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Environmental Heavy Metal Exposure and Chronic Kidney Disease in the General Population
김남희,현영열,이규백,장유수,유승호,오국환,안규리 대한의학회 2015 Journal of Korean medical science Vol.30 No.3
Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins and causetoxicological renal effects at high levels, but the relevance of low-level environmentalexposures in the general population is controversial. A total of 1,797 adults whoparticipated in the KNHANES (a cross-sectional nationally representative survey in Korea)were examined, and 128 of them (7.1%) had chronic kidney disease (CKD). Our studyassessed the association between Pb, Hg, Cd exposure, and CKD. Blood Pb and Cd levelswere correlated with CKD in univariate logistic regression model. However, theseenvironmental heavy metals were not associated with CKD after adjustment for age, sex,BMI, smoking, hyperlipidemia, hypertension, diabetes, and these metals in multivariatelogistic regression models. We stratified the analysis according to hypertension or diabetes. In the adults with hypertension or diabetes, CKD had a significant association withelevated blood Cd after adjustment, but no association was present with blood Pb and Hg. The corresponding odds ratio [OR] of Cd for CKD were 1.52 (95% confidence interval [CI],1.05-2.19, P = 0.026) in adults with hypertension and 1.92 (95% CI, 1.14-3.25,P = 0.014) in adults with diabetes. Environmental low level of Pb, Hg, Cd exposure in thegeneral population was not associated with CKD. However, Cd exposure was associatedwith CKD, especially in adults with hypertension or diabetes. This finding suggests thatenvironmental low Cd exposure may be a contributor to the risk of CKD in adults withhypertension or diabetes.
문병섭,김종호,김지현,현영열,박세은,오형근,박철영,이원영,오기원,이규백,김향,박성우,이은정 대한내분비학회 2016 Endocrinology and metabolism Vol.31 No.3
Background: The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunctionusing the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA)guidelines in Korean adults. Methods: Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stages 3 to 5, eGFR <60 mL/min/1.73 m2. Statin eligibility in thesegroups was determined using the ATP III and ACC/AHA guidelines, and the risk for 10-year atherosclerotic cardiovascular disease(ASCVD) was calculated using the Framingham Risk Score (FRS) and Pooled Cohort Equation (PCE). Results: There were 3,546 (18.9%) and 4,048 (21.5%) statin-eligible subjects according to ATP III and ACC/AHA guidelines, respectively. The proportion of statin-eligible subjects increased as renal function deteriorated. Statin eligibility by the ACC/AHAguidelines showed better agreement with the Kidney Disease Improving Global Outcomes (KDIGO) recommendations compared tothe ATP III guidelines in subjects with stage 3 to 5 chronic kidney disease (CKD) (κ value, 0.689 vs. 0.531). When the 10-year ASCVDrisk was assessed using the FRS and PCE, the mean risk calculated by both equations significantly increased as renal functiondeclined. Conclusion: The proportion of statin-eligible subjects significantly increased according to worsening renal function in this Koreancohort. ACC/AHA guideline showed better agreement for statin eligibility with that recommended by KDIGO guideline comparedto ATP III in subjects with CKD.
Genetic Polymorphism in Corticotropin-releasing Hormone Receptor Type-1 in Preeclamptic Korean Women
임지혜,김신영,박소연,김도진,김미진,안현경,한정열,김문영,박현영,이광수,김영주,류현미 대한의학유전학회 2011 대한의학유전학회지 Vol.8 No.2
Purpose: Placental corticotropin-releasing hormone receptor type 1 (CRHR1) expression is reduced in pregnancies with abnormal placental function such as preeclampsia (PE), and the levels and/or function of CRHR1 are genetically influenced. The aim of this study was to investigate the association between the c.33+8199C>T polymorphism in the CRHR1 gene and PE in a Korean population. Materials and Methods: Using a case-control design, the association between the CRHR1 polymorphism and the risk of PE was investigated in 203 individuals with PE and 211 normotensive controls. Genotypes were determined using a SNapShot kit and an ABI Prism 3100 Genetic analyzer. Results: Genotypes and allele frequencies for the CRHR1 polymorphism did not differ between PE and normotensive pregnancies. The variant T allele was more frequent than the ancestral C allele in both of the groups and was more frequent in the controls than in the cases. In risk analysis for PE, there was not an increased risk of preeclampsia in subjects who were concomitant homozygous rare allele genotypes (CC) (OR, 0.3; P=0.15) or heterozygous rare allele genotypes (TC) (OR, 0.8; P=0.29). There were no differences in the complications of PE such as severity or preterm delivery in patients with the CRHR1polymorphism. Conclusion: Our findings indicate that the CRHR1 polymorphism was not associated with PE in the present Korean study group.