Modified Free Wrap-around flap을 이용한 수무지 재건술

최영화,황치원,정병훈,한명호 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

The thumb is the most important part in the hand and its loss results in severely diminished function of the hand for pinch and grasp. There are several microsurgical and other methods to reconstruct and amputated or lost thumb such as toe-to-thumb transfer1)2)9) as well as several varieties of flaps. Among them, a free wrap around flap taken from the big toe, including the nail and an iliac bone graft as the cone of the reconstruction was a quite satisfactory procedure, but there were some problems. We performed a free wrap around flap on traumatically missing thumb with modification to include all part of the distal phalanx without iliac bone graft. The resorption and atrophy of a grafted iliac bone, a constant problem with Morrison's original procedure8), could be prevented by the modified method. The donor site defects were covered by remained medial flap for weight bearing area first, and full thickness skin graft for remained defected area. The results were good cosmetically and functionally without significant problems.

이산화질소 및 아황산 가스에 노출된 흰쥐에 대한 連翹敗毒散과 수종 한약물에 대한 실험적 연구

崔仁和,蔡炳允 慶熙大學校 1997 論文集 Vol.26 No.-

Sulfur dioxide and nitrogen dioxide are two major air pollutants. As it has been well known, the former plays indispensible role in London type smog incident and the latter is one of major components of photochemical oxidants. In the of industrial toxicology these two noxious gases are classified as irritant gas physiologically. And many reports on the acute and chronic intoxication by these two gases have been filed. Especially,a strong irritating nitrogen dioxide effect on the epithelium of air way tract are the formation or methemoglobin has been known as the main toxic action. Clinically pulmonary edema and congestion are beli-eved to main causes of death. Yongyopaedoksan(연요패독산) has been used in the oriental medical treatment of acute and chrom respiratory diseases, including laryngeal disorders and ocular irritant symptoms such as congestion burning, itching and scratch and so on. In order to investigate the clinical effect of Yongyopaedoksan(연요패독산), Maekmundong(麥門冬) Saengjihwang(生地黃) and Ilhwangyon(日黃連) on the rats exposured to 50ppm SO_2 & NO_2 for 5 hours an experimental study was done on hematologic changes, organ water contents and histopathologic pictures. The experimental groupe are the normal group, control group, S-1 group(oral medication Yongyopaedoksan), S-2 group(oral medication of Maekmundong), S-3 group(oral medication of Saengjihwang) and S-4 group(oral medication of Ilhwangyon). The results were summarized as follows; 1. On the hematologic change in the rats exposured to SO_2 in the Yongyopaedoksan group compared to the control, the increase in the value of hemoglobin & leucocytes was significant. In Maekmundong group, the number of leucocytes & eosinophil ratio were different significantly. In Saengjihwang group, the hematocrit values were increased significantly. 2. On the hematologic change in the rats exposured to NO_2 in the Yongyopaedoksan group compared to the control the hemoglobin hematocrit values and eosinophil ratio were decreased significantly. However the number of leucocytes was increased significantly. In the Maekmundong group, the reduction of hemoglobin & hematocrit values was significant. In the Saengjihwang group, the value of hemoglobin was reduced significantly. In the Ilhwangyon group, the decrease of the eosinophil ratio was significant. 3. On the change of water contents of left lung in the SO_2 exposure group, the Yongyopaedoksan Maekmundong & Saengjihwang group as compared to the control. the reduction was significant. 4. In the laryngeal histopathologic changes of SO_2 exposure group, all the sample groups were admitted of significant difference at congestion & inflammatory infiltrates as compared to the control. The edema of trachea in Saengjihwang & Ilhwangyon group as compared to the control were improved significantly. The congestion & inflammatory infiltrates of trachea ti four sample groups as compared to the control were improved significantly. 5. In the case of NO_2 exposure group, the edema and inflammatory infiltrates of larynx in Ilhwangyon on group as compared to the control were improved significantly. The edema of trachea in Saengjihwang & Ilhwangyon group as compared to the control was improved significantly. And the congestion & inflammatory infiltrates of trachea in all the sample groups as compared to the control were improved significantly.

