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S-548 Fludarabine and Rituximab in Relapsed or Refractory Hairy Cell Leukmia Variant: A Case Report
( Ji Won Lee ),( Seung-hyun Nam ),( Youn Mi Choi ),( Jae Yun Yang ),( Seung Moon Han ),( Bong Seog Kim ),( Tae Kyu Lim ),( Hae Soo Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Hairy cell leukemia is rare,chronic B cell leukemia characterized by cells with abundant cytoplasm and hair-like projection can be found within the peripheral blood,bone marrow. Hairy cell leukemia variant is similar to clinical feature of classic HCL,but has only infrequently demonstrated reactivity for tartrate-resistent acid phosphatase. The treatment for HCL is splenectomy or chemotherapy with the purine analogs, pentostatin and cladribine. However, patients continue to relapse. Retreatment with the same or alternate purine analog produces lower response rates and a shorter duration of response. There is insufficient data for guidance of medical treatment for relapsed or refractory HCL. Fludarabine is another purine analog widely used in indolent lymphoid cancers,often in combination with rituximab,but there are few reports of its use in HCL. We experienced a case of hairy cell leukemia variant in a 60-year-old man who was recurrently relapse to treatments with splenectomy,cladribine retreatment. For the treatment of relapsed HCL,the patient was treated with fludarabine and rituximab combination chemotherapy. After the treatment,he had complete remission,continued for 35 months after fludarabine and rituximab treatment initiation.
Nam, Hyo Suk,Han, Sang Won,Ahn, Seong Hwan,Lee, Jong Yun,Choi, Hye-Yeon,Park, In Cheol,Heo, Ji Hoe S. Karger AG 2007 Cerebrovascular diseases Vol.23 No.4
<P><I>Background:</I> The need for rapid evaluation and treatment of acute stroke patients has been well documented. A computerized physician order entry (CPOE) system can improve communication and provide immediate access to information, which may be useful for an effective team approach program targeted to reduce in-hospital time delays. <I>Methods:</I> To reduce the time from a patient’s arrival at the emergency department to thrombolysis, a team approach program using CPOE was developed, and its efficacy was investigated by comparing time intervals from arrival to evaluation and intravenous tissue-type plasminogen activator (tPA) treatment before and after the implementation of the program. <I>Results:</I> Among 379 consecutive patients who were screened as potential candidates for thrombolysis, 25 patients (6.6%) received tPA during a 1-year period after initiation of the program. Fourteen patients were treated with tPA in the previous year. After program implementation, time from arrival to computed tomography scan was reduced from 34 to 19 min (p = 0.01). Time to report of complete blood count was also shortened from 52 to 33 min (p < 0.01). Finally, time from arrival to tPA treatment was reduced by 23 min (from 79 to 56 min; p < 0.01). Onset-to-door time tended to be longer after the program implementation (from 41 to 60 min; p = 0.14). <I>Conclusions:</I> Implementation of the CPOE-based team approach program significantly reduced time from emergency department arrival to evaluations and treatment.</P><P>Copyright © 2007 S. Karger AG, Basel</P>
Nam, Ji Won,Jung, Na Young,Park, Eun Suk,Kwon, Soon Chan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.5
Objective : Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy technique, the Aspiration-Retriever Technique for Stroke (ARTS), which is composed of a flexible large lumen distal access catheter and a retrievable stent as the first-line strategy of mechanical thrombectomy. Methods : We retrospectively reviewed 62 patients with AIS who underwent mechanical thrombectomy from 2018 to 2019 at our institute by a senior neurointerventionalist. Among them, patients who were treated using the ARTS technique with the soft torqueable catheter optimized for intracranial access (SOFIA<sup>®</sup>; MicroVention-Terumo, Tustin, CA, USA) as the first-line treatment were included. Patients who had tandem occlusions or underlying intracranial artery stenosis were excluded. The angiographic and clinical outcomes were evaluated. The angiographic outcome was analyzed by the rate of successful recanalization, defined as a Thrombolysis in Cerebral Infarction score of 2b or 3 at the end of all procedures and the rate of successfully achieving the first pass effect (FPE), defined as complete recanalization with a single pass of the device. The clinical outcomes included the National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS), and mortality. Results : A total of 27 patients (mean age, 59.3 years) fulfilled the inclusion criteria. The successful recanalization rate was 96% (n=26) while the FPE rate was 41% (n=11). The mean post-procedural NIHSS change was -3.0. Thirteen patients (48%) showed good clinical outcomes after thrombectomy with the ARTS technique (mRS at 90 days ≤2). Postoperative complications occurred in seven of 25 patients : hemorrhagic transformation in six patients (22%) and distal embolization in one patient (4%). Mortality was 15% (n=4). Conclusion : Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA<sup>®</sup> catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.
