The Application of Everyday Behavioral Pattern to Gesture Interface

Jang,Sun Hee,Lee,Kyung Won (사)한국디지털디자인협의회 2006 (사)한국디지털디자인협의회 conference Vol.2006 No.2

고랭지 농업 용수확보를 위한 소규모 빗물 이용시설 적용방안

전계원(Kye Won Jun)(全桂元),장창덕(Chang Deok Jang)(張昌德),정승권(Seung Kwon Jung)(鄭承權),전병희(Byong Hee Jun)(田炳熙) 위기관리 이론과 실천 2013 Crisisonomy Vol.9 No.8

최근 기후변화로 지난 2009년과 2012년에 강원도 태백시에서는 가뭄으로 인하여 엄청난 피해를 경험한 적이 있다. 또한 가뭄과 장마의 예측은 점점 더 어려워져 가는 실정이다. 특히 태백시의 87일간의 가뭄과 제한급수에 따른 피해액은 일상생활 134억원, 산업부문 338억원, 공공부문 47억원, 정신적ㆍ사회적 피해 1, 430억원 등 총 1, 949억원에 달하는 것으로 분석되었다. 태백시에 또 다른 큰 문제점은 가뭄으로 인한 고랭지 농업 피해로 인한 손실이다. 고랭지 배추를 생산하는 태백시는 우리나라 유일의 고산지역의 도시로서, 고랭지 농업이 특히 발달한 지역이다. 특히 태백 고랭지 배추는 태백시 농산품의 95.9%, 총 경지면적의 86.6%를 차지하고 있으므로, 배추의 생산성이 태백시 농산품 생산성을 대변한다고 할 수 있다. 본 연구에서는 태백시의 공공기관과 고랭지 농업 지역을 직접 방문하여 소규모 빗물 이용 시설에 대한 현황조사 및 시설의 상태를 점검하고 가뭄발생시 고랭지 농업지역의 피해를 최소화 할 수 있도록 소규모 빗물 이용 시설의 적용 방안 및 효과를 분석하였다. Recently, drought and rainy season are getting more serious. It is getting hard to forecast about drought because drought frequency is getting shorter than before. In 2009(winter) and 2012(summer), Taebaek-si was suffered from enormous damage due to the drought. Particularly, in 2009, cost of damage due to drought and restriction on water supply for 87days were estimated daily life sector 134 billion won, industry sector 338 billion won, the public sector 47 billion won, mental and social damage 1, 430 billion won. The other big issue of Taebaek is decrease in products of Highland Agricultural caused by the drought. Highland chinese cabbage which is the most important agricultural product in Taebaek-si account for 95.9% of all agricultural production of Taebaek-si and account for 86.6% of all gross area. For this reason, chinese cabbage of Taebaek-si is tropical agricultural product and is in charge of supply cabbage definitely. It is considered that if small scale rainwater harvesting system would be installed in highland agriculture area, it could reduce damage of drought at low cost and damage of cabbage would be decrease by system. For this study, We have researched regarding current status of Small Scale Rainwater Harvesting System of Highland Agriculture area in Taebaek-si and have compared with the amount of damage and installation cost in case of drought for the beneficial effects of Small Scale Rainwater Harvesting System, flexible supply of water and damage minimization of agricultural products.

흡연이 치과 외래 이용 및 치과 외래 의료비에 미치는 영향

정선락 ( Sun Rak Jeong ),김영희 ( Young Hee Kim ),장지언 ( Ji Eon Jang ),이원기 ( Won Kee Lee ) 대한예방치과·구강보건학회 2015 大韓口腔保健學會誌 Vol.39 No.4

Objectives: The objectives of this study were to evaluate the effect of smoking on utilization of and expenses in ambulatory dental care. Methods: The subjects of this study were 5,751 men aged over 20 years selected from the Korea Health Panel data collected during 2010-2012. Pack-years of smoking were calculated based on the survey data. Dental utilization was defined as dental outpatient clinic use least once in three years. The expenses in ambulatory dental care were summed to determine total dental health care spending for three years. To detect the effect of smoking, we used multiple logistic regression analysis for dental utilization and multiple linear regression for expenses in ambulatory dental care after changing log. Results: The pack-years had a significant effect on dental utilization and expenses in participants aged 40-59 years. After controlling for income level, bedtime brushing, and the presence of chronic disease, dental care utilization rates in the over 10 to less than 25 pack-year and the over 25 pack-year groups were about 1.4 (OR=1.37, (P =0.007)) and 1.6 times (OR=1.59, (P =0.001)) those in the 0 pack-year group. In comparison with the 0 pack-year group, the over 10 to less than 25 pack-year group spent 50,000 won more over dental expenses, while the corresponding number for the over 25 pack-year group was about 100,000 won. Thus, the ambulatory dental care expenses increased with the packyears of smoking. Conclusions: Smoking significantly influenced the utilization and expense in ambulatory dental care in men aged 40-59 years.