생체내 흰쥐 해마 CA1 세포에서 가바성 억제에 대한 전기생리학 특성

최병주,김영진,조진화 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

가바성 억제 신경세포는 해마의 정상적인 기능을 조절하는데 중요한 역할을 하며 해마 병변을 유발하는 중요한 요소이다. 본 연구는 in vivo실험법을 사용하여 해마 CAI영역에서의 전기 생리학적 반응을 측정함으로써 가바성 신경세포의 기능을 분석하고 이를 슬라이스 실험법과 비교하고자 하였다. Fimbria-fonix 전기자극시 전형적인 Population spike가 나타났고 10μm bicuculline 존재하에서는 전기자극에 의해 burst 형태의 population spike가 나타났다. Population spike의 크기는 자극 강도에 비례하였으며 그 숫자도bicuculline 전극사용시와 같이 동일한 양상을 보였다. CAI영역의 흥분성 수준을 측정하기 위해 paired-pulse자극을 하였는데 짧은 자극 간격에서 억제성 반응을 보였고 burst형태의 afterdischarge를 나타내었다. CAI영역에서 in vivo 실험법을 사용한 가바성 신경세포반응의 결과는 추체세포의 흥분성 조절을 효과적으로 분석할 수 있으며 in vitro 실험법에 비해 기능적 평가가 더욱 이상적임을 알 수 있다. Inhibitory cells are critically involved in shaping normal hippocampal function and are thought to be important elements in the development of hippocampal pathologies. The present study was carried out in hippocampal CA1 area in vivo to compare with hippocampal slice studies. Intracellular and extracellular recordings with or without bicuculline electrodes were obtained in the intact brain of anesthetized rats, and cells were intracellularly labelled with neurobiotin. Electrical stimulation of fimbria-fornix resulted in an initial short-latency population spike. In the presence of 10μM bicuculline, orthodromic stimulation resulted in bursts of population spike. The amplitude of population spikes in the CA1 region increased with stimulus intensity. as did the number of population spikes when the field recording electrode contained 10μM bicucilline. We measured the level of excitability in the CA1 area, using a paired-pulse stimulus paradigm to evoke population spokes. Population spikes showed strong paired-pulse stimulus. These result suggest that hippocampal CAI inhibitory interneurons can affect the excitabillity of pyramidal neurons that can not be appreciated in conventional in vitro preparation.

醫療保險制度의 變化에 따른 醫療利用 樣相과 病床利用度 比較硏究

최병록,함정오,김화성,이병국 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

This study was conducted to identify the effects of rural-fishing village health insurance system and the whole national health insurance system on the number of out-patient and in-patient cases and the hospital bed utilization, and the number of hospital persons in a university located in Choong Chung Nam Do. The results were as follows. 1. The number of out-patients was increased by 6.8% and 18.8% after the implementation of the rural fishing village health insurance system and the whole national health insurance system respectively. The number of out-patient visit cases was increased by 31.5% and 63.5% after implementation of the rural fishing village health insurance system and the whole national health insurance system respectively. 2. The number of in-patients was increased by 13.8% and 22.8% after the implementation of the rural fishing village health insurance system and the whole national health insurance system respectively. The number of bed days was increased by 27.1% and 32.8% after the implementation of the rural fishing village health insurance system and the whole national health insurance system respectively. 3. The hospital bed utilization rates were 77.3% and 98.4% before and after the rural fishing village health insurance system respectively, and 102.6%, after the whole national health insurance system. The bed rotation rate was increased from 23.6 times before the rural fishing village health insurance system to 27.0 times after the system. After the whole national health insurance program, it was also increased to 29.1 times. The average length of stay was 11.9 days before the rural fishing village health insurance system and 13.3 days after that, and 12.9 days after the whole national health insurance system. 4. Before the rural fishing village health insurance system the physicians per 100 beds was 19.0 persons. The physicians per 100 beds was increased to 25.2 persons and 29.3 persons, after the rural fishing village health insurance system and the whole national insurance system respectively. Before the rural fishing village health insurance system the nurses per 100 beds was 26.8 persons. The nurses per 100 beds was increased to 35.4 persons and 38.3 persons, after the rural fishing village health insurance system and the whole national health insurance respectively. Before the rural fishing village health insurance system the manpower per 100 beds was 101.6 persons. The manpower per 100 beds was increased to 128.6 persons and 138.9 persons, after the rural fishing village health insurance system and the whole national insurance respectively.

