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김병진 ( Byung Jin Kim ),함경완 ( Kyung Wan Ham ),박경배 ( Kyung Bae Park ),김대현 ( Dae Hyeon Kim ),조범연 ( Beom Yeon Jo ),조창래 ( Chang Re Cho ),조길환 ( Gil Hwan Cho ),배기상 ( Gi Sang Bae ),박경철 ( Kyoung Chel Park ),구본순 대한본초학회 2009 大韓本草學會誌 Vol.24 No.3
Objectives: The purpose of this study was to investigate the anti-inflammatory effects of extract from Trogopterorum Faeces (TF) on the RAW 264.7 cells. Methods: To prove the TF`s anti-inflammatory effects, we investigated nitric oxide (NO) production and own cell viability. We examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also cellular regulatory mechanisms. Results: TF does not have any cytotoxic effect. TF reduced LPS-induced NO production, interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. TF inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. TF reduced the serum levels of IL-1b, IL-6, TNF-a. The survival rate of LPS-induced endotoxin shock was increased by TF administration. Conclusions: TF down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties.
GO-19 : Postoperative Outcomes of MR-negative Ib1 cervical cancers
( Jin Young Park ),( Jeong Won Lee ),( Aera Yoon ),( Ha Jeong Kim ),( Yoo Young Lee ),( Chel Hun Choi ),( Tae Joong Kim ),( Duk Soo Bae ),( Byoung Gie Kim ),( Sung Yoon Park ),( Chan Kyo Kim ),( Byung 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
To retrospectively evaluate the postoperative outcomes of Ib1 cervical cancers which were invisible on magnetic resonance imaging (MRI). Between January 2001 and December 2007, we reviewed the medical records of 86 patients with Ib1 cervical cancer (MR-negative cancer) which was invisible on MRI. During the same period, we also reviewed medical records of 260 patients with Ib1 cervical cancer (MR-positive cancer) which was visible on MRI. These MR-negative and positive cancers were both treated with radical hysterectomy and pelvic lymph node dissection. Both cancers were compared in terms of postoperative tumor size, parametrial invasion, vaginal invasion, lymphovascular invasion, lymphatic metastasis, and long-term outcome using unpaired t-test, Fisher exact test, and Kaplan-Meier survival curve. The mean sizes of MR-negative and MR-positive cancers were 0.5 ± 0.7 cm and 2.9 ± 1.5 cm, respectively (p<0.0001). Lymphovascular invasion, parametrial invasion, vaginal invasion, and lymphatic metastasis were 4.7% (4/86) and 26.9% (70/260) (p<0.0001, odd ratio=7.6), 0% (0/86) and 6.5% (17/260) (p=0.015, odd ratio=10.0), 0% (0/86) and 5.0% (13/260) (p=0.035, odd ratio=6.5), and 1.2% (1/86) and 18.8% (49/260) (p<0.0001, odd ratio=19.7) in the MR-negative and MR-positive cancers, respectively. Recurrent tumor and recurrence-free 5-year survival rate were 1.2% (1/86) and 9.6% (25/260) (p=0.010, odd ratio=9.0) and 98% and 89% in the MR-negative and MR-positive cancers, respectively. MR-negative cancer provides higher recurrence-free long-term survival rate because of much lower tumor burden than MR-positive cancer. Less invasive surgical technique might be one of treatment options for MR-negative Ib1 cervical cancer.
양측성 슬동맥 포착증 : 증례 보고 A case report
김성,최창식,우영민,이봉화,김이수,강형길,임민균,황대현,위병철 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1
A case of symptomatic bilateral popliteal artery entrapment syndrome is reported. A twenty-one-year old male, a candidate of athlete, complained of coldness, weakness, pallor and cyanosis of right lower leg and intermittent claudication to both calves during walking or exercise for ten months. Studies revealed that the right popliteal artery was completely occluded, but the left popliteal artery was non-occlusive. An endarterectomy and onlay vein patch graft to the thrombosed and fibrotic right popliteal artery, and myotomies of bilateral medial heads of gastrocnemius muscle were done (May 20, 1998). Follow-up examinations for the last ten months showed a complete relief of symptoms with normal distal arterial flow. It is thought that even though the majority of patients present with unilateral calf claudication, the possiblity of bilateral problems need to be also considered.
