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Self-transforming of multi-layered and compartmented hydrogel designed for 4D soft mask
임준우,장연서,권혜진,정재현 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
A hydrogel-based soft material similar to the physical properties of extracellular matrix (ECM) has been studied as a facial mask material. In this study, the hydrogel mask was designed to self-transform using a multi-layered and compartmented hydrogel. The hydrogel consisting of two layers with different swelling ratios were fabricated to have specific radius of curvature by self-folding assembly at facial skin temperature. The radius of curvature formed by self-folding increases the adhesion between the mask pack and the curved skin, such as the nose and chin. In addition, a multi-compartmented hydrogel could be introduced different effective substances for each facial part and the release rate could be controlled through different mechanical properties. Overall, this new strategy to prepare the hydrogel mask using the multi-layered and compartmented hydrogels would be directly applied for developing 4D mask pack.
임준우,김희진,민대진,이성훈,이해광,정재현 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
There is increasing evidence that matrix stiffness and permeability modulates various phenotypic activities of cells surrounded by threedimensional (3D) matrix in native tissue. Therefore, we hypothesized that a collagen assembled with the improved structural integrity in dermis layer would regulate dermal fibroblasts activities to remodel, repair, and recreate skin dermis. This study examines the effects of hydrophobically-modified 3D networked microporous gel on enhancing the structural integrity of the collagen assembly and further regulating the morphology, growth rates, and glycosaminoglycan (GAG) production of dermal fibroblasts.
A hydrogel-based actuator for working and stimulating 3D tumor cell clusters
임준우,김희진,정재현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
The hydrogel has been studied for various applications. In this study, we present active extracellular matrix (ECM) consisting of two different layers with significantly different expansion ratio in response of the environments. This multi-layered extracellular matrix was prepared by assembling a bi-layered hydrogel, in which each layer consisted of poly(ethylene glycol) diacrylate (PEGDA) with different molecular weights and their concentrations. Then, characteristics of each layer of active ECM were examined by expansion ratio, swelling ratio and elastic modulus. The behavior of the expansion ratio was defined at different concentrations and temperatures. This study examines the effects of the active extracellular matrix on stimulating and regulating tumor cell clusters of the morphology, growth rates, and proangiogenic growth factor production.