하악 제1대구치 이소맹출의 치험례

소정원,이광희,라지영,안소연,김윤희,반재혁 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

Ectopic eruption is caused by an abnormal direction of eruptive path, most common in maxillary first molar, mandibular lateral incisor, and maxillary canine, and sometimes mandibular first molar. Ectopic eruption of first molar leads to abnormal root resorption of second deciduous molar, which, if left untreated, could cause premature loss of second deciduous molar; mesial tilting and rotation of first permanent molar; lack of space for eruption of second premolar; and occlusal problems. Therefore early treatment is advised when diagnosed as ectopic eruption. Treatment of ectopic eruption in the first permanent molar involves providing proper guidance for the direction of eruption using interproximal wedging and distal tipping methods while preserving second deciduous molar. This case report shows satisfactory results of the ectopic eruption of mandibular first molars in young patients who were treated with Humphrey appliance and Halterman appliance. 이소맹출은 치아가 비정상적인 위치로 맹출하는 경우를 말하며, 주로 상악 제1대구치, 하악 측절치, 상악 견치에서 발생하며 하악 제1대구치에서는 드물게 발생한다. 제1대구치의 이소맹출은 흔히 제2유구치의 비정상적인 치근흡수를 야기하며, 이를 방치하게 되면 제2유구치의 조기상실, 제1대구치의 근심경사 및 회전, 제2소구치의 맹출 공간 부족 및 교합문제 등을 야기하게 되므로 이소맹출로 진단될 경우 조기 치료가 추천된다. 이소맹출은 대개 통상적인 방사선검사를 통해 발견되나, 간혹 제2유구치의 치근흡수가 심할 경우 치수가 감염되어 동통을 야기하는 경우도 있다. 이소맹출의 치료는 제2유구치를 보존하면서 제1대구치의 맹출 방향을 바로 잡아 주는 것으로 크게 치간이개(interproximal wedging)와 원심경사이동(distal tipping)을 이용한 방법을 사용한다. 본 증례들은 하악 제1대구치의 이소맹출을 보이는 환아들로, Humphrey appliance와 Halterman appliance를 이용하여 양호한 치료 결과를 얻었기에 보고하는 바이다.

