Morphology controllable synthesis of ZnSn(OH)<SUB>6</SUB> and their applications as quartz crystal microbalance measurements

Ji Won Lee,Sang-Hun Nam,Ki-Hwan Hwang,Hyeon Jin Seo,Jung-Hoon Yu,Dong In Kim,Rak Hyun Jeong,Jin-Hyo Boo 한국진공학회 2018 한국진공학회 학술발표회초록집 Vol.2018 No.8

Effect of Salviae Radix extract on renal function in cisplatin-intoxicated rabbits

Hwang, Won Man,Jeong, Ji Cheon 대한한방성인병학회 1999 韓方成人病學會誌 Vol.5 No.1

이전 연구에서 단삼추출물이 강력한 항산화 효과를 가지고 있음을 확인한바 있어 본 연구에서는 항암제인 cisplatin에 의해 유발된 시장기능 장애가 단삼추출물에 의해 방지될 수 있는 지를 조사하였다. 토끼에 cisplatin을 5㎎/㎏ 되게 복강내 주사하여 급성신부전을 유발하였고, 단삼추출물의 효과는 cisplatin을 주사하기 전 7일 동안 0.05%액 0.3 g/㎏용량을 구강을 통해 먹여 관찰하였다. Cisplatin을 주사하기 전 24시간 동안 요와 혈액을 채취하여 신장기능을 측정하여 대조시간 (basal period)의 값으로 하였고, cisplatin을 주사한 수 24시간 동안 요와 혈액을 얻어 cisplatin에 의한 신장기능 변화를 평가하였다. Cisplatin 처리에 의해 사구체여과율이 현저하게 감소하였고, 혈청내 creatinine 농도가 현저하게 증가되었다 이러한 결과들은 cisplatin 주사가 급성신부전을 유발하였음을 가르킨다. Cisplatin을 주사한 토끼의 신장에서 포도당 및 인산의 배설분율이 증가함으로서 신세뇨관 물질의 재흡수가 저해되었으며, 지질의 과산화가 증가하였다. 단삼추출물을 전 처리한 수 cisplatin을 주사한 경우 cisplatin에 의해 유발된 사구체여과율의 감소와 혈청내 cisplatin 농도증가 현상이 완화되었다. Cisplatin에 의한 세뇨관에서 물질의 재흡수장애가 단삼추출물의 전처치에 의해 방지되었다. 단삼추출물은 cisplatin에 의한 지질의 과산화를 억제하였다. 신피질절편을 이용한 실험관내 실험을 통해 cisplatin은 lactate dehydrogenase (LDH)유출을 증가시켰으며, 동시에 지질의 과산화를 증가시켰다. 이러한 증가는 단삼추출물에 의해 방지되었는데, 그 효과는 항산화제들과 유사하였다. 이상의 결과를 종합하면 cisplatin에 의한 급성신부전의 유발과정에 지질의 과산화가 중요한 역할을 할 가능성을 보이고 있으며, 단삼추출물은 cisplatin에 의한 신장기능 장애 및 지질의 과산화를 방지하였다. 이러한 단삼추출물의 방지 효과는 항산화 작용에 기인할 것으로 思料된다.

Efficacy of Unilateral Laminectomy for Bilateral Decompression in Elderly Lumbar Spinal Stenosis

Ji, Yong-Cheol,Kim, Young-Baeg,Hwang, Sung-Nam,Park, Seung-Won,Kwon, Jeong-Taik,Min, Byung-Kook The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.6

Objective: The aim of our study is to evaluate the effectiveness of unilateral hemilaminectomy for bilateral decompression in elderly patients with degenerative spinal stenosis. For this purpose, we studied the co-morbid condition and clinical outcome of patients who underwent decompressive surgery using the unilateral approach technique. Methods: Thirty-four patients over 65years of age who underwent unilateral partial laminectomy for bilateral decompression from January 2000 to October 2003 were analyzed. These patients were studied for preoperative co-morbid condition and physical status according to the American Society of Anesthesiologists(ASA) classification, postoperative morphometrical change, and clinical outcomes, including visual analogue scale(VAS) score. The mean follow-up was 23months (range 6 - 48months). Results: A patient's physical status was recorded as class I, II, or III by ASA classification, which correlated to 41.2%, 44.1%, and 14.7% of patients, respectively. The cross-sectional area of the pre- and postoperative dural sac at the level of the stenosis was $52.5{\pm}19.9mm^2$ and $110.6{\pm}18.2mm^2$, respectively. The outcome was excellent in 8.8%, good in 58.8%, fair in 23.6%, and poor in 8.8% of the patients. The VAS was changed postoperatively to $3.1{\pm}1.2$. There was no operation-related transfusion yet there was no evidence of postoperative instability at the follow-up examination. Conclusion: Unilateral laminectomy for bilateral decompression, in spite of the limited exposure, can result in satisfactory decompression of the lumbar spinal stenosis and tolerable clinical outcome. This approach is thought to be appropriate for elderly patients who have a greater surgical burden.

