(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

분자역학적 방법을 이용한 부산시내 대형건물 냉각탑수의 레지오넬라균의 형별 분류

김정만,정석훈,서대영,박은희,송은주,최재철,이은엽,장철훈 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

Effect of 2-Deoxy-D-Glucose on Metabolic Status, Proliferative Capacity and Growth Rate of FSall Tumor

Hyesook Chang(장혜숙) , Eun Kyung Choi최은경) , Jeong Gill Cho(조정길) , Tae-Hwan Lim(임태환) , Tae-Keun Lee(이대근) ,Yun Yi(이윤) ,Young Joo Cho(조영주) , Gon Sup Kim(김곤섭) 대한방사선종양학회 1991 Radiation Oncology Journal Vol.9 No.1

2-DDG가 쥐의 섬유육종(FSall)에 미치는 영향에 대한 연구로 에너지 신진대사는 체내에서의 ³¹P - 자기공명 분광기를 이용하여 관찰하였고 세포 증식 능력은 유세포 분석기를 사용하여 연구하였다. 성장속도는 개의 세포를 C₃Hj/Sed 쥐의 발등에 이식한 후 3차원적으로 측정하여 관찰하였다. 2-DDG를 투여한 경우에는 이식후 12일에 복강내로 주사하였다. 이식후 12일의 종양의 평균 크기는 250㎣이었다. FSall 종양의 성장속도는 semilog graph의 기울기와 종양의 doubling time으로 측정하였다. 2-DDG를 투여한 후 성장속도가 감속되었다. 5~12일 사이의 성장속도의 기울기가 0.828, 종양의 Idubling time이 0.84일이고 대조군에서는 13~28일 사이의 기울기가 0.218, doubling time이 3.2일인 반면 2-DDG 투여군에서는 성장속도의 기울기가 0.135이고 doubling time이 5.1일이었다. ³¹P-자기공명 분광기를 이용하여 2-DDG의 영향을 분석해 본 결과 2-DDG 투여후 종양증식 속도의 감속과 더불어 phosphomonester (PME)와 inorganic phosphate (Pi)의 증가속도가 감소하였다. 이것은 2-DDG 투여후 세포의 괴사가 감소하였다는 의미가 있다. 유세포 분석기를 이용하여 종양의 증식 능력을 분석한 결과는 2-DDG 투여후 S-phase와 G₂+M phase의 DNA 분포가 크게 증가하였다. 이것은 2-DDG 투여후 세포가 좀더 방사선에 민감한 cycle로 진행함을 의미하는 것으로 해석할 수 있다. 이에 저자들은 2-DDG가 FSall 종양세포에 미치는 흥미있는 결과를 토대로 방사선 치료에 미치는 영향과 실제 이용 가능성에 대하여 더 연구하고자 한다. The effect of 2-deoxy-d-glucose (2-DDG) on C₃H mouse fibrosarcoma(FSall) was studied, Metabolic status, especially for energy metabolism, was studied using in vivo P-MRS, prolifer-ative capacity was observed on flow cytometry(FC) and growth rate was measured after trans-plantation of viable tumor cells in the dorsum of foot of C₃Hf/Sed mice. One gram of 2-DDG per kg of body weight was injected intraperitoneally on 12th day of implantation. Average tumor size on 12th day of implantion was 250㎣. Growth rate of FSall tumor was measured by tumor doubling time and slope on semilog plot. After 2-DDG injection, growth rate slowed down. Tumor doubling time between tumor age 5-12 days was 3.2 days with slope 0.218 in control group. After 2-DDG injection, tumor doubling time was elongated to 5.1 days with slope 0.136. The effect of 2-DDG studied in vivo P-MRS suggested that the increase of phosphomonoes-ter (PME) and inorganic phosphate (Pi) by increasing size of tumor, slowed down after 2-DDG injection. Flow cytometry showed significantly increased S-phase and G₂ + M phase fraction suggesting increased proliferative capacity of tumor cells in the presence of 2-DDG. Authors observed an interesting effect of 2-DDG on FSall tumor and attempt to utilize as an adjunct for radiotherapy.

