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      • KCI등재
      • KCI등재

        Neonatal Patent Ductus Arteriosus Ligation Operations Performed by Adult Cardiac Surgeons

        정윤상,조대윤,강현,이나미,홍준화 대한흉부외과학회 2017 Journal of Chest Surgery (J Chest Surg) Vol.50 No.4

        Background: Patent ductus arteriosus (PDA) ligation is usually performed by congenital cardiac surgeons. However, due to the uneven distribution of congenital cardiac surgeons in South Korea, many institutions depend solely on adult cardiac surgeons for congenital cardiac diseases. We report the outcomes of PDA ligations performed by adult cardiac surgeons at our institution. Methods: The electronic medical records of 852 neonates at Chung-Ang University Hospital, Seoul, South Korea from November 2010 to May 2014 were reviewed to identify patients with PDA. Results: Of the 111 neonates with a diagnosis of PDA, 26 (23%) underwent PDA ligation. PDAs were ligated within 28 days of birth (mean, 14.5±7.8 days), and the mean gestational age of these patients was 30.3±4.6 weeks (range, 26 to 40 weeks) with a mean birth weight of 1,292.5±703.5 g (range, 480 to 3,020 g). No residual shunts through the PDA were found on postoperative echocardiography. There was 1 case of 30-day mortality (3.8%) due to pneumonia, and 6 cases of in-hospital mortality (23.1%) after 30 days, which is comparable to results from other centers with congenital cardiac surgery programs. Conclusion: Although our outcomes may not be generalizable to all hospital settings without a congenital cardiac surgery program, in select centers, PDA ligations can be performed safely by adult cardiac surgeons if no congenital cardiac surgery program is available.

      • Carbofuran이 흰쥐의 간조직과 Cytochrome P-450효소계에 미치는 영향과 Phenobarbital-Sodium의 보상효과에 관한 연구

        정윤상,한두석 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.1

        In order to investigate the toxicity of carbofuran and compensatory effects of phenobarbital sodium(PB) against carbofuran toxicity on hepatic tissues and cytochrome P-450 enzyme system of the rat. Sprague-Dawley male rats were administered carbofuran only, PB only or combination of carbofuran and PB. Carbofuran was severely damaged in hepatic tissues by dose-or time-dependent manner and increased the level of cytochrome P-450 enzyme system at 6hrs or 12hrs after administration. PB were not damaged in hepatic tissues, but the level of cytochrome P-450 enzyme system was increased the same as that of carbofuran. Histopathlogical changes were observed on hepatic tissues at 12hrs after carbofuran and PB combination f treatment, but were already recovered at 48hrs. PAS-positive cells were increased at 12hrs after carbofuran only administration and most hepatic cells of carbofuran and PB combination treated group showed PAS-positive reaction, but hepatic cells were normally recoverd. Also, glycogen granule were increased at 12hrs after carbofuran only administration, but glycogen granules were decreased at 12hrs. After carbofuran and PB combination treatment in best camine stain. The level of cytochrome P-450 enzyme system after carbofuran and PB combination treatment were more increased than that of carbofuran only or PB only treatment. The results indicate that PB decreased carbofuran toxicity by the elevation in the level of cytochrome P-450 enzyme system.

      • KCI등재후보

        우리나라 주요 호소의 퇴적물 내 중금속 오염도에 따른 특성 분석

        정윤상,이대성,이다영,곽인실,박영석 한국하천호수학회 2022 생태와 환경 Vol.55 No.2

        In this study, 46 reservoirs in South Korea were characterized based on heavy metal concentration in sediments. We analyzed the relationship between heavy metal concentrations, physicochemical water quality and hydromorphological factors in each reservoir. Study reservoirs were classified into five groups of reservoirs, by hierarchical cluster analysis based on the similarities of heavy metal concentration. Group 1 had the most severe sediment heavy metal contamination among the groups, whereas Groups 2 and 3 showed low levels of heavy metal contamination. Group 4 displayed high value of Ni, and Group 5 showed high contamination of Pb, Cu, Cr, Ni, and Hg. Groups 1 and 5, which had high concentration of heavy metals in sediments, showed a high density of mines in the catchment of reservoirs. Heavy metal concentration was high in reservoirs with large capacity or the ones located at higher elevation, and also highly related with number of mines in the catchment of reservoir. This study can contribute to the systematic management of sediment heavy metals in reservoirs.

