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신경인지재활치료가 편마비 환자의 손 기능에 미치는 영향 이지현, 강보라
이지현,강보라 한국인지운동치료협회 2019 한국신경인지재활치료학회지 Vol.11 No.2
목적: 본 연구는 손 기능이 손상된 급성기 편마비환자에게신경인지재활치료를 적용하여 손 기능과 과제를 수행하는능력에 미치는 영향을 알아보고자 한다. 방법: 대상자는 고양시 Y재활병원에 입원하여 치료받고있는 환자로 뇌졸중 진단을 받았으며, 실험의 내용을 이해하고 참여 의사를 밝힌 자로 선정하였다. 대상자는 49세 여성으로 2019년 2월 24일 발병되어 우측 뇌기저핵 부위의 뇌내출혈로 인한 좌측 편마비를 진단받았다. 연구 기간은 2019년3월 18일부터 5월 10일까지 진행되었으며, 8주 동안 주 5회30분씩 총 40회기의 신경인지재활치료를 실시하였다. 결과: 연구 결과 뇌졸중 상지 기능 검사에서 치료 전 오른쪽32점, 왼쪽 23점, 치료 후 오른쪽 32점, 왼쪽 29점으로 왼쪽상지의 기능변화가 나타났다. 그루브드 막대 검사 결과 치료전 오른손 57초(수행 개수 25개, 떨어진 개수 0개)에서 치료후 62초(수행 개수 25개, 떨어진 개수 0개)였으며, 왼손은323초(수행 개수 25개, 떨어진 개수 2개)에서 126초(수행 개수 25개, 떨어진 개수 0개)로 왼손의 시간 단축과 수행도의증가가 나타났다. 상자와 나무토막 검사에서는 오른손 80개에서 81개, 왼손 25개에서 48개로 오른손 1개, 왼손 23개로향상되었다. 결론: 신경인지재활치료가 급성기 뇌졸중 환자의 손 기능및 과제수행의 질에 효과가 있는 것으로 나타났다. The purpose of this study is to reveal the effect of neurocognitive rehabilitation therapy on hand function for hemiplegic patients. The subject of the study was a female patient aged 49 with left hemiplegia caused by intracranial hemorrhage, and the cognitive-therapeutic exercise was applied to her for 30minutes once a day from March 18, 2018 to May 10, 2019. In this study, after neurocognitive treatment, the results of the MFT found no change found in the right hand. The left hand improved from 23 to 29 scores. The results of the grooved pegboard test, which evaluated the hand function, were as follows. The right hand performed from 57 seconds (25 performed, 0 dropped) to 62 seconds (25 performed, 0 dropped) after treatment, and the left hand improved from 323 seconds (25 performed, dropped 2) to 126 seconds (25 performed, dropped 0) after the treatment. The results BBT, the right hand performed from 81 to 80, The left hand improved from 25 to 48. Neurocognitive rehabilitation therapy was found to be effective on hand function and task performance in acute stroke patients.
이지현,조양제,김원주,이민구,이지현 한국유전체학회 2013 Genomics & informatics Vol.11 No.4
The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions(ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Ourobjective was to investigate the effect of ABCC2 polymorphisms on ADRs caused by VPA in Korean epileptic patients. Weexamined the association of ABCC2 single-nucleotide polymorphisms and haplotype frequencies with VPA related to adversereactions. In addition, the association of the polymorphisms with the risk of VPA related to adverse reactions was estimatedby logistic regression analysis. A total of 41 (24.4%) patients had shown VPA-related adverse reactions in CNS, and the mostfrequent symptom was tremor (78.0%). The patients with CNS ADRs were more likely to have the G allele (79.3% vs. 62.7%,p = 0.0057) and the GG genotype (61.0% vs. 39.7%, p = 0.019) at the g.‒1774delG locus. The frequency of the haplotypecontaining g.‒1774Gdel was significantly lower in the patients with CNS ADRs than without CNS ADRs (15.8% vs. 32.3%, p= 0.0039). Lastly, in the multivariate logistic regression analysis, the presence of the GG genotype at the g.‒1774delG locuswas identified as a stronger risk factor for VPA related to ADRs (odds ratio, 8.53; 95% confidence interval, 1.04 to 70.17). Wedemonstrated that ABCC2 polymorphisms may influence VPA-related ADRs. The results above suggest the possible usefulnessof ABCC2 gene polymorphisms as a marker for predicting response to VPA-related ADRs.
