클러스터간 중첩성과 분리성을 이용한 퍼지 분할의 평가 기법

김대원,이광형,Kim, Dae-Won,Lee, Kwang-H. 한국지능시스템학회 2003 한국지능시스템학회논문지 Vol.14 No.7

본 논문에서는 퍼지 클러스터링 알고리즘에 의해 구해진 퍼지 분할에 대한 최적 클러스터 수를 결정하는 방법을 제안한다. 제안된 척도는 퍼지 클러스터들간의 중첩성과 분리성을 이용한다. 중첩성은 클러스터간 인접도를 이용하여 계산하며, 분리성은 데이터에 대한 상관성 정도로 나타낸다. 따라서 중첩성이 낮고 분리성이 높을수록 좋은 클러스터 결과라고 할 수 있다. 표준 데이터 집합을 대상으로 기존의 척도들과 비교 실험함으로써 제안된 척도의 신뢰성을 검증하였다. A new cluster validity index is proposed that determines the optimal partition and optimal number of clusters for fuzzy partitions obtained from the fuzzy c-means algorithm. The proposed validity index exploits an overlap measure and a separation measure between clusters. The overlap measure is obtained by computing an inter-cluster overlap. The separation measure is obtained by computing a distance between fuzzy clusters. A good fuzzy partition is expected to have a low degree of overlap and a larger separation distance. Testing of the proposed index and nine previously formulated indexes on well-known data sets showed the superior effectiveness and reliability of the proposed index in comparison to other indexes.

다발성 낭종성 병변을 보인 급성 파종성 뇌척수염 - 증례보고 -

김대원,김태영,김종문,윤기중,Kim, Dae Won,Kim, Tae Young,Kim, Jong Moon,Yun, Ki Jung 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5

Acute disseminated encephalomyelitis(ADEM) is an uncommon immune-mediated inflammatory demyelinating disorder that typically affects the white matter of the central nervous system. Radiologic findings of acute disseminated encephalomyelitis are not pathognomomic. The differential diagnosis is always difficult. Occasionally, the clinical features, radiological and histopathological findings of patients with acute disseminated encephalomyelitis mimic the brain tumor or other space occupying lesions. The authors report a 6-year-old girl who presented with right hemiparesis two days after nausea and vomiting. Brain MRI of the patient revealed non-enhanced multiple cystic lesions in subcortical white matter of both cerebral hemisphere with prominent edema. One of the cystic lesions was resected to differentiate with metastatic tumor or inflammatory disease such as abscess and confirmed as the acute disseminated encephalomyelitis via various immunohistochemical stains. Pertinent literature is reviewed with discussion on this uncommon ADEM associated with multiple cystic lesions.

RTLS기술을 이용한 터널공사현장의 실시간 안전관리 적용방안

김대원,문성모,조훈희,강경인,Kim, Dae-Won,Moon, Sung-Mo,Cho, Hun-Hee,Kang, Kyung-In 한국건설관리학회 2011 한국건설관리학회 논문집 Vol.12 No.2

Recently, construction site scale has been growing larger along with the growth of national economy. As construction market requires time reduction, cost saving, and improving quality, a cutting-edge technology applied research has been gradually studied for more efficient project management. In particular, the Real Time Location System (RTLS) technology, a real-time location tracking system of construction resources, can be effectively used in safety management. This technology has been studied and applied in various industries including architectural, marine, urban, and other industries. However, although tunnel construction in civil engineering has a narrow space and many safety risks, there are not researched about this content. Therefore, this study proposes an advanced safety management model for tunnel construction using the RTLS technology and a measurement method of the feasibility of this model in the construction site. 최근 국가경제규모의 성장과 더불어 단위 건설현장의 규모도 대형화, 복합화되어 가고 있다. 이에 건설시장은 공기단축, 원가절감, 품질개선을 요구하게 되었고, 보다 효율적인 프로젝트 관리를 위해 첨단기술을 적용한 연구가 다양하게 진행되고 있다. 특히, 건설현장의 인력, 자재, 장비 등의 다양한 자원에 대한 실시간 위치추적기술인 RTLS기술은 안전관리에 효과적인 것으로 평가받고 있다. 하지만 건축공사 뿐만아니라 해양, 도시 및 타 산업분야에서 연구와 적용이 이뤄지는 것과는 달리 협소하고 위험요소가 많은 터널공사에 대한 연구는 거의 전무한 실정이다. 따라서 본 연구에서는 RTLS기술을 이용한 터널현장에서의 안전관리를 위한 모델을 제시하고, 이의 현장적용성 검토를 실시하였다. 적용성 검토 결과, 제시된 모델은 발생되는 일부의 오차로 인해 현장에 바로 적용하기 힘드나 하드웨어기술의 발전과 위치보정에 대한 노력으로 극복할 수 있을 것으로 판단된다. 본 연구를 통해서 토목분야의 효율적인 프로젝트관리는 물론 안전관리의 방향을 제시하는데 이바지할 것으로 사료된다.

