(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

Scanning tunneling microscopy investigation of nano-structured α-K5PW11(M x OH2)O39(M = Mn(II), Co(II), Ni(II), and Zn(II)) Keggin heteropolyacid catalyst monolayers.

Choi, Jung Ho,Kang, Tae Hun,Bang, Yongju,Yoo, Jaekyeong,Jun, Jin Oh,Song, In Kyu American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.11

<P>Nano-structured α-K5PW11(M x OH2)O39 (M = Mn(II), Co(II), Ni(II), and Zn(II)) Keggin heteropolyacids (HPAs) were investigated by scanning tunneling microscopy (STM) and tunneling spectroscopy (TS) measurements in order to elucidate their redox property and oxidation catalysis. HPA molecules formed two-dimensional self-assembled monolayer arrays on highly oriented pyrolytic graphite (HOPG) surface. Furthermore, HPAs exhibited a distinctive current-voltage behavior referred to as negative differential resistance (NDR) phenomenon. The measured NDR peak voltage of HPAs was correlated with the reduction potential and the absorption edge energy determined by electrochemical method and UV-visible spectroscopy, respectively. NDR peak voltage of HPAs appeared at less negative voltage with increasing reduction potential and with decreasing UV-visible absorption edge energy. The correlations strongly suggested that NDR phenomenon was closely related to the redox property of HPAs. Vapor-phase oxidation of benzyl alcohol to benzaldehyde was carried out as a model reaction to track the oxidation catalysis of HPAs. NDR peak voltage appeared at less negative voltage with increasing yield for benzaldehyde.</P>

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

중·고등학교 아랍어 교재 집필 및 교재 내용에 관한 연구 보고서

오명근,송경숙,전완경,사희만,이규철,조희선,정규영,최진영 한국아랍어아랍문학회 1999 아랍어와 아랍문학 Vol.3 No.1

한국인 당뇨병 및 비당뇨병 환자에서의 뇌혈관 질환 유무에 따른 PAI-1 촉진자 유전자형과 인슐린저항성에 관한 연구

오승준,김영설,박철영,김덕윤,김성운,양인명,김진우,최영길,팽정령,정경천 대한비만학회 2000 The Korean journal of obesity Vol.9 No.2