Bonding efficacy of cured or uncured dentin adhesives in indirect resin

Ji-Hyun Jang,Bin-Na Lee,Hoon-Sang Chang,Yun-Chan Hwang,Won-Mann Oh,In-Nam Hwang 大韓齒科保存學會 2011 Restorative Dentistry & Endodontics Vol.36 No.6

Objectives: This study examined the effect of the uncured dentin adhesives on the bond interface between the resin inlay and dentin. Materials and Methods: Dentin surface was exposed in 24 extracted human molars and the teeth were assigned to indirect and direct resin restoration group. For indirect resin groups, exposed dentin surfaces were temporized with provisional resin. The provisional restoration was removed after 1 wk and the teeth were divided further into 4 groups which used dentin adhesives (OptiBond FL, Kerr; One-Step, Bisco) with or without light-curing, respectively (Group OB-C, OB-NC, OS-C and OS-NC). Pre-fabricated resin blocks were cemented on the entire surfaces with resin cement. For the direct resin restoration groups, the dentin surfaces were treated with dentin adhesives (Group OB-D and OS-D), followed by restoring composite resin. After 24 hr, the teeth were assigned to microtensile bond strength (μTBS) and confocal laser scanning microscopy (CLSM), respectively. Results: The indirect resin restoration groups showed a lower μTBS than the direct resin restoration groups. The μTBS values of the light cured dentin adhesive groups were higher than those of the uncured dentin adhesive groups (p < 0.05). CLSM analysis of the light cured dentin adhesive groups revealed definite and homogenous hybrid layers. However, the uncured dentin adhesive groups showed uncertain or even no hybrid layer. Conclusions: Light-curing of the dentin adhesive prior to the application of the cementing material in luting a resin inlay to dentin resulted in definite, homogenous hybrid layer formation, which may improve the bond strength. [J Kor Acad Cons Dent 2011;36(6):490-497.] 연구목적: 본 연구는 간접 레진수복시 상아질 접착제의 중합 여부가 레진인레이와 상아질간의 미세인장결합강도와 결합계면 의 형태에 미치는 영향을 공초점 현미경 관찰을 통하여 평가하고자 하였다. 연구 재료 및 방법: 24개의 발거된 대구치를 절단하여 교합면 상아질을 노출시켰다. 수복 방법에 따라 크게 간접 레진수복과 직접 레진수복의 두 군으로 나누었다. 간접 레진수복군은 임시 수복하여 1주일 후, 상아질 접착 과정에 따라 4군(OB-C와 OB-NC군, OS-C와 OS-NC군)으로 나누었다. 간접 레진수복군은 산부식 처리된 상아질면에 OptiBond FL (Kerr) 또는 One-Step (Bisco) 상아질 접착제를 중합 여부에 따라 나누어 적용하였다. 처리된 상아질면에 제작된 3 mm 높이의 레진 인 레이(Tescera, Bisco)를 Variolink II (Ivoclar Vivadent)를 사용하여 제조사의 지시에 따라 합착하였다. 직접 레진수복군은 산부식 처리된 상아질면에 상아질 접착 후, 복합레진 (EsteliteΣ, Tokuyama)으로 즉시 수복하였다(OB-D군, OS-D군). 수 복을 마친 모든 치아는 24시간 후, 미세인장 결합 강도 평가와 공초점 레이저 주사 현미경 관찰(CLSM)을 시행하였다. 결과: 간접 레진수복군은 직접 레진수복군에 비하여 낮은 미세인장결합강도를 나타내었으며, 상아질 접착제를 광중합한 군 (OB-C군, OS-C군)이 광중합을 시행하지 않은 군(OB-NC군, OS-NC군)에 비하여 높은 미세인장결합강도를 나타내었다. 접착 계면에 대한 CLSM 관찰에서 상아질 접착제를 광중합한 군에서 더 분명하고 균일한 혼성층이 관찰되었다. 상아질 접착 제를 광중합하지 않은 군에서는 혼성층이 불분명하거나 거의 관찰되지 않았다. 결론: 간접 레진수복물의 합착시 레진시멘트의 적용 전에 상아질 접착제의 광중합은 분명하고 균일한 혼성층의 형성하며, 이 는 결합강도의 향상에 기여한다.

