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      • SCOPUSKCI등재

        희토류 금속이온 (Ln(III))과 Acetamide 사이의 상호작용에 대한 연구

        이상원,유정아,윤창주,전유혁,최영상,Sang-Won Lee,Jeonga Yu,Chang-Ju Yoon,Yoo-Hyek Jun,Young-Sang Choi 대한화학회 1992 대한화학회지 Vol.36 No.2

        아세트아미드(AA)의 CO기와 희토류 금속이온(Ln(II))을 포함하는 몇 가지 lanthanide shift reagent(LSR) 사이의 상호작용을 이해하기 위하여 AA의 $2{\nu}_{C=0}$ + amide III 조합띠를 $15^{\circ}$ ${\sim} 45^{\circ}C$에서 조사하였다. 묽은 $CCl_4$ 용액속에서 하나의 AA가 사용된 LSR에 배위되어 1 : 1 AA-LSR 복합체를 이루며, Ln(Ⅲ)이온에 대한 AA의 배위 위치는 카르보닐의 산소임을 알았다. 온도 및 농도에 따른 이 조합띠의 변화로부터 Ln(III)${\cdot}$O=C 결합에 대한 여러가지 열역학적 함수들을 구했다. Eu$(dpm)_3$, Yb$(dpm)_3$ 및 Pr$(dpm)_3$에 대한 AA의 결합의 세기를 나타내는 ${\Delta}H^{\circ}$는 각각 -39.1, -28.4 및 -25.5kJ/mol이다. 이들 값을 비교해보면 AA 분자가 배위될 때 중심금속이온의 ionic potential 효과보다는 이미 배위되어 있는 커다란 dpm 분자에 의한 입체장애효과가 더 큼을 알 수 있다. The $2{\nu}_{C=0}$ + amide III combination band spectrum of acetamide (AA) was obtained in very dilute solutions of AA+lanthanide shift reagents (LSR) in carbon tetrachloride over the range of $15^{\circ}$ to $45^{\circ}C$. It was found that only 1 : 1 AA-LSR complex is formed by the interaction between carbonyl oxygen of AA and central metal ion(Ln(Ⅲ)) in LSR. The thermodynamic parameters for Ln(III)${\cdot}$O=C bond were determined by computer analysis of concentration and temperature dependent spectra. ${\Delta}H^{\circ}$ for the coordination of AA to Eu$(dpm)_3$, Yb$(dpm)_3$, and Pr$(dpm)_3$ have been found to be -39.1, -28.4, and -25.5 kJ/mol, respectively. It has shown that this type of ion-dipole interaction is more than twice stronger compared to the dipole-dipole interaction in the amide linkage, and largely depending on the steric hindrence effect by the bulky dpm groups around central metal ion (Ln(III)) rather than the ionic potential effect of central metal ion itself.

      • SCOPUSKCI등재

        농촌지역 주민의 고혈압 치료순응도와 관련요인

        이상원,천병렬,예민해,강윤식,김건엽,이영숙,박기수,손재희,오희숙,안문영,임부돌,감신,Lee, Sang-Won,Chun, Byung-Yeol,Yeh, Min-Hae,Kang, Yun-Sik,Kim, Keon-Yeop,Lee, Young-Sook,Park, Ki-Soo,Son, Jae-Hee,Oh, Hee-Sook,Ahn, Moon-Young,Lim, Pu-D 대한예방의학회 2000 예방의학회지 Vol.33 No.2

        Objective : The purpose of this study was to examine the therapeutic compliance and its related factors in the rural hypertensives. Method : A questionnaire survey and blood pressure measurement were performed to 3,876 residents of a rural area, and 660 hypertensives were selected as subjects of study. The study employed a hypothetical model which was composed of constructs from the health belief model and KAP model. The analysis techniques employed included contingency table analysis and structural equation modeling. Result : The proportion of those who were compliant to the treatment of hypertension was 44.2% of subjects. As the result of structural equation modeling, when patients had more favorable attitude toward treatment, higher perceived benefit, or lower perceived barriers to treatment, the therapeutic compliance was significantly higher(T>2.0). When patients had more knowledge about hypertension, or higher perceived severity of hypertension, the attitude toward the treatment of hypertension was more favorable significantly(T>2.0). And when patients had the support for treatment from family or neighbor, the attitude toward treatment was more favorable(T>2.0). When patients had experience of health education, they had more knowledge, higher perceived susceptibility of complication, perceived severity for hypertension, and perceived benefit of treatment, compare to patients without health education(T>2.0). Conclusion : In consideration of above findings, in order to improve the therapeutic compliance in the rural hypertensives, it would be necessary to change attitude, perception, knowledge about hypertension and its treatment, by various methods such as effective health education and programs for maintaining the supportive environment for hypertension treatment.