연구배경 : 혈전현상을 특징으로 하는 질환에서는 Plasminogen activator inhibitor-1 (PAI-1) 이 높은 활성도를 보이는데, PAI-1 치는 당뇨병, 심근경색증, 비만 등에서 높다고 밝혀진 바 있다. 또한 당뇨병 환자들의 합병증의 주요한 병인은 죽상경화증으로 혈전현상이 특징인 질환에서 증가하는 PAI-1이 당뇨병 환자에서 높다. 목적 : 정상인에서의 PAI-1 유전자 촉진자의 유전자형의 분포 및 혈액농도를 관찰하고, 당뇨병 및 뇌혈관 질환 환자군에서의 PAI-1 유전자 촉진자 유전자형의 분포 및 혈액농도를 측정하여 정상인과 차이점을 알아본다. 당뇨병 환자군에서의 혈장 PAI-1 치와 인슐린 저항성, 전구 인슐린 등과의 상관관계를 살펴보고, 인슐린저항성과 대혈관질환의 지표로 사용될 수 있는지 알아보았다. 방법 : 대상으로는 정상인 76명, 제2형 당뇨병 환자 56명, 뇌혈관질환이 동반된 제2형 당뇨병 환자 48명, 뇌혈관질환 환자 51명을 선택하여, 환자의 혈액에서 인슐린, 공복시 혈당, 전구인슐린, 중성지방, 총콜레스테롤 및 기타 생화학 검사 및 이학적 검사를 시행하였다. 환자의 DNA를 채취하여 전사개시 -675bp를 포함하는 대립형질 특이 시발체를 사용하여 중합효소 연쇄 반응을 실시하여, 그 유전자형을 판독하였다. 결과 : 정상 대조군 76명 (46.4±11.1세), 2형 당뇨병 환자 56명 (58.3±12.6세), 뇌경색증 환자 51명 (63.1±13.2세) 대상으로 하였다. PAI-1 촉진자 유전자형의 (4G/4G, 4G/5G, 5G/5G)빈도는 정상 대조군이 각각 23.7%, 75.0%, 1.3%, 뇌경색 환자군이 19.6%, 66.7%, 13.7%, 뇌경색이 동반된 당뇨병 환자군이 33.3%, 58.3%, 8.3% 였다. (X2=12.6, p=0.05). 이러한 사실은 서구인에 비해 4G/4G, 5G/5G 동형 유전자형이 낮은 결과였다. 각 군별 혈장 PAI-1 농도는 정상 대조군 13.4, 1.8 ~ 65.2 ng/mL (중앙값 , 범위 ) 2형 당뇨병 환자군 14.4, 2.9 ~ 47.8 ng/mL, 뇌경색 환자군 21.9, 6.2 ~ 154.7 ng/mL , 뇌경색이 동반된 2형 당뇨병 환자군 28.8, 3.2 ~ 139.3 ng/mL 로 차이를 보였다 (p=0.000). 전체 대상에서 PAI-1 촉진자 부위의 유전자형에 따른 PAI-1 활성도와 항원 농도는 차이를 보이지 않았다. 그러나 PAI-1 활성도는 혈중 중성지방, 전구인슐린, 체질량지수와 독립적인 상관관계를 보였다 (p=0.000, p=0.000 and p=0.005). 결론 : 결론적으로 PAI-1 촉진자 부위의 유전자형은 뇌경색증의 지표는 아니며, PAI-1 활성도를 결정짓는 인자는 유전적 요인보다는 혈중 중성지방, 전구 인슐린, 체질량지수와 같은 대사적 요인으로 생각된다. Plasminogen activator inhibitor-1 (PAI-1) is known be related to insulin resistance and several components of the large vascular disease. Notably, the high frequencies of diseases such as coronary heart disease or stroke are related to type 2 diabetes complications. We studied to find out whether the PAI-1 promother genotype could be a marker for cerebral infarction in type 2 patients. Subject patients were; 56 type 2 diabetics (age 58.3±12.6), 51 patients with cerebral infarction (age 63.1±13.2), 48 type 2 diabetics with cerebral infarction (age 64.8±9.3) , and 76 healthy control (age 46.4±11.1). The 4G/5G genotype of PAI-1 promoter was evaluated by polymerase chain reaction and endonuclease digestion. PAI-1 promoter genotype frequency (4G/4G, 4G/5G, 5G/5G) was 23.7%, 75.0% and 1.3% in healthy control, 17.9%, 67.9% and 14.3% in type 2 diabetes patients, 19.6%, 66.7% and 13.7% in cerebral infarction patients, 33.3%, 58.3% and 8.3% in type 2 diabetics with cerebral infarction (X^2=12.6, p=0.05). This finding is lower in frequency of 5G/5G homozygote than that reported in Caucasians. The plasma PAI-1 concentrations according to the disease were 13.4, 1.8 ~ 65.2 ng/mL (median, range) for healthy control, 14.4, 2.9 ~ 47.8 ng/mL for type 2 diabetes, 21.9 6.2 ~ 154.7 ng/mL for cerebral infarction , and 28.8, 3.2 ~ 139.3 ng/mL, for cerebral infarction with type 2 diabetes (p=0.000). In the all subjects, PAI-1 concentration and activity of PAI-1 promoter genotype did not show any significant difference. However, the PAI-1 activity was independently associated with serum triglyceride level, plasma proinsulin and BMI (p=0.000, p=0.000 and p=0.005 respectively). We concluded that PAI-1 genotype is not a marker for the cerebral infarction ; however, the genotype is related to PAI-1 concentration , and therefore it seems to be that metabolic factors such as triglyceride level or plasma proinsulin or BMI are more in relations with determining the PAI-1 concentration than the genotype.

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 血淸 脂質組成에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1

발작성상심실성 빈맥환자에서 Adenosine과 Verapamil의 치료효과

최성욱,오진호,김승호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Background. According to the 1992 version of ACLS guideline, adenosine is recommended as the first line drug for the treatment of paroxysmal supraventricular tachycardia(PSVT). But adenosine is not used frequently in our country, despite currently proven effect and safety. Therefore we tried to compare the efficacy and safety of adenosine with verapamil for the treatment for PSVT. Materials and Methods. We prospectively reviewed charts of PSVT patients admitted to YongDong Severance Hospital from Jan. 1995 to Dec. 1996. These patients were randomly divided into two groups. The first group was given 6mg of adenosine initially , and another 12mg was given within 5minutes if first dose failed. The other group was given 5mg of verapamil initially, and if failed, 10mg was given within 10minutes. The results were analyzed by Chi-square test and student- t method Results. In converting PSVT to normal rhythm, adenosine and verapamil showed similar results and there was no difference between the two groups in frequency of side effects, but serious arrhythmia such as ventricular fibrillation and ventricular tachycardia was not seen in the adenosine group. Conclusion. Adenosine not only showed comparable effect and safety, but also had shorter action time than verapamil. Therefore we recommand sdenosine, as a safe and effective first line drug for PSVT.

