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Da Hyeon Choi,Jue-Yeon Lee,Jae-Hwan Nam,Yang-Hoon Kim,Yoon Jeong Park,Yoon Shin Park 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3
Backgrounds: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. However, little is known about the molecular mechanisms of HCC development, progression, or effective therapeutic approaches. Recently, granulin-epithelin precursor (GEP) has been suggested as a novel factor that can control HCC cell proliferation. Thus, we aimed to develop new cell-permeable and stable genetic agents that can control GEP expression in HepG2 cells. Methods: Small interfering RNA-GEP (GEP siRNA) was used for the development of therapeutic agents for HCC treatment. GEP siRNA was first modified by adding polyethylene glycol (PEG) at the terminus. Arginine- rich peptide (ARP) was chemically conjugated with PEGylated GEP siRNA. Chemical conjugates of GEP siRNA-PEG-ARP were evaluated for cytotoxicity and bioavailability, including stability against DNase I enzymatic activity and GSH. The conjugate was further evaluated for intracellular distribution and cell proliferation effects. Results: The optimal conjugation ratio of GEP siRNA to ARP was a 1:10 molar ratio, and stability was confirmed using DNase I and glutathione stability assays. Conjugates showed increased intracellular uptake and distribution in HepG2 cells. Interestingly, HepG2 cells treated with conjugates showed significantly decreased cell proliferation. Conclusion: These results provide insights into the importance of chemical modification of unstable genetic therapeutics for HCC treatment. Conjugation of PEGylated GEP siRNA with ARP may be a potential HCC therapeutic agent.
Association between Carotid Plaque and Cognitive Function in the elderly: the KURE study
( Da-lim Yoon ),( Chang Oh Kim ),( Yumie Rhee ),( Hyeon Chang Kim ),( Yoosik Youm ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Object: Few studies have investigated the association between carotid intima-media thickness (IMT) and cognitive function in the elderly. However, the role of carotid plaques in the development of incident dementia remains unclear. We aimed to evaluate the association between carotid plaques and cognitive function in the elderly. Methods: Total 2,942 subjects aged ≥65 years were recruited through the Korean Urban Rural Elderly cohort study from 2012 to 2014. Participants underwent carotid ultrasonography measures of carotid plaque and carotid IMT at four sites, including the bilateral common carotid arteries and carotid bulbs. Cognitive function was assessed using the Korean version of the Mini-Mental Status Examination for dementia screening (MMSE-DS). Results: Multivariable analyses adjusted for sex, age, smoking history, and comorbidity, revealed that the presence of plaques were significantly associated with lower test scores on the MMSE-DS (p=0.002). The number of plaques (β=-0.056, p<0.011) and the total plaque area (β=-0.031, p<0.001) were associated with lower MMSE-DS scores. However, maximal IMT and mean IMT of carotid artery were not significantly associated with cognitive function after additional adjustment. Conclusions: Our findings suggest that carotid atherosclerosis measures such as the presence and number of plaques and total plaque area were independent predictors of lower cognitive function in the elderly. Keywords: Carotid plaque; Carotid IMT; Cognition; Elderly. Acknowledgements: This research was supported by a fund (2011-E63005-00, 2012-E63001-001, 2013-E63007-00, 2013-E63007-01, 2013-E63007-02) by Research of Korea Centers for Disease Control and Prevention.
Da Ye Kim,Seung Jin Maeng,Seung Wook Lee,Eun Bi Hong,Hyeon Cheol Yoon,Ju Ha Hwang,Won Beom Kim 위기관리 이론과 실천 2021 Crisisonomy Vol.17 No.5
우리나라의 저수지는 지자체와 한국농어촌공사의 관리로 이루어지고 있다. 지자체에서 관리하는농업용 저수지의 97% 정도가 미계측 저수지로 저수지에서 공급되는 용수량을 간접적인 방법에 의해 추정하고 있는 실정이다. 미계측 저수지의 신뢰성 있고 정확한 용수공급량 산정이 필요하다. 본연구에서는 미계측 저수지의 저수량 예측을 위해 관측자료가 있는 저수지 200개를 선정하였다. 저수지별 TANK 모형의 매개변수 신뢰성을 평가하기 위해 NSE와 ROV 분석 결과 좋음 이상으로 판정된101개 저수지를 선별하였다. 101개 저수지의 물리적 특성과 TANK 모형의 매개변수 추정 결과를대상으로 그룹화를 실시하였다. 101개 저수지는 총 6개의 그룹으로 결정되었고 그룹별 대표 값을제시하였다. 그룹별 TANK 모형의 매개변수를 적용하여 계측된 저수지를 미계측 저수지라 가정한후 관측유입량과 모의유입량을 비교·분석하였다. The reservoir in Korea is managed by the local government and Korea Rural Community Corporation. About 97% of agricultural reservoirs managed by local governments are ungauged reservoirs, and the water supply amount from the reservoirs is estimated by an indirect method. Reliable and accurate water supply amount a calculation of ungauged reservoirs is required. In this study, 200 reservoirs with observation data were selected for the prediction of the water supply amount in the ungauged reservoir. To evaluate the reliability of the parameters of the TANK model for each reservoir, 101 reservoirs that were judged as good or more than among the NSE and ROV analysis results were selected. The physical properties of 101 reservoirs and the parameter estimation results of the TANK model were grouped. The 101 reservoirs were estimated into a total of 6 groups, and representative values were presented for each group. After applying the parameters of the TANK model for each group, the gauged reservoir was assumed to be an ungauged reservoir, and then the observed and simulated inflows were compared and analyzed.
