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두경부 편평세포암종세포주에서 retinoic acid가 linear-quadratic 모델을 적용한 방사선감수성과 apoptosis 유발에 미치는 영향
이은숙,강범현,허민석,이삼선,최현배,최순철,박태원 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.3
Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods : We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2,4,6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1, 2, 3, 4 and 5 after irradiation (2,10 and 20 Gy) combined with retinoic acid. Results and Conclusion : SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive, For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714(NHOK), 4.098(HEp-2) and 11.79(FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis. (Korean J Oral Maxillofac Radiol 2001; 31 : 135-43)
( Da Eun Kim ),( Hyeri Yang ),( Won Hee Jang ),( Kyoung Mi Jung ),( Miyoung Park ),( Jin Kyu Choi ),( Mi Sook Jung ),( Eun Young Jeon ),( Yong Heo ),( Kyung Wook Yeo ),( Ji Hoon Jo ),( Jung Eun Park ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
In order for a novel test method to be applied for regulatory purposes, its reliability and relevance, I.e., reproducibility and predictive capacity, must be demonstrated, Here, we examine the predictive capacity of a novel non-radioisotopic local lymph node assay, LLNA:BrdU-FCM (5-bromo-2`-deoxyuridine-flow cytome-try), with a cutoff approach and inferential statistics as a prediction model. 22 reference substances in OECDTG429 were tested with a concurrent positive control. Hexylcinnamaldehyde 25%(PC), and the stimulation index(SI) representing the fold increase in lymph node cells over the vehicle control was obtained. The optimal cutoff SI(2.7≤cutoff<3.5), with respect to predictive capacity, was obtained by a receiver operating character-istic curve, which produced 90.9% accuracy for the 22 substances. To address the inter-test variability in respon-siveness, SI values standardized with PC were employed to obtain the optimal percentage cutoff(42.6≤Cutoff<57.3%of PC), which produced 86.4% accuracy. A test subastance may be diagnosed as a sensitizer if a statistically significant increase in Si is elicited. The parametric one-sided t-test and non-parametric Wilcoxon rank-sum test produced 77.3% accuracy. Similarly, a test substance could be defined as a sensitizer if the SI means of the vehicle control, and of the low, middle, and high concentrations were statistically significantly different, which was test-ed using ANOVA or Kruskal-Wallis, with post hoc analysis, Dunnett, or DSCF(Dwass-Steel-Critchlow-Fligner), respectively, depending on the equal variance test, producing 81.8% accuracy. The absolute SI-based cutoff approach produced the best predictive capacity, however the discordant decisions between prediction models need to be examined further.
중년여성의 영적안녕, 사회적 지지가 건강증진행위에 미치는 영향
허제은(Heo, Je eun),정경숙(Jeong, Kyeong Sook),태영숙(Tae, Young sook) 고신대학교 전인간호과학연구소 2015 전인간호과학학술지 Vol.7 No.-
Purpose: This study was to identify the impact of spiritual wellbeing and social support on the Health promotion behavior among middle aged women. The research design was descriptive study. Methods: The subjects completed structured questionnaires: the ‘Spiritual Well-being Scale’, developed by Paloutzian & Ellison, Social Support Scale developed by Zimert et al MSPSS, ‘HPLP scale’ developed by Sechrist & Pender. Data were collected from 214 middle aged women in B metropolitan city, J city. The data were analyzed using t-test, ANOVA, Scheffe s test, Pearson s correlation coefficients, and multiple Stepwise regression. Results: Participants with higher health promotion behavior had higher scores for spiritual wellbeing (r=.22, p<.001) and higher scores for social support (r=.49, p=.011). The factors seen as contributing to health promotion behavior were spiritual wellbeing, social support, utilization of spare time, and perceived health status. These variables were explained 42% of the variance in health promotion behavior. Conclusion : The health promotion behavior of middle aged women can be increased if social support and spiritual wellbeing is improved. Therefore, we suggested to develop nursing intervention programs in order to improve social support and spiritual wellbeing of middle aged women for increasing their health promotion behavior.
