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      • 세로토닌성 항우울제가 백서의 Schedule-Induced Polydipsia에 미치는 영향

        이기철,이정호,박중섭,최영민,전성일,정홍경,하준명,정재현 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

        Object : Schedule-induced polydipsia is considered as an animal model of obsessive-compulsive disorder inrats. The authors evaluated the chronic effects of fluoxetine and clomipramine as serotonergic antidepressants and haloperidol as dopaminergic antagonist on the schedule-induced polydipsia in rat.Methods : Spraque-Dawley rats weighing 200-250gm were individually housed, maintained and allowed free access to water for 1 week. And then the rats were placed on a restricted diet. To induce polydipsia, rats were placed in automatic cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT 60s) feeding schedule over 150-minute test session for a day. Water was available at all times during the feeding schedule in automatic cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 4 groups of rats were administered fluoxetine(5mg/kg/i.p.), clomipramine(5mg/kg/i.p.), haloperidol(0.1mg/kg/i.p.), vehicle(1cc/kg/i.p.) for 3 weeks. Rats were tested once a week to access schedule induced polydipsic behavior. The chronic effects of experimental drugs on schedule induced polydipsic behavior were analyzed with repeated analysis of variance and Scheffe test as a post-hoc comparison.In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5 gm) of food per day which maintained them at their average body weight.Results and Conclusion : The results were as follows ;1) After 4 weeks of daily feeding procedure with fixed time schedule for 60 seconds per day, the experimental group showed significant differences than the control in the amount of water consumption as compared with their baseline water intakes. At the same periods, there were no differences between the experimental group and the control in body weight. 2) The clomipramine treated group and the fluoxetine treated group showed significant decrease in the amount of water intake as compared with their baseline of polydipsic water intakes for 3 weeks of treatment. However, the haloperidol treated group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their baseline of polydipsic water intakes. 3) At 2 weeks of drug treatment, clmipramine treated group(16.88±6.51ml) and the fluoxetine treated group(22.50±10.35ml) showed significantly lower amounts of water intake than the haloperidol treated group (41.25±7.06ml) or vehicle control group(37.50±12.54ml). And also the clomipramine treated group(13.75±5.18ml) and the fluoxetine treated group(18.75±3.54ml) showed significantly lower amounts of water intake than the haloperidol group(35.00±11.65ml) and the vehicle control(34.38±6.78ml) at 3 weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The author confirmed that schedule-induced polydipsia was successfully decreased for 3 weeks of administration of clomipramine and fluoxetine but there was no response to haloperidol.

      • KCI등재

        교잡종 찰옥수수에 대한 연구 : Ⅰ. 찰옥수수 "연농×재래" 교잡종의 생육 및 수량특성 Ⅰ. Growth and Yield Characteristics in Waxy Maize Hybrid Yeonnong × Jaerae

        이희봉,정재영,최현구,김기훈,김효기,주정일 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.2

        재래종 찰옥수수 F₁ 교잡종에 대한 생육 및 수량비교를 위해 충남대학교 농과대학 실험포장에서 육성한 이들 교잡종의 식물학적 특성에 대한 연구 결과는 다음과 같다. 1. 간장은 대조구에 비해 대학찰×재래찰, FR805/1K₃×고령찰이 가장 크게 나타났으나, FR805/1K₃×대학찰, 찰옥 1호에서 대조구와 비슷하게 나타내었다. 2. 착수수는 간장에서와 마찬가지로 대학찰×재래찰, FR805/1K₃×고령찰이 대조구보다 높게 나타났으나 대학찰×재래찰, 찰옥 1호는 비슷하였다. 3. 분얼수는 각 교잡종들간에 큰 차이가 없었다. 4. 이삭의 길이는 대조구에 비해 교잡종들이 거의 2배이상의 크기를 나타내었다. 5. 이삭직경은 FR805/1K₃× 고령찰의 교잡종을 제외하고 대조구와 비슷하게 나타났다. 6. 이삭열수는 Daehakchal×1K₁/LE만이 대조구와 유의성을 나타내고 기타 교잡종은 대조구와 비슷하였다. In order to evaluate the characteristics of growth and yield in F_(1) waxy hybrids using Korean local maize lines, six hybrids including check, Chalok # 1, were planted at the experinental field of e Chungnam National University. Stem and ear heights of Yeonnong × Jaerae and FR805/IK_(3) × Koryong hybrids were higher than the check hybrid. Number of fillers per plant in all hybrids were similar as 0.3 to 0.5 per plant Ear length of waxy hybrids was longer than 15㎝ of check hybrid and ear diameter was also thicker than check except FR805/IK_(3) × Koryong waxy hybrid. A final result, Yeonnong × Jaerae among hybrids was comparatively superior to other hybrids in the test.