A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells

Ji Hyun LEE,Ji Woong KIM,Rim YANG,Seong-Won SONG,Song-Jae LEE,Yeongha JEON,Anna JU,Narim LEE,Min-Gu KIM,Minjoo KIM,kyusang HWANG,Jin Hwan YOON,Hyunbo SHIM,Sukmook LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Genome-wide Association Study Identification of a New Genetic Locus with Susceptibility to Osteoporotic Fracture in the Korean Population

Hwang, Joo-Yeon,Lee, Seung-Hun,Go, Min-Jin,Kim, Beom-Jun,Kim, Young-Jin,Kim, Dong-Joon,Oh, Ji-Hee,Koo, Hee-Jo,Cha, My-Jung,Lee, Min-Hye,Yun, Ji-Young,Yoo, Hye-Sook,Kang, Young-Ah,Oh, Ki-Won,Kang, Moo- Korea Genome Organization 2011 Genomics & informatics Vol.9 No.2

Osteoporotic fracture (OF), along with bone mineral density (BMD), is an important diagnostic parameter and a clinical predictive risk factor in the assessment of osteoporosis in the elderly population. However, a genome-wide association study (GWAS) on OF has not yet been clarified sufficiently. To identify OF-associated genetic variants and candidate genes, we conducted a GWAS in a population-based cohort (Korean Association Resource [KARE], n=1,427 [case: 288 and control: 1139]) and performed a de novo replication study in hospital-based individuals (Asan and Catholic Medical Center [ACMC], n=1,082 [case: 272 and control: 810]). In a combined meta-analysis, a newly identified genetic locus in an intergenic region at 10p11.2 (near genes FZD8 and ANKRD30A ) showed the most significant association (odd ratio [OR] = 2.00, 95% confidence interval [CI] = 1.47~2.74, p=$1.27{\times}10^{-6}$) in the same direction. We provide the first evidence for a common genetic variant influencing OF and genetic information for further investigation in bone metabolism.

[P8-04] Protective Effect of Administrated Glutathione-enriched Saccharomyces cerevisiae FF-8 against Carbon Tetra-chloride(CCl<SUB>4</SUB>)

Ji-Won Hwang,Chi-Hyeoung Lee,Bang-Sil Jun,Jae-Chul Moon,Ki-Soo Yoo,Jae-Young Cha,Young-Su Cho 한국식품영양과학회 2005 한국식품영양과학회 학술대회발표집 Vol.2005 No.10

Microwave Synthesis of a Porous Metal-Organic Framework, Nickel(II) Dihydroxyterephthalate and its Catalytic Properties in Oxidation of Cyclohexene

Ji Sun Lee,Shiva B. Halligudi,Nak Han Jang,Dong Won Hwang,장종산,Young Kyu Hwang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.6

A porous coordination solid of nickel(II) dihydroxyterephthalate has been synthesized by the microwave-assisted (MW) method. The synthesized nickel(II) dihyroxylterephthalate was designated by the general formula of [Ni2(dhtp)(H2O)2]·8H2O (where, dhtp = 2,5-dihydroxyterephthalate, denoted by Ni-DHTP). The effect of microwave-irradiation temperature and time of irradiation on the porosity and morphological changes in the solids have also been investigated. The catalytic performance of Ni-DHTP synthesized by MW method has been studied in the oxidation of cyclohexene with aqueous H2O2, which gave cyclohexene oxide as the primary product and 2-cyclohexene-1-ol as a major product.

Analysis of Microbiological Contamination in Kimchi and Its Ingredients

Ji-Hyun Lee,Ji-Hyoung Ha,Hae-Won Lee,Jae Yong Lee,Ye-Seul Hwang,Hee Min Lee,Sung Hyun Kim,Su-Ji Kim 한국식품위생안전성학회 2018 한국식품위생안전성학회지 Vol.33 No.2