      • 인체 치은섬유모세포에 대한 니켈의 세포독성과 Ferulic Acid 및 Vitamin E의 독성경감효과

        정윤상,한두석 원광대학교 치의학연구소 2004 圓光齒醫學 Vol.13 No.1

        Nickel is major metal used in the nickel-chromium alloys of most orthodontic appliances and partial denture. But this metal is known to cause hypersensitivity, dermatitis and asthma. In addition, significant carcinogenic and mutagenic potentials has been demonstrated for compounds containing nickel. The purpose of this study was to develop the compounds repairing on the cytotoxicity of nickel in cultured human gingival fibroblasts. The cytotoxicity of nickel sulfide and nickel oxide in human gingival fibrobalsts treated with dose dependent nickel was measured by MTT assay for cell viability and XTT assay for cell adhesion activity. The cytotoxicity of ferulic acid itself also was investigated by the same cells and methods. The procedure of repairment in human gingival fibroblasts injuried by NiS_50 (nickel sulfide IC_50) and Ni0_50 (nickel oxide IC_50) was carried out to observe after treatment of ferulic acid by dose dependent manner. The 5×10⁴ cells/㎖ of human gingival fibroblasts in each well of 24 multidish were cultured. After 24 hrs, the cells were treated with solution of all groups. After the human gingival fibroblasts were cultured in same condition for 48 hrs, the colormetric methods were performed to evaluate the cytotoxicity. The light microscopic study was carried out to observe morphological changes of cultured human gingival fibroblasts. The results were as follows : 1. According to the MTT absorbance, nickel sulfide and nickel oxide were significantly decreased in 25μM and 50μM, respectively. IC_50 of nickel sulfide and nickel oxide were 138.1μM and 311.7μM, respectively. 2. According to the XlT absorbance, nickel sulfide was significantly decreased in 50 μM and nickel oxide was significantly decreased in 100μM, IC_50 of nickel sulfide and nickel oxide were 104.4μlM and 367.8μM, respectively. 3. MTT_50 and XTT_50 of ferulic acid were 2,130.3μM and 1,773.7μM, respectively. These results were determind to nontoxic by Borenfreund at., al. 4. The inhibitory effects of ferulic acid against nickel-induced cytotoxicity were significantly increased from 25μM ferulic acid, but inhibitory effects of 100μM ferulic acid was more decreased than that of 50μM ferulic acid. 5. Treatment of ferulic acid and vitamin E combination was more assumed an upward curve than that of ferulic acid only. 6. The cell numbers and cell shapes were repaired from 1μM ferulic acid. However 100μM ferulic acid showed degeneration again. These results suggest that ferulic acid and vitamin E may be decrease the cytotoxicity of nickel sulfide and nickel oxide in cultured human gingival fibroblasts.

      • KCI우수등재

        경유 내 불순물 함유량 측정을 위한 마이크로스트립 패치 센서

        정윤상(Yoonsang Jeong),이기배(Kibae Lee),이종현(Chong Hyun Lee) 대한전자공학회 2018 전자공학회논문지 Vol.55 No.7

