Radiation stability and radiolysis mechanism of hydroxyurea in HNO3 solution: Alpha, beta, and gamma irradiations

Qin Yilin,Liao Wei,Lan Tu,Li Fengzhen,Li Feize,Yang Jijun,Liao Jiali,Yang Yuanyou,Liu Ning 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.12

Hydroxyurea (HU) is a novel salt-free reductant used potentially for the separation of U/Pu in the advanced PUREX process. In this work, the radiation stability of HU were systematically investigated in solution by examining the effects of the type of rays (a, b, and g irradiations), the absorbed dose (10 e50 kGy), and the HNO3 concentration (0e3 mol L1 ). The influence degree on HU radiolysis rates followed the order of the absorbed dose > the ray type > the HNO3 concentration, but the latter two had moderate effects on HU radiolysis products where NH4 þ and NO2 were found to be the most abundant ones, suggesting that the differences of a, b, and g rays should be considered in the study of irradiation effects. The radiolysis mechanism was explored using density functional theory (DFT) calculations, and it proposed the dominant radiolysis paths of HU, indicating that the radiolysis of HU was mainly a free radical reaction among $H, eaq e , H2O, intermediates, and the radiolytic free radical fragments of HU. The results reported here provide valuable insights into the mechanistic understanding of HU radiolysis under a, b, and g irradiations and reliable data support for the application of HU in the reprocessing of spent fuel.

Influence of Silane-based Impregnation Agent on the Permeability of Concretes

Baoju Liu,Jiali Qin,Minghua Sun 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.8

Three types of silane-based impregnation agent (short for SIA) are used to treat the concrete surface, and the influence of water/ binder (W/B) ratio, mineral admixtures, curing methods, the type and dosage of SIA on the capillary water absorption and electric flux of concretes is examined. Results show that the penetration depth of SIA increases with the increasing of the W/B ratio and SIA dosage, and is related to the type of SIA. Surface treatment by SIA can reduce capillary water absorption and electric flux of concretes, the W/B ratio and curing methods are no longer the main factor, the increasing of the SIA dosage can further improve the surface protection effect of concrete. Mineral admixtures improve the compactness of concretes, and the combined effects of surface treatment and admixtures can evidently enhance the impermeability of concrete. Different types of SIAs have different mechanisms of action on the surface treatment of concrete, and thus have different impacts on the permeability of concrete. The concrete treated by SIA2 with the effects of the penetration and the formation of surface film layer has lower permeability.

A biothiols and H 2 O 2 responsive fluorescence probe for selective cancer imaging

Yin Nan,Qin Guixin,Wang Yuting,Tang Jiali,Yao Xin,Xu Qingling 대한화학회 2024 Bulletin of the Korean Chemical Society Vol.45 No.3

Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near‐infrared (NIR) fluorescent probe ( IRAPA ) using a hemi‐cyanine skeleton as fluorophore and 3‐acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H 2 O 2 , glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH . IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS. Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near-infrared (NIR) fluorescent probe (IRAPA) using a hemicyanine skeleton as fluorophore and 3-acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H2O2, glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH. IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS.

Anti-periodic Synchronization of Quaternion-valued Generalized Cellular Neural Networks with Time-varying Delays and Impulsive Effects

Yongkun Li,Yanchao Fang,Jiali Qin 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5

In this paper, a class of quaternion-valued generalized cellular neural networks (QVGCNNs) with timevaryingdelays and impulsive effects is considered. Firstly, by constructing an appropriate Lyapunov function andapplying inequality techniques, some sufficient conditions on the existence of anti-periodic solutions are established. Then, the global exponential anti-periodic synchronization of delayed QVGCNNs with impulsive effectsand anti-periodic coefficients is investigated by designing a novel nonlinear state-feedback controller and constructingsuitable Lyapunov functions. Our results are completely new even if the considered quaternion-valued systemsdegenerated into real-valued or complex-valued systems. Finally, two numerical examples are given to illustrate thefeasibility and effectiveness of the obtained results.

Tea seed saponin(TSS) improve lipid metabolism and oxidative stress in high fat diet(HFD)-induced obese mice

Shuang Liu,Huishan Qin,Yanmin Su,Jiali Li,Wenjing Cao,Wen He,Zhen Zeng,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

To investigate the effect of TSS on lipid metabolism and oxidative stress in HFD mice. The body weight and food intake were observed. The serum SOD, MDA, GSH, TC, TG, HDL-C, LDL-C were determined by kits. Western Blotting was used to detect the levels of PPAR-γ, AMPK, SIRT1 and PGC-1α. TSS treatment reduced the body weight, Lee"s index and fat organ indices of mice in the HFD group. Compared with the control(CON) group, the serum TC, TG and LDL-C in the HFD group were increased, Administrated with TSS can improve abnormal blood lipid levels. Compared with the CON group, the serum SOD level in HFD group was significantly reduced(P<0.05), and MDA level was increased; while the levels of serum MDA in the TSS group decreased and SOD level increased. The pathological sections showed that TSS could improve the degree of hepatic steatosis. TSS also increased the levels of PPAR-γ, AMPK, SIRT1 and PGC-1α, and the effect of the high-dose group was the most significant. TSS can reduce body weight and fat accumulation, improve lipid metabolism disorder and oxidative stress caused by HFD.

Effect of cement as mineral filler on the performance development of emulsified asphalt concrete

Liu, Baoju,Wu, Xiang,Shi, Jinyan,Wu, Xiaolong,Jiang, Junyi,Qin, Jiali Techno-Press 2020 Advances in concrete construction Vol.10 No.6

Cold-mixed asphalt mixture is a widely recommended asphalt pavement materials with potentially economic and environmental benefits. Due to the reduction of natural non-renewable mineral resources, powder minerals with similar properties are considered as new mineral fillers in asphalt mixtures. This study explored the feasibility of using cement to replace natural limestone powder (LP) in emulsified asphalt concrete modified by styrene-butadiene styrene copolymer. The experimental tests, including compressive strength, Marshall stability as well as moisture susceptibility test, were used to investigate the mechanical properties, the Marshall stability, flow value, as well as the moisture damage. In addition, the influence of material composition on the performance of asphalt concrete is explained by the microstructure evolution of the pore structure, the interface transition zone (ITZ), and the micromorphology. Due to mineralogical reactivity of cement, its replacement part of LP improved the mechanical properties, Marshall stability, but it will reduce the moisture susceptibility and flow value. This is because with the increase of the cement substitution rate, the pore structure of the asphalt concrete is refined, the width of ITZ becomes smaller, and the microstructure is more compact. In addition, asphalt concrete with a larger nominal particle size (AC-16) has relatively better performance.