고위험군 가와사끼병에서 스테로이드 추가 요법의 효과

강선미,문은경,인수미,길홍량 대한소아과학회 2002 小兒科 Vol.45 No.12

Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

병원 근로자들의 고용형태에 따른 직무 스트레스와 삶의 질의 관계

전은숙,이강숙,이선영,유재희,홍아름 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 본 연구는 병원에 종사하는 정규직 비정규직 근로자의 직무스트레스와 삶의 질 수준을 파악하고 직무스트레스와 삶의 질과의 관련성 및 삶의 질에 영향을 미치는 요인을 규명하기위해 수행되었다 방법 자기기입형 설문조사를 실시하였으며 정규직 172명 비정규직 189명이 최종 분석하였다 일반적 특성과 한국인 직무스트레스 측정도구-단축형 (Korean occupational stress scale short form) 삶의 질 측정을 위한 도구 WHOQOL-BREF를 사용하였다 결과 정규직에 비해 비정규직에서 직무스트레스 수준이 높았다 정규직은 직무요구도와 직장문화의 항목에서 비정규직은 직무자율성 직무불안정성 보상부적절의 항목에서 직무스트레스 요인이 유의하게 많았다 삶의 질수준은 정규직 근로자에서 유의하게 높았으며 심리적 영역 사회적 영역 생활환경 영역에서 비정규직보다 유의하게 높은 수준을 보였다 결론 정규직과 비정규직 근로자의 직무스트레스 요인과 삶의 질 수준은 달랐다 고용형태를 막론하고 직무스트레스는 삶의 질에 부정적인 영향을 미치고 있었으며 비정규직은 직장문화로 인한 스트레스 요인이 많을수록 삶의 질이 낮았다 따라서 병원근로자의 삶의 질 향상을 위하여 적절한 관리 혹은 프로그램이 제공되어야 할 것이며 특히 비정규직 근로자의 직무스트레스를 일으키는 요인들에 대한 적절한 관리가 필요할 것이다 Objective This study was conducted to evaluate the relationship between job stress and quality of life for hospital workers by type of employment Methods Data were obtained for 361 workers in a large hospital 172 of whom were categorized as typical workers defined by permanent employee and 189 of whom were categorized as atypical workers defined by fixed term contraction Job stress was assessed using the Korean Occupational Stress Scale Short Form and the World Health Organization Quality of Life-BREF Questionnaire Results Atypical workers had significantly higher scores for job related stress in the domains Of insufficient control over work job insecurity and lack of reward in the workplace compared with typical workers who had higher scores for stress in the domains of job demands and occupational climate Test scores also indicated that typical workers had a significantly better quality of life than atypical workers especially in terms of mental health social relationships and environment Conclusion These findings suggested that factors contributing to job-related stress were different between typical and atypical hospital and typical workers are likely to have a better quality of life

성인 자원자에서 B방식 초음파를 이용해 측정한 경동맥 내막중막두께의 분포

이선규,황희영,김형식,장미선,이은주,강문호,고광곤 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

한국어판 모호한 의도-적개심 설문지 개발

장형윤,이선구,김경란,이수영,박진영,김은주,강지인,이은,안석균 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives We studied the psychometric properties of a Korean version of the Ambiguous Intentions Hostility Questionnaire (K-AIHQ), which measures hostile social-cognitive biases for use in the research on paranoia. Methods The translation and back-translation of the AIHQ with concern for the cultural differences were done according to the standard procedure. A sample of 83 healthy volunteers completed the K-AIHQ. Results The scores of the K-AIHQ were comparable to the results of the original studies. The Paranoia Scale was correlated with the K-AIHQ, but Magical Ideation and Perceptual Aberration scales were not correlated with the K-AIHQ. The interrater reliabilities of the items in each situation were in the acceptable range. Conclusion The KAIHQ seems to be a reliable and valid test to measure the hostile social Cognitive biases of patients with paranoia.

만성정신질환자의 직업재활 사례

황태연,한은선,이영문,강순정,정경선 용인정신의학연구소 1995 용인정신의학보 Vol.2 No.1

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

Genetic Diversity and Relationship of Radish (Raphanus spp.) Accessions Revealed by Molecular Markers, Morphological Traits and Geographical Information

Eun Seon Kang,Sun Mi Ha,Ho Cheol Ko,Seoung-Ryong Cheong,Myeong-Whoon Seo,Won Byoung Chae 한국원예학회 2015 한국원예학회 학술발표요지 Vol.2015 No.5