콜롬비아 소가모스에서 미세먼지 감축 시나리오 분석

박일수(Park, Il-Soo),장유운(Jang, Yu-Woon),하상섭(Ha, Sang-Sub),장수환(Jang, Su-Hwan),정경원(Chung, Kyung-Won),김혜원(Kim, Hye-Won),김희선(Kim, Hee-Sun) 한국외국어대학교 중남미연구소 2016 중남미연구 Vol.35 No.2

콜롬비아 소가모스 지역에서 미세먼지 감축 시나리오를 TAPM 모델을 활용하여 도출하고 평가하였다. 시나리오 1의 제철소 및 금속 등 중공업 오염원을 대상으로 미세먼지 방지 기술을 이용하여 배출량을 80% 감축하는 방안에서는 도시 중심 평균 농도는 6.5 μg m-3로 1.5 % 감소하였고, 모델영역에서 최고 평균농도는 387 μg m-3 로 변동 없었다. 시나리오 2의 벽돌 및 석회공장 등을 대상으로 연료를 석탄에서 코크스로 교체하여 90 % 감축하는 방안에서는 도시 중심 평균 농도는 4.5 μg m-3로 31.8%, 모델영역에서 최고 평균농도는 111 μg m-3 로 71.6 % 감소하였다. 시나리오 1과 시나리오 2를 결합한 시나리오 3에서는 도시 중심에서 평균 농도는 4.3 μg m-3로 34.8 %, 모델영역에서 최고 평균농도는 110 μg m-3 로 71.7 % 감소하였다. 소가모스 지역에서 대기환경을 개선하는 로드맵 수립에는 수공업에서 주로 사용되는 석탄 연료를 청정연료인 코크스로 교체하는 방안이 최우선으로 고려되어야 하겠다. 이후 미세먼지 방지 시설을 굴뚝에 설치하는 방안도 차선책으로 고려하여 환경과 경제가 선 순환하는 녹색성장관점에서 장기적인 미세먼지 개선 마스터 플랜이 수립되어야 하겠다. Reduction scenarios for PM10 concentration in Sogamoso, Colombia were analyzed using the TAPM( The Air Pollution Model). The average concentration of PM10 in the downtown area was 6.5 μg m-3, a reduction of 1.5 %. The maximum average concentration in the model domain was 387 μg m-3 without any reduction in scenarios 1 which the PM10 emissions from heavy industries such as iron and metal was reduced by 80 % using the prevention technology. In scenario 2 which the PM10 emissions from the brick and lime industries was reduced by 90 % substituting coke (a cleaner fuel) for coal, the average concentration of PM10 in the downtown area was 4.5 μg m-3, a reduction of 31.8 % , the maximum average concentration in the model domain was 111 μg m-3 , a reduction of 71.6 %. In scenario 3 which the scenarios 1 and 2 were combined, the average concentration of PM10 in the downtown area was 4.3 μg m-3, a reduction of 34.8 % and the maximum average concentration was 110 μg m-3, a reduction of 71.7 %. To put forward a road map for the reduction of PM10 in the Sogamos region, substituting coke for coal in manual industries should have priority over reduction policies. Also, it is highly recommended that a longterm master plan for reducing PM10 concentrations should be established with a focus on environmentally-friendly development and future green growth policy with a win-win relationship between economy and environment.

