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생간건비탕가삼칠근(生肝健脾湯加三七根)이 흰쥐의 간섬유화 억제에 미치는 영향
이은,김영철,고흥,Lee, Eun,Kim, Young-Chul,Ko, Heung 대한한방내과학회 2008 대한한방내과학회지 Vol.29 No.2
The aim of this study was to investigate the inhibitory effect of Saengangeonbitang-gasamchilgn(SGGBTGSCG) on collagen production in rat hepatic stellate cells(HSC) and on the TAA-induced chronic liver injury model in rats. Methods : 1) HSCs were treated with SGGBTGSCG extract powder(50% EtOH SGGBTGSCG, dw SGGBTGSCG). After the treatment, MTT assay, BrdU assay and procollagen assay were done. In addition, gene expressions of collagen type $1{\alpha}2$, ASMA, TIMP1, and TIMP2, all of which are known to be associated with liver fibrosis, were analyzed by RT-PCR. 2) Liver fibrosis was developed in rats by injection of TAA 3 times a week for 5 weeks. After the SGGBTGSCG-treatment, body weight, liver & spleen weight, liver function test, the complete blood cell count and the change of portal pressure were studied. Results : In MTT assay, SGGBTGSCG significantly decreased the viability of HSCs in a dose-dependent manner. In BrdU assay, SGGBTGSCG significantly inhibited the HSC proliferation in a dose-dependant manner. In procollagen assay, SGGBTGSCG decreased procollagen production by HSC. In the change of rats' liver and spleen weight, TAA+SGGBTGSCG groups showed little difference compared with TAA-only group. In the liver function test, SGGBTGSCG decreased the serum level of ALT, AST, and Alp elevated by TAA. In the complete blood cell count, SGGBTGSCG significantly decreased WBC elevated by TAA and increased RBC and Hct lowered by TAA. In the change of portal pressure, SGGBTGSCG decreased portal pressure elevated by TAA. Conclusions : These results suggest that SGGBTGSCG is beneficial in the treatment of cirrhotic patients as well as for patients with chronic hepatitis.
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알코올 사용 장애의 최신 지견 : 여성 알코올 사용 장애의 특징 및 치료
이은 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.6
The paper reviews recent advances regarding characteristics and treatment issues of alcohol use disorders in women. Women's greater sensitivity to alcohol might explain why alcohol dependence and the physical damage caused by alcohol progress more rapidly in women. There was a significantly higher lifetime prevalence of psychiatric comorbidity in women than in men with alcohol use disorders. Furthermore, comorbid diagnoses are more often primary in women. All of these differences have important treatment implications.
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이은,강미진,김정현,이승화,이소연,조현주,윤지선,정성수,박양순,오동규,홍상범,홍수종 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.2
An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlyingHDLI have yet to be conducted. This study aimed to investigate methylation changes and their potential role in HDLI after exposureto HDs containing polyhexamethylene guanidine-phosphate. DNA methylation analysis was performed in blood samplesfrom 10 children with HDLI and 10 healthy children using Infinium Human MethylationEPIC BeadChip. Transcriptome analysiswas performed using lung tissues from 5 children with HDLI and 5 controls. Compared to healthy controls, 92 hypo-methylatedand 79 hyper-methylated CpG sites were identified in children with HDLI at the statistical significance level of |Δβ|>0.2 andp<0.05. NOTCH1 was identified as a candidate network hub gene in cases. NOTCH1 transcripts significantly increased in lung tissuesfrom HDLI cases compared to unexposed controls (p=0.05). NOTCH1 may play an important role in pulmonary fibrosis of HDLI.
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한국형 양극성 장애 약물치료 알고리듬 2010 : 급속 순환
이은,박원명,윤보현,민경준,김원,신영철,주연호,서정석,안용민,이정구,김병수,전덕인 대한우울조울병학회 2011 우울조울병 Vol.9 No.2
Objectives : Bipolar disorder is an illness with significant morbidity and mortality that contributes to disturb social function. Our objective for this study is to revise Korean Medication Algorithm Project for Bipolar Disorder 2006 for rapid cycling. Methods : The questionnaires to survey the expert opinion of medication for rapid cycling were completed by the review committee consisting of 70 Korean expert psychiatrists. We classified the experts’ opinion to 3 categories based on the lowest category in which the confidence interval fall (6.5≤ for first-line and 3.5≤ for second-line treatment). Results : The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. The first-line medications in all cases are valproic acid, lithium, quetiapine, and olanzapine. For the treatment of depressive phase, lamotrigine is the first-line medication. Conclusion : Compared to the surveys in 2006, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased. (J of Kor Soc for Dep and Bip Disorders 2011;9:103-108)
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