김병수,이승철,은희철,유재학,정승용,이일수,여운철,김영걸,고우석,김계정,최호철,이시원 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5
Background: It is a trend that the average life span is prolonged in proportion to the advance of socio-economy and medical science. Consequently, the number of elderly patients with skin diseases is increasing. Objective: This study was performed to see the change of patterns of skin diseases in elderly patients. Methods: One thousand four hundred and twenty elderly patients, over the age of 65, who visited the departments of dermatology and in five hospitals, from January 1, 1997 to December 31, 1997 were selected. We surveyed the frequeney of skin disease by types and the distributions by month, season and age. Results: The results were as follows; 1. The frequent skin diseases were herpes zoster and postherpetic neuralgia (12.3%), fungal infection (11.3%), pruritus (9.2%), contact dermatitis (6.8%), and seborrheic dermatitis (5.7%). 2. The most frequent was herpes zoster and postherpetic neuralgia in January, February, March, April, June, August and October, in January, July, September and December, fungal infection; in May, contact dermatitis; in November, pruritus. 3. The most frequent skin desease was herpes zoster and postherpetic nueralgia in spring, summer and winter; in autumn, fungal infection. 4. The most frequent skin disease for the 65-74 aged-group was herpes zoster and postherpetic neuralgia; for the over 85 aged group, herpes zoster and postherpetic neuralgia. Conclusion: The results showed that, in contrast to previous studies, herpes zoster and postherpetic neuralgia increased in elderly patients. These findings may be helpful for the government and medical centers to plan and establish a management system on the skin diseases of elderly patients.
김만균,장문철,최병관,함효준 대한설비관리학회 1999 대한설비관리학회지 Vol.4 No.1
Recently, the situation of the new product development has been drastically changed. Also, the development of DR(Design Review) Model for analysis has been interested by researchers. Presented in the paper is concerned with the set-up of DR model for improvement of design quality. The proposed model describes the relationship between input/output and factors of production such as quality, cost, delivery, moral, safety and design quality, etc. Also, these factors are associated with a significant positive correlation between DR and design quality, development and delivery on the production. So, DR is applied broadly in whole process of new product development and we can make it very successfully in developing time, quality, function, cost and delivery.
만성 간질환에서 비장종대와 Platelet Associated IgG가 혈소판 감소에 미치는 영향
박병채,한병훈,김지현,이철희,임진형,정효균 대한소화기학회 1998 대한소화기학회지 Vol.31 No.4
Background/Aims: Thrombocytopenia is frequently found in patients with chronic liver disease. The mechanism of thrombocytopenia has been attributed to hypersplenism. Recently, several reports have shown that platelet associated IgG (PA-IgG), which has been thought to be closely related to idiopathic thrombocytopenic purpura (ITP), may play a role in the pathogenesis of thrombocytopenia in patients with chronic liver disease. The aim of this study was to elucidate the prevalance of PA-IgG and to evaluate the effect of splenomegaly and PA-IgG on thrombocytopenia in patients with chronic liver disease. Methods: The 125 patients with chronic liver disease (31 chronic hepatitis, 44 liver cirrhosis, 50 hepatocellular carcinoma) were studied. The prevalance of PA-IgG was checked using direct platelet immunofluorescent test. Spleen index was obtained by multiplying the long axis by short axis (cm2). Results: The prevalance of PA-IgG increased gradually according to the severity of liver disease, and was significantily higher in patients with hepatocellular carcinoma (44.0%) than in patients with chronic hepatitis (6.5%) or liver cirrhosis (18.2%)(p$lt;0.001, p$lt;0.01, respectively). For all patients groups platelet count in PA- IgG positive poup was not significantly different from that in PA-IgG negative group. Noticeably, there was a significant correlation between platelet count and spleen index (r=-0.36, p$lt;0.0001). Conclusions: The prevalance of PA-IgG increased gradually according to the severity of liver disease form chronic hepatitis to hepatocellular carcinoma. Spleen enlargement showed important roles in thrombocytopenia, but PA-IgG had no effect on platelet count.