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이민진,강아름,강양호,윤미숙,이동원 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.5
Background: The present study investigated the role of synergistic interaction between hyperuricemia and abdominal obesity as a risk factor for the components of metabolic syndrome.Methods: We performed a cross-sectional study using the data of 16,094 individuals from the seventh Korean National Health and Nutrition Examination Survey (2016 to 2018). The adjusted odds ratios of metabolic syndrome and its components were analyzed by multivariate logistic regression analysis. The presence of synergistic interaction between hyperuricemia and abdominal obesity was evaluated by calculating the additive scales—the relative excess risk due to interaction, attributable proportion due to interaction, and synergy index (SI).Results: There was a synergistic interaction between hyperuricemia and abdominal obesity in hypertriglyceridemia (men: SI, 1.39; 95% confidence interval [CI], 1.01 to 1.98; women: SI, 1.61; 95% CI, 1.02 to 2.69), and low high-density lipoprotein cholesterol (HDL-C) (men: SI, 2.03; 95% CI, 1.41 to 2.91; women: SI, 1.70; 95% CI, 1.05 to 2.95). There was no significant synergistic interaction between hyperuricemia and abdominal obesity for the risk of high blood pressure (men: SI, 1.22; 95% CI, 0.85 to 1.77; women: SI, 1.53; 95% CI, 0.79 to 2.97), and hyperglycemia (men: SI, 1.03; 95% CI, 0.72 to 1.47; women: SI, 1.39; 95% CI, 0.75 to 2.57).Conclusion: Hyperuricemia and abdominal obesity synergistically increased the risk of hypertriglyceridemia and low HDL-C in both sexes.
이민진,김상수,김인주,송상헌,김은희,서지영,김종호,김상수,전윤경,김보현,김용기 대한의학회 2017 Journal of Korean medical science Vol.32 No.5
Urinary angiotensinogen (AGT) is potentially a specific biomarker for the status of the intrarenal renin-angiotensin system (RAS) in patients with diabetes mellitus. We explored whether changes in urinary AGT excretion levels were associated with the deterioration of kidney function in type 2 diabetes patients with preserved kidney function. Urinary baseline AGT levels were measured in 118 type 2 diabetic patients who were not taking RAS blockers and who had estimated glomerular filtration rates (eGFRs) ≥ 60 mL/min/1.73 m2. A total of 91 patients were followed-up for 52 months. Changes in urinary levels of AGT (ΔAGT) were calculated by subtracting urinary AGT/creatinine (Cr) at baseline from urinary AGT/Cr after 1 year. ΔAGT was significantly inversely correlated with annual eGFR change (β = −0.29, P = 0.006; β = −0.37, P = 0.001 after adjusting for clinical factors). RAS blockers were prescribed in 36.3% of patients (n = 33) during follow-up. The ΔAGT values were lower in the RAS blockers users than in the non-RAS blockers users, but the differences were not statistically significant (7.37 ± 75.88 vs. 22.55 ± 57.45 μg/g Cr, P = 0.081). The ΔAGT values remained significantly correlated with the annual rate of eGFR change (β = −0.41, P = 0.001) in the patients who did not use RAS blockers, but no such correlation was evident in the patients who did. ΔAGT is inversely correlated with annual changes in eGFR in type 2 diabetes patients with preserved kidney function, particularly in RAS blocker-naïve patients.
이민진,최병현,지미정,홍선기,강영진,황해진 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
SOFC anode에 주로 사용되는 Ni/YSZ는 NiO의 환원에 의한 crack 감소를 위해 Ni을 core로 사용하고 YSZ를 shell 로서 사용한 Ni/YSZ core-shell을 합성하였다. Ni/YSZ core-shell 합성방법에는 하이드라진 환원제를 이용하여 Nickel입자를 합성하는 과정에서 수열합성법으로 합성한 YSZ와 양이온 계면활성제를 함께 첨가하여 합성하였다. Ni/YSZ core-shell은소결 후 표면을 감싼 YSZ에 의해 Ni입자들이 뭉치지 않고 주위의 Ni들끼리만 necking을 형성하여 구성물과 기공이 조밀하게 분포된 입자 연결도가 우수한 미세구조를 형성하였다. Ni/YSZ core-shell을 연료극으로서 전기전도도와 최대 출력 밀도(max power density)그리고 Ohmic &polarization resistance를 평가하였다.