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롤러스케이트 선수의 운동상해발생과 예방에 대한 조사 연구
김동희,김도수,채양석,이하얀,김선호,조성채 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
The study was intended to research the fact of roller skate players injury. For the study, kinds and parts of injuries, skills to be hurted, facility, injured time, cause, remedy, mental response and protecting were investigated through 182 roller skate players. The results were as follows : 1. The injury body part was showed that leg was the highest and followed by knee and ankle. 2. In the cause of injury was showed as follows: skills on corner work, bank track with concrete, 200m distance. 3. In the general cause of injury was showed: chronic fatigue by over training. 4. In the treatment and participation period after injury outbreak were showed: treatment period was toward the inside 1 week and participation to play during the treatment. 5. To the injury prevention players responded warm up, and cool down and mental-concentration were needed. Supervisor, coach and players responded knee protector wearing was needed in elementary school players and helmet-chin protector wearing in general players. The game rule revision was not necessary and the agree and disagree for ground unity to resemble. Almost players to be like concrete ground.
OB-04 : Maternal serum pregnancy-associated plasma protein-A as a predictor of severe preeclampsia
( Ha Yan Kwon ),( Hyo Ryun Lee ),( Ju Hyun Cho ),( Hee Young Cho ),( Young Han Kim ),( Yong Won Park ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The aim of study was to evaluate whether a level of maternal serum PAPP-A was associated with preeclampsia and to investigate the role of these screening serum analysis in the prediction of severe preeclampsia. 방법: A retrospective study was conducted in pregnant women presenting for first-trimester aneuploidy screening between January 2009 and December 2013. A total of 33 patients who had developed preeclampsia during the subsequent pregnancy course and 151 woman who had not any adverse obstetric outcomes were identified. Maternal and neonatal data were reviewed from the medical records and PAPP-A, free ß-hCG and NT MoM values were compared between the two groups. 결과: NT and CRL values were no significant difference between two groups(p= 0.501 and p=0.964, respectively). Although free ß-hCG values showed no statistically significant difference(p=0.786), the levels of PAPP-A were significantly decreased in the preeclampsia group compared to the control group(<p=0.05). However, PAPP-A levels were no significant difference between non-severe and severe preeclampsia groups(p=0.268). 결론: Our study showed than low PAPP-A value is associated with preeclampsia, although it is limited as a predictor of preeclampsia severity.
YAN, BING CHUN,JEON, YONG HWAN,PARK, JOON HA,KIM, IN HYE,CHO, JEONG-HWI,AHN, JI HYEON,CHEN, BAI HUI,TAE, HYUN-JIN,LEE, JAE-CHUL,AHN, JI YUN,KIM, DONG WON,CHO, JUN HWI,WON, MOO-HO,HONG, SEONGKWEON SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.6
<P>Brain inflammation has a crucial role in various diseases of the central nervous system. The hippocampus in the mammalian brain exerts an important memory function, which is sensitive to various insults, including inflammation induced by exo/endotoxin stimuli. Tetanus toxin (TeT) is an exotoxin with the capacity for neuronal binding and internalization. The present study investigated changes in inflammatory mediators in the mouse hippocampus proper (CA1-3 regions) and dentate gyrus (DG) after TeT treatment. The experimental mice were intraperitoneally injected with TeT at a low dosage (100 ng/kg), while the control mice were injected with the same volume of saline. At 6, 12 and 24 h after TeT treatment, changes in the hippocampal levels of inflammatory mediators cyclooxygenase-2 (COX-2) and nuclear factor kappa-B (NF-κB/p65) were assessed using immunohistochemical and western blot analysis. In the control group, moderate COX-2 immunoreactivity was observed in the stratum pyramidal (SP) of the CA2-3 region, while almost no expression was identified in the CA1 region and the DG. COX-2 immunoreactivity was increased by TeT in the SP and granule cell layer (GCL) of the DG in a time-dependent manner. At 24 h post-treatment, COX-2 immunoreactivity in the SP of the CA1 region and in the GCL of the DG was high, and COX-2 immunoreactivity in the SP of the CA2/3 region was highest. Furthermore, the present study observed that NF-κB/p65 immunoreactivity was obviously increased in the SP and GCL at 6, 12 and 24 h after TeT treatment. In conclusion, the present study demonstrated that systemic treatment with TeT significantly increased the expression of COX-2 and NF-κB/p65 in the mouse hippo-campus, suggesting that increased COX-2 and NF-κB/65 expression may be associated with inflammation in the brain induced by exotoxins.</P>
Yan, Bing Chun,Park, Joon Ha,Chen, Bai Hui,Cho, Jeong-Hwi,Kim, In Hye,Ahn, Ji Hyeon,Lee, Jae-Chul,Hwang, In Koo,Cho, Jun Hwi,Lee, Yun Lyul,Kang, Il-Jun,Won, Moo-Ho Medknow PublicationsMedia Pvt Ltd 2014 Neural regeneration research Vol.9 No.19
