측두엽 간질에서 일측성과 양측성 포도당 대사저하 군의 임상양상의 차이

주은연,홍승봉 대한간질학회 2004 대한간질학회지 Vol.8 No.1

지속적 양압기의 실제 임상 사용

주은연 대한수면연구학회 2008 Journal of sleep medicine Vol.5 No.2

Positive airway pressure (PAP) is the treatment of choice for patients with moderate-to-severe obstructive sleep apnea (OSA). PAP can effectively reduce the apnea-hypopnea index and improve subjective and objective sleepiness. Also it can gives benefits in sleep quality and quality of life for both the patient and bed partner. Since continuous PAP (CPAP) treatment of OSA was described, additional modes of pressure delivery have been developed (bilevel PAP, autoadjusting PAP, flexible PAP). While none of the variants of PAP improves adherence in unselected patients compared to CPAP, individual patients may respond to a change in pressure mode. Although attended PAP titration remains the standard of practice for selecting a treatment pressure, use of autotitrating PAP devices in the unattended setting can provide an effective titration alternative with careful patient selection and review of titration results. However, despite the increase in PAP treatment options, lack of acceptance and inadequate adherence to PAP therapy remain the major causes of treatment failure. Heated humidification can improve PAP adherence, especially in patients with nasal congestion or dryness.

Deep Learning Based Symbol Detection in Engineering Drawings

Joon-Young Kim(김준영),Taekyong Lee(이태경) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12

초기 파킨슨병의 임상척도와 뇌파의 비선형성의 관계

주은연,김지현,채승희,김응수,박기덕,최경규 대한신경과학회 2001 대한신경과학회지 Vol.19 No.3

기면증과 과다수면을 유발하는 다른 질환들

주은연,홍승봉 대한수면연구학회 2004 Journal of sleep medicine Vol.1 No.2

Ten to 15% of general population suffers from excessive daytime sleepiness (EDS). EDS is observed more frequently in school-age children or young adults than in middle-aged adults. The most common cause of EDS is “voluntary” sleep restriction causing night sleep deprivation. Among the EDS conditions arising from central nervous system dysfunction, so-called primary disorders of somnolence, narcolepsy is the most well known and extensively studied. Narcolepsy is characterized by chronic EDS and abnormal manifestations of rapid eye movement sleep such as cataplexy, hypnagogic hallucination, and sleep paralysis. It is a frequently occurring but under-diagnosed condition that affects 0.02~0.18% of the general population in various countries. Idiopathic hypersomnia, the recurrent hypersomnias, and posttraumatic hypersmonias also must be well understood to provide appropriate evaluation and management of the patient with EDS. Idiopathic hypersomnia is frequently overdiagnosed due to a tendency to label as such all hypersomnias that do not fit the criteria of either narcolepsy or sleep apnea syndrome. The authors reviewed the clinical features and pathogenesis of narcolepsy and other hypersomnias and described diagnostic procedures and differential points between narcolepsy and other hypersomnias

Gray Matter Concentration Abnormality in Brains of Narcolepsy Patients

주은연,김성태,홍승봉,태우석 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.6

Objective: To investigate gray matter concentration changes in the brains of narcoleptic patients. Materials and Methods: Twenty-nine narcoleptic patient with cataplexy and 29 age and sex-matched normal subjects (mean age, 31 years old) underwent volumetric MRIs. The MRIs were spatially normalized to a standard T1 template and subdivided into gray matter, white matter, and cerebrospinal fluid (CSF). These segmented images were then smoothed using a 12-mm full width at half maximum (FWHM) isotropic Gaussian kernel. An optimized voxel-based morphometry protocol was used to analyze brain tissue concentrations using SPM2 (statistical parametric mapping). A one-way analysis of variance was applied to the concentration analysis of gray matter images. Results: Narcoleptics with cataplexy showed reduced gray matter concentration in bilateral thalami, left gyrus rectus, bilateral frontopolar gyri, bilateral short insular gyri, bilateral superior frontal gyri, and right superior temporal and left inferior temporal gyri compared to normal subjects (uncorrected p < 0.001). Furthermore, small volume correction revealed gray matter concentration reduction in bilateral nuclei accumbens, hypothalami, and thalami (false discovery rate corrected p < 0.05). Conclusion: Gray matter concentration reductions were observed in brain regions related to excessive daytime sleepiness, cognition, attention, and memory in narcoleptics with cataplexy.