어린이의 치과치료시 약물에 의한 진정요법 사용에 대한 실태조사

안소연,최병재,곽지윤,강정완,이제호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

진정요법은 소아치과에서 사용하는 보상, 속박, 체계적 탈감작법(말-시범-시행), 친밀감 같은 통상의 방법으로는 환자의 반응이 개선되지 않아 일반적인 치과치료가 불가능할 때 사용하는 행동조절법이다. 최근 국내에서도 진정요법을 이용하는 사례가 증가하는 추세이나 그 기준이나 방법들에 대한 연구는 매우 부족한 상태이다. 미국소아치과학회의 진정요법에 관한 기준이 있기는 하지만 국내의 상황이 미국과 다르므로 한국에서의 연구가 필요하다. 이에 저자는 국내에 거주하고 있는 소아치과의사들을 대상으로 국내 소아치과에서의 진정요법 현황에 대한 실태를 조사, 그 결과를 정리하여 향후 소아치과 임상에서의 진정요법에 대한 임상 기준을 정하는데 기여하고자 국내에 거주하고 있는 대한소아치과학회 회원 573명을 대상으로 진정요법 사용 실태에 관한 설문지를 발송하여 이 중 회신을 한 220명의 설문을 분석하여 다음의 결과를 얻었다. 1. 응답자의 약 66%가 진정요법을 사용하고 있다고 답했다. 진정요법에 관한 이전 연구 결과와 비교해 볼 때, 국내 소아치과에서 진정요법의 사용빈도가 증가하였다. 2. 진정요법으로 치료를 결정 하게 된 요인은 행동조절, 치료내용과 양, 보호자의 요구, 내원횟수, 전신질환의 순서이었다. 3. 진정요법으로 치료받는 환자의 연령은 만 3세가 가장 많았고, 만 4-5세, 만 2세 미만, 만 6-10세, 만 10세 이상의 순서로 조사되었다. 4. 진정요법 시 chloral hydrate는 60-70mg/kg, hydroxyzine은 10-40mg/kg(25mg/kg)을 사용하고 있었고, 경구 투여가 가장 선호하는 약물투여 경로였다. 5. 진정요법 시 사용하는 환자감시 방법은 피부나 손톱색 둥의 관찰을 포함한 환자 평가와 맥박 산소측정기(pulse oximeter)를 통한 환자감시를 선호하는 것으로 조사되었다. 6. 진정요법을 사용하고 있다고 응답한 사람의 약 56%에서 심폐소생술 교육을 받은 것으로 조사되었다. Sometimes the dentists encounter a child who can not be treated with traditional behavior management techniques (for example, reward, restraint, Tell-Show-Do, familialization). In such a case, the dentists use sedation technique. Recently, in Korea, the use of sedation by pediatric dentists is increased. But, the guideline and survey of sedation is very insufficient. Now, we need a survey of sedation practice in Korea. We carried out research on the actual condition about sedation with a questionaire to pediatric dentists in Korea. Followings are the conclusions 1. Sixty six percent of pediatric dentists use sedative agents in their practice. In this study, using sedation shows an increase as compared with the past. 2. Determinative factors of using sedation were orderly behavior management, number of visiting, guidian's opinion, amount of treatment, general condition. 3. Distribution of ages in patients sedated with agents was orderly 3 years, 4-5 years, under 2 years, 6-10 years, more than 10 years. 4. Particular sedative drugs were chloral hydrate 60-70mg/kg, hydroxyzine 10-40mg/kg(25mg/kg), and oral route was the most favorable route. 5. Observation of skin and nail color, pulse oximeter were the most frequently utillized monitoring method during sedation. 6. Only fifty six percent of pediatric dentists complete the cardiopulmonary resuscitation course.

군집분석과 다차원척도법으로 본 유치열의 우식패턴

정승열,이광희,라지영,안소연,김윤희 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

The purpose of this study was to identify patterns of caries in the dentition of preschool children using cluster analysis and multidimensional scaling. 815 preschool children aged 36-71 months old were examined for caries experience. The first four clusters in the cluster analysis were (1) molars, (2) upper incisors, (3) lower 1st molars, and (4) upper 1st molars in teeth, (1) occlusal surfaces of lower molars and upper 2nd molars, (2) mesial surfaces of upper central incisors, (3) occlusal surfaces of lower 1st molars, and (4) separation between occlusal surfaces of upper and lower 2nd molars in tooth surfaces, and (1) proximal surfaces of upper anterior teeth, (2) occlusal surfaces of lower molars, (3) buccolingual surfaces of upper anterior teeth and (4) buccolingual, proximal, and occlusal surfaces of upper molars and buccolingual and proximal surfaces of lower molars in tooth surfaces groups. In the multidimensional scaling analysis, teeth could be divided into lower 1st molars, upper 1st molars, upper central incisors, upper lateral incisors, lower 2nd molars, upper 2nd molars, and the rest(canines, lower incisors), tooth surfaces could be divided into occlusal surfaces of lower molars, mesial surfaces of upper central incisors, occlusal surfaces of upper molars, and the rest, and tooth surface groups could be divided into proximal surfaces of upper anterior teeth, buccolingual surfaces of upper anteiror teeth, occlusal surfaces of lower molars, and the rest in the order of the distance from others. In the cluster analysis and the multidimensional scaling analysis, caries patterns were different according to the age. 유치열에 존재하는 우식패턴을 연구하기 위하여 유치열을 가진 유아들을 대상으로 치면별 우식경험도 조사를 실시하고 군집분석과 다차원척도분석을 실시하였다. 연구대상은 367H 월 이상 71 개 월 이하의 어린이 815명 이 었다. 군집분석에서 먼저 분리된 네 개의 군집은, 유치는 (l) 유구치, (2) 상악 유절치, (3) 하악 제1유구치, (4) 상악 제1유구치, 유치면은 (1) 하악 유구치 교합면과 상악 제 2유구치 교합면, (2) 상악 유중절치 근심면, (3) 하악 제1유구치 교합면, (4) 상하악 제2유구치 교합면의 분리, 유치면군은 (l) 상악 유전치 인접면, (2) 하악 유구치 교합면, (3) 상악 유전치 협설면, (4) 상악 유구치 협설면, 인접면, 교합면 및 하악 유구치 협설면과 인접면이었다. 다차원척도분석에서 상호간에 가장 멀리 떨어진 순서로 보았을 때, 유치는 하악 제 1유구치 , 상악 제 1유구치 , 상악 유중절치, 상악 유측절치, 하악 제 2유구치, 상악 제 2유구치, 기타 유치(유견치, 하악 유절치)로 나눌 수 있었고, 유치면은 하악 유구치 교합면, 상악 유중절치 근심면, 상악 유구치 교합면, 기타 유치면으로 나눌 수 있었으며, 유치면군은 상악 유전치 인접면, 상악 유전치 협설면, 하악 유구치 교합면, 기타 유치면군으로 나눌 수 있었다.

