황갈색 재래닭의 간에서 성장 단계별 차등 발현 유전자 분석

이경연,유성란,정기철,장병귀,최강덕,이준헌,Lee, K.Y.,Yu, S.L.,Jung, K.C.,Jang, B.K.,Choi, K.D.,Lee, J.H. 한국가금학회 2007 韓國家禽學會誌 Vol.34 No.2

한국 재래닭에서 성장에 따른 유전자들의 발현 변화를 알아보고 성장 촉진, 대사 및 면역 관련 유전자를 발굴하기 위하여 주령별로 닭의 간에서 RNA를 추출하였으며 10개의 arbitrary ACPs를 이용하여 차등 발현되는 유전자를 조사하였다. 발현량에 현저한 차이를 보이는 5개의 유전자들이 선별되었으며, 이 중 3개의 유전자들은 BLAST search 결과 이미 기능이 알려진 FTH1, SAA와 HSP90B1으로 밝혀졌다. 그러나 2개의 유전자들은 닭의 genome sequence가 끝났음에도 불구하고 기능이 밝혀져 있지 않아 앞으로 이 유전자들의 기능에 대한 연구가 지속되어야 함을 의미한다. 본 연구에서 닭의 간에서 성장 단계별로 발현 차이를 보이는 유전자들은 앞으로 다른 유전자와 단백질들과의 관계를 통하여 닭의 성장 및 지방 대사를 이해하는데 도움을 줄 것으로 사료된다. The chicken liver has been involved in various biological functions including detoxification, glycogen storage and plasma protein synthesis. The aim of this study was to investigate differentially expressed genes in chicken liver in four different growing stages. Using 10 arbitrary Annealing Control Primers (ACPs), five differentially expressed genes have been identified. Based on the Basic Local Alignment Search Tool (BLAST) search results, three of them were matched with previously known genes, and the other two were matched with unknown EST sequence and a hypothetical protein, respectively. In order to confirm the expression results, quantitative real-time PCR was also performed. The high similarities between the expression data using arbitrary ACPs and quantitative real-time PCR indicate that the identified genes are the real differentially expressed genes in different growing stages. The genes identified in this study can be used as valuable biomarkers in chicken with further investigation of the functions.

Electrochemical Aptasensor for Salivary Cortisol and Interleukin 6 (IL-6) Detection in Inflammatory Bowel Disease (IBD) Patients

이경연,박성현,이경은,김자영 한국고분자학회 2024 한국고분자학회 학술대회 연구논문 초록집 Vol.49 No.1

두피 피부 무형성증을 동반한 양막대증후군 1례

이경연,김자형,정진영,박상규,김준성,오기원 대한신생아학회 2009 Neonatal medicine Vol.16 No.1

The amniotic band syndrome is an uncommon congenital fetal abnormality, presumably due to fetal entanglement in strands of ruptured amniotic sac. The defects caused by this syndrome vary from simple limb defects to major visceral and craniofacial defects. We cared for a newborn infant with this syndrome, who showed constriction rings of the right leg and right axilla, right club foot, thoracic scoliosis, polydactyly, absence of the right thumb and aplasia cutis of the scalp. We report this case with a brief review of the literature.

직하방과 빗각 촬영 운용을 위한 초분광 영상센서 구동방식에 관한 연구

이경연 한국군사과학기술학회 2019 한국군사과학기술학회지 Vol.22 No.4

General Hyperspectral Image Sensor acquires an image of line form such as a thin rectangle shape because of using 1D array Push Broom or Whisk Broom scanning method. A special mechanism is required for a Hyperspectral Image Sensor to operate for nadir and slant range. To design the mechanism, the characteristics of the flight motion and the overlap rate between consecutive frames were analyzed. Also, system requirements were proposed through modeling and simulation.

