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서울시 일부 대학생들의 건강습관과 건강상태의 관련성 연구
옥찬명,문인옥,김연희 대한보건협회 2001 대한보건연구 Vol.27 No.3
The purpose of this study was to find the association with the health practices and health status for university students. The subjects were taken 804 university students in seoul. The data were collected by self-administered questionnaire during 2 weeks from October 15, 2000. The findings were as follows: 1. Only 33.3% of the subjects had taken a health education-related class. 2. The male students showed better health practices than females on no snacks (p<0.001), going to bathroom regularly(p<0.001), taking a walk(p<0.01), and doing exercise(p<0.001). On the other hands the female students showed better practices such as no smoking and no drinking. 3. Religious showed higher health practice scores than non-religious ones(p<0.001). 4. Seventy five point nine percent of the respondents were in healthy group showing significant difference by sex (p<0.001) with 2.79 odds ratio. 5. The healthy group showed better health practices than non-healthy group such as on going to bathroom regularly(p<0.01), taking a walk (p<0.01), and having low stress(p<0.001). And the healthy group got more stress than the unhealthy group showing significant difference statistically (p<0.001). 6. To designate the factors influencing students' health status, logistic regression analysis has been done. According to the results of this analysis, health practices, and sex were selected as significant factors associated with the health status. The students who got higher health practices perceived their health better than lower health practices with odds ratio [OR] = 3.73 (p<0.001). And health practices had the most significant effect on health status. And the odds ratio of good health status was 2.61 for male students(p<0.001).
Ock, Sun-Myeong,Hwang, Seung-Sik,Lee, Jeong-Seop,Song, Chan-Hee,Ock, Chan-Myung The Korean Nutrition Society 2010 Nutrition Research and Practice Vol.2 No.4
There has been little data on the prevalence of supplement use and the characteristics of the dietary supplement users in the Republic of Korea. This study presents the prevalence and the details of any dietary supplement use and the characteristics of the adults who use dietary supplements in the Republic of Korea. Between May 18 and June 16, 2006, nationwide and population-weighted personal interviews with 6,201 adult aged from 30 to 69 years were conducted and the final sample consisted of 3,000 people with a 49.8% response rate. We examined the prevalence and details of the use of dietary supplements and the characteristics of those who use the dietary supplement among adults. About sixty two percent of adults had taken any dietary supplement during the previous 12-month period in 2006. The most commonly reported dietary supplement was ginseng, followed by multivitamins, glucosamine, probiotics, and vitamin C. Female (versus male), an older age group, a higher family income, those living in metropolitan cities, those with marital experience, those with a higher level of education, and those having medical problems had a greater likelihood of reporting the use of any dietary supplements. The particular relationships differed depending on the type of supplement. The most Korean adults took one more dietary supplement and the dietary supplement users had different demographic and health characteristics compared to those of the nonusers. Research on diet supplements by the medical community is needed in the future.
Sun-Myeong Ock,Seung-Sik Hwang,Jeong-Seop Lee,Chan-Hee Song,Chan-Myung Ock 한국영양학회 2010 Nutrition Research and Practice Vol.4 No.1
There has been little data on the prevalence of supplement use and the characteristics of the dietary supplement users in the Republic of Korea. This study presents the prevalence and the details of any dietary supplement use and the characteristics of the adults who use dietary supplements in the Republic of Korea. Between May 18 and June 16, 2006, nationwide and population-weighted personal interviews with 6,201 adult aged from 30 to 69 years were conducted and the final sample consisted of 3,000 people with a 49.8% response rate. We examined the prevalence and details of the use of dietary supplements and the characteristics of those who use the dietary supplement among adults. About sixty two percent of adults had taken any dietary supplement during the previous 12-month period in 2006. The most commonly reported dietary supplement was ginseng, followed by multivitamins, glucosamine, probiotics, and vitamin C. Female (versus male), an older age group, a higher family income, those living in metropolitan cities, those with marital experience, those with a higher level of education, and those having medical problems had a greater likelihood of reporting the use of any dietary supplements. The particular relationships differed depending on the type of supplement. The most Korean adults took one more dietary supplement and the dietary supplement users had different demographic and health characteristics compared to those of the nonusers. Research on diet supplements by the medical community is needed in the future.
Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine.
Ock, Chan Young,Kim, Eun-Hee,Hong, Hua,Hong, Kyung Sook,Han, Young-Min,Choi, Ki-Seok,Hahm, Ki-Baik,Chung, Myung-Hee American Association for Cancer Research, Inc 2011 CANCER PREVENTION RESEARCH Vol.4 No.9
<P>Colitis-associated cancer (CAC) is one of clear examples of inflammation-carcinogenesis sequence, by which the strict control of colitis with potent anti-inflammatory or antioxidative agent offers the chance of cancer prevention. Supported with the facts that Rac1 binds and activates STAT3, which are significantly upregulated in inflammatory bowel disease (IBD) as well as CAC, but 8-hydroxydeoxyguanosine (8-oxo-7,8-dihydrodeoxyguanosine or 8-OHdG) paradoxically can block Rac1 activation and subsequent NADPH oxidase (NOX) inactivation in various inflammation models, we hypothesized that attenuated Rac1-STAT3 and COX-NF-관B pathway by exogenous 8-OHdG administration may ameliorate inflammatory signaling in dextran sodium sulfate (DSS)-induced colitis and can prevent CAC. Before commencing carcinogenesis model, we checked whether exogenous 8-OHdG can alleviate IBD, for which interleukin (IL)-10 knockout mice were designed to ingest 5% DSS for 1 week, and 8-OHdG is given through intraperitoneal route daily. 8-OHdG treatment groups significantly reduced pathologic grade of DSS-induced colitis as well as various inflammatory mediators such as TNF-관, IL-6, COX-2, and iNOS in a dose-dependent manner. To document the cancer prevention effects of 8-OHdG, mice were injected azoxymethane followed by drinking 2.5% DSS for 1 week, after which 8-OHdG-containing diets were given for 20 weeks. As results, mice that consumed 8-OHdG-containing diet significantly reduced both tumor incidence and multiplicity. Rac1 activity and phosphorylated STAT3 level were significantly attenuated in the 8-OHdG-treated group. Significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, COX-2, NOX4, and 관-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-OHdG. In conclusion, we clearly showed cancer-preventive effect of exogenous 8-OHdG against CAC.</P>
Ock, Chan-Young,Kim, Eun-Hee,Choi, Duck Joo,Lee, Ho Jae,Hahm, Ki-Baik,Chung, Myung Hee WJG Press 2012 World journal of gastroenterology Vol.18 No.4
<P>Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG), which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is generally regarded as a biomarker of mutagenesis consequent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-관B signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1, IL-6, cyclo-oxygenase-2, and inducible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1, NOX organizer-1 and NOX activator-1 in various conditions of inflammation-based gastrointestinal (GI) diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carcinogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the prevention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.</P>
Jang, Hye-Ock,Kim, Ji-Suk,Kwon, Woo-Cheol,Kim, Jeong-Kuk,Ko, Myung-Suk,Kim, Dong-Hoo,Kim, Won-Il,Jeon, Young-Chan,Chung, In-Kyo,Shin, Sang-Hun,Chung, Jin,Bae, Moon-Kyung,Yun, Il 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). $Pb^{2+}$ inhibited the immediate CRACI dose-dependent manner. Influx of $Pb^{2+}$ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of $Pb^{2+}$ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of $Ca^{2+}$ upon $Ca^{2+}$ readdition, is partially inhibited by $Pb^{2+}$ and (2) the influx of $Pb^{2+}$ was enhanced after CRACI had been induced.
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
( Hyerim Ha ),( Bhumsuk Keam ),( Chan-young Ock ),( Tae Min Kim ),( Jin Ho Kim ),( Eun-jae Chung ),( Seong Keun Kwon ),( Soon-hyun Ahn ),( Hong-gyun Wu ),( Myung-whun Sung ),( Dae Seog Heo ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.