호기수소측정법을 이용한 Cisapride 와 Tiropramide 의 구강 - 맹장 배출시간의 영향

임영국(Young Guk Lim),정태홍(Tat Hong Jung),조희충(Hee Choong Cho),김원식(Won Sik Kim),정종훈(Jong Hoon Chung),정춘해(Choon Hae Chung),박찬국(Chan Gook Park),김만우(Man Woo Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.5

N/A Objectives: A few gastroenterologists would underrate the importance of gastrointestinal motility in the pathogenesis of gut symptoms, particularly as the majority of clinic patients have functional symptoms. The aim of the present study was to determine whether changes in oral to cecal transit time affect the magnitude of the hydrogen (H2) excretion after ingestion of unabsorbable carbohydrate. The lactulose H2 breath test is in use as a simple non-invasive measurement of oral to cecal transit time and its reproducibility. The effect of tiropramide hydrochloride and cisapride on oral to cecal transit time have been compared in a placebo-controlled study. Methods: This studies including forty-one healthy volunteers by interval sampling of end expiratory H2 concentration after ingestion of: (1) 10 g lactulose with placebo; (2) 10 g lactulose with tiropramide hydrochloride (Tiropa®); (3) 10 g lactulose with cisapride (Prepulside®). A minimum of six days elapsed between the difference tests to avoid colonic bacterial metabolic changes. Results: The oral to cecal transit time (OCTT) measured by placebo ingestion, tiropramide and cisapride were 90.24±28.33, 102.44±31.37 and 83.41±27.17 minutes. A short of OCTT in cisapride ingestion showed significance compared with the placebo, tiropramide (p<0.0005). Area under curve (AUC) of the H2 concentration versus time curves from the OCTT after ingestion of placebo, tiropramide and cisapride were 35.50±24.35, 33.78±24.28, 45.65±26.04 (ppm×min×100), respectively. A rise of AUC in cisapride ingestion showed no significance compared with the placebo, tiropramide. Conclusion: The present findings indicate that changes of the OCTT do not significantly influence the H2 excretion as measured by interval sampling of end expiratory H2 concentrations after different drugs. In conclusion, within the ranges observed, the OCTT does significantly affect the shape of the H2 concentration after ingestion of differential drug.

전자 상거래 인증 기술

하영국(Young-Guk Ha),임신영(Shin-Young Lim),강상승(Sang-Seung Kang),함호상(Ho-Sang Ham),박상봉(Sang-Bong Park) 한국전자거래학회 1999 한국전자거래학회지 Vol.4 No.2

기업 정보체계의 키 복구 기술

임신영(Shin-Young Lim),강상승(Sang-Seung Kang),하영국(Young-Guk Ha),함호상(Ho-Sang Ham),박상봉(Sang-Bong Park) 한국전자거래학회 1999 한국전자거래학회지 Vol.4 No.3

자바 기반의 배달증명이 가능한 전자메일 시스템 구현

우준,하영국,임신영,이재광,Woo, Joon,Ha, Young-Guk,Lim, Shin-Young,Lee, Jae-Kwang 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.11

E-mail system is the most important service that enterprises and normal users in internet use. However, because a data security is not satisfied yet, and E-mail system with security service is essential. In this paper, We implemented the E-mail system with Certification of Delivery that was not provided in prior mail system with basic security services and can prove that sender's document is properly sent to the intended receipt. And an implementation of the system used Java Cryptography API.

