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Lee, Tae Kwon,Kong, Dae Sol,Jin, Da Woon,Yun, Shinhee,Yang, Chan-Ho,Jung, Jong Hoon ELSEVIER 2019 Current Applied Physics Vol.19 No.6
<P><B>Abstract</B></P> <P>We investigated the ferroelectricity in proton-irradiated flexible Pb(Zr<SUB>0.52</SUB>Ti<SUB>0.48</SUB>)O<SUB>3</SUB> (PZT) thick films and their non-volatile memory characteristics. The Ni-Cr metal foil substrate allowed high-quality polycrystalline PZT films with flexible functionality to be fabricated using conventional sol-gel and high-temperature annealing methods. The 10-MeV proton-irradiated PZT film exhibited an almost square polarization−electric field hysteresis curve with saturated (<I>P</I> <SUB>s</SUB>) and remnant (<I>P</I> <SUB> <I>r</I> </SUB>) polarizations of 18.9 and 17.0 μC/cm<SUP>2</SUP>, respectively; which are slightly lower than as-grown PZT with <I>P</I> <SUB>s</SUB> = 28.7 μC/cm<SUP>2</SUP> and <I>P</I> <SUB> <I>r</I> </SUB> = 24.3 μC/cm<SUP>2</SUP>. The <I>P</I> <SUB> <I>r</I> </SUB> did not decrease even after 1000 cycles of continuous bending and unbending at a bending radius of 2.14 mm and decreased slightly to ∼80% of its initial value after 10<SUP>5</SUP> s. Although the <I>P</I> <SUB> <I>r</I> </SUB> decreased to ∼55% after 10<SUP>10</SUP> cycles, the electric polarization remained switchable under positive and negative electric fields. These characteristics suggest that the flexible PZT films could be utilized in non-volatile memory device applications in environments with high doses of proton irradiation, such as those in aeronautics and nuclear power plants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sol-gel growth of flexible PZT thick films on a Ni-Cr metal foil substrate. </LI> <LI> Large saturated and remnant electric polarization in proton-irradiated films. </LI> <LI> Mechanical stability, long retention time, and high fatigue resistance even after the high energy proton-irradiation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성
강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47
Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.
Novel quinolone-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping
Da-Sol Lee,Sijoon Lee,Kyung-ku Kang,Soo-eun Sung,Kil Soo Kim,Ghilsoo Nam,Yong Hyun Jeon 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects. In vivo fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without in vivo toxicity, which was consistent with the findings of ex vivo imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging application.
Lee Eunyoung,Park Sehee,Choi Jae-Phil,Kim Min-Kyung,Yang Eunmi,Ham Sin Young,Lee Seungjae,Lee Bora,Yang Jeong-Sun,Park Byoung Kwon,Kim Da Sol,Lee So-Young,Lee Joo-Yeon,Jang Hee-Chang,Jeon Jaehyun,Park 대한의학회 2023 Journal of Korean medical science Vol.38 No.8
Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group with nirmatrelvir/ritonavir therapy versus a control group with supportive care. Serial viral load and culture from the upper respiratory tract were evaluated for seven days, and clinical responses and adverse reactions were evaluated for 28 days. Results: A total of 51 patients were analyzed including 40 in the treatment group and 11 in the control group. Faster symptom resolution during hospitalization (P = 0.048) was observed in the treatment group. Only minor adverse reactions were reported in 27.5% of patients. The viral load on Day 7 was lower in the treatment group (P = 0.002). The viral culture showed a positivity of 67.6% (25/37) vs. 100% (6/6) on Day 1, 0% (0/37) vs. 16.7 (1/6) on Day 5, and 0% (0/16) vs. 50.0% (2/4) on Day 7 in the treatment and control groups, respectively. Conclusions: Nirmatrelvir/ritonavir against the omicron was safe and resulted in negative viral culture conversion after Day 5 of treatment with better symptomatic resolution.