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Development of a Rabbit Model for a Preclinical Comparison of Coronary Stent Types In-Vivo
이주명,이재원,Heewon Jeong,Won-Seok Choe,Won-Woo Seo,Woo-Hyun Lim,Young-Chan Kim,허진,이상언,양한모,조현재,김효수 대한심장학회 2013 Korean Circulation Journal Vol.43 No.11
Along with the development of innovative stent designs, preclinical trials in animal models are essential. Many animal models have been used and appear to yield comparable results to clinical trials despite substantial criticisms about their validity. Among the animal models,porcine coronary artery models have been the standard models for the preclinical evaluation of endovascular devices. However, rapid growth rate, high body weight potential, and the propensity to develop granulomatous inflammatory reactions are major limitations of the porcine coronary artery model. Compared with porcine coronary artery models, the comparative rabbit iliac artery model has the advantages of being small and easy to handle and relatively inexpensive. Furthermore, the rabbit model has been known to reliably reflect human restenosis histopathologically and have major advantages such as pairwise comparison, which makes each animal serve as its own control subject, therefore, maximizing its statistical power for comparative testing. However, despite the widespread use of this model, a systematic description of the procedure and harvest protocols has never been published. This article describes the surgical procedure,stent implantation procedure, method for tissue harvesting, and how measurements are performed. Although the results of animal models may not perfectly extrapolate to humans, the comparative rabbit iliac artery model may be a useful tool for assessing and comparing the efficacy of new coronary stents with conventional stent systems. This thorough description of the techniques required for vascular access, stent implantation, tissue preparation, and measurement, should aid investigators wishing to begin using the comparative rabbit iliac artery model.
이주명,남치주,장광호 한국임상수의학회 1998 한국임상수의학회지 Vol.15 No.1
Abomasal motility was observed by needling to acupoints for 20 min. The acupoints used were guan yuan yurt da chang yurt dei yup pi yurt and hou hoi. The acupoint which showed the increase of the largest wave type was pi yu and the increase of wave type was observed 20 minutes after needling in hou hoi and dei yu acupoint. But there was no effect on abomasal motility after needling to guan yuan yu and da chang yu. On the other hands change in amplitude of the abomasal contraction after needling to these acupoints was not abserved. These results indicate that stimulation to pi yu acupoint would be the most useful to increase the abomasal motility.
개의 하악골에서 신생골 조기 골경화에 Calcium Sulfate와 Sodium Hyaluronate가 미치는 영향
이주명,조병채 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.3
The aim of this experiment was to study the calcium sulfate on early bone consolidation in distraction osteogenesis in the canine mandible. Twelve dogs were used and divided into control group (group A, 4 heads), sodium hyaluronate injection group (group B, 4 heads), mixture of calcium sulfate and sodium hyaluronate injection group (group C, 4 heads). Each group were subdivided into 3 weeks testing group (totally 6 heads) and 5 weeks testing group (totally 6 heads). Mandibular distraction was started at the 5th day after the mandibular osteotomy and continued for 10 days by 1 mm a day. After the distraction on the 10th day of mandibular distraction, 0.5 m1 saline in group A, 0.5 m1 sodium hyaluronate in group B, and 0.5 ml mixture of calcium sulfate and sodium hyaluronate in group C were each injected in mandibular distraction lesion. And X-ray examination, bone mineral density, and histopathological findings were examined. The radiological findings were the most radiopaque in group C, and the most radiolucent in group A in both 3 and 5 week testing group. The level of bone mineral density was also the highest in group C, and the lowest in group C in both 3 and 5 week testing group. The histopathological findings of new bone formation were the most remarkable in group C in both 3 and 5 week testing group. New bone formation of group A was not present in both 3 and 5 week testing group. In conclusion, calcium sulfate is a kind of material that can stimulate early bone formation and can shorten the duration of bone consolidation. And it can be effective in clinical usage.
고양이에서 Streptococcus sp. 감염에 의한 자궁농축증 1례
이주명,남치주 한국임상수의학회 2001 한국임상수의학회지 Vol.18 No.4
A female Russian blue cat has invited Animal Hospital because of diarrhea after the mating. The eggs on internal parasite and Giardia sp. were diagnosed in the feces floating test, and treated with metronidazole, pyrantel pamoate and antibiotics. There were no diarrheal sign in the reevaluation, but anorexia, polydipsia, polyuria, and vaginal discharge was newly induced. Streptococcus sp. was inspected by smearing of vaginal discharge, and enlarge-ment of uterus was evaluated by x-ray examination. This case was confirmed as pyometra and recovered by ovariohysterectomy on the basis of that examination. The rate of incidence in feline pyometra is not so high as in the canine.