<i>FGFR1 </i> is amplified during the progression of <i>in situ </i> to invasive breast carcinoma

Jang, Min Hye,Kim, Eun Joo,Choi, Yoomi,Lee, Hee Eun,Kim, Yu Jung,Kim, Jee Hyun,Kang, Eunyoung,Kim, Sung-Won,Kim, In Ah,Park, So Yeon BioMed Central 2012 Breast cancer research Vol.14 No.4

<P><B>Introduction</B></P><P>Gene amplification is an important mechanism for activating oncogenes in malignant tumors. Although amplification of <I>HER2</I>, <I>C-MYC</I>, <I>CCND1 </I>and <I>FGFR1 </I>has been reported in breast cancers, their role in the progression of <I>in situ </I>to invasive breast carcinoma is unclear. To investigate this question we compared the amplification frequencies of these genes in pure ductal carcinoma <I>in situ </I>(DCIS), DCIS associated with invasive carcinoma, and invasive carcinoma.</P><P><B>Methods</B></P><P>We performed fluorescence <I>in situ </I>hybridization of the selected genes on tissue microarrays composed of 179 pure DCIS and 438 invasive carcinomas. Two hundred and sixteen of the latter had DCIS components, and in those cases we compared gene amplification in the intraductal and invasive components of each carcinoma.</P><P><B>Results</B></P><P>The rate of amplification of <I>FGFR1 </I>was higher in invasive carcinomas than in the pure DCIS, but the opposite was true for <I>HER2 </I>amplification. These findings applied consistently to high-grade tumors, but not to low/intermediate-grade tumors. The amplification status of <I>HER2</I>, <I>C-MYC</I>, <I>CCND1 </I>and <I>FGFR1 </I>was generally similar in the matched invasive and DCIS components of the same tumors. However, <I>FGFR1 </I>amplification was more common in the invasive components than in the DCIS components. In survival analyses, <I>FGFR1 </I>amplification was found to be an independent prognostic factor for poor disease-free survival for all patients with invasive carcinoma and for the hormone receptor-positive subgroup.</P><P><B>Conclusion</B></P><P>Amplification of <I>HER2</I>, <I>C-MYC </I>and <I>CCND1 </I>seems to play a role in the early development of breast cancer, but not in its progression. However, the increased frequency of <I>FGFR1 </I>amplification in invasive carcinomas compared with pure DCIS and in the invasive components of individual tumors, and its association with decreased disease-free survival, suggests a role for <I>FGFR1 </I>amplification in the progression of breast cancer including <I>in situ</I>-to-invasive transition, as well as initiation.</P>

Efficacy of Living Donor Liver Transplantation in Patients with Methylmalonic Acidemia

Jang, Jae Guk,Oh, Seak Hee,Kim, Yu Bin,Kim, Seo Hee,Yoo, Han-Wook,Lee, Beom Hee,Namgoong, Jung-Man,Kim, Dae Yeon,Kim, Ki-Hun,Song, Gi-Won,Moon, Deok-Bog,Hwang, Shin,Lee, Sung-Gyu,Kim, Kyung Mo The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.3

Purpose: Despite aggressive medical and nutritional management, patients with methylmalonic acidemia (MMA) often suffer from multi-organ damage. Early deceased donor liver transplantation (DDLT) has emerged as an intervention to prevent disease progression. We investigated the efficacy of living donor LT (LDLT) with a potential carrier of MMA and a small volume of graft in patients with MMA as an alternative to DDLT. Methods: Of five patients (three male, two female; median age 5.7 years; range, 1.3-13.7 years), four underwent carrier LDLT, while one underwent non-carrier auxiliary LDLT. All patients received pre- and post-LT continuous renal replacement therapy and were provided with minimal restriction diet according to serum MMA level after LT. MMA levels in the serum and urine, the incidence of metabolic crisis, and clinical findings before and after LT were compared. Results: The survival rate was 100% during 2.2 years of follow up period after LT. In all five cases, MMA titer in the serum after transplantation decreased with less restrictive diet. Metabolic crisis was not observed during the follow-up period. In addition, no patient showed progression of severe renal impairment requiring hemodialysis. Progression of delayed cognitive development was not observed. Social functioning with improved neuropsychiatric development was observed. Conclusion: This study showed that LDLT achieved improved quality of life with less restrictive diet, therefore it could be a feasible alternative option to DDLT for the treatment of patients with MMA, even with an auxiliary LT.