Nam, Jutaek,La, Wan-Geun,Hwang, Sekyu,Ha, Yeong Su,Park, Nokyoung,Won, Nayoun,Jung, Sungwook,Bhang, Suk Ho,Ma, Yoon-Ji,Cho, Yong-Min,Jin, Min,Han, Jin,Shin, Jung-Youn,Wang, Eun Kyung,Kim, Sang Geol,Ch American Chemical Society 2013 ACS NANO Vol.7 No.4
<P>A challenge in using plasmonic nanostructure–drug conjugates for thermo–chemo combination cancer therapy lies in the huge size discrepancy; the size difference can critically differentiate their biodistributions and hamper the synergistic effect. Properly tuning the plasmonic wavelength for photothermal therapy typically results in the nanostructure size reaching ∼100 nm. We report a new combination cancer therapy platform that consists of relatively small 10 nm pH-responsive spherical gold nanoparticles and conjugated doxorubicins. They are designed to form aggregates in mild acidic environment such as in a tumor. The aggregates serve as a photothermal agent that can selectively exploit external light by their collective plasmon modes. Simultaneously, the conjugated doxorubicins are released. The spatiotemporal concertion is confirmed at the subcellular, cellular, and organ levels. Both agents colocalize in the cell nuclei. The conjugates accumulate in cancer cells by the rapid phagocytic actions and effective blockage of exocytosis by the increased aggregate size. They also effectively accumulate in tumors up to 17 times over the control because of the enhanced permeation and retention. The conjugates exhibit a synergistic effect enhanced by nearly an order of magnitude in cellular level. The synergistic effect is demonstrated by the remarkable reductions in both the therapeutically effective drug dosage and the photothermal laser threshold. Using an animal model, effective tumor growth suppression is demonstrated. The conjugates induce apoptosis to tumors without any noticeable damage to other organs. The synergistic effect <I>in vivo</I> is confirmed by qRT-PCR analysis over the thermal stress and drug-induced growth arrest.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-4/nn400223a/production/images/medium/nn-2013-00223a_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn400223a'>ACS Electronic Supporting Info</A></P>
Liver Protection from Nonalcoholic Fatty Liver Disease by Pinus densiflora Heat-Wood Ethanol Extract
Ji Won Choi,Nam Hee Kim,Hun Suk Choi,Dae-Hee Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Fat accumulation in the liver causes nonalcoholic steatohepatitis (NASH). In this study, the improvement effect of red pine heartwood (RPH) on steatohepatitis was studied. It was found that domestic red pine heartwood did not affect cell proliferation inhibition in normal liver cells. Lipid peroxide and reduced glutathion content were measured, and the antioxidant efficacy of domestic red pine heartwood was confirmed. As a result of measuring nitric oxide and cytokines in macrophages, it was possible to confirm the anti-inflammatory effect of RPH. In addition, it was possible to identify proteins that prevent lipid accumulation (SREBP-1) and apoptosis (PARP) through Western blot. In addition, C57BL/6J mice were orally administered for 8 weeks at a high concentration (300mg/ml) and low concentration (100mg/ml) of RPH along with a CDHFD (L-Amino Acid Diet with 60 kcal% Fat With 0.1% Methionine and No Added Choline) diet. As a result of the experiment, it was observed that the RPH group had ALT and AST levels, decreased steatosis, and antioxidant effects compared to the CDHFD diet group. Taken together, these results indicate that RPH may help ameliorate NASH-induced liver damage.
Friction-Assisted Dissimilar Solid State Lap Joining of Aluminum and Copper Pipes
Ji-Won Kang,Shengwei Zhang,Tu-Anh Bui Thi,Sung-Tae Hong,Siwhan Lee,Heung Nam Han 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.2
The friction-assisted solid state lap joining process of dissimilar metal pipes is proposed by joining copper (Cu) and aluminum (Al) pipes. The joining process is designed to have two successive stages. In the first stage, the Cu pipe rotating with a mandrel rotates against the inner surface of the Al pipe. In the first stage, the relative rotation between the Cu and Al pipes breaks the oxide layers on the contacting surfaces and increases the temperature at the interface. In the second stage, as the area of the contact surface between the Cu and Al pipes increases due to the linear motion of the mandrel; as the mandrel begins to rotate alone against the Cu pipe, which now becomes stationary to induce diffusion bonding between the Cu and Al pipes. The results of microstructural analysis and mechanical testing show that solid state lap joining between the Cu and Al pipes for a light-weight heat exchanging component is successfully achieved. The microstructure evolution suggests that grain refinement by recrystallization occurs in the joining region for both the Cu and Al sides.
( Ji Won Hong ),( Hyoung Min Suh ),( Oh Hong Kim ),( Nam Sook Lee ) 한국균학회 2015 Mycobiology Vol.43 No.4
A fungal internal transcribed spacer region was used to identify the mycorrhizae of Cymbidium kanran. The family Russulaceae was found to be the most frequently occurring group in both root and soil samples. In phylogenetic analyses, the majority of the Russulaceae clones were clustered with Russula brevipes and R. cyanoxantha. Therefore, C. kanran may form symbiotic relationships with the genus Russula.