<P>Long-term administration of scopolamine, a muscarinic receptor antagonist, can inhibit the survival of newly generated cells, but its effect on the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus remain poorly understood. In this study, we used immunohistochemistry and western blot methods to weekly detect the biological behaviors of nerve cells in the hippocampal dentate gyrus of adult mice that received intraperitoneal administration of scopolamine for 4 weeks. Expression of neuronal nuclear antigen (NeuN; a neuronal marker) and Fluoro-Jade B (a marker for the localization of neuronal degeneration) was also detected. After scopolamine treatment, mouse hippocampal neurons did not die, and Ki-67 (a marker for proliferating cells)-immunoreactive cells were reduced in number and reached the lowest level at 4 weeks. Doublecortin (DCX; a marker for newly generated neurons)-immunoreactive cells were gradually shortened in length and reduced in number with time. After scopolamine treatment for 4 weeks, nearly all of the 5-bromo-2′-deoxyuridine (BrdU)-labeled newly generated cells were located in the subgranular zone of the dentate gyrus, but they did not migrate into the granule cell layer. Few mature BrdU/NeuN double-labeled cells were seen in the subgranular zone of the dentate gyrus. These findings suggest that long-term administration of scopolamine interferes with the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus, but it does not induce cell death.</P>
Yan, Bing Chun,Park, Joon Ha,Ahn, Ji Hyeon,Choi, Jung Hoon,Yoo, Ki-Yeon,Lee, Choong Hyun,Cho, Jun Hwi,Kim, Sung Koo,Lee, Yun Lyul,Shin, Hyung-Cheul,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.7
<P>It has been reported that young animals are less vulnerable to brain ischemia. In the present study, we compared gliosis in the hippocampal CA1 region of the young gerbil with those in the adult gerbil induced by 5 min of transient cerebral ischemia by immunohistochemistry and western blot for glial cells. We used male gerbils of postnatal month 1 (PM 1) as the young and PM 6 as the adult. Neuronal death in CA1 pyramidal neurons in the adult gerbil occurred at 4 days post-ischemia; the neuronal death in the young gerbil occurred at 7 days post-ischemia. The findings of glial changes in the young gerbil after ischemic damage were distinctively different from those in the adult gerbil. Glial fibrillary acidic protein-immunoreactive astrocytes, ionized calcium-binding adapter molecule (Iba-1), and isolectin B4-immunoreactive microglia in the ischemic CA1 region were activated much later in the young gerbil than in the adult gerbil. In brief, very less gliosis occurred in the hippocampal CA1 region of the young gerbil than in the adult gerbil after transient cerebral ischemia.</P>
( Ha Yan Kwon ),( Kyung Mee Choi ),( Hee Young Cho ),( Young Han Kim ),( Yong Won Park ),( Ja Young Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
To evaluate the risk of cesarean section due cephalopelvic disproportion or induction failure according to maternal pre-pregnant body mass index (BMI), 2009 Institute of Medicine (IOM) gestational weight gain guideline and large for gestational age (LGA) infant. We conducted a retrospective study and analyzed data of 1519 women with singleton full-term birth from 2010 to 2012. Pregnancy with preeclampsia, chronic hypertension, diabetes, gestational diabetes, previous myomectomy status, planned cesearean section due to CPD or elderly primigravida, placenta previa and delivery due to fetal distress or fetal anomaly were excluded. Odds ratio (OR) and 95% confidence intervals of cesarean section were obtained with adjustment for maternal age, parity, gestational age, fetal gender, pre-pregnant BMI, weight gain and birthweight. Of 1519 pregnancies, 178 (11.7%) cases underwent emergency cesarean delivery. Higher pre-pregnant BMI and weight gain tended to have an increased risk of cesarean section, however it was not significant stastically. Pregnancies with LGA infant had a significant association with increasing risk of cesarean section (OR, 2.38 ;95% confidence interval, 1.5-3.5). Women with LGA infant has an increased risk of cesarean section when adjusting for BMI and weight gain. However, maternal pre-pregnant BMI and excess weight gain were not clearly associated with risk of cesarean section in this study.
Yan, Bing Chun,Park, Joon Ha,Ahn, Ji Hyeon,Lee, Young Joo,Lee, Tae Hun,Lee, Choong Hyun,Cho, Jun Hwi,Kim, Myong Jo,Kim, Tae Young,Kang, Il-Jun,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.5
<P>In the present study, we compared the immunoreactivities and levels of Trx/prx redox system, thioredoxin 2 (Trx2), thioredoxin reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), as well as neuronal death in the hippocampal CA1 region between the adult and young gerbil after 5 min of transient cerebral ischemia. At 4 days post-ischemia, pyramidal neurons (about 90%) in the adult stratum pyramidale of the CA1 region showed 'delayed neuronal death (DND)'; however, at this time point, few pyramidal neurons showed DND in the young stratum pyramidale. At 7 days post-ischemia, about 56% of pyramidal neurons showed DND in the young stratum pyramidale. The immunoreactivities of all the antioxidants in the young sham-group were similar to those in the adult sham-group. At 4 days post-ischemia, the immunoreactivity of TrxR2, not Trx2 and Prx3 in the adult ischemia-group was dramatically decreased in CA1 pyramidal neurons. At this time point, the immunoreactivities of all the antioxidants in the young ischemia-group were apparently increased compared to the adult ischemia-group. From 7 days pots-ischemia, non-pyramidal cells showed the immunoreactivities of all the antioxidants in the ischemic CA1 region; however, in the young ischemia-groups, the immunoreactivities were much lower than those in the adult ischemia-groups. In brief, our results showed that the immunoreactivities of Trx2, TrxR2 and Prx3 were dramatically increased in CA1 pyramidal neurons of the young ischemia-groups at 4 days post-ischemia compared to those in the adult ischemia-groups induced by transient cerebral ischemia.</P>