외과계 중환자에서의 초기 정맥영양공급의 현황 분석과 열량대단백비의 임상적 의의
허은정 ( Eun Jeong Heo ),박가영 ( Ka Young Park ),전수정 ( Su Jeong Jeon ),남궁형욱 ( Hyungwook Namgung ),이은숙 ( Eun Sook Lee ),송인애 ( In Ae Song ) 한국정맥경장영양학회 2015 한국정맥경장영양학회지 Vol.7 No.3
Purpose: Surgical critically ill patients require adequate nutrition support and the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) guidelines recommend low non-protein calorie: nitrogen ratio (NPC:N ratio, 70∼100) for critically ill pateints. In this study, we assess the current use of early parenteral nutrition of surgical critically ill patients and analyze the clinical significance of NPC:N. Methods: This is a retrospective study of critically ill adult patients who remained in the intensive care unit (ICU) for over 3 days and could not receive enteral nutrition for the first 7 days. Data on parenteral intake of patients were collected from electronic medical records. Association of NPC:N scores with clinical outcome (length of ICU stay, length; of hospital stay, duration of ventilation, and mortality) were analyzed using Pearson correlation and multiple regression. Results: The study included 72 cases, average parenteral calorie intake was 14.6 kcal/kg/day and protein intake was 0.5 g/kg/day. We assessed the NPC:N scores to determine the patients’ NPC:N for the first 7 days in ICU close to the A.S.P.E.N guidelines. NPC:N scores showed weak negative correlation with length of hospital stay and duration of mechanical ventilation (r=-0.259, P=0.028; r=-0.495, P=0.001). Multiple regression adjusted with APACHE (Acute Physiology and Chronic Health Evaluation) II score, age, and body mass index showed correlation of higher NPC:N score with decreased length of hospital stay and shorter duration of ventilation (P=0.0001, P=0.035, respectively). However, length of ICU stay and mortality within 60 days showed no significant correlation with NPC:N scores. Conclusion: Parenteral calories and protein intakes of critically ill patients in ICU were lower in comparison to A.S.P.E.N. recommendation in this study. Low NPC:N scores might be related to shorter length of hospital stay, duration of mechanical ventilation. Consultation of a nutritional support team could have a positive effect in providing appropriate nutrition support.
Heo, Youn-Jung,Kim, Jueng-Eun,Weerasinghe, Hasitha,Angmo, Dechan,Qin, Tianshi,Sears, Kallista,Hwang, Kyeongil,Jung, Yen-Sook,Subbiah, Jegadesan,Jones, David J.,Gao, Mei,Kim, Dong-Yu,Vak, Doojin Elsevier 2017 Nano energy Vol.41 No.-
<P><B>Abstract</B></P> <P>We report organic cation additives in lead iodide solutions as a practical approach for roll-to-roll production of perovskite solar cells. Sequential deposition, which is known to be more reliable than 1 step process, is modified to be even more reliable and suitable in roll-to-roll process. Addition of less than stoichiometric amount of organic cations in PbI<SUB>2</SUB> solution effectively improves processability by working as crystallization retardant and make dried PbI<SUB>2</SUB> film more reactive for faster conversion to perovskite. The printing-friendly sequential deposition is used in air with slot die coating, an industrial up-scaling technique, to produce a perovskite solar cell on glass with a 14.4% power conversion efficiency (PCE). The process is then used in actual roll-to-roll machine in air to produce flexible perovskite solar cells with up to 11.0% PCE.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Conventional sequential deposition is modified to be more suitable for roll-to-roll process. </LI> <LI> Reactive intermediate shows more rapid conversion to perovskite than conventional PbI<SUB>2</SUB> intermediate. </LI> <LI> Fully slot die coated perovskite solar cells under ambient condition shows a power conversion efficiency of 14.4%. </LI> <LI> Roll-to-roll processed flexible perovskite solar cells show power conversion efficiency of 11%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Eun-sook Park ),( Hye-ryeon Heo ),( Ji-hye Jang ),( Young-youl Kim ),( Hyun Joung Lim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Inhaled PM2.5 could induce adverse health effects in respiratory systems, but the underlying mechanisms are not well defined. We aim to explore the intrinsic mechanisms and new therapeutic targets regulating the PM2.5- exposed pathological conditions. Methods We performed a transciptomic analysis of cells isolated from PM2.5 (NIST 1650b) exposed 3D mucociliary tissues model (EpiAirway FT), in order to identify PM2.5-dependent mRNA and miRNA expression changes. Results A number of genes, miRNAs, biological process, KEGG pathways were identified during PM2.5 exposure in 3D mucociliary tissues. Compared with control DMSO group, we identified 779 upregulated or downregulated genes in PM2.5 exposed 3D EpiAirway groups. The top functions impacted by these gene expression changes included regulation of epithelial cilium movement, cilium-dependent cell motility and cilia structure. With respect to miRNA changes, we found that 23 targets were significantly changed and particularly identified 6 targets associated cilium. Using paired mRNA/miRNA-sequencing data, we found that targets gene and miRNAs can affect abnormal cilia motility. Conclusions This study suggests that PM2.5-induce changes in gene/miRNA expression may contribute to mucociliary clearance dysfunction via defects in cilia structure and function. And these changed target gene and miRNAs may contribute to the adverse respiratory effect of air pollution exposure (This work was supported by the Research Program funded by the Korea Disease Control and Prevention Agency (2020-NI-099-02)).