도심 속 도로변 녹지공간에 대한 정원으로서의 대안적 접근

이경연,주이슬,이경미 (사)한국정원디자인학회 2020 한국정원디자인학회지 Vol.6 No.3

In metropolitan city where space for garden is extremely scarce, interest in the use of unused space is increasing to secure space for gardens near living areas. This Study tried to find out the possibility of using the street unused space as a garden. In the study, the four street gardens where reflecting recent garden trends were selected, then planted plants were investigated. Planting combination analysis was conducted based on the four visual elements of plants, such as color, form, texture, and height. In the study sites, it was found that herbaceous plants were planted in the highest proportion, and most of woody plants were short shrubs. In addition, as reflecting the natural planting style that represents the recent garden trends, a complex planting combination was used, such as making mass planting by mixing grass, and emphasizing planting using various flower types. It was found that the use of color has changed from the style that mainly used green and add the strong color as a point, to the style that create a calm atmosphere using white, purple, or light pink. The planting combination type has changed from the using of woody plants to herbaceous plants, and a planting combination using grass with a fine texture has emerged. This shows the changing of trend form a planting combination that only considered color to a more complex planting combination that considers both color, shape and texture. 녹지를 위한 공간이 극히 부족한 대도시에서 생활권 내 정원을 위한 공간 확보를 위해 사용되고 있지 않은 유휴공간의 활용에 관한 관심이 높아지고 있다. 본 연구는 유휴공간 중 일상생활에서 빈번히 접할 수 있는 가로공간의 정원으로서 활용 가능성에 대해 알아보고자 하였다. 단순 목본류 위주의 기존 가로수와 차별되는 정원 트랜드를 반영한 초본류 중심으로 조성된 도로변 녹지공간 4개소를 대상으로 식재식물을 조사하였고, 식물이 가지는 시각적 요소인 색, 형태, 질감, 높이 4가지 요소를 바탕으로 식재조합을 분석하였다. 연구대상지의 식재식물은 초본류가 가장 높은 비율을 차지하였고, 목본류의 경우 대다수가 키가 작은 관목 위주로 식재된 것을 볼 수 있었다. 또한, 최근 정원 경향을 나타내는 자연적인 식재 스타일을 반영하듯 그래스류를 혼식하여 풍성한 부피식재를 하고, 수직형, 구형 등 다양한 꽃 형태를 가진 초화류를 이용하여 강조식재를 하는 등 복합적인 식재조합을 만들어 주었다. 색상의 사용은 과거 초록색 위주에 강렬한 원색을 포인트로 사용하던 스타일에서 흰색이나 보라색, 연한 분홍색 등을 이용한 차분한 분위기에 주황색, 노란색 등을 이용하여 활기를 더하는 식재조합을 선호하는 경향으로 변화하고 있는 것으로 나타났다. 목본류 중심에서 꽃의 형태가 다양한 초본류 위주의 식재형태로 변화하였고, 고운 질감을 가진 그래스류를 사용한 풍성한 식재조합이 새롭게 등장하고 있다. 이는 단순히 색상 중심이었던 식재조합에서 형태와 질감을 더해 더 복합적인 식재조합으로 변하는 추세를 보여주고 있다.

저혈당성 경련으로 내원한 환자에서 진단된 Silver-Russell 증후군 1례

이경연,이정용,김영아,오기원,김자형,김준성,정진영,박상규 대한소아신경학회 2010 대한소아신경학회지 Vol.18 No.1

The Silver-Russell syndrome(SRS) is a clinically heterogeneous syndrome characterized by intrauterine and postnatal growth retardation with spared cranial growth, characteristic facial features, and body asymmetry. Although mild to moderate hypoglycemic symptoms occasionally appear in children with SRS especially those who are not fed frequently and regularly, hypoglycemic seizures rarely occur. We report a rare case of SRS which was diagnosed in a 4-year-old female who admitted with hypoglycemic seizure. The patient showed the characteristic features of SRS. Endocrinologic studies were normal except for partial growth hormone insufficiency. To prevent seizures and chronic neurologic deficits in children with SRS, the early recognition and appropriate management of hypoglycemia is critical. 저자들은 저혈당성 경련을 주소로 내원한 4세 여아에서 자궁 내 성장 지연, 출생 후 지속되는 저신장과 저체중, 몸에 비해 상대적으로 큰 머리, 신체의 좌우 비대칭, 특징적인 얼굴 모양을 보인 Silver- Russell 증후군 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

유연체 동역학을 이용한 솔라셀 반송로봇의 시뮬레이션 모델링

이경연,변경석 제어로봇시스템학회 2011 제어로봇시스템학회 국내학술대회 논문집 Vol.2011 No.5

국내 초등학교 발명교육 연구 현황 분석을 통한 유아교육에서의 방향 탐색

이경연,박은선 한국영유아교원교육학회 2016 유아교육학논집 Vol.20 No.3

This study examines the state of research on teaching invention to elementary school students in an attempt to ascertain the orientation of Early Childhood Education. For the purpose of this investigation, a total of 81 research papers and articles published in South Korean publications between 2000 and 2015 have been analyzed. The results of the literature review indicate the following: 2014 was the most active year in terms of the number of related publications (19), followed by 2013 (13) and 2009 (11). General students were the most frequently studied research subjects followed by talented youth, teachers and