광주전남지역 정상신생아의 상부 구순 계측치와 형태에 대한 연구

조안영,양정열,이승찬,천지선 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background and objectives : The face is the one of the most variable parts of the body and characterized not only by separated part but also by interrelation of the parts. Especially, in the case of bilateral cleft lip and palate, compared with unilateral case, it is necessary to establish the facial anthropometry in newborns, because of current trend of early intervention, such as fetal surgery, lip adhesion, and nasoalveolar molding device. Millard presented the concept of rotation advancement for unilateral cleft lip repair, and, thesedays, this method of cleft lip closure is acknowledged as the most optimal principle. However, it can produce a scar that crosses the upper one third of the philtrum obliquely. The purpose of this study is to determine the configuration of the vermillion tubercle, the Cupid's bow, and the philtrum, and to suppose that which anthropometric data and proportional index could be significant to determine the configulation of the philtrum in case of bilateral cleft lip and other deformity, which can't identify the philtral shape. Materials and Methods : 74 newborn infants, who were full-term normal infant In Gwangju-Jeonnam area were examined from April to June 2003. Mean gestational ages were 39 weeks. Mean birth weight was 3.3 Kg. Five anthropometric data, which were base of columella to tubercle, nasal base to Cupid's bow peak, Cupid's bow to commissure, philtrum, peak to peak, and mouth width were measured. And the proportional indexes of each data were evaluated. Morphologic parameter, which were the shape of vermillion tubercle, the Cupid's bow, the philtrum, were analized. Results : Mean values of five anthropometric data were 14.1±2.2, 10.5±2.7, 16.5±2.5, 6.9±1.8, and 26.7±4.9 each. And the one of these, Philtral width, peak to peak, and 7 proportional indexes which were ①/④, ②/④, ③/④, ⑤/④, ④/③, ④/②, ④/① have a significance according to 3 types of the philtral shape. The most common shape of vermillion tubercle is protrusion type (89.2%), and that of Cupid's bow is normal type (52.7) and that of philtrum is parallel from nostril base to vermilion border (70.7%). Conclusion : My study supplies the plastic surgeon and others with specialized interests in the craniofacial surgical area with fundamental normative population data that will help them decide what IS abnormal. And corrective surgery of the face and cranium is becoming so precise that the techniques and data detailed in this paper are essential to its further development.

상악 유전치부의 치간공간과 인접면 우식에 관한 조사연구

김진영,이광희,라지영,안소연,정승열,임경욱,반재혁 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