Slide Session : OS-END-05 ; Diabetes : Carotid Artery Plaque and Apolipoprotein B to Apolipoprotein A-I Ratio Predict Cerebrovascular Stenosis in Asymptomatic Patients with Type 2 Diabetes

( Hee Sun Kwon ),( Jin Kyeong Shin ),( Jang Won Son ),( Sung Rae Kim ),( Soon Jib Yoo ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Diabetes mellitus (DM), as a strong risk factor of atherosclerosis, is associated with coronary artery disease (CAD) and ischemic stroke. Common carotid artery intima-media thickness (CCA-IMT) is considered as a surrogate marker of atherosclerosis and is used for a primary prevention of CAD. But CCA-IMT is used as a secondary prevention in ischemic stroke restrictively. This cross sectional study assessed CCA-IMT cut-off point and associating factors for predicting cerebrovascular stenosis in asymptomatic patients with type 2 diabetes. Methods: Type 2 diabetic patients without past stroke history were enrolled between January 2011 and February 2013. We measured CCA-IMT and other risk factors of atherosclerosis. Cerebrovascular stenosis was evaluated by magnetic resonance angiography (MRA) for patients with carotid artery thickness. Carotid artery thickness was defined as CCA-IMT =0.9 mm or the presence of plaque (i.e. focal CCA-IMT =1.5 mm). Results: Among 65 subjects, 47(72%) showed cerebrovascular stenosis on MRA. Maximun CCA-IMT(max-IMT) was 1.8 ± 0.5 mm in subjects with no cerebrovascular stenosis, 2.5 ± 0.8 mm in subjects with cerebrovascular stenosis(p< 0.0001). The apolipoprotein B/A-I (Apo B/A-I) ratio was 0.5 ± 0.1 in subjects with no cerebrovascular stenosis, 0.7 ± 0.0 mm in subjects with stenosis after adjusting atherosclerosis risk factors like age, sex, hypertension and smoking(p < 0.024). The area under the curves (AUC) for max-IMT was 0.782(95%CI 0.661-0.875; p<0.0001) and for Apo B/A-I ratio was 0.712(0.578-0.823; p=0027) by ROC curve analysis. The cutoff value for the greatest sensitivity and specificity for max-IMT was 2.12 mm (sensitivity 65.2, speci- ficity 83.3). Conclusions: We suggest the carotid artery plaque and Apo B/A-I ratio might be independent predictors of cerebrovascular stenosis in asymptomatic patients with type 2 diabetes.

Effect of roasting treatment on the chemical composition of Citrus (Citrus unshiu) peel

Hee Chul Ko,Jeong Yong Park,Jung Min Oh,Mi Gyeong Jang,Jae-Won Kim,Songyee Baek,Se-Jae Kim 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

Polymorphisms in the <i>survivin</i> gene and the risk of lung cancer

Jang, Jin Sung,Kim, Kyung Mee,Kang, Kyung Hee,Choi, Jin Eun,Lee, Won Kee,Kim, Chang Ho,Kang, Young Mo,Kam, Sin,Kim, In-San,Jun, Jae Eun,Jung, Tae Hoon,Park, Jae Yong Elsevier 2008 Lung cancer Vol.60 No.1

<P><B>Summary</B></P> <P><B>Background</B></P> <P>Survivin is an apoptosis inhibitor and plays an important role in the development and progression of cancer. Polymorphisms in the <I>survivin</I> gene may influence survivin production or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the association between <I>survivin</I> polymorphisms and the risk of lung cancer in a Korean population.</P> <P><B>Methods</B></P> <P>We first screened for polymorphisms in the <I>survivin</I> gene by direct sequencing of genomic DNA samples from 27 healthy Koreans. We selected identified SNPs based on their frequency, linkage disequilibrium status and haplotype tagging status, and then genotyped the selected SNPs in 582 lung cancer patients and 582 healthy controls who were frequency matched for age and gender.</P> <P><B>Results</B></P> <P>We identified 8 single nucleotide polymorphisms (SNPs): 6 known SNPs [−644T>C, −625G>C, −31C>G, 9194A>G (K129E), 9386T>C and 9809T>C] and 2 novel SNPs (9974C>T and 10347G>A). Among the SNPs studied, only the −31C>G genotype distribution was significantly different between the cases and controls (<I>P</I> =0.04). Individuals with at least one −31G allele were at a significantly decreased risk of lung cancer compared to those individuals with the −31CC genotype [adjusted odds ratio (OR)=0.74, 95% confidence interval (CI)=0.57–0.96, <I>P</I> =0.02]. When the lung cancer cases were categorized by tumor histology, the −31G allele was associated with a significantly decreased risk of adenocarcinoma (adjusted OR=0.59, 95% CI=0.41–0.84, <I>P</I> =0.003). Consistent with the results of the genotyping analysis, the −625G/−31G/9194A/9809T haplotype carrying the −31G allele was associated with a significantly decreased risk of adenocarcinoma (adjusted OR=0.56, 95% CI=0.40–0.77, <I>P</I> =0.0004). The promoter assay revealed the −31G allele to have a significantly lower promoter activity than the −31C allele.</P> <P><B>Conclusion</B></P> <P>These results suggest that the <I>survivin</I> −31C>G polymorphism influences <I>survivin</I> expression, thus contributing to the genetic susceptibility to lung cancer.</P>

