Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.

Jang, Byeong-Churl,Lim, Ki-Jo,Choi, In-Hak,Suh, Min-Ho,Park, Jong-Gu,Mun, Kyo-Chul,Bae, Jae-Hoon,Shin, Dong-Hoon,Suh, Seong-Il D.A. Spandidos 2007 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.19 No.5

<P>The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role in the innate immunity. We have previously demonstrated that IL-1beta induced HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), or phosphatidylinositol-3-kinase (PI3K). In this study, we investigated effects of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells. Triptolide inhibited IL-1beta-induced HBD-2 mRNA expression in a dose-dependent manner. Addition of triptolide did not suppress activation of p38 MAPK, JNK, or PI3K in response to IL-1beta. Triptolide inhibited IL-1beta-induced MAPK phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK, explaining the little effect of triptolide on IL-1beta-induced phosphorylation of these kinases. Although triptolide partially suppressed IL-1beta-mediated degradation of IkappaB-alpha and nuclear translocation of p65 NF-kappaB, triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells. These results collectively suggest that the inhibitory effect of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells seems to be at least in part mediated through nuclear inhibition of NF-kappaB transcriptional activity, but not inhibition of p38 MAPK, JNK, or PI3K. This inhibition may explain the ability of triptolide to diminish innate immune response.</P>

전기적화상에 의한 구순결손의 재건 -증례보고-

박진규,김경원,김병린,민병일 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Electrical burns of the lips are most frequently seen in small children, who are apt to chew on electrical cord or plug, the ends of extension cords in their mouth, saliva creates a short circuit across the terminals within the plug, causing an electrical burn. Tissue destruction with electrical burns is sudden and extensive. Extensive, deep coagulation necrosis is instaneously produced by the extreme temparatures of electrical arc. If the child is well grounded, the circuit flow through his body may cause cardiac arrest. The purpose of this report is to document two cases of electrical lip burn and reconstruction of the lip defect with some local flap techniques. For case 1, Z plasty & V - Y plasty and lengthening of the commissure and in case 2, Abbe flap technique was used and scar was revised later. Z - plasty and V- Y plastry were used for scar release and Abbe flap was designed on lower lip to meet the need of upper lip. For short of right lip width, lengthening of the commissure was done. We are to report the improvement with forementioned operation on the patient of electrical burn upon the lip.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

전북 익산지역에서의 묘화 이용실태 조사

박윤점,이일병,정주연,장흥기,허북구 한국식물인간환경학회 2001 인간식물환경학회지 Vol.4 No.1

This study was surveyed to know utilization of the in graveyard the military and the police(MP), the catholic graveyard(CG) and graveyard of mausoleum(GM). The items of investigation were the ratio, kinds of flower, color of cut flower and form of offering a bunch of flowers. The time of investigation were New Year's day, Chusok(the korean thanksgiving day) and a weekday. On a week day, the ratio of offering a bunch of flowers was 6.3 perrcent in GM. CG and GM were 2 and 6 percent, respectively, On Chusok MP was 9 percent, CG was 25 percent and GM was 55.9 percent. On New Year's Day MP was 17.9 percent, CG was 43.3 percent and GM was 49.8 percent. Except for GM, when we compared the chusok with a week day, they were offered 12-24 times. Of the kinds of cut flower offered a bunch of flowers, chrysanthemum was 60 percent or more without regard to MP, CG and GM. About color of cut flower, white was 39.2 percent or more and yellow was 8.8 percent or more. Most of used colors were white and yellow. And they were 48 percent or more. That of on a week day was low remarkably. The form of offered flower on a graveyard were various: a flower, a basket of flower, a potflower, a flower in a case of glass, and a flower in a vase. Of that, a bunch of flowers were 33 percent or more in GC, MP and CG. KEY WORDS : flower, graveyard, new year's day, chusok, chrysanthemum

허브식물의 속명 어원에 관한 조사분석

허북구,박윤점,이일병,윤재길 한국화훼연구회 2002 화훼연구 Vol.10 No.2

원예치료용으로도 다수 이용되고 있는 허브식물의 특성 파악과 정확한 구분, 교육 및 연구에 효율적으로 이용할 수 있는 기초자료 수립측면에서 허브식물 97종의 속명 어원을 조사하였다. 허브식물의 속명 유래를 조사한 결과 성분 및 용도(27.8%), 언어명(23.7%), 형태(13.4%), 신화(7.2%), 향기(6.2%), 생육습성(6.2%), 색깔(5.2%), 인명(4.1%), 기타(00%)에서 유래된 것 순이었다. 성분 및 용도에서 유래된 것은 주로 약리 작용에서 유래된 비율이 높았다. 언어명에서 유래된 것은 주로 고대 그리스 및 로마시대의 식물명이었다. 형태에서 유래된 것은 허브식물의 잎과 줄기, 꽃 및 뿌리가 속명의 유래원이었다. 신화에서 유래된 것은 주로 기쁨이나 약효와 관련된 것이었다. 향기에서 유래된 것은 식물의 전체 혹은 종자에서 냄새가 나는 것에서 유래되었다. 생육습성은 자생지역이나 개화습성, 덩굴성 등의 특성이 반영되어 있었다. 기타 식물의 꽃, 잎, 뿌리의 색깔과 왕의 이름, 맛 지명, 벌, 꽃이 아름다운데서 유래된 것이 있었다. The derivation of genera names in 97 herb plants were investigated to obtain the basis information useful for understanding the characteristics of herbs, classifying correctly, teaching and researching about them. Most genera names were derived from constituent and utilization(27.8%), and followed by language(23.7%), morphological characters(13.4%), myth(7.2%), odor(6.2%), color(5.2%) and human's name(4.1%) orderly. Genera names derived from constituent and utilization were originated mostly from medicinal effect, and those from language name were mostly originated from the plant names of Greek and Rome. Genera names derived from myth were mostly originated from delight and medicinal effect, and those from oder were originated from order of whole plant or seed. Genera names derived from growth habit indicate the character of flowering habit, native location and vine. The others of genera names were originated from the color of flower, leaf and root, king's name, taste, place name and flower beauty.