25 Vitamin D3 측정에 있어서 화학발광미세입자 측정법과 화학발광면역 측정법 간의 비교 및 고찰

김대원,이정희,정안나,서소연,Kim, dae-won,Lee, jung-hee,Jung, an-na,Seo, so-yoen 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.2

Purpose Vitamin D to Anti- Rickets both steroid compounds showing activity, By acting on bone tissue secretary and the key to maintain serum Ca homeostasis. The blood level of vitamin D is the largest in D3 that the concentration of the metabolite is reflected in the holding state of vitamin D in vivo. Sunlight to change the 7-dehydrocholesterol in the skin and through the skin to D3, In the liver in combination with the D2 and D3 D4 changes. The Radioimmunoassay(RIA) method is measuring the D 3, the sensitivity can be measured also difficult trace substance to measure the normal test because it is very sensitive, but recently, a check is possible, for the Total D3 in Chemimicroparticle immunoassay(CMIA) or Chemiluminescent immunoassay(CLIA) measuring using microparticle RIA and CMIA(Architect i2000SR) / use the CLIA(DXI-800) method to compare and evaluate the correlation between the tests in the same test items. Materials and Methods Commissioned from January 2014 to March 2015 patients were enrolled in a total of 273 people. 29 out of 273 people conducted by RIA were compared with CMIA, 244 patients were compared with CLIA. Using reagents and equipment were used RIA(Diasource), CMIA(Architect i2000SR, Abbott Diagnostics) / CLIA( Unicel DXi-800, Beckman coulter). Results Correlation of the RIA and CLIA was a R2 = 0.1844 (y = 0.7303x + 3.9005), and the correlation of RIA CMIA is R2 = 0.2762 (y = 0.8862x + 4.56) respectively. (According to statistics, during the same period RIA is Deficiency 4.31%, Insufficiency 90.53%, Sufficiency 5.16%, was Excess 0%, CLIA / CMIA is Deficiency 17.02%, Insufficiency 75.91%, Sufficiency 7.03%, indicating the distribution of 0.03 % Excess) Conclusion Serum vitamin D and parathyroid hormone that show an inverse relationship, the level above which are not parathyroid hormone and vitamin D reduced the increase. The density is different for each study, at most 20 is reported to be the maximum between 30 ng / ml. In Korea it requires a proposed standard of vitamin D deficiency, reference to the WHO lack the case more than 10ng/ml, 20ng/ml and defined by the lack of, if not more than, the IOM, but looking at 12ng/ml or less to the normal to lack, at least 20ng/ml, the reference do not match the deficit under 20ng/ml, 21-29ng/ml relative lack between, was also defined as a sufficient condition for more than 30ng/ml. Although not statistically is between RIA and CLIA two ways to vitamin D levels change according to season match, when seasonally seen in summer as commonly known (April to September), winter (October to March) relative to the increase measured than it was found. Finally, the study on the correlation between the two methods have been expected to result in a consistent and apply the same view high reference value on the graph is difficult. However, there may be differences between the test equipment and methods, and could be especially the case of RIA method using an organic solvent is difficult to compare different methods and correlated view similar trend in vitamin D deficiency and quarterly aspect ratio.

스퍼터링 타겟용 Cu-50In-13Ga 3원계 합금 분말의 소결 및 압연 거동

김대원,김용호,김정한,김대근,이종현,최광보,손현택,Kim, Dae-Won,Kim, Yong-Ho,Kim, Jung-Han,Kim, Dae-Guen,Lee, Jong-Hyeon,Choi, Kwang-Bo,Son, Hyeon-Taek 한국분말야금학회 2012 한국분말재료학회지 (KPMI) Vol.19 No.4

In this study, we mainly focus on the study of densification of gas-atomized Cu-50 wt.%In-13 wt.%Ga alloy powder without occurrence of crack during the forming process. Cu-50 wt.%In-13 wt.%Ga alloy powder was consolidated by sintering and rolling processes in order to obtain high density. The phase and microstructure of formed materials were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM) and optical microscopy (OM), respectively. Warm rolling using copper can result in the improvement of density. The specimen obtained with 80% of rolling reduction ratio at $140^{\circ}C$ using cooper can have the highest density of $8.039g/cm^3$.

CAN 프로토콜을 이용한 네트워크 시스템의 성능 분석

김대원,최환수,Kim, Dae-Won,Choi, Hwan-Soo 대한전기학회 2001 전기학회논문지 D Vol.50 No.4

This paper analyses the performance of network system using the CAN(Controller Area Network) protocol. Given messages are assumed to be scheduled by the DMS(Deadline Monotonic Scheduling) algorithm. The mathematical models for time-delay that can be occurred between CAN nodes are defined. The effectiveness of modeling is shown by comparing the difference of time-delay between simulations and practical experiments. We analyse the results according to the variation of factors, such as the number of nodes, the transmission speed, the message size and the number of aperiodic messages through simulation and confirm the real-time performance of lower priority messages. We also investigate the real-time performance of periodic messages when aperiodic message generates.