본 연구는 상악 유전치부의 치간공간과 인접면 우식의 상관관계를 평가해보고자 하였다. 익산에 거주하는 만3-7세의 어린이 555명을 대상으로 하였으며 탐침이 통과하는지 여부로 치간공간이 있음과 없음으로 분류하였고 와동이 형성되었거나 법랑질 표면이 연화되었을 경우 인접면 우식이 존재하는 것으로 판단하였다. 연구 결과 다음과 같은 결론을 얻었다. 1. 상악 유전치부의 치간공간은 영장류 공간이 77.4%, 발육공간이 유측절치와 유중절치 사이에서 54.4%, 양유중절치 사이에서 39.0%로 나타났다. 2. 인접면 우식발생율은 우측유견치가 6.3%, 우측유측절치가 14.7%, 우측유중절치가 33.5%, 좌측유중절치가 33.7%, 좌측유측절치가 16.0%, 좌측유견치가 4.7%로 나타났다. 3. 치간공간의 수가 많을수록 상악 유전치의 우식발생율은 낮아졌으나 그 상관관계(r=0.024)는 미약하였다. 4. 상악 유전치부에 공간이 존재하지 않을 경우 존재할 때 보다 평균 우식발생율이 높았으며, 치간공간이 전혀 존재하지 않는 경우 한 곳이라도 치간공간이 존재하는 경우보다 평균 우식발생율이 2배 이상 높은 것으로 나타났다. The purpose of this study was to assess the relationship between interdental spaces and proximal caries in maxillary anterior primary teeth. 555 children aged 3-7 inhabit in Iksan were divided into two groups, depending on the presence of interdental space which was detected by a dental explorer. They were determined to have proximal caries if cavity was formed or the enamel surface was softened. The results were as follows : 1. Regarding interdental spaces, 77.4% had primate spaces; 54.4% had developmental spaces between central and lateral incisor, and 39.0% between central incisors. 2. Interproximal caries incidences in right primary canine, lateral incisor, and central incisor were 6.3%, 14.7%, and 33.5%, respectively. Also interproximal caries incidences in left primary central incisor, lateral incisor, and canine were 33.7%, 16.0%, and 4.7%, respectively. 3. Children with more interdental spaces had less caries incidence, but the relationship was weak(r=-0.024). 4. The mean caries incidence was higher in absence of interdental space of maxillary primary incisors than in presence of space. The mean caries incidence with no interdental space was twice as high as that with presence of interdental space.

정신분열병 환자의 인지과제수행에서 삼차원적 시공간-운동 방해자극 처리의 특성

정혜정,김재진,박성혁,전종희,김지혜,염태호,이장한,김선일,구정훈,조원근,안석균,이홍식 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : Abnormalities of cognitive responses to verbal and visual distracter in schizophrenia have been demonstrated in numerous studies but little is known about three dimensional visuospatial-motor distracter processing. The purpose of this study was to investigate the vulnerability of patients with schizophrenia to three dimensional visuospatial-motor distracter. Methods : 14 patients with schizophrenia and 14 normal volunteers were assessed on three dimensional maze tasks requiring on working memory and reasoning ability in the virtual reality environment. Performances were compared according to with- or without-distracter conditions. Results : Patients with schizophrenia showed significantly lower performances than normal control group on cognitive flexibility, simple motor function or motor control and motor coordination, working memory span and delayed performance times. The performance index tended to be more deteriorated, but not significantly, in with-distracter condition than in Without-distracter condition in schizophrenia. Conclusions : Patients with schizophrenia tend to be vulnerable to visuospatial-motor distracter which simulate the real world of three dimensional environment.

Topical film prepared with <i>Rhus verniciflua</i> extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong, Ji Heun,Back, Seung Keun,An, Jong Hun,Lee, Nam‐,Seob,Kim, Do‐,Kyung,Na, Chun Soo,Jeong, Young‐,Gil,Han, Seung Yun John Wiley Sons, Inc. 2019 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B Vol.107 No.7

<P><B>Abstract</B></P><P>Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with <I>Rhus verniciflua</I> extract (RVE)‐loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier‐transform infrared spectroscopy and an <I>in vitro</I> release assay. Rat pups were randomly divided into two groups: vehicle‐treated (VEH; <I>n</I> = 5) and capsaicin‐treated (<I>n</I> = 15). The latter were given capsaicin subcutaneously at 24 h after birth for AD induction and further divided into three groups (<I>n</I> = 5 per each): not treated (CAP), pullulan hydrogel‐applied (PH), and RVE@PH‐applied (RVE‐PH). The pullulan hydrogel and RVE@PH were topically applied on shoulder lesions for 14 days (from 42 to 56 days after birth). Their phenotypes were compared based on the dermatitis score, epidermal thickness, mast cell infiltration, and serum myeloperoxidase (MPO) activities. The PH group showed significant attenuation in all the aforementioned values compared to the CAP group, suggesting that pullulan hydrogel itself has therapeutic activity against AD. Notably, the attenuations were more potent in the RVE‐PH group than the PH group, indicating that the therapeutic efficacy against AD is augmented by the presence of RVE, a loaded pharmaceutic. Collectively, these results indicate that RVE@PH inhibits AD through exerting the dual roles, that is, the pullulan hydrogel‐mediated physical and RVE‐mediated pharmaceutical actions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2325–2334, 2019.</P>