Da-Hye Shin,Na-Hyeon Jung,Ji-Hye Lee,Sang-Hwan Kim,Jong-Taek Yoon 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Present study, it is demonstrated that MMP-9 serum as well as follicular concentrations are related to a successful IVF resulting in pregnancy. Currently, a limited number of studies have investigated intrafollicular and serum MMPs, with inconsistent conclusions. However, MMPs theoretically could be important players in IVF processes. Moreover, different behaviors of MMP-2 and MMP-9 during the embryo development were confirmed; only MMP-9 has shown a vast difference between follicular and maturation oocyts. The main objective of this study is to examine the mode of MMPs activation during bovine in vitro fertilization. In particular, the relative employment of two major embryo culture medium in embryo development; e.g. ES(non-bovine serum) and CR(bovine serum) was compared. This results found that the level of MMP-2 and MMP-9, which degrades basal membrane, was different in the ES and CR in cultured at each stage of embryo development. In ES cultured system, MMP-9 was highly expressed throughout blastocyst inner cell mass and exhibited strong gelatinase activity. The MMP-9 expression continually increased as the embryo develops from oocyte maturation to fertilization, Meanwhile, the level of MMP-2 remained insignificant throughout these periods. However, decreased MMP-2 and 9 expression on the CR culture system. Interestingly, MMP-9 was actively expressed in ES culture system, inner cell mass is showing levels higher than trophoblast cell. Our result suggests a possibility that different subtype of MMP partakes major functions in the remodeling of inner cell mass in blastocyst. Such differences in MMP expression may impact to the distinct mode of follicular development in the two species.
( Da Eun Jeong ),( Tae Eun Kim ),( Eunwook Joo ),( Kwanghee Ahn ),( Hyeon Ji Kim ),( Jee Yoon Park ),( Kyung Joon Oh ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: To evaluate the maternal serum levels of sFlt-1, PlGF and sFlt-1/PlGF ratio in suspected preeclampsia patients with twin pregnancies compared to singleton pregnancies. Methods: This was a retrospectively study on women who had received the laboratory tests including maternal serum levels of sFlt-1, PlGF and sFlt-1/PlGF ratio for the purpose of evaluation for preeclampsia at Seoul National University Bundang Hospital between March 2019 and June 2020. Two triplet pregnancies were excluded. A total of 104 singleton pregnancies and 35 twin pregnancies were included and divided into groups according to the diagnosis of preeclampsia. Obstetric and neonatal outcomes were compared in the groups classified by the well-known cut-off of the sFlt-1/PlGF ratio: below 38, 38-85, and over 85 in singletons and twins, respectively. Results: Among the study population, 35% (49/139) were diagnosed as preeclampsia (38/66 in singleton pregnancies and 11/35 in twin pregnancies). The levels of sFlt-1 and PlGF were significantly different between twins and singletons when analyzed both in the group without and with preeclampsia (p-values, all < 0.05). However, the sFlt-1/PlGF ratio were comparable between twins and singletons in the group without and with preeclampsia. The rates of preterm birth before 34 weeks of gestation were significantly different according to the cut-offs of the sFlt-1PlGF ratio in singletons (2.8% in below 38 vs. 12.5% in 38-85 vs. 43.8% in over 85, p<0.001), however the difference did not reach statistical significance in twin pregnancies. Conclusion: Unlike the sole level of sFlt-1 or PlGF, the sFlt-1/PlGF ratio in twin pregnancies with preeclampsia is not different from that in singletons. Nevertheless, the predictive value of the sFlt-1/PlGF for the adverse outcomes of preeclampsia seems to be better in singletons than twins.