      • KCI등재후보

        우리나라 일부 석면사업장의 석면폐 유병률

        백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

        Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

      • 생후 0-15 개월 소아의 볼거리 항체가 측정

        정은경,나기찬 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2

        To determine the proper age of the Mumps vaccination, we measured the degree of immunity of 55 children with the age from birth to 15 months to mumps antibody titer by indirect immunofluorescent antibody method. 1) 40.0% (22/55) of the children was positive for mumps Ig G antibody and 3.6%(2/5) was positive for mumps Ig M antibody. 2) By age group, 19 of 31 children with the age from birth to 4 months were positive mumps Ig G antibody, but all the children was negative between 4 month and 12 months. And, 3 of 7 children with the age between 13 months and 15 months were negative for mumps Ig G antibody. 3) One child was positive both Ig G and Ig M antibody. In conclusion, passive mumps antibody began to diappear after 4 months of age, and also began to develop inapparent infection of mumps before 15 months of age, therefore, it is considered that the early mumps vaccination will be required before 15 months of age.

      • 特用作物 利用에 關한 硏究(第1報) : 韓國産枸杞子와 木瓜의 化學的 成分과 그 製品에 關하여 On the Chemical composition of Lycium chinense MILL and Chaenomeles sinensis KOEHNE and their products

        鄭址炘,김 관,裵顯錫 全南大學校 農漁村開發硏究所 1980 農業科學技術硏究 Vol.15 No.-

        韓國産구기자와 모과의 化學的 成分과 그 製品에 關한 結果는 다음과 같다. 1. 구기자의 一般成分에 있어서 진도산-1이 粗蛋白質 12.7%로 가장 적은 含有量을 제외하면 一般的으로 진도산이 공주산보다 成分含量이 많았다. 2. 구기자의 特殊成分中 Vitam A 含量은 試料間 1.4∼55.1mg%으로 差異가 基하였는데 그 原因은 保存中의 條件에 따라 달라진다고 思料된다. 3. 구기자중의 Fe含量은 공주산 6.6mg%보다 진도산 11.2∼11.9mg%으로 진도산에 많다. 4. 구기자의 試料와 焙燥한 試料를 比較하여 볼 때 Vit. A는 1.7mg%에서 0.5mg%으로, 휘발산은 0.24mg%에서 0.01mg%으로 total ester은 3.9mg%에서 1.2mg%으로 減少하지만 alkaloid와 mineral은 變動이 없다. 5. 모과試料間에 있어서 실생은 mineral中, 燐酸 18mg% 以外의 各 成分含量이 他試料보다 많았다. 6. 구기차의 官能檢査結果는 試料間의 맛에 對한 有意性을 認定하여 抽出粉末茶가 가장 좋았다. 7. 구지주에 關하여는 試料間에 맛, 香氣, 色에 對한 有意性을 認定할 수 없다. 8. 모과차에 對한 官能檢査結果는 試料에 대하여 맛과 香氣에 관한 有意性이 認定되며 모과의 生果磨碎설탕졸임 茶가 가장 좋았다. 끝으로 本 硏究는 전남도 농촌진흥청 작물과의 '80共同硏究課題로 遂行되었으며 進行하는데 있어서 本 大學院生 金龍斗君의 勞苦에 對하여 感射하는 바이다. The results obtained from the experiments about the chemical compositions and the product quality of Lycium Chinense M?? and Chaenomels Sinensis K??? in Korea are summarized as follows: 1. The concents of proximate components of Lycium Chinense M?? were hgiher in the Jindo-products than that of the Kongju-products, except the content of crude protein of Jindo-products which was the least one(12.7%). 2. The content of Vitamine A, one of the special components of Lycium Chinense M???, was varied from 1.4mg% to 55.1mg%. It was thought because that samples were affected by the several factors during storage. 3. The Fe content of Lycium Chinense M??? of Jindo-products(11.2∼11.9mg%) was higher than that of Kong-ju-product.(6.6mg%) 4. Comparing the parched Lycium Chinense M??? with dried one, the contents of Vitamine A, volatile acid and total ester were decreased from 1.7 to 0.5mg%, 0.24 to 0.01mg% and 3.9mg% to 1.2mg%, respectively. But it was found that the contents of alkoloid and mineral were not changed. 5. In ungrafted seedling, the contents of the tested minerals except for phosphorous(18mg%) were higher than those of the other species. 6. The extracted powder tea was best according to the panel test. 7. There was no significant difference among the Lycium Chinense M??? liguors in taste, flavor and color. 8. By means of panel test on Chaenomeles Sinensis Koehne tea, the significant difference about taste and flavor of each sample was recognized and grinding fresh fruit sugared tea was the best.