Safety of Laparoscopic Sentinel Basin Dissection in Patients with Gastric Cancer: an Analysis from the SENORITA Prospective Multicenter Quality Control Trial

An, Ji Yeong,Min, Jae Seok,Lee, Young Joon,Jeong, Sang Ho,Hur, Hoon,Han, Sang Uk,Hyung, Woo Jin,Cho, Gyu Seok,Jeong, Gui Ae,Jeong, Oh,Park, Young Kyu,Jung, Mi Ran,Park, Ji Yeon,Kim, Young Woo,Yoon, Ho The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.1

Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS). Materials and Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial. Results: Among the 108 eligible patients who were enrolled in the quality control trial, 8 (7.4%) experienced complications during the early postoperative period. One patient with gastric resection-related duodenal stump leakage recovered after percutaneous drainage (grade IIIa in CDC). The other postoperative complications were mild and patients recovered with supportive care. No complications were directly related to the laparoscopic SBD procedure or tracer usage, and there were no mortalities. The laparoscopic SBD complication rates and patterns that were observed in this study were comparable to those of a previously reported trial. Conclusions: The results of our prospective, multicenter quality control trial demonstrate that laparoscopic SBD is a safe procedure during SNNS for gastric cancer.

Protective effect of Rhus verniciflua Stokes extract in an experimental model of postmenopausal osteoporosis

Ji Heun Jeong,Jong Hoon An,Hui Yang,Do-Kyung Kim,Nam-Seob Lee,Young-Gil Jeong,Chun Soo Na,Dae Seung Na,Mi-Sook Dong,Seung Yun Han 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.3

Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor–binding affinities. In this study, the protective potential of RVS in PMO was evaluated by using an experimental animal model of PMO, which was established by ovariectomy (OVX) of female Sprague Dawley rats. The oral administration of RVS at 20 mg/kg or 100 mg/kg for 8 weeks markedly protected against OVX-induced atrophy of the uterine tube and reversed the elevation in the ratio of serum receptor activator of nuclear factor-kB ligand to osteoprotegerin, which is a marker of disease severity. In addition, RVS inhibited OVX-induced tibia bone loss, activated osteogenic activity, and suppressed osteoclastic activity in the tibial epiphyseal plate, a region of bone remodeling. Collectively, these factors indicated that the oral intake of RVS might be beneficial for the prevention of PMO.

Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial

An, Ji Yeong,Min, Jae Seok,Lee, Young Joon,Jeong, Sang Ho,Hur, Hoon,Han, Sang Uk,Hyung, Woo Jin,Cho, Gyu Seok,Jeong, Gui Ae,Jeong, Oh,Park, Young Kyu,Jung, Mi Ran,Park, Ji Yeon,Kim, Young Woo,Yoon, Ho Hindawi 2017 Gastroenterology Research and Practice Vol.2017 No.-

<P><B>Background</B></P><P> We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). </P><P><B>Methods</B></P><P> Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). </P><P><B>Results</B></P><P> Failure in step 7 (<I>n</I> = 23) was the most common followed by step 3 (<I>n</I> = 15) and step 6 (<I>n</I> = 13). We did not find any differences of clinicopathological factors between success and failure group in steps 1~6. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI < 23 kg/m<SUP>2</SUP> and 80.3% in those with BMI ≥ 23 kg/m<SUP>2</SUP> (<I>P</I> = 0.028). </P><P><B>Conclusions</B></P><P> Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.</P>