본 연구에서는 김치 제조시 철저한 재료 세척의 필요성을 확인하고, 더불어 비가열 식품인 김치의 위생 안전성 실태를 파악하여 효율적 미생물 저감화 방안을 마련하고자 국내에서 유통되는 김치 원·부재료 200건의 세척 전과 후의 비교분석과 시판 김치 100건에 대하여 미생물 분석을 실시하였다. 김치 원·부재료 및 완제품에 대하여 일반 세균수, 대장균 및 대장균군을 모니터링 하였으며, 병원성 미생물 9종(Bacillus cereus, Clostridium perfringens 정성·정 량, Staphylococcus aureus, Enterohemorrhagic Escherichia coli, Campylobacter jejuni/coli, Yersinia enterocolitica, Salmonella spp., Vibrio parahaemolyticus, Listeria monocytogenes 정성)을 분석 하였다. 모니터링 결과, 김치 원· 부재료 및 완제품에서 일반세균은 1.4~9.0 log CFU/g 수준 으로 확인되었으며, 원·부재료 중 생강에서 8.8 log CFU/g, 완제품 중 총각김치에서 9.0 log CFU/g으로 일반세균이 가장 높게 나타났다. 대장균군은 0.5~7.3 log CFU/g으로 확 인되었으며, 생강에서 7.3 log CFU/g으로 가장 높게 나타 났고, 병원성 미생물 9종의 분석결과, Bacillus cereus를 제 외한 나머지 8종의 식중독균은 모든 시료에서 검출되지 않았다. 김치 제조 시 사용되는 김치 원·부재료들의 세척 공정 후 미생물 수는 일반세균수 0.2~3.2 log CFU/g, 대장 균군 0.3~2.7 log CFU/g, Bacillus cereus 1.0~3.9 log CFU/g 감소하였다. 따라서, 김치 원·부재료의 세척 공정으로 미생물 오염도를 감소 시켰으며, 이 결과를 통하여 김치 완 제품의 위생 및 저장성 증진에 기여 할 수 있을 것으로 확인되었다. Although Kimchi has health benefits, food poisoning associated with consumption of Kimchi has been frequently reported. Accordingly, microbiological properties of Kimchi (100 samples) and washing effects on microbial reduction against its ingredients (200 samples) were examined. Total aerobic bacteria, coliforms, Escherichia coli, Bacillus cereus, and Clostridium perfringens were quantified. In addition, B. cereus, Salmonella spp., Enterohemorrhagic E. coli, C. perfringens, Campylobacter jejuni/coli, Staphylococcus aureus, Vibrio parahaemolyticus, Listeria monocytogenes, and Yersinia enterocolitica were analysed qualitatively. Total aerobic bacteria count was approximately 1.4-9.0 log CFU/g, which were highest in ginger (8.8 log CFU/g), and Chonggak Kimchi (9.0 log CFU/g). The range of coliform counts detected in all raw materials was 0.5-7.3 log CFU/g and ginger showed the greatest number 7.3 log CFU/g among others. Contamination was decreased to 0.2-3.2, 0.3-2.7, and 1.0-3.9 log CFU/ g for total aerobic bacteria, coliforms, and B. cereus, respectively, after washing. Minimising microbial contamination in Kimchi ingredients is necessary to ensure the safety of Kimchi. These results indicate that washing is a useful method to reduce bacterial contamination in Kimchi.

Clinical characteristics of male and female Korean patients with systemic Lupus erythematosus: a comparative study

( Ji Won Hwang ),( Jae Joon Lee ),( Joong Kyoung Ahn ),( Eun Jung Park ),( Hoon Suk Cha ),( Eun Mi Koh ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2

Background/Aims: To compare the clinical characteristics and outcomes of systemic lupus erythematosus between male and female Korean patients. Methods: A retrospective analysis was performed at a single tertiary hospital from August 1994 to May 2010. Male patients were matched with two to three female patients based on age and disease duration. Organ damage was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR DI). Results: Fifty-three male patients were compared with 150 female patients. Renal disorders were found more frequently in male patients at disease onset (p < 0.001); the adjusted odds ratio (OR) demonstrated a significant sex preponderance for renal manifestations (OR, 3.26; 95% confidence interval [CI], 1.62 to 6.57). Diffuse proliferative lupus nephritis and end-stage renal disease requiring dialysis during the disease course were more prevalent in male patients (p = 0.025 and p < 0.001, respectively). The risk for requiring long-term dialysis was significantly higher in male than in female patients (OR, 4.02; 95% CI, 1.07 to 15.06), as was the mean SLICC/ACR DI (1.55 ± 1.35 vs. 1.02 ± 1.57, respectively; p = 0.028). Conclusions: Our data demonstrate that Korean patients with lupus have characteristics similar to those of cohorts reported previously. Male patients had significantly higher incidences of renal manifestations and organ damage.