      • 진단검사의학과 검사건수에 영향을 미치는 요인 분석

        정상혁,황기범,이혜진 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

        Objective : The purpose of this study is investigating variables affecting the numbers of clinical laboratory tests. Method : Data about the number of clinical laboratory tests, hospital characteristics, and the number of patients between January 1999 and December 1999 was collected. Data resources were Statistical Yearbook, Standardization Audit by Korean Hospital Association and Internal Data Set of each hospital. Hospital characteristics were hospital ownership, tertiary care hospital, duration since opening, licensed hospital beds, the rates of medical inpatient and outpatient. Multiple regression analysis was applied to find factors affecting the number of clinical laboratory tests. Models for WBC, RBC, Hb, Hct, PLT, LDC, PT, PTT, AST, ALT, and GLU were statistically adequate. Results : As the results, hospital ownership, duration since opening, licensed hospital beds, the rate of medical outpatient were statistically significant. Private hospitals showed higher numbers than public hospitals, hospitals within 5 years since opening showed higher numbers than others. The licensed hospital beds was positively correlated with the numbers of the tests, whereas the rates of medical outpatient was negatively correlated. Conclusion : In conclusion, hospital characteristics affect the numbers of clinical laboratory tests. It could be a clue why the costs of medical services were different among medical facilities. 연구목적: 진단검사의학은 환자의 진료에 필수적인 요소로서 정확한 진단, 치료방향의 결정, 치료효과의 판정, 질병경과의 판단 및 예후 추정의 근거가 된다. 국내 의료기관에서는 혈액학적 검사, 미생물검사, 면역혈청검사, 면역혈액검사, 생화학검사, 기생충검사, 응급검사, 최근 효소법으로 대체되고 있는 방사성동의원소검사, 병리조직검사, 기타 특수검사 등 많은 검사를 시행하고 있다. 의료기관의 검사검수는 질병의 종류, 중증도 등에 따라 다를것으로 예상되나 검사건수에 영향을 미치는 요인을 설명하는 연구는 많지 않다. 병원의 특성은 병원의 지리적, 조직적 특성을 말하는 것으로 병원의 특성에 따라 환자의 종류 및 구성이 다르며 의료기관 종류, 진료시설, 장비수준, 관리운영상의 차이, 조직구성 등에 따라 진료비도 많은 영향을 받는다. 또한 의학기술 발달과 자동화로 인해 장비의 보유 및 사용에 의료기관이 특성이 반영될 수 있다. 이 연구에서는 의료기관의 특성이 진단의학과 검사건수의 변화에 어떠한 영향을 미치는지 알아보고자 하였다. 구체적으로 병원급 이상 의료기관의 진단검사의학과에서 발생하는 검사건수에 영향을 미치는 요인들과 그방향서을 분석하고자 하였다. 방법 : 199년 1월 1일부터 1999년 12월 31일까지의 진단검사의학과 검사건수, 각 병원별 특성, 환자 진료실적을 각 병원의 통계연보, 각 병원 표준화 심사자료, 각 병원 내부자료를 이용하여 수집하여 분석하였다. 병원조직의 특성 변수로는 설립구분, 종합전문요양기관 유무, 개설연도, 허가병상수를 선정하였고, 환자구성의 특성 변수로는 내과계 입원환자비율, 내과계 외래환자비율을 선정하였다. 검사건수는 대상 의료기관 전체에서 공토으로 시행하는 진단검사의학과의 16갖 검사항목에 대하여 분석하였다. 연구대상 의료기관의 병원특성 및 환자특성과 검사건수의 분포를 살펴보았으며 병원조직의 특성과 환자구성의 특성 변수에 대하여 t-검정 및 상관분석을 시행하여 검사건수와 관련성을 보이는 변수를 분석하였다. 검사건수에 영향을 미치는 요인들에 대하여 중회귀분석을 시행하여 16개 검사항목 중 WBC, RBC, Hb, Hct, PLT, LDC, PT, PTT, AST, ALT, GLU에 대하여 통계학적으로 타당한 모형을 구성하였다. 결과 : 1) WBC의 검사건수의 변화는 44.1%를 설명할 수 있었으며 민간병원에서, 허가병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 검사건수가 감소하였다. 2) RBC의 검사건수의 변화는 37.7%를 설명할 수 있었으며 민간병원에서 허가병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였다. 3) Hb의 검사건수의 변화는 43%를 설명할 수 있었으며 민간병원에서 허가병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 검사건수가 감소하였다. 4) Hct의 검사건수의 변화는 39.8%를 설명할 수 있었으며 민간병원에서 허가병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 감소하였다. 5) PLT의 검사건수의 변화는 73.7%를 설명할 수 있었으며 민간병원에서 허가병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였고 내과계 외래환자 비율이 높을수록 통계학적으로 유의하게 감소하였다. 6) PT의 검사건수의 변화는 52.0%를 설명할 수 있었으며 개설연도가 5년 이하인 병원에서, 하거병상수가 많을수록 통계학적으로 유의하게 검사건수가 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 감소하였다. 7) PTT의 검사건수의 변화는 37.5%를 설명할 수 있었으며 허가병상수가 증가할수록 검사건수는 통계학적으로 유의하게 증가하였다. 8) AST의 검사건수의 변화는 39.1%를 설명할 수 있었으며 허가병상수가 증가할수록 검사건수는 통계학적으로 유의하게 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 감소하였다. 9) ALT의 검사건수의 변화는 41.0%를 설명할 수 있었으며 허가병상수가 증가할수록 검사건수는 통계학적으로 유의하게 증가하였고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 감소하였다. 10) GLU의 검사건수의 변화는 25.8%를 설명할 수 있었으며 민간병원에서 통계학적으로 유의하게 검사건수가 높았고 내과계 외래환자비율이 높을수록 통계학적으로 유의하게 감소하였다. 결론 : 이상의 결과를 종합하면 검사종류에 따라 차이가 있으나 설립구분, 개설연도, 허가병상수, 내과계 외래환자비율에 따라서 검사건수에 통계학적으로 유의한 영향을 미친다고 볼 수 있다. 공공병원에 비하여 민간병원에서, 설립한 지 5년이 지난 병원에 비해 5년 이내인 병원에서 검사건수가 많고 허가병상수가 많을수록 검사건수가 증가하며 내과계 외래환자비율이 높을수록 검사건수는 감소한다. 이 연구결과에서 의료기관의 특성이 진단으학과 검사건수에 영향을 미치는것을 알 수 있었다. 검사비용은 진료비에서 큰 비중을 차지하고 있으므로 검사비용의 발생에 영향을 미치는 요인을 밝히는 것은 진료비 관리 방안 개발에 중요할 것으로 판단된다. 향후에는 보다 다양한 의료기관에 대해서 풍부한 자료를 바탕으로 진단검사 의학과 검사건수에 영향을 미치는 여러 요인들에 대한 분석이 이루어져 의료 서비스와 진료비 관리방안 개발에 기여할 수 있기를 바란다.