The Scaffolding Protein WAVE1 Associates with Kinesin 1 through the Tetratricopeptide Repeat (TPR) Domain of the Kinesin Light Chain (KLC)

Won Hee Jang(장원희),Young Joo Jeong(정영주),Sang-Hwa Urm(엄상화),Dae-Hyun Seog(석대현) 한국생명과학회 2016 생명과학회지 Vol.26 No.8

Kinesin superfamily proteins (KIFs)은 세포 내 소기관이나 단백질복합체를 미세소관을 따라 운반하는 모터단백질이다. Kinesin 1은 경쇄단위체(light chain subunit)를 통하여 결합함으로써 세포 내 소기관, 신경소포, 신경전달물질수용체, 신호전달단백질, mRNA 등 다양한 운반체를 운반하는 KIFs의 한 종류이다. Kinesin light chains(KLCs)은 모터기능이 없는 단위체로서 kinesin heavy chains (KHCs) 이량체와 결합하여 kinesin 1을 구성한다. KLCs은 여러 단백질과 결합하지만 아직 결합단백질이 충분히 밝혀지지 않았다. 본 연구에서 KLC1의 tetratricopeptide repeat (TPR) 영역과 결합하는 단백질을 분리하기 위하여 효모 two-hybrid 탐색을 수행한 결과 Wiskott-Aldrich syndrome의 원인단백질이며 액틴 세포골격 조절단백질인 WASP/WAVE family의 하나인 WAVE1을 분리하였다. WAVE1은 KLC1의 TPR 영역을 포함한 부위와 결합하지만 KHCs인 KIF5A, KIF5B, KIF5C 와는 결합하지 않았다. 또한 KLC1은 WAVE1의 C-말단에 존재하는 verprolin/cofilin/acidic (VCA) 도메인과 결합하였으며, 다른 WAVE isoform인 WAVE2와 WAVE3과도 결합하였다. HEK-293T 세포에 WAVE1과 KLC1을 동시에 발현시켰을 때 두 단백질이 세포 내에서 같은 부위에 존재하며, WAVE1을 면역침강한 결과 KLC1뿐만 아니라 KIF5B가 같이 침강함을 확인하였다. 이러한 결과들은 kinesin 1이 WAVE 단백질복합체 혹은 WAVE로 덮여있는 운반체를 운반함을 시사한다. Kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motor proteins essential for the intracellular transport of organelles and protein complexes in cells. Kinesin 1 is a member of those KIFs that transport various cargoes, including organelles, synaptic vesicles, neurotransmitter receptors, cell signaling molecules, and mRNAs through interaction between its light chain subunit and the cargoes. Kinesin light chains (KLCs) are non-motor subunits that associate with the kinesin heavy chain (KHC) dimer. KLCs interact with many different binding proteins, but their particular binding proteins have not yet been fully identified. We used the yeast two-hybrid assay to identify proteins that interact with the tetratricopeptide repeat (TPR) domain of KLC1. We found an interaction between the TPR domain of KLC1 and Wiskott-Aldrich syndrome protein family member 1 (WAVE1), a member of the WASP/WAVE family involved in regulation of actin cytoskeleton. WAVE1 bound to the six TPR domain-containing regions of KLC1 and did not interact with KHCs (KIF5A, KIF5B, and KIF5C) in the yeast two-hybrid assay. The carboxyl (C)-terminal verprolin-cofilin-acidic (VCA) domain of WAVE1 is essential for interaction with KLC1. Also, other WAVE isoforms (WAVE2 and WAVE3) interacted with KLC1 in the yeast two-hybrid assay. When co-expressed in HEK-293T cells, WAVE1 co-localized with KLC1 and co-immunoprecipitated with KLC1 and KIF5B. These results suggest that kinesin 1 motor protein may transport WAVE complexes or WAVE-coated cargoes in cells.