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조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성
김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.
인터넷상에서 페트리 넷을 이용한 하이퍼-프리젠테이션의 명시 표현 및 불일치성을 검증하기 위한 방법 연구
우시연,조종근,임영환,임기욱 한국정보처리학회 2002 정보처리논문지 Vol.9-b No.5
하이퍼-프리젠테이션 개념은 하이퍼-미디어 개념을 확장한 것으로, 동적으로 연출되고 있는 상황에서 링크개념을 설정하여 특정시점이나 지점에서 원하는 다음 정보를 보기 위해서 비순차적으로 연출할 수 있도록 하는 연출이다. 이러한 비순차적인 연출방법인 하이퍼-프리젠테이션 개념을 도입함으로써, 자유로운 멀티미디어 연출이 가능하게 되었지만, 이러한 동기화 방법에 의해서 혼합된 여러 프레젠테이션들간에는 일관성 문제가 발생할 수 있다. 본 논문에서는 하이퍼-프리젠테이션 명시 프로그램의 일관성 검증을 위해서 Petri Net을 이용한 하이퍼-프리젠테이션 명시 방법을 제시하고, 그것을 이용한 명시 프로그램의 일관성을 검증하는 방법을 제안한다. The concept of a hyperpresentation, as an extension of a hypermedia, is the presentation in which time-varying multimedia presentations are dynamically linked together and a hyperlink's context can be changed over time at any time during a continuous presentation. While this concept provides users with a flexible and powerful tool for their descriptions of the multimedia presentation, inconsistency problems in the synchronized presentations connected by hyper links can be introduced. This paper introduces a method of describing the hyperpresentation using Petri Net and proposes a methods of detecting inconsistent hyper link loop in the hyperpresentation description.
複合組織鋼의 母相粒徑이 乾式로링 磨耗特性에 미치는 影響
吳世旭,姜鎬珉,金時綜 동아대학교 공과대학 부설 한국자원개발연구소 1985 硏究報告 Vol.9 No.2
The wear specimens of M.E.F. steel were conducted by Amsler type abrasive test machine under sliding ratio 9 09%. The relationship between weight loss ratio of wear, rolling life and scanning electron microscope investigation of micro wear surface was investigated during the test. The results of the experiment are summarized as follows. The amount and the weight loss ratio of the rolling wear are decreased when tensile strength is high and the amount of rolling wear of M E F. steel is lower than that of raw materials. As the ferrite grain size of M E F. steel is small, the amount and the weight loss ratio of the rolling wear are decreased. The amount of rolling wear is increased with increasing rolling revolution and wear of dual phase steel under dry rolling condition is characterized by three modes, initial, stationary wear and abnormal wear. Abnormal wear is caused by pitting occurrence on the exfoliation of sub-surface layer because of compression, shear, sliding of this wear surface. The wear surface condition is getting better as the ferrite grain size is getting smaller, which is caused by the promotion of the second phase sketetal strength.
조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험
최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1
Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.
Jong Myeon Hong, Si Wook Kim, Jin young Ahn, Kee Man Lee, Kang Hyeon Choe 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
A 40-year-old male was admitted with dry cough of two months’ duration. Radiologic examination revealed an endobronchial mass obstructing the right middle lobar bronchus and poststenotic pneumonia. Despite failure in bronchoscopic diagnosis, due to suspected malignancy and difficulty for bronchoscopic resection, we performed a right middle lobectomy. The histopathological diagnosis was a lipomatous hamartoma, which was exophytic and endobronchial. We report on a rare surgical case of endobronchial lipomatous hamartoma which had occlusive and exophytic growth across the bronchial wall.
Design and Implementation of an Around View Monitoring System of Selecting Scope of View
Sweung-Hwan Cheon,Jong-Wook Jang,Si-Woong Jang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.11
Recently certain driver convenience systems including ADAS (Advanced Driver Assistance System) such as navigation and GPS, and driver’s infotainment devices such as DVD players have been produced. AVM systems of these driver convenience systems support safety driving by providing situations around the vehicle to a driver. A driver can't fully monitor the situation around the vehicle at a glance using only rearview mirrors, a room mirror, and front and rear cameras, and using of only these devices causes blind spot which hinders driver’s safety. Blind spot is cause of personal injury and vehicle damage when parking vehicle, passing on a narrow street and turning left or right. Therefore studies on AVM systems have actively been progressing which provides surroundings of vehicles for drivers. Though existing AVM systems combines video images from four cameras and provides a driver with a full vision around the vehicle with no blind spots, the system has limitations that its monitoring area is narrow and fixed. Thus they are suitable for parking but are not suitable for monitoring situations around vehicle in various purposes. Therefore, in this paper, we will design and implement AVM system with adjustable around view to be shown that the proposed system provides multiple scopes of around views.
Microtubule Inhibitory Effects of Various SJ Compounds on Tissue Culture Cells 436
Jong Han Lee,Dong Wook Kang,Ho Suk Kwon,Sun Hwan Lee,Si Kyung Park,Sun Gan Chung,Eui Hwan Cho,백순영,이주헌 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.4
SJ compounds (SJ8002 and related compounds) are a group of novel anticancer agents (Cho, Chung, Lee, Kwon, Kang, Joo, and Oh. PCT/KR02/00392). To explore the anticancer mechanism of these compounds, we examined the effect of SJ8002 on microtubules of six human cell lines. At a high concentration (2 mg/mL), SJ8002 effectively disrupted microtubules of the six cell lines within 1 h. At lower concentrations (0.05~1.0 mg/mL), the antimicrotubule activity of SJ8002 varied defending on cell lines. The inhibition of in vitro polymerization of pure tubulin by SJ8002 suggested that SJ8002 acts on free tubulin, inhibits the polymerization of tubulin dimer into microtubules, and hence induces the depolymerization of microtubules.