      • 상호운용성 지원을 위한 이동 에이전트 시스템 설계

        정성옥,이정기,홍성표,송기범,이준 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1

        A mobile agent is a computer program that acts autonomously on behalf of a person or organization and that has the unique ability to transport itself from one system in a network to another. An agent system is a platform that can create, interpret, execute, transfer and terminate agents. But, most current mobile agent systems adopted their own architectures, being implemented in various ways. Since those agent systems provide different interfaces, agens created in one mobile agent system could not move to other agent systems perform their task. To solve this problem, interoperability becomes one of the important issues on mobile agent systems. The OMG(Object management Group) proposed: the MAF(Mobile Agent Facility) specification for the interoperability among heterogeneous mobile agent systems. The MAF specification contains MAFAgentSystem and MAFFinder interfaces, and defines agent management, code mobility and naming rule. In this paper, we propose an execution model that can execute mobile agents within an agent system and migrate them to a remote agent system as conforming MAF, and design the structure and functions of its agent system. Our model uses Java and CORBA ORB in its the implementation and exploits their characteristics appropriately. Specifically its agents beside its clients can spawn child agents and control other agents.

      • SCOPUSKCI등재

        하악과두에 발생된 골연골종

        정기훈,김은경 大韓口腔顎顔面 放射線學會 1993 Imaging Science in Dentistry Vol.23 No.2

        Although osteochondroma is not rare in the axial skeleton and long bones, it is very rare in the jaw. It is a benign chondroma within which partial endochondral ossification occurs. There are two types, the central one and the peripheral one. Peripheral type is more common than central one in the jaw, but it is not frequent. Especially it is rare at the mandibular condyle. When it occurred at the mandibular condyle, it is generally located at lateral portion of the condyle. In that case, facial asymmetry with occlusal change is the characteristic clinical feature. But it is similar to condylar hyperplasia so that misdiagnosis can sometimes occur. The differential point is as follows: Hyperplasia generally appears as a generalized enlargement of the condylar process with a normal cortical thickness, but osteochondroma usually appears as focal growth or mass. We report a very rare case of peripheral osteochondroma at the mandibular condyle in a 27-year-old male patient who visited DKUDH with a chief complaint of the facial asymmetry.

      • 방사상 운전 전력계통에 대한 정전복구 시스템

        정정원,이기원 경성대학교 공학기술연구소 1999 공학기술연구지 Vol.6 No.-

        In this paper the hardware and algorithm of APRS(Automatic Power Reconfiguration System) are represented. These days power systems are often operated in the radial operation manner. This is due to the increase of fault current capacities as power flow go higher and loop figures of power systems become more complex. Fundamentally radial operation of power systems result in loss of reliability. So, the need to develop automatic restoration system to recover supply reliability. We develop APRS for practical application.

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