급성 신부전증을 초래한 Wegener씨 육아종증 1례

박일,임영국,최성도,임현성,정종훈,문철웅 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

호흡기 증상과 급성신부전증이 발생된 환자에서 혈액검사, 혈청학적 검사, 방사선학적 검사, ANCA test 및 신생검을 통하여 Wegener씨 육아종증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 본질환이 재발하는 경우는 cyclophosphamide에서 azathioprine으로 치료약을 바꾸었을때나 특히 ANCA 반응이 양성으로 지속시 발생한다. Godman과 Churg는 상기도의 괴사성 육아성 병변, 하기도의 괴사성 혈관염, 국한성 신사구체염을 진단의 지표로 삼았다. 특히 상기도 점막의 생검 소견상 괴사성 육아성 혈관염이 보이면 일단 본 증을 의심하고 폐 생검과 신 생검이 필요로 한다. Wegener's Granulomatosis is an uncommon disease which is characterized by granulomatous vasculitis of both lung and kidney. Although the cause is unknown, it's suggesting that disordered immunity with both antibody and cell-mediated tissue damage occurs. The disease affects patients of any age. Characteristic clinical manifestations are diverse but in clude saddle nose deformity, sinusitis, productive coughing, myalgia, fever etc. Characteristic laboratory abnormalities include elevated ESR, neutrophilic leukocytosis, anemia and positive test for ANCA test. Renal biopsy is important for diagnosis. The treatment of choice is a combination of corticosteroid and cytotoxic agent. A53-year-old woman was admitted to our hospital because of productive coughing, short of breathing, oliguria, nausea, and vomiting. Three months ago, she was suffered from general weakness, poor appetite, tingling sensation on extremity, and loosely stool. Twenty days ago, above symptoms were aggravated, she admitted local clinic. Six days ago, because of CBC showed anemia , she was done transfusion. During transfusion, she was developed urticaha then productive coughing, dyspnea, increased serum BUN and creatinine levels. She was transferred to our hospital under the impression of ARF. On the admission, she was chronic ill-looking appearance with pale conjunctiva, tachypnea, dyspnea, and cold sweating. We have checked the patient by CBC, serum and serologic test, X-ray, ANCA test, renal biopsy. With renal biopsy microscopic examination study revealed necrotizing vasculitis, We treated a combination therapy with methyl-PDS and cyclophosphamide. She had a good response. So we report wegener's granulomatosis with the review of relevant literature.

만성폐쇄성 폐질환 환자에서 적혈구 항산화효소의 변화

국기용,이만재,조희충,임영국,박일,김원식,이승일,이병래 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disordesrs. Enhandng the intracellular content of antioxidant enzymes can provide means of limiting biological damage caused by oxygen free radicals. Many investigations have examined the potential of various oxyradical scavengers to modulate oxyradical injury. The oxygen free radicals play a role in the pathogenesis of chronic obstructive pulmonary disease. To investigate the pulmonary oxyradical injury and the protective role of antioxidant enzymes, author measured the amount of thiobarbituric acid reactants, the activiteies of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) and the sulfhydryl groups in serum and red blood cells from the chronic obstructive pulmonary disease groups and the normal controls. The thiobarbituric acid reactant in chronic obstructive pulmonary disease groups was increased than the controls in both serum and red blood cells, and the superoxide dismutase activity in red blood cells was no statistically difference in both groups. But, the glutathione peroxidase and catalase activities were lowered in chronic obstructive pulmonary disease groups than the controls. The sulfhydryl groups in serum and red blood cells were no statistically difference in both groups. These results suggest that the increased thiobarbituric acid reactant in chronic obstructive pulmonary disease groups mean oxygen radical toxicity, and the decreased glutathione peroxidase and catalase activities may play a role in cellular injury.

대동맥 이첨판과 승모판 이탈증을 동반한 대동맥 판하부 협착 1예

김용화,장경식,양태영,임영국,안기완,홍순표 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Discrete subaortic stenosis is a rare cardiac disorder especially in Orientals which occupies eight to ten percent of aortic stenosis, It occurs mainly before age of eighteen and accompanies with aortic valve abnormalities such as aortic stenosis, supravalvrlar stenosis, bicuspid valve and muscular hypertrophic subaortic stenosis, and other cardiac abnormalities such as ventricular septal defect, pulmonary stenosis and coarctation of aorta. There is no report of discrete subaortic stenosis accompanied with mitral valve prolapse. The major complications of discrete subaortic stenosis are aortic insufficiency, and subacute bacterial endocarditis. We report a case of asymptomatic nineteen-year-old male of discrete subaotic stenosis with bicuspid aortic valve and mitral valve prolapse, which is comfirmed by two-dimensional and Doppler echocardiography including transesophaigeal echocardiography.

간 낭종을 동반한 성인 다낭신 환자에서 간 낭종의 감염 1예

정규성,서정철,주기산,김원식,임영국,정종훈,문철웅 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Adult polycystic kidney disease(APKD) usually accompanies with renal and extrarenal manifestations and liver cysts are present in aproximately 30% of patients with APKD. Kidney cysts often accompany with hemorrhage, rupture, infection, however, liver cysts are usually asymptomatic and do not impair liver function. Rare complication of liver cysts in patient with APKD include portal hypertension with bleeding esophageal varices and hepatic failure with encephalopathy. But, in APKD patient, infection of liver cysts without infection of renal cysts is extremely rare. We report a case of infected liver cyst in a patient with APKD who has complained generalized abdominal pain and high fever which was confirmed by ultrasound and aspiration. The patient was treated successfully with repeated aspiration and systemic antibiotics.