후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

흔치않은 대상포진 치험 2예 : 비전형적 부위와 다른 부위로 재발한 예 Unusal Dermatome and Recurs Other Dermatome

김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Herpes zoster is well known as an acute, self-limited disease of unilateral sensory dermatome caused by varicella-zoster virus and characterized by grouped vesicular skin eruption and pain over several dermatomes as well as single. This virus usually affects the thoracic dermatome and there are a few reports that this virus involves lower lumbar or sacral area, and recurrent cases. We experienced 2 cases that zoster virus involved L4 or S2 dermatome and left typical skin lesions, of which one was a recurrent case involving different dermatome at an interval of 8 years and the other was a rare case involving sacral dermatome.

데빅병 치료에 사용한 Interferon β-1b의 부작용 1예

김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

A 63 year-old woman who had diagnosis of multiple sclerosis complaining left hemiparesis and fluctuating decreased visual acuity in her right eye and abnormal findings in pattern shift visual evoked potentials(PSVEPs) and on T2 weighted MR scanning. We treated her subcutaneously with 250μg interferon (3-lb(ITFß -lb) every other day. There were detected pancytopenia, skin rash, and abnormal liver function test seven days after the therapy. In spite of reducing the dose of interferon injection, abnormal laboratory findings were not returned to normal. Dose adjustment of interferon-I3 for body weight or race, may be helpful to reduce the side effects.

Acinetobacter sp. BE-254에 의한 유화제의 생산

최경숙,장경립,임이종,김순한,정영기,이태호 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The strain producing bioemulsifier was isolated from soil samples. The isolated strain was identified as the genus Acinetobacter through its morphological, cultural and physiological characteristics. The highest emulsification activity and stability by Acinetobacter sp. BE-254 was observed after 5 days of cultivation in the culture medium containing n-hexadecane 4%, NaNO₃0.2%, KH₂PO₄0.01%, MgSO₄·7H₂O 0.01%, CaCl₂0.01%, and yeast extract 0.01%. The optimum pH and temperature for bioemulsifier production were pH 7.0 and 30℃, respectively. Furthermore the most of bioemulsifier was produced during the exponential growth phase, and this suggested that the bioemulsifier production was growth-associated. The bioemulsifier showed good emulsification activity on various emulsifying substrates such as hydrocarbons, edible oils, and petroleum fractions.

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

상아질형성부전증에 대한 증례보고

한강석,이상호,최용성 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.2

Dentinogenesis imperfecta is inherited as a single autosomal dominant trait. Clinical features of dentinogenesis imperfecta is one in which the primary and permanent teeth are a characteristic reddish brown to gray opalescent color. Enamel is usually brokedown and exposed soft dentin abrades rapidly. Radiographs show slender roots and bulbous crown. The pulp chamber is small and pulp canals are small and ribbon-like. A 8-year-old and 9-year-old brother with complaint of abnormal crown shape and color of the teeth came to department of Pediatric Dentistry for complete rehabilitation. Family history revealed the wearing the complete denture due to premature loss of permanent teeth is several relatives. The obtained results were as follow. 1. Teeth showed yellowish brown color. The crown of teeth showed severe attrition and breakdown of enamel in both deciduous and permanent dentitions. 2. Partial or complete obliteration of the pulp chambers and pulp canals, and small teeth buds of permanent premolar were observed on radiographs. 3. Family history revealed the complete denture due to premature loss of permanent teeth in several rlatives. 4. Restorations of anterior teeth with composite resin veneering showed good esthetic result. But brokendown easily due to loss of dentinal support. 5. Restoration of posterior teeth with preformed crown rehabilitated the masticatory function and estabilished the vertical dimension of occlusion. But further care is needed for estabilishment of final vertical dimension of occlusion after completion of the permanent dentition.

대학주도의 사회교육 모형을 위한 실천적 연구 -새마을 대학의 개설과 운영을 중심으로-

최학주/ 김성회 / 박용진 / 한상각 / 이창섭 공주교육대학교 초등연구원 1977 公州敎大論叢 Vol.13 No.2

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위절제술 후 발생하는 당뇨병의 원인과 병태생리에 관한 연구

최영식,고용호,박요한 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2

Recently several cases of diabetes were found after undergoing gastrectomy. The loss of stomach profoundly affects glucose metabolism which may lead to the development of diabetes in a certain group of patients, particularly those with diabetic risk factors such as family history. obesity, and other insulin resistance states. The purpose of this study is to investigate the changes in the plasma lipids and glucose metabolism and the risk factors of diabetes in patients who are planned to undergo gastrectomy so that it may help for the treatment and prevention of gastrectomy-related diabetes. The non-diabetic patients who admitted to Kosin Medical Center for gastrectomy were prospectively studied since March 1, 1995. They were divided into 2 groups; those with family history of diabetes, overweight, obesity, or impaired glucose tolerance on oral glucose tolerance test (OGTT) (group Ⅰ, n=5) and those without (group Ⅱ, n=5). The ability to control blood glucose was evaluated by measuring blood glucose, insulin, C-peptide and glucagon during OGTT which was performed before and 1 month after gastrectomy. Ten out of 34 patients who entered the study were followed at 1 month after gastrectomy. Body weight decreased from 58.1±9.7 kg to 54.9±7.3 kg and values of other parameters of nutritional status also decreased. The levels of blood glucose, insulin, C-peptide, and glucagon generally increased at 0, 60, and 120 minutes during postoperative OGTT as compared to those levels during preoperative OGTT. The blood glucose level increased from 147.6±31.5 to 178.2±45.7 mg/dl at 60 min. (p=0.07) and the insulin level increased from 38.1±27.0 uU/ml to 113.6±96.1 uU/ml at 60 min. (p=0.05). In preoperative OGTT the insulin level was higher at 60 min. and at 120 min. in group I than in group Ⅱ (56.7±23.9 uU/ml vs. 19.4±11.6 uU/ml, p=0.03, 36.1±21.4 uU/ml vs. 8.51±6.9 uU/ml, p=0.03, respectively). Most patient took three meals a day and highly concentrated carbohydrate such as honey between meals. Impaired glucose tolerance developed postoperatively in one woman of overweight group but none of normal weight group. The development of impaired glucose tolerance in one of 3 overweighted women and abnormal glucose metabolism in general after gastrectomy suggests that postoperative risk of development of impaired glucose tolerance be substantial, particularly in patients with diabetic risk factors such as obesity. To prevent the development of postoperative abnormal glucose metabolism adequate weight control before operation, preferably from young age, and postoperative measures to decrease excessive insulin secretion and hence insulin resistance, such as frequent small meals which consist of low carbohydrate and increased mono- and polyunsaturated fatty acid are suggested.

기어가 부착된 회전축계의 연성진동

최용문,손종동,윤한익 東義大學校産業技術開發硏究所 1992 産業技術硏究誌 Vol.6 No.-

The coupled effect on natural frequencies of Rotor System is studies by transfer matrix method. The results of this study are summarized as follows; (1) In case of coupled longitudinal vibration with flexural vibration the coupled effect of longitudinal vibration were 11.76% in comparison with first natural frequency of flexural vibration, 10.44% in comparison with second natural frequency, 3.1% in comparison with third natural frequency and 4.25% in comparison with fourth natural frequency. (2) In case of coupled longitudinal vibration with torsional and flexural vibration the coupled effects were almost same above. (3) It is found that the coupled effect have an influence on the mode shapes of flexural vibration.