불국사 석탑의 물성 및 지반특성 조사

최희수,서만철,오진용 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

경주 불국사의 다보탑과 석가탑은 751년에 축조된 국보급 문화재이나 오늘날은 석재의 풍화 및 지대석의 어긋남 현상들이 관찰된다. 이에 대한 정확한 이해는 두 석탑의 안정성 진단에 필수적이며 따라서 석탑의 지반환경과 석재 물성에 관한 비파괴 정밀 조사가 필요로 한다. 이 연구에서는 석재의 역학적 성질을 위해 초음파 속도 측정을 실시하였고 천부지질구조를 위해 탄성파, 전기비저항, 지하레이더 등의 비파괴 복합 지구물리탐사를 석탑 주변에서 수행하였다. 초음파 속도범위는 석가탑에서는 1217~4403 m/s이며, 다보탑에서는 584~5845 m/s이며 이로부터 추정한 일축강도 평균치는 각각 463 kg/cm^(2), 409 kg/cm^(2)이다. 대체로 두 석탑 주변의 북서쪽 구역에서 낮은 탄성파 속도와 비저항 값이 나타나, 이 부분을 비교적 연약한 지반으로 해석한다. 그리고, 탄성파 속도분포에서는 다보탑 지반이 더 큰 속도를 보여 상대적으로 석가탑 지반보다 견고함을 보여준다. 대체로 석탑지반의 전기비저항은 최대 2200 Ωm이며 200 Ωm내외의 외부지반보다 더 높은 값을 보인다. 복합 지구물리탐사 결과를 종합하면 다보탑지반의 형태는 8각형(한 변은 6 m)으로 그 깊이는 약 4 m 이나, 석가탑지반은 약 8x10 m의 직사각형 형태로 깊이는 약 3 m 이다. Two three-story stone pagodas, Seokgatap and Dabotap, built in 791 at Bulkuksa temple, are well-known national treasures. However, they have experienced weathering process and an offset of the stone alignment is observed at the base part of Dabotap. Understanding of these phenomena is essential for the structural safety diagnosis for them, and therefore the nondestructive geophysical methods was applied. Direct measurements of ultrasonic velocities was introduced for the mechanical properties of the stone. Multidisciplinary geophysical prospectings including seismic, resistivity, ground-penetrating radar(GPR) methods were carried out around two pagodas for their site characteristics. The velocity ranges of ultrasonic waves for Dabotap and Seokgatap are 1217~4403m/s and 584~5845m/s, respectively, and the estimated averages of the uniaxial compressive strength are 463 kg/cm^(2) and 409 kg/cm^(2), respectively. At the northeast of each pagodas, the lower seismic velocities and resistivities are shown, which is interpreted to be weaker subsurface section. On the basis of the higher velocity structure, the site of Seokgatap appears to have solider stability than the Seokgatap site. Near the pagodas, higher(up to 2200 Ωm) resistivity is present whereas their outskirts have as low as 200 Ωm. By the combined results of each geophyscial methods, the subsurface boundaries of each stone pagodas are revealed. The Dabotap site is in the form of an octagon having 6-m-long side with the depth of ~4 m, whereas the Seokgatap site is the 8x10 m rectangle with the depth of 3 m.

무선 인터넷 환경에서 동적 지도 생성을 위한 Generalization 기법

최진오 부산 외국어 대학교 2001 外大論叢 Vol.22 No.1

According to the rapid advance of computer and communication technique, the request of mobile internet services is highly increasing.However, the current level of mobile web technique could not satisfy all the services, as the wired internet ones.Mobile map service is one of the examples.Spatial data have very large data volume, thus, it takes large resource of client machine to display and store the map which is transferred from the server.It requires also large bandwidth to transfer the data to client.The main obstacle of wireless environment is small bandwidth and often loss of connection.Thus, the study of reducing the data volume to transfer is required. This paper deals with the method to reduce the volume of spatial data at server for mobile map service.This paper proposes the new generalization scheme which endures the dynamic environment change of bandwidth.Predefined generalization plans are evaluated at run-time by generalization constraint to pick up best one.

Primary Copy 기법을 확장한 공간 데이터 중복 제어 방법

최진오 부산 외국어 대학교 2000 外大論叢 Vol.21 No.1

When spatial objects are replicated at several sites in the UIS application system, the updates of a long transaction in a specific site should be propagated to the other sites for maintaining the consistency of replicated spatial objects. This thesis deals with the problems of replication control of spatial objects. These problems could not be overcome by applying existing traditional replication control techniques, due to the new requirements of long transaction. This thesis presents the concepts of floating primary copy, which is the expansion of existing primary copy replica control method. Initially, the primary copy site is selected among the transactions to update same region, by the time, at which they set the region lock. When the plenary copy finishes its transaction, then, new primary copy site is selected by the same method. This expansion loose the strict restrictions of existing primary copy approach, which make it to be not applied to long transaction applications.