        본 논문에서는 경유 내 불순물 함유량 측정을 위한 전자파 기반의 마이크로스트립 패치 센서를 제안한다. 경유는 고유 유전율을 가지고 있으며, 이는 경유 내 불순 성분의 함유량에 따른 변화를 가진다. 제안하는 마이크로스트립 패치 센서는 경유를 포함하는 담는 용기(Enclosure)와 경유와 접촉하는 방사 패치로 구성되며, 경유의 유전율의 변화에 따른 공진주파수의 변화를 가짐으로써 경유 내 불순물 함유량의 측정을 가능하게 한다. 설계된 센서에 대한 전체파(Full wave analysis) 분석 결과, 유전율 0.05변화에 대해 약 24MHz의 공진주파수 변화를 가지는 것을 확인하였다. 또한 실측 실험 결과, 6.3ppm의 불순물 함유량 변화에 따라 300kHz에서 800kHz의 공진주파수 변화 폭을 가지며, 엔진세척제 첨가율 5% 미만에 대해 2153.4MHz 이상의 공진주파수와 10% 첨가율에 대해 2152.6MHz를 공진주파수를 가지는 것을 확인하였다. 끝으로, 타 경유사 경유에 대한 실험을 통해 경유의 품질 관리를 위한 실용화 가능성을 확인하였다. In this paper, we propose an electromagnetic wave based microstrip patch sensor for the determination of impurity content in diesel. Diesel has an inherent dielectric constant, which has variance with the content of impurity in diesel. The proposed microstrip patch sensor is composed of an enclosure including diesel and a radiation patch in contact with diesel. Since the sensor has a variance of resonance frequency in accordance with variance of the dielectric constant of the diesel, it is possible to measure the impurity content in the diesel. As a result of full wave analysis of the designed sensor, it was confirmed that the resonance frequency variation of about 24MHz was observed with respect to the variation of the dielectric constant of 0.05. As a result of the experiment, the sensor has a resonance frequency variation width of 300kHz to 800kHz according to sulfur content variation of 6.3ppm, it was confirmed that the resonance frequency was 2153.4MHz or more for an engine cleaner addition ratio of less than 5% and the resonance frequency was 2152.6MHz for a 10% addition ratio. Finally, we confirmed the feasibility of practical use for the quality control of diesel through experiments on commercialized diesel.

      • EPUB3.0 기반 N-Screen 전자책 리더 구현 및 설계

        정윤상 ( Yoon-sang Jeong ),김진아 ( Jin-ah Kim ),문남미 ( Nammee Moon ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.1

        텍스트(Text)와 이미지(Image)만을 지원하던 EPUB2.0에서 오디오(Audio), 비디오(Video), 벡터 그래픽(SVG), 벡터 수학식(MathML), 다중 CSS3, 무제한 글꼴 내장, 세로쓰기, 자바 스크립트(Java Script)등의 멀티미디어(Multimedia) 기능을 지원하는 EPUB3.0이 발표되면서 전자책의 시장이 더욱 발전하고 있다. 본 연구는 이러한 최근 동향에 따라 EPUB3.0 기반의 전자책 리더를 EPUB File Controller, EPUB File Analyzer, File Analyzer, EPUB Viewer로 분류하여 설계하고 다양한 콘텐츠를 N-Screen에서 사용할 수 있도록 구현하였다.

      • Facebook 뉴스피드를 이용한 사용자 성향 분석

        정윤상 ( Yoon-sang Jeong ),김경록 ( Kyung-rog Kim ),문남미 ( Nammee Moon ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.2

        최근 페이스북(Facebook), 트위터(Twitter) 등의 SNS(Social Network Service)의 사용자가 급격하게 증가하고 있다. SNS가 발달하면서 언제 어디서나 쉽게 자신의 위치, 현재의 감정들을 온라인상에서 공유한다. 이에 따라 사람의 감정을 표현하는 단어 100여개를 7가지 감정(기쁨, 흥미, 슬픔, 분노, 놀람, 지루함, 통증)으로 분류하였으며[1]. 이를 분석하기 위한 감정 표현 분석기 모듈을 설계하였다. 설계한 모듈을 사용하여 페이스북의 사용자 뉴스피드(News-Feed)를 분석하여 사용자의 성향을 분석하였다.

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