흰쥐 안면신경핵 세포의 전기생리학적 및 형태학적 특성

최병주,조진화,배용철,김영진 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.3

흰쥐의 안면신경핵을 구성하는 신경세포들의 시냅스 연결 양태 및 세포막 특성을 규명하기 위해 in vivo 필드전위 및 세포내 전위 측정법을 이용하여 전기생리적 반응을 관찰하였다. 말초 안면신경 분지를 역행성으로 전기자극시 자극세기에 비례하여 전위의 크기가 증가되었고 필드 전위의 양태는 두 가지 반응으로 나타났는데 전기자극 직후 1ms 부근에서 정점을 나타내는 양태와 이와 더불어 7~8ms 부근에서 후기 정점을 동반하는 양태가 있었다. 안면신경핵은 염색시 내측, 배외측, 중간측 및 외측등 4부분의 소핵으로 구분되었다. Neurobiotin으로 채워진 단일 신경세포를 형태학적으로 재구축하였는데 세포체는 추체형태를 나타내었고 주 수상돌기는 모든 방향으로 뻗어져 있었고 각 수상돌기의 영역은 해당 소핵 내에 한정되어 있었다. 일련의 과분극 전류(-1.2~+1.2nA)를 세포내에 가하였을 때 동반되는 세포내 전위변화를 입력저항 값으로 계산하였을 때 그 기울기가 직선형으로 나타났다. 탈분극 전류를 세포내 주입시 지속적인 활동성 전위가 나타났으며 전류의 크기에 비례하여 각 전위의 개수가 증가하였고 spike-빈도 적응 현상이 나타났다. 그러나 시간 의존성 내향성 정류현상은 관찰되지 않았고 anodal break excitation이 나타났다. 이상의 실험결과로 보아 안면신경핵을 구성하고 있는 세포들 사이의 시냅스는 다양한 형태로 존재할 가능성이 있다고 사료되며 이들 시냅스간의 변화를 통하여 안면 신경마비, 반쪽 안면 경련, hypoglossal-facial anastomosis등에서 나타날 수 있는 임상적 신경성 증상 기전을 설명할 수 있을 것으로 여겨진다. 주요어 : 안면신경핵, 시냅스, 신경세포막 특성, 안면신경마비, 반쪽 안면 경련 This study used in vivo intracellular and extracellular fIeld potential recording to evaluate the intrinsic membrane properties and connection pattern within facial nucleus. 1.There were four subdivisions of medial, intermediate, lateral, and dorsolateral in facial nucleus. 2.Principal cells in the facial nucleus was recorded from and filled with neurobiotin in anesthetized rats. The extent of their dendrites and the characteristics of cell body were examined. 3.Principal cells had a large amplitude action potential and afterhyperpolarization was followed a single action potential. 4.The response from facial motonucleus to electrical stimulation of the facial nerve was mainly a monophasic wave, with a latency of 1 msec, which was assumed to reflect antidromic activation of facial motoneurons. In some of rats the response in addition showed late components at a latency of about 7-8 msec, but its amplitude was small. 5.Mest of cells exhibited accommodation of spike discharge upon depolarization of membrane by 0.8 nA for 400 ms. Our results support the hypothesis that there normally are weak connections between different parts of the facial motonucleus to explain pathophysiology of hemifacial spasm and facial nerve paralysis.

위성영상을 이용한 갯녹음 면적 산출에 관한 연구

이병걸,안영화,최영찬 제주대학교 해양과환경연구소 2005 해양과환경연구소 연구논문집 Vol.29 No.2

한국인에서 미맹출 견치와 소구치의 근원심 폭경 예측을 위한 최적의 치아조합

김소화,김성오,최형준,최병재,이제호 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

FET형 반도체 마이크로센서 개발(Ⅲ)

손병기,이흥락,박이순,조진호,이성필,최평,서화일,박재윤,송경은,김창수 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

현재 의료진단, 화학공정의 모니터링이나 환경공학적 감시 및 제어 등의 분야에서 사용되고 있는 기존의 센서는 고가이며 용적이 클 뿐만 아니라 분석시간이 길고 사용하기 까다로운 것 등 여러 가지 문제점이 있다. 또한 측정환경에 영향을 주지 않을 만큼 충분히 작으며 빠른 분석시간을 가진 센서를 필요로 하고 있다. 본 연구에서는 기존의 센서들의 난점을 극복할 수 있는 새로운 형태의 FET형 전해질(electrolyte : H^+, K^+, Ca^2+, Na^+)센서소자 및 분석 시스템, 용존가스(O_2, CO_2)센서의 개발을 중점적으로 추진하였으며, FET형 압력센서, 습도센서 둥의 개별 FET형 센서에 관한 기초연구도 병행하였다. The conventional sensors have many problems such as high cost, large dimension, long analysis time and troublesome handling to apply to the fields of medical diagnosis, monitoring of chemical process and environmental monitoring/control. The main objects of this research are to develope a new FET type electrolyte(H^+, K^+, Ca^2+, Na^+)sensors, analysis system, and dissoved gas(O_2, CO_2)senors that can overcome the problems of the conventional sensors, and parallel basic researches on FET. type sensors such as pressure and humidity are also in progress.

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

FET형 반도체센서 및 시스템 개발

손병기,조진호,최평,박이순,서화일,권대혁,고광락 경북대학교 센서기술연구소 1996 연차보고서 Vol.1996 No.-

기존의 센서들의 난점을 극복할 수 있는 새로운 형태의 FET형 전해질(electrolyte :H^+, K^+, Ca^2+, Na^+)센서소자 및 분석 시스템의 개발을 중점적으로 추진하였으며, FET형 포도당센서 및 압력센서의 개별 FET형 센서에 관한 연구도 병행하였다. FET형 전해질센서를 이용한 휴대용 전해질 측정기와 desktop형 4채널 전해질 분석기를 제작하였다. 또한 이 시스템을 소형화하기 위한 주문형 아날로그-디지탈 변환기 내장형 CMOS 프로세서를 설계하고 검증하였다. The main object of this research is to develope a new FET type electrolyte(H^+, K^+, Ca^2+, Na^+) sensors and analysis system which can overcome the problems of the conventional sensors. Parallel researches on FET type sensors such as glucose and pressure humidity are also in progress. A portable electrolyte meter and desktop 4-channel electrolyte analysis system is fabricated. A customized CMOS processor with built-in analog-to-digital converter is designed and verified.