억제대 적용지침 개발을 통한 불필요한 억제대 적용율 감소활동

곽경선,김성은,배은경,이은숙,이은혜,최윤정,이윤경 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 억제대 적용에 대한구체적 적용지침 없이 의례적으로 억제대를사용함으로 인해 환자들의 신체적 또는 정신적 안전을 위협할 수 있다. 목적: 완전 진정상태 이거나 근력이 약하여 발관능력이 없는 환자에 대한 예방적 적용, 바빠서 환자를볼수 없 는경우, 간호사본인의 판단이 없이 타인의 요구에 따르는등의 불필요한 억제대 적용이 증가하는 원인을 파악하여 중환자실의 특수성에 맞는 억제대 적용및 제거 지침을 마련하고자 한다. 의료기관: 인천광역시에 소재한 의과대학 소속병원의 집중치료실 개선효과: 억제대 적용에 대한중환자실 간호사에게 미치는 영향을 보면 태도 정도 p=0.09(p<0.1), 올바른 수행 능력은 p= 0.005 (p <0.0히로통계적으로유의한것으로 나타났다. 지식 정도 p=0.172(p<0.05) 통계적으로 유의 하지는 않지만 모든항목이 개선 활동전 에 비해 2,3차 개선 활동후에 향상한 것으로 나타났다. 개선활동전에 8.1%였던 간호 기록, 0.7%였던 간호중재, 0%였던 의사처방율이 3차 개선 활동 후 3가지 모두 100% 달성되었다. 이는 억제대 적용율 갑소 및 부적절한 억제대 적용율은 유의하게 감소하였다. 교훈: 중환자실 간호사의 억제대 적용에 대한태도, 지식, 올바른 간호 수행 능력은 지속적으로 재평가 되어지고, 교육내용은좀더 나은 간호제공을 위하여 개발 되어져야 할 것이다. 억제대 적용 기준과 제거 기준을 Check List 하여 객관성의 유지를 위한 개선 활동은계속적으로 Feedback 되어야 할 것이다.

알케인류 상변화물질의 열적 특성 해석

崔恩洙,鄭東柱 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - The objective of the present study is to reveal thermal characteristics of various alkane phase-change-material which have high latent heat during phase change from solid to liquid. In order to analysis thermal characteristics of various phase-change-material, phase-change temperature and energy of various phase-change-material were measured by using differential scanning calorimeter. The phase-change-material slurries which are used in this study were paraffin particle, microcapsulated octadecane and microcapsulated lauric acid. The heating rate of differential scanning calorimeter and the size of phase-change-material were changed during phase-change temperature and energy measurement.

Rheology of Decamethylceclopentasiloxane (cyclomethicone) W/O Emulsion System

Choi, Min-Hyung,Jeong, So-Ra,Nam, Sang-In,Shim, Sang-Eun,Chang, Yoon-Ho The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.12

A highly dispersed W/O emulsion of silicone oil (cyclomethicone)/water system was prepared with a nonionic surfactant. The surface and interfacial tension between the oil and water were characterized in terms of the droplet size distribution and viscosity change of the emulsion. When the dispersed phase concentration was relatively high, the viscosity of the emulsion was rapidly increased and the droplet size of the emulsion was decreased. The rheological behavior of the emulsion system showed non-Newtonian and shear thinning phenomena depending upon the content of the dispersed phase. The droplet size of the emulsion was decreased with increasing surfactant content and water concentration. The relative viscosity of the emulsion was better predicted with the Choi-Schowalter model than with the Taylor model. The value of the complex modulus increased with increasing surfactant concentration. The linear viscoelastic region was expanded with a dispersed phase concentration. According to the change in the viscosity, the behavior was classified into three distinct regions: [I] linear viscoelastic, [II] partially viscoelastic, and [III] viscous. The creep/recovery behaviors in each region were characterized.

