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Genotoxicity Safety Evaluation on Gamma-Irradiated Milk and Icecream
Ji-Sook Ryu,Sun-Kyung Han,Myeong-Su Shin,Bon-Chul Koo,Ji-Hyun Choi,Ju-Woon Lee,Cheorun Jo,Jun-Sang Ham,Wan-Kyu Lee 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.1
Gamma irradiation can be applied to the dairy products for eradicating microbial contamination and making hypo-allergenic foods. However irradiation technology has not been put practical use because of prejudice against safety of gamma-irradiation. To evaluate the safety of gamma-irradiated dairy product, genotoxicological test was performed. In vitro mutagenicity of gamma-irradiated milk and ice cream (5, 10 kGy) was evaluated by chromosome aberration test in the presence or absence of metabolizing activation (S-9 mix). And in vivo safety test was carried out by the micronucleus test in ICR mice. The gamma-irradiated milk and icecream did not increase chromosome aberration rate at any irradiation doses or concentration. In micronucleus test, gamma-irradiated milk and icecream did not induce any significant increase statistically in micronucleated polychromatic erythrocytes (MNPCE) at any irradiation doses. These results of this study indicate that irradiation on milk and icecream may not induce genotoxicity and can be an additional safety tool for manufacturing dairy products.
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Coronary artery intramural hematoma following stent implantation
( Ji Hyun Kim ),( Min Kim ),( Eun Bee Kim ),( Ju Hee Lee ),( Sang Yeub Lee ),( Jang Whan Bae ),( Kyung Kuk Hwang ),( Dong Woon Kim ),( Myeong Chan Cho ),( Sang Min Kim ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
An intramural hematoma formation is a rare complication of percutaneous coronary intervention (PCI). A 72 year-old woman who has treated for rheumatoid arthritis (RA) transferred to our hospital due to suspicious acute coronary syndrome with resting chest pain for 6 hours. Emergent coronary angiogram (CAG) showed 3 narrowed coronary arteries of which culprit lesion was a right coronary artery (RCA). After predilatation with conventional balloon, drug eluting stents (DES) 3.0×28 mm for proximal RCA and 2.75×28 mm for distal RCA were implanted. After implantation of a distal stent, no-reflow phenomenon was developed. Although an improvement was observed in the TIMI flow grade from grade 0 to grade 2 after injection of nicorandil, and abciximab, PCI for other residual lesions was withheld. After 3 days, she was discharged and readmitted for elective PCI for residual lesions because of exertional chest pain 1 month later. CAG showed left anterior descending artery (LAD) was concerned about an only target at first, because of complexity of mid LAD. After implantation of 2.75×23 mm DES for proximal LAD, a type B dissection was developed just below the distal edge of stent. Therefore, additional DES implantation should be considered for dissecting lesion. Although 2.75×23 mm DES for mid LAD was implanted by dual wire support, fluoroscopy showed the staining of dye with luminal narrowing in LAD ostium during positioning of stent for implantation which was suspicious of new formation of dissection. Therefore, intravascular ultrasound (IVUS) was performed and identified differentially not a dissection but an extensive coronary intramural hematoma (CIH). An additional 3.0×18mm DES was implanted for CIH of LAD ostium. Followed IVUS revealed the lumen was preserved and size of CIH was decreased. After PCI, the patient was followed without symptoms. We present a case who had several critical complications especially CIH during sequential PCI and IVUS-guided differential diagnosis and additional stent implantation was successful.
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김영숙 ( Young Sook Kim ),이명석 ( Myeong Seok Lee ),염지희 ( Ji Hee Yeom ),송자경 ( Ja Gyeong Song ),이인경 ( In Kyoung Lee ),여운형 ( Woon Hyung Yeo ),윤봉식 ( Bong Sik Yun ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.1
Ginseng (Panax ginseng) is one of the most widely cultivated medicinal herb in Korea. However, yield losses reached up to 30~60 % due to various diseases during 3 or 5 years of ginseng cultivation. Therefore, successful production of ginseng roots depends primarily on the control of diseases. The objective of this study is to select potential multifunctional biocontrol agents from actinomycetes for the control of multiple ginseng diseases as an alternative to fungicides. Ninety three Streptomyces strains were selected and their ability to produce antibiotics, siderophore and lytic enzymes such as protease and cellulose were investigated. Eight of the isolates, strains A75, A501, 515, 523, A704, A1444, A3265 and A3283 produced cellulase and protease. These strains also produced siderophore and showed potent antifungal activity against Botrytis cinerea, Cylindrocarpon destructans, Collectotricum gloeosporioides, Phytophthora capsici and Rhizoctonia solani causing ginseng root rot.
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정지선,홍광표,김운용,조명우,Jeong, Ji-Seon,Hong, Kwang-Pyo,Kim, Woon-yong,Cho, Myeong-Woo 한국금형공학회 2017 한국금형공학회지 Vol.11 No.2
Nitinol, a shape memory alloy (SMA), is manufactured from titanium and nickel and it used in various fields such as electrical applications, micro sensors. It is also recommended as a material in medical for implant because it has excellent organic compatibility. Nitinol is intended to be inserted into the human body, products require a high-quality surface and low residual stress. To overcome this problems, explore electrolyte polishing (EP) is being explored that may be appropriate for use with nitinol. EP is a particularly useful machining method because, as a non contact machining method, it produces neither machining heat nor internal stress in the machined materials. Sandpaper polishing is also useful machining method because, as a contact machining method, it can easily good surface roughness in the machined materials. The electrolyte polishing (EP) process has an effect of improving the surface roughness as well as the film polishing process, but has a characteristic that the residual stress is hardly generated because the work hardened layer is not formed on the processed surface. The sandpaper polishing process has the effect of improving the surface roughness but the residual stress remains in the surface. We experimented with three conditions of polishing process. First condition is the conventional polishing. Second condition is the electrochemical polishing(EP). And Last condition is a mixing process with the conventional polishing and the EP. Surface roughness and residual stress of the nitinol before a polishing process were $0.474{\mu}mRa$, -45.38MPa. Surface roughness and residual stress of the nitinol after mixing process of the conventional polishing and the EP were $1.071{\mu}mRa$, -143.157MPa. Surface roughness and residual stress of the nitinol after conventional polishing were $0.385{\mu}mRa$ and -205.15MPa. Surface roughness and residual stress of sandpaper and EP nitinol were $1.071{\mu}mRa$, -143.157MPa. The result shows that the EP process is a residual stress free process that eliminates the residual stress on the surface while eliminating the deformed layer remaining on the surface through composite surface machining rather than single surface machining. The EP process can be used for biomaterials such as nitinol and be applied to polishing of wafers and various fields.
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