정전기적 상호작용이 단백질 폴딩 반응에 끼치는 영향

김대원,박순호,Kim, Dae Won,Park, Soon-Ho 대한화학회 2014 대한화학회지 Vol.58 No.6

단백질 폴딩 반응에서 정전기적 상호작용의 역할을 라이신 29를 알라닌으로 치환한 변이 유비퀴틴을 사용하여 탐색하였다. 유비퀴틴의 입체구조에서 라이신 29의 곁사슬은 글루탐산 16과 아스파르산 21의 곁사슬과 근접한 거리에 있어서 곁사슬끼리 정전기적 상호작용을 통하여서 삼차원 입체구조를 안정화시킬 것으로 예측되었다. 라이신을 알라닌으로 치환하여 정전기적 상호작용을 제거하였을 때 유비퀴틴의 native state의 구조적 안정성이 ~20% 감소한 점은 라이신 29에 의한 정전기적 상호작용이 단백질 삼차구조의 안정성에 상당히 기여하고 있다는 점을 시사하였다. 폴딩 반응의 진행 과정을 stopped-flow 장치로 측정한 folding kinetics 실험은 이전에 관찰된 것과 마찬가지로 unfolded state에서 native state로 진행하는 과정에 중간단계를 거치는 three-state on-pathway 메커니즘을 따르는 것으로 나타났다. 더욱이 라이신 29에 의한 정전기적 상호작용이 중간단계의 구조적 안정성에 기여하는 정도가 native state의 구조적 안정성에 기여하는 정도의 ~55%인 것으로 나타났다. 이는 유비퀴틴 폴딩의 중간단계의 구조도 라이신 29에 의한 정전기적 상호작용에 의하여 상당히 안정화 된다는 것을 의미하며 따라서 정전기적 상호작용이 단백질 삼차원 입체구조의 골격이 완성된 폴딩의 마지막 단계에 형성되어 단백질 native state의 안정성에만 기여하는 것이 아니라 중간단계가 형성되는 폴딩 반응의 초기에도 형성되어 폴딩 반응을 이끌어가는데도 기여한다는 것을 의미한다. The contribution of electrostatic interactions to protein folding reaction was studied by using mutant ubiquitin with lysine to alanine mutation at residue position 29. Based on the three dimensional structure of ubiquitin, lysine 29 is located close to negatively charged glutamate 16 and aspartate 21 and considered to stabilize the native state of ubiquitin by electrostatic interactions between these residues. The equilibrium unfolding experiment showed that the native stability was decreased by about ~20% upon mutation. This observation indicates lysine 29 indeed forms electrostatic interactions with nearby residues. Folding kinetics measurements using stopped-flow device and quantitative analysis of kinetics data indicate that ubiquitin folds from unfolded state to native state via intermediate state as observed previously. This intermediate state was observed to form immediately after the initiation of folding reaction. The folding intermediate was shown to be destabilized considerably upon lysine to alanine mutation. These observations indicate that electrostatic interactions can form early stage of protein folding and hence lead the folding reaction.

지역사회 평생교육을 고려한 학교시설의 개방과 복합화 방향 모색 - 제주지역 초·중등학교를 대상으로 -

김대원,이재림,Kim, Dae-Won,Lee, Jae-Rim 한국교육녹색환경연구원 2007 교육·녹색환경연구 Vol.6 No.2

The knowledge-based 21st century requires lifelong education for the development of qualification of man's life and self-development. Schools are considered a place of lifelong education due to easy access to human resources as well as facilities. Furthermore, schools need a more multi-functional openness in order to lead lifelong education of the local society. Jeju schools are in the early stages of creating multi-functional facilities to meet to the needs of the knowledge-based 21st century. In order to bring change into the local school s, this needs to be solved. therefore, the purpose of this research is to complement the elements to needed to open schools, project, management, and operation of multi-functional facilities, so that schools can play a role In lifelong education. To achieve this purpose, this research examined programs and the area of lifelong education at schools through investigating documents on the definition of local society and lifelong education, and analyzed the relationship of schools and local society, and public access of schools' facilities. The results of this study are summarized as follows; 1) Comparing to traditional middle and high school facilities, it occurs various types of plane and the area is somewhat expanded in the school with same class size, however, it needs to improve facility standards in its reality to deal with the change of future educational environment actively. 2) Spatial composition of educational facilities should functionally designed considering that the characteristics of design process mood. In facilities arrangement of middle and high schools, it shows diverse forms of arrangement from existing uniform straight type, however, most of schools do not being against the simple in their external space. Therefore, it requires an expansion of space size and facilities for the change of school life outside class.

산업용 로봇 기술의 현황 및 전망

김대원,이범희,Kim, Dae-Won,Lee, Beom-Hui 재료연구소 1993 機械와 材料 Vol.5 No.3

Glass fiber 제조설비의 기술 동향

김대원,김종수,강희신,Kim, Dae-Won,Kim, Jong-Su,Gang, Hui-Sin 재료연구소 2007 機械와 材料 Vol.19 No.3