조기위암의 형태학적인 분류에 따른 임파절 전이 양상

최은서,강길,박정희,장정환,김권천,김경종,민영돈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Currently, in the limited cases of early gastric cancer (EGC), endoscopic mucosal resection (EMR) is used for curative treatment. However, its completeness is still controversial. The purpose of this study was to review the suggested indications of EMR. We retrospectively analyzed 234 patients with EGC who underwent curative (RO) gastrectomy. The enrolled cases were further classified into mucosal and submucosal types, and mucosal EGC were further classified according to the size, gross type and histologic pattern. 133 patients had mucosal cancers and 101 patients submucosal. The overall incidence of positive lymph node was 14.1% (33/234), the incidence of mucosal cancer was 8. 3% (11/133), which was significantly lower than that of submucosal, 22% (22/101). Of 133 patients with mucosal EGC, 90 were smaller than 2㎝ in size and the incidence of lymph node metastasis was 5.6% (5/90), compared to 43 of larger than 2㎝ with the incidence of 14% (6/43). According to the gross type classification of mucosal cancer, incidence of lymph node metastasis in protruded type (EGC type Ⅰ, Ⅱa, Ⅰ+Ⅱa) was 15.4% (4/26), nat type(EGC type Ⅱb) 2. 9% (1/35), depressed type (EGC type Ⅱc, Ⅲ) 8.3% (6/72). Lymph node metastasis in differentiated type of mucosal cancer was 6.9% (5/72) and undifferentiatcd type 9.8% (6/61). In this study, there was no single indication free from lymph node metastasis, It is thought that the selection of EMR for the curative treatment of EGC should be considered carefully and more clinical studies with long-term follow up are necessary for EMR to be generally acceptable.

미립피복 로릭산 슬러리의 열물성치 및 겉보기 점도 특성에 관한 연구

鄭東柱,崔恩洙 明知大學校 産業技術硏究所 2005 産業技術硏究所論文集 Vol.24 No.-

The objective of the present study is to reveal the thermal and flow characteristics of MC lauric acid slurry. The thermal characteristics of pure lauric acid and MC lauric acid were tested by a differential scanning calorimeter. The cooling curve of MC lauric acid showed a double curve, while that of the lauric acid showed a single curve. The effects of encapsulation was measured and explained. The flow characteristics of MC lauric acid slurry were tested by a capillary tube viscometer and a rotating cylindrical viscometer. The slurry showed shear thinning behavior, when the fraction of MC lauric acid is over 5%.

Thiopental Sodium, Propofol(Diprivan^�) 및 Midazolam이 안압에 미치는 영향

최정은,서경덕,서동선,최세진 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Intraocular pressure(IOP) were measured during induction of anesthesia with thiopental sodium(n = 10), propofol(n=10), and midazolam(n=10). IOP were measured using a Schioetz tonometer before and after induction, and 1min and 3min after endotracheal intubation. All patients were divided into three groups as follows ; Group Ⅰ(n=10) : thiopental sodium 5mg/kg was administered intravenously for induction of anesthesia Group Ⅱ(n=10) : propofol 2mg/kg was administered intravenously for induction of anesthesia Group Ⅲ(n=10) : midazolam 0.2mg/kg was administered intravenously for induction of anesthesia Succinylcholine 1mg/kg were administered intravenously for endotracheal intubation in all groups. The results were as follows ; 1) Induction of anesthesia with propofol and thiopental sodium are associated with a significant reduction in IOP. 2) Induction of anesthesia with propofol is associated with more significant reduction in IOP than thiopental sodium. 3) Induction of anesthesia with midazolam is not associated with reduction in IOP. From above results, propofol can be used as effectively as thiopental sodium for general anesthesia in patients who undergo ophthalmic surgery.

가토를 이용한 PYROST(Porous Hydroxyapatite)의 골 재생에 관한 실험적 연구

최응옥,정전은,최정호,김태연 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.3

PYROST is a biocompatible porous matrix implantable as a bone graft substitute. This biomaterial has been used in a bariety of experimental settings over the past years and more recently has been used in clinical applications for the filling of bone defects. its use in human may help to eleminate the morbidity the morbidity of autogenous bone graft donor sites and resorption of autogenous bone graft. We studied the new bone regeneration within a PYROST block which were placed end to end in a subperiosteal pocket on the nasal dorsum of 1.8-2.0 kg New Zealand white rabbit. En block specimen were harvested at 4.8 and 12 weeks post onlay. These were then decalcified. imbedded and sectioned in the sagittal plane. For the confimation of bone regeneration within a PYROST we used weighing the PYROST and light microscope, point-counting technique and fluorescent microscope. The results obtained were summarized as follow : 1. There was no volume change of PYROST 2. The activation of osteoblasts and bone matrix were found of 4 weeks and matrix of lamellar pattern was found 12 weeks post onlay. 3. The quantity of the regenerated new bone within a PYROST was increased at 12 weeks (32 ±2.1%) than 4 weeks(15 ±1.8%).