한국에서 동물간호사제도의 필요성과 자격시험에 대한 분석 및 평가

이성호,박영석,박병권,곽명순,강종일,조성진,김선균,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The study examined qualification test of the 1st term Animal Nurse Technician and conducted questionnaire survey as well as site investigation to settle Animal Nurse Technician system in Korea. The objects were undergraduates, graduates and director of animal hospital. 115 applicants applied to the qualification test of animal specialists, and 50 applicants passed the test to record 43.47% of ratio of successful applicants. The subjects having relative difficulty were anatomy physiology and public hygiene to record 19 points in average: In particular, the anatomy physiology recorded 35 points of the highest score and 6 points of the lowest score to have the highest deviation and to require adjustment of difficulties. 89.2% of the interviewee supported needs of animal nurse technician system in Korea to show positive response. At the survey of actual conditions of recruitment of animal nurse technicians at animal hospitals, 28.6% of the interviewee was employing the technicians, and 35.7% had employment plan, and 32.1% wanted to employ them under good conditions. In other words, 96 4% of the interviewee responded positively, while no more than 3.6% did negatively. In Korea, the animal nurse technicians had roles as follows: The animal hospitals gave priority to reception service and customer controls followed by medical examination support,whilethecollegesdidtomedicalexaminationsupport. To differentiate hospitals in accordance with the increase of number of animal hospitals, the animal hospitals should employ animal nurse technicians having specialty and qualifications on animal nurse technician examination. In particular, the roles and demand of animal nurse technicians were expected to grow because of developed technologies of veterinary medical science, development of medical supplies and instrument, and the increase of aged animals, etc. Therefore, job analysis on animal nurse technicians should be done to adjust the subjects of qualification test and to develop questions.

동결건조 장미의 화색과 형태적 특성

서춘순,박윤점,이일병,허북구 한국화훼연구회 2001 화훼연구 Vol.9 No.2

Rosa hybrida L. 'Sandra' was freeze dried and investigated the length fur drying, color change of petal, leaf and stem, and the change of flower diameter, 12 days were needed to dry flower completely by natural drying method, otherwise 2 days needed by freeze drying. There was significant difference between fresh flower and natural dried flower in terms of L, a, b value of petal color, otherwise there was no significant difference between fresh flower and freeze-dried flower. L, a and b value of leaf and stem of freeze-dried flower was different comparing with those of fresh flower, however the degree of difference was not higher than these of natural-dried flower, There was no significant difference between fresh flower and freeze-dried flower in terms of anthocyanin content in petal. The change of flower diameter of natural-dried flower and freeze-dried flower comparing with fresh flower was respectively 52.0% and 9.9%.

기-액병류상향 충전탑에서 액체체류량과 축방향혼합특성

조지훈,손민일,박용성,함병호,김태옥 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For upward cocurrent gas-liquid flow in a packed column, holdup and axial mixing characteristics of liquid were investigated. In an air-water-glass bead system. liquid holdup and residence time distribution(RTD) were measured and Peclet number based on axial dispersion model was evaluated from experimental RTD. We found that liquid holdup was increased with increasing liquid velocity and size of packing material, and it was decreased with increasing gas velocity. Also, liquid holdup for the cocurrent up flow system was larger than that for the downflow system at the same experimental conditions. As increasing gas velocity, the in fluence of packing size and operation method on liquid holdup was reduced. The calculated Peclet number was not affected by gas velocity, and it was increased with increasing liquid velocity and with decreasing packing size. Furthermore, the effect of liquid velocity on Petlet number for higher liquid Reynolds number(Re1>70) was larger than that for lower Re1. In these conditions, correlations of the dynamic liquid holdup and the Bodenstein number were obtained.

자동차 공조용 핀형 열교환기의 성능특성에 관한 연구

홍경한,전상신,이승재,박찬수,권일욱,김재열,김병철,하옥남 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4

Fin-tube type(Fin-type) heat exchanger has been tested in order to replace the heat exchanger of parallel flow type(P.F-type) which is now widly used in automobile air conditioning system. The following conclusions are drawn by the comparison of the characteristics of the heat exchangers. Evaporator and condenser capacities and COP(Coefficience of performance) were varied as with the compressor speed, outdoor air temperature and air flow rate changed, which much influenced on the characteristics of the air conditioning system. Evaporator and condenser capacities were increased with increasing compressor speed and outdoor air temperature. Evaporator and condenser pressures of Fin- type were decreased by 7% and 5% respectively compared with those of P.F-type. The COP of Fin-type was decreased with increasing outdoor air temperature and compressor speed. The COP of P.F-type was decreased by 14% compared with that of Fin-type.

Establishment of the Extraction Process by Evaluation of Morroniside, Loganin, and Cornin Contents of Sansuyu (Corni fructus) Extracts

Ji-Suk Jeong,No-Jin Park1,Byeong-Gil Son,Kyung-Il Kim,Bok-Sun Shim,Yung Hyun Choi 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10