Jacobsen's Catalyst에 의한 효율적 (-)-R-Decursinol의 입체선택적 합성
이지현,조수현,윤은주,김지선,오유석,송규용 충남대학교 약학대학 의약품개발연구소 2016 藥學論文集 Vol.31 No.-
(-)-Decursinol is a stereoisomer of the (+)-decursinol. (-)-Decursinol can be obtained through semi-synthetic method via xanthyletin and epoxy compound, using (+)-decursinol as the source material. The epoxidation of xanthyletin, key step in determining the symmetry, provides a convenient new method for stereoselective synthesis of (-)-decursinol in high yields. These reactions are effectively catalysed by Jacobsen's catalyst: [(R,R)-(-)-N,N’-bis(3,5-di-tert-butyl-salicylidene)-1,2-cyclohexane-diamino mangannese(III)chloride] and bases such as soduim hydroxide.
코칭리더십과 청소년 핸드볼 선수의 팀회복탄력성, 팀효능감 및 혁신행동의 관계
이지현,최유리,김일광 한국체육대학교 체육과학연구소 2025 스포츠사이언스 Vol.43 No.3
본 연구는 청소년 핸드볼 지도자의 코칭리더십과 팀회복탄력성, 팀효능감 및 혁신행동의 관계를 구명하는데 그 목적이 있다. 연구대상은 2023년 대한핸드볼협회에 등록되어있는 중학교 및 고등학교 각 26개팀, 20팀을 군집표집으로 378명의 자료를 분석하였다. 조사도구는 설문지였으며, SPSS 26.0과 AMOS 23.0을 이용하여 확인적 요인분석, 신뢰도분석, 구조방정식모형(SEM) 분석을 실시하였다. 연구결과는, 첫째, 코칭리더십의 하위변인 중 방향제시와 수행평가가 팀회복탄력성에 유의한 영향을 미쳤으며, 둘째, 코칭리더십의 하위변인 중 관계가 혁신행동에 유의한 영향을 미쳤다. 셋째, 팀회복탄력성은 팀효능감 및 혁신행동에 유의한 영향을 미쳤으며, 넷째, 팀효능감은 혁신행동에 유의한 영향을 미쳤다. 이는 청소년 핸드볼 선수의 긍정경험과 창의적 플레이를 증진시키기위해서는 지도자의 코칭 전략과 팀이 어려운 상황에서 극복할 수 있다는 선수들간의 상호 믿음이 중요하다는 것을 의미한다. The purpose of this study was to investigate the relationship between the coaching leadership of youth handball coaches and players' team resilience, team efficacy, and innovative behavior. Data from 378 players were analyzed, selected via cluster sampling from 26 middle school and 20 high school teams registered with the Korea Handball Federation in 2023. A questionnaire was used as the research tool, and the data were analyzed using SPSS 26.0 and AMOS 23.0 to conduct confirmatory factor analysis (CFA), reliability analysis, and structural equation modeling (SEM). The results were as follows: First, among the sub-factors of coaching leadership, ‘direction setting’ and ‘performance evaluation’ had a significant effect on team resilience. Second, the ‘relationship’ sub-factor of coaching leadership had a significant effect on innovative behavior. Third, team resilience had a significant effect on both team efficacy and innovative behavior. Fourth, team efficacy had a significant effect on innovative behavior. These findings imply that to enhance experiences and play of youth handball players, the coach's coaching strategy and mutual trust among players that the team can overcome difficult situations are crucial.