원예치료가 시설보호아동의 자아개념 및 인성발달에 미치는 영향

주은연,김홍열 인간식물환경학회 2006 인간식물환경학회지 Vol.9 No.4

기면증 환자의 뇌 포도당대사 이상

주은연,태우석,김지현,한선정,조용원,김린,윤창호,김명희,김병태,홍승봉 대한신경과학회 2004 대한신경과학회지 Vol.22 No.4

Background: The purpose of this study was to investigate the differences of cerebral glucose metabolism between narcoleptic patients and normal controls. Methods: We enrolled 24 patients with narcolepsy who underwent night polysomnography and multiple sleep latency tests to confirm the narcolepsy. 18F-fluorodeoxy glucose positron emission tomography scan was performed in all narcoleptic patients and 24 normal age-sex matched controls. To compare the cerebral glucose metabolism between the two groups, statistical parametric mapping (SPM99) was used. Results: Patients with narcolepsy showed significant decreases of cerebral glucose metabolism in the bilateral rectal and subcallosal gyri, right superior frontal gyrus, right medial frontal gyrus, bilateral precuneus, right inferior parietal lobule, and left supramarginal gyrus of the parietal lobe at the uncorrected P<0.001. The bilateral posterior hypothalami and mediodorsal thalamic nuclei showed glucose hypometabolism at the level of corrected P<0.05 with small volume correction. Conclusions: This study showed cerebral glucose hypometabolism of hypothalamus-thalamus-orbitofrontal pathways in narcoleptic brains. The distribution of abnormal glucose metabolism is concordant to the cerebral pathways of the hypocretin system.

뇌파의 연령별 스펙트럼 및 비선형적 분석

주은연,김응수,박기덕,최경규 대한임상신경생리학회 2001 Annals of Clinical Neurophysiology Vol.3 No.1

Background & Objectives : Fractal Dimension(FD) could be an index of correlation between variable parameters in non-linear chaotic signals. We tried to demonstrate that EEG wave is compatible with chaotic waves by measuring the Lyapunov exponent index and compared the difference of FD between variable age groups(teens, 30's, 50's) Methods : We estimated the Lyapunov exponent index and the FD from digital EEG data among five persons in each normal age groups by using the software which is programmed in our laboratory. Statistical analysis was done with SPSS win 8.0. The statistical differences of Lyapunov exponent index and FD between each electrodes and each age groups were done with ANOVA and paired sample t-test. Result : The Lyapunov exponent indexes were larger than 1 in each electrode and age groups. Except in 30 th age group. In this group the FD of right hemisphere is larger than that of left hemisphere. Conclusion : The result of Lyapunov exponent index means EEG wave is a non-linear chaotic signal. And the results of FD suggest that chaotic parameters of right hemisphere is larger than those of left hemisphere at rest at least in younger people. We think that chaotic parameters can be a useful tool in investigating the variable diseases or brain states.

원예치료가 시설보호아동의 정서발달 및 대인관계에 미치는 영향

주은연,김홍열 인간식물환경학회 2008 인간식물환경학회지 Vol.11 No.1

The purpose of this study is to examine effect of horticultural therapy on mental development and interpersonal relationship of institutionalized children. This study executed horticultural therapy program of the total 16 times by one time a week to institutionalized children who have used H-Institution for children in Kyungsang Buk-do from September 21, 2006 to January 4, 2007. To examine effect of horticultural therapy, this study used the korean personality rating scale for children(KPRC), withdrawn scale, self-concept scale, and interpersonal relationship scale, and investigated before and after executing the program for comparison.Mental development was reduced from 90.87 before executing to 72.25 after executing horticultural therapy, and it was statistically significant(P<0.01). Also in withdrawn scale test, the mean point was appeared to be significantly raised(P<0.05) from 8.875 before executing to 6.25 after executing the program, and horticultural therapy was considered to be effective to mental stability of institutionalized children. In result of evaluating self-concept, it was raised from 207.37 before executing to 228.5 after executing, and it showed the significant difference(P<0.01). Also in result of evaluating interpersonal relationship, it was raised from 73.25 before executing to 83.75 after executing, and it showed the significant difference(P<0.05). Accordingly, horticultural therapy is considered to be effective to mental development and interpersonal relationship of institutionalized children.