노후 고속도로 콘크리트 포장 리모델링 지수 회귀모형 개발
이주명,문기훈,이준혁,김진철,강민수,정진훈 한국도로학회 2017 한국도로학회 학술대회 발표논문 초록집 Vol.2017 No.10
국토교통부의 도로보수현황에 따르면 2016년 말 기준 전국 고속국도 유지보수연장은 75,766km에 달하며, 보수비용으로 4,019억 원이 사용되었다. 이 중 약 30% 금액에 해당하는 1,237억 원이 포장 보수비용에 해당하며, 포장보수로 대부분 소파보수와 덧씌우기와 같은 단면보수가 적용되었다. 하지만 이러한 소규모의 국부적인 보수는 2차 파손을 반복적으로 야기하고 있어서 유지관리 측면에서 비효율적인 모습을 보이고 있다. 따라서 본 연구에서는 리모델링 지수(Remodeling Index;RMI)를 개발하여 노후 콘크리트 포장의 리모델링 우선순위를 결정하고자 한다. 한국도로공사의 HPMS(Highway Pavement Management System) 자료와 기상청의 기상자료를 수집·분석하여 패널레이팅을 위한 대표구간을 선정하였으며, 패널레이팅을 실시하여 RMI 개발을 위한 종속변수를 획득하였다. 패널레이팅을 통해 획득한 각 대표구간의 RMI를 종속변수로 하고 포장 파손, 교통, 환경 인자를 독립변수를 하는 RMI 회귀모형을 개발하였다. RMI 모형의 독립변수별 민감도 분석을 수행했으며, RMI 모형으로 예측한 결과와 측정된 RMI 결과를 비교하여 모형의 정확성을 검증하였다.
이주명,조현성,Choi Ki Hong,Hong David,박택규,Yang Jeong Hoon,송영빈,Choi Jin-Ho,Choi Seung-Hyuk,정진옥,이종영,Choi Young Jin,Chae Jei-Keon,허승호,Bae Jang-Whan,Oh Ju-Hyeon,전국진,Kim Hyun-Joong,조병렬,Shin Doosup,Lee Seung Hun 대한의학회 2023 Journal of Korean medical science Vol.38 No.5
Background: The risk of device thrombosis and device-oriented clinical outcomes with bioresorbable vascular scaffold (BVS) was reported to be significantly higher than with contemporary drug-eluting stents (DESs). However, optimal device implantation may improve clinical outcomes in patients receiving BVS. The current study evaluated mid-term safety and efficacy of Absorb BVS with meticulous device optimization under intravascular imaging guidance. Methods: The SMART-REWARD and PERSPECTIVE-PCI registries in Korea prospectively enrolled 390 patients with BVS and 675 patients with DES, respectively. The primary endpoint was target vessel failure (TVF) at 2 years and the secondary major endpoint was patientoriented composite outcome (POCO) at 2 years. Results: Patient-level pooled analysis evaluated 1,003 patients (377 patients with BVS and 626 patients with DES). Mean scaffold diameter per lesion was 3.24 ± 0.30 mm in BVS group. Most BVSs were implanted with pre-dilatation (90.9%), intravascular imaging guidance (74.9%), and post-dilatation (73.1%) at proximal to mid segment (81.9%) in target vessel. Patients treated with BVS showed comparable risks of 2-year TVF (2.9% vs. 3.7%, adjusted hazard ratio [HR], 1.283, 95% confidence interval [CI], 0.487–3.378, P = 0.615) and 2-year POCO (4.5% vs. 5.9%, adjusted HR, 1.413, 95% CI, 0.663–3.012, P = 0.370) than those with DES. The rate of 2-year definite or probable device thrombosis (0.3% vs. 0.5%, P = 0.424) was also similar. The sensitivity analyses consistently showed comparable risk of TVF and POCO between the 2 groups. Conclusion: With meticulous device optimization under imaging guidance and avoidance of implantation in small vessels, BVS showed comparable risks of 2-year TVF and device thrombosis with DES.
Acute Coronary Stent Thrombosis in Cancer Patients: A Case Series Report
이주명,Chang-Hwan Yoon 대한심장학회 2012 Korean Circulation Journal Vol.42 No.7
There have been a growing numbers of patients diagnosed with malignancy and coronary artery disease simultaneously or serially. In the era of percutaneous coronary intervention (PCI), stent thrombosis has been a rare but challenging problem. Recently, we experienced two unique cases of acute stent thrombosis in patients with malignancy. The first case showed acute and subacute stent thrombosis after PCI. The second case revealed simultaneous thromboses in stent and non-treated native coronary artery. We believe that we need rigorous precautions in the treatment of patients with coronary artery disease and malignancy, especially with regards to deciding how and whether to revascularize, as well as which anti-platelet agents to select.