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KRUGLYAK과 LANDER의 유전연관성 비모수 방법과 반복 자료를 고려한 가중 회귀분석법의 비교
최은경,송혜향,Choi, Eun-Kyeong,Song, Hae-Hiang 한국통계학회 2008 응용통계연구 Vol.21 No.1
The ordinary least squares regression method of Haseman and Elston(1972) is most widely used in genetic linkage studies for continuous traits of sib pairs. Kruglyak and Lander(1995) suggested a statistic which appears to be a nonparametric counterpart to the Haseman and Elston(1972)'s regression method, but in fact these two methods are quite different. In this paper the relationships between these two methods are described and will be compared by simulation studies. One of the characteristics of the sib-pair linkage study is that the explanatory variable has only three different values and thus dependent variable is heavily replicated in each value of the explanatory variable. We propose a weighted least squares regression method which is more appropriate to this situation and the efficiency of the weighted regression in genetic linkage study was explored with normal and non-normal simulated continuous traits data. Simulation studies demonstrated that the weighted regression is more powerful than other tests.
도금전류밀도 및 도금액 온도에 따른 비시안계 Au 범프의 표면 형상과 높이 분포도
최은경,오태성,Choi, Eun-Kyung,Oh, Tae-Sung,Englemann, G. 한국마이크로전자및패키징학회 2006 마이크로전자 및 패키징학회지 Vol.13 No.4
Surface roughness and wafer-level thickness distribution of the non-cyanide Au bumps were characterized with variations of the electroplating current density and the bath temperature. The Au bumps, electroplated at $3mA/cm^{2}\;and\;5mA/cm^{2}$, exhibited the surface roughness of $80{\sim}100nm$ without depending on the bath temperature of $40^{\circ}C\;and\;60^{\circ}C$. The Au bumps, electroplated with $8mA/cm^{2}$ at $40^{\circ}C\;and60^{\circ}C$, exhibited the surface roughness of 800nm and $80{\sim}100nm$, respectively. Wafer-level thickness deviation of the Au bumps became larger with increasing the current density from $3mA/cm^{2}\;to\;8mA/cm^{2}$. More uniform thickness distribution of the Au bumps was obtained at a bath temperature of $60^{\circ}C$ than that of $40^{\circ}C$.
약제내성 Mycobacterium tuberculosis의 rpoB 유전자 분석과 클로닝 발현
최은경,권태동,배선준,조해선,홍성갑,Choi, Eun Kyeong,Kweon, Tae-Dong,Bai, Sun-Joon,Cho, Hae Sun,Hong, Seong-Karp 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.4
Using DNA sequencing method, we analyzed mutations of rpoB (RNA polymerase beta subunit) rifampin-resistant Mycobaterium tuberculosis strains which were identified by conventional test at Masan National Hospital and The Korean Institute of Tuberculosis. Though it has been reported different mutations of rpoB region of rifampin-resistant M. tuberculosis strains in the south of Korea, it is not confirmed whether these mutations of rpoB region actually express rifampin resistance through experiment. We confirmed experimentally these mutations of rpoB region of M. tuberculosis strains induced rifampin-resistance through ampified rpoB by polymerase chain reaction (PCR) and cloning of mutant rpoB into rifampin sensitive-M. tuberculosis strain.
중국공산당 총서기의 교체 혹은 유임이 정책의제의 변화와 연속성에 미치는 영향: 후진타오와 시진핑 시기의 당대회 보고를 중심으로
최은경 한국외국어대학교 중국연구소 2023 中國硏究 Vol.94 No.-
Xi Jinping did not follow informal rules of retirement in the 20th Chinese Communist Party (CCP) Congress in 2022. Based upon Bunce’s argument that leadership succession in the Communist Party tends to lead to policy changes in the Soviet Union, this study examines whether policy agenda changes with leadership succession and whether remaniing in power tends to be associated with policy continuities. Analysing political reports of the party congress in the Hu Jintao and Xi Jinping eras, this study confirms it. This suggests that in the next coming five years, policy agenda are likely to show great continuty with the last ten years of Xi Jinping’s rule. 2022년에 개최된 20차 중국공산당 전국대표대회 (이하 당대회)에서 시진핑 3기가 시작되어, 개혁개방 시기에 주기적으로 이루어진 권력 교체가 이루어지지 않았다. 이것이 향후 5년 동안 중국공산당의 정책의제에 어떤 영향을 줄 것인가를 고찰하기 위해서 본 연구는 당대회 보고를 분석한다. 본 연구는 소련공산당 일당 지배체제에서 총서기의 변동이 정책의제의 변화를 가져온다는 분스의 주장을 중국공산당에 적용하여, 후진타오와 시진핑이 총서기로서 발표한 당대회 보고에서 나타난 정책의제를 비교하였다. 본 논문은 총서기가 유임할 경우에는 정책의제가 연속성을 보이고, 교체될 경우에는 상당한 변화를 보인다는 것을 밝힌다. 이에 기반하여 시진핑 3기의 정책의제는 지난 10년 동안 시진핑 시기의 정책기조와 상당한 유사성을 띨 것으로 전망한다.