      • KCI등재

        $H_{2}O_2$와 A$\beta$로 유도된 pc12 cell에서 생산조인(生酸棗仁) 수추출물의 항산화 및 항치매 효과

        이상원,김대현,윤종현,김진우,정은영,이성근,이기상,김태헌,류영수,강형원,Lee, Sang-Won,Kim, Dae-Hyun,Yun, Jong-Hyun,Kim, Jin-Woo,Jung, Ejun-Young,Lee, Seoung-Geun,Lee, Key-Sang,Kim, Tae-Heon,Lyu, Yeoung-Su,Kang, Hyung-Won 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3

        Objective: The antioxidant and anti-Alzheimer effects of Semen Ziziphi Spinosae (SZS) water extract against the amyloid beta peptide (1-42) or H202-induced oxidative damage and cell death were investigated in rat pheochromocytoma line PC 12. Methods: The cells were incubated with SZS water extract and oxidative damage-inducing materials, amyloid beta peptide (1-42) or H2O2 for 24 h. The cellular viability was assessed by WST-1 assay, cytotoxic damage by LDH activity assay, oxidative damages of cells by fluorescence spectrophotometric method, and apoptosis by TUNEL staining assay. Results and Conclusions: 1. Preincubation of the cells with SZS water extract prior to amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) exposure elevated the cell survival close to the control and decreased the level of LDH activity and the fluorescence from the cell homogenates and TUNEL staining of the cells, compared to only amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) treated conditions. 2. Our study suggests that Semen Ziziphi Spinosae (SZS) water extract has protective effects against amyloid beta peptide (1-42) or H2O2-induced cell toxicity through the antioxidation mechanism, which might be beneficial for the treatment of Alzheimer's disease.

      • KCI등재

        서울 경찰(警察)의 방범체제(防犯體制) 개선(改善)에 관한 연구(硏究)

        이상원,Lee, Sang-Won 한국경호경비학회 1997 시큐리티연구 Vol.- No.1

        I study the actual condition and the problem of the crime prevention system of two seoul police station. that is operated on the unit of police box, and present the new improvement. Stragic and active is the new crime prevention system that introduces a concept of community oriented policing, the tendency of a developed country police. I present a medium - sized police station where 250${\sim}$300 policemen work. It consist of a patrol division, a community division and a administration support division. The chief of police bears the responsibility only for crime prevention service by concentrating on pure Patrol - centered crime prevention activity and community relation activity. Next I present a police inspector system. The most important on this paper is the community policing officer system that a policeman bears responsibility on district apart from a patrol division and support a police service related community. To be operated these systems effectively, these need to be regulated according to a police distinct, a police purpose and it's demand. Also a scale, function, authority of a existing. Police station must be regulated and the police training must be carried out.

      • KCI등재

        미국도시경찰(美國都市警察)의 법죄예방활동(犯罪預防活動)에 관한 연구(硏究) - NYPD를 중심(中心)으로 -

        이상원,Lee, Sang-Won 한국경호경비학회 1999 시큐리티연구 Vol.- No.2

        The Police is the provider of the Police Service that is the most evident and active. This paper centers on the crime prevention activity of New york City Police Department that is most large and representable in America on account of the enormity of the scale and the material selection. I examine the duty and organization of the City Police Department the Crime Prevention activity of the city police and I research a conclusion.

      • KCI등재

        고등학교(高等學校) 학생(學生)의 대수(代數) 문제(問題) 해결(解決) : 전략(戰略)과 오류(誤謬) 분석(分析)

        이상원,전평국,Lee, Sang-Won,Jeon, Pyung-Kook 한국수학교육학회 1997 수학교육논문집 Vol.2 No.-

        The purpose of this study is to provide the primary sources to improve the problem solving performance by analyzing the errors and the strategies selection of the high school students when solving given algebraic problems. To attain the purpose of this study, the questions for investigation in this study are : 1. What are the differences / similarities in the patterns of errors committed by successful and unsuccessful problem-solvers when solving particular algebraic problems ? 2. What are the error types chosen by unsuccessful problem-solvers when solving particular algebraic problems? 3. Do students utilize checking, either locally or globally, when solving particular algebraic problems? Twenty students were drawn out of 10th grade students in J girls' high school in Yengi -gun, Chung-Nam, for this study. The problem-solving test was used as a test instrument. From the data, the verbal protocols and the written protocols were analyzed by the patterns. The conclusions drawn from the results obtained in the present study are as follows: First, in solving particular algebraic problems, when the problems were solved with one strategy, most students didn't give any consideration to other strategies. So mathematics teachers should teach them to use the various strategies, and should develop the problems to be used the various strategies. Second, in solving particular algebraic problems, errors on notions or transformations of equations were found. Thus, the basic knowledges related to equation should be taught. In addition, most unsuccessful students seleted the strategies inadequately to solve the problems because of misunderstanding the problems. So, to improve the problem solving performance the processes of 'understanding problem' should be emphasized to students. Third, although the unsuccesful students used the 'checking' processes when solving the problems, most of them did not find the errors because of misconceptions related to the problems, carelessness, and unskillfulness of checking. Thus, students must be taught more carefully and encouraged to use the checking.

      • KCI등재

        XML 포함질의를 위한 확장형 인덱스

        이상원,Lee, Sang-Won 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.2

        XML 문서에 대한 포함질의는 XML의 핵심 질의 중의 하나이다. 따라서, XML 데이터를 지원하는 DBMS에서 이런 유형의 질의를 효과적으로 처리하는 것은 매우 중요한 문제이다. 최근 들어, 객체관계형 DBMS에 XML 데이터를 저장하려는 많은 노력들이 시도되고 있다. 본 논문에서는 객체관계형 DBMS에 BLOB 형태로 저장된 XML 데이터를 대상으로 포함질의를 효과적으로 처리하기 위한 확장형 인덱스를 제시한다. 즉, 객체관계형 DBMS의 확장성을 이용해서 포함질의 처리를 위한 효과적으로 처리하는 확장형 인덱스의 구현과 이 인덱스의 사용 방법을 기술한다. Containment queries for XML documents is one of the most important query types, and thus the efficient support for this type of query is crucial for XML databases. Recently, object-relational database management system (ORDBMS) vendors try to store and retrieve XML data in their products. In this paper, we propose an extensible index to support containment queries over the XML data stored as BLOB type in ORDBMSs. That is, we describe how to implement the index using the extensibility feature of an ORDBMS, and describe its usage.

      • SCIEKCI등재

        Aspergillus awamori와 Zymomonas mobilis로 구성된 혼합고정화 배양계의 에탄올 생산에 미치는 Neupectin-L의 영향

        이상원,조용운,김홍출,박석규,성낙계 ( Sang Won Lee,Yong Un Cho,Hong Chul Kim,Seok Kyu Park,Nack Kie Sung ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.2

        In order to reduce energy input in direct ethanol production from raw starch by co-immobilized Aspergillus awamori(A) and Zymomonas mobilis(Z), A-Z 36 culture system which was changed to anaerobic after 36 h of aerobic fermentation without sterilization was investigated. This immobilized cell system can not be carried out under unsterile conditions because of growth of microbial contaminants from original medium. Among some food additives such as sorbic acid, benzoic acid, dehydroacetic acid, p-hydroxybenzoic acid, Vantocil IB and Neupectin-L, Vantocil IB and Neupectin-L were a potent antibacterial agent in A-Z 36 culture cell system and were not affected in hydrolysis of substrate as compared with the case of control. Ethanol yield(6.9 g/ℓ) in system of addition of 0.1% Neupectin-L was slightly higher than that in control(6.4 g/ℓ). When 2% starch was fed five times in fed-batch culture with 0.1% Neupectin-L, ethanol yield and productivity were 34 g/ℓ and 2.0 g/ℓ/day, respectively.

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