor 2, and pyruvate kinase. Together, our data suggest that the aberrant expression of these genes attributes to the mutant clogging phenotype. We propose that these genes can be targeted to foster normal growth in F. velutipes.
Ju Ri Ham,Mi Ja Lee,Hyun-Jin Lee,Young-Jin Son,Hae-In Lee,Mi-Kyung Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The antidiabetic property of β-glucan is well known. This study investigated the hypoglycemic effects of β-glucan (BG, 500 mg/kg, oral) concentrated from betaone barley and its underlying mechanism by comparing with metformin (Met, 400 mg/kg, oral) in a high-fat diet and streptozotocin-induced diabetic mice. After six weeks, BG and Met significantly lowered fasting blood glucose, hepatic triglyceride and free fatty acid level, while they increased pancreas insulin expression compared to the control group. BG improved glucose and insulin intolerances in diabetic mice. BG and Met down-regulated hepatic genes expression of gluconeogenesis-related (PEPCK and G6Pase), lipid synthesis-related (PAP and DGAT2), and inflammation-related (NFκB, TNFα, and IL6), whereas they up-regulated fatty acid β-oxidation-related genes (PGC1α and Acsl1) levels compared to the control group. Thus, β-glucan of betaone barley effectively lowered blood glucose in diabetic mice and alleviated fatty liver and inflammatory response by mechanism similar to metformin. These results suggest beta-glucan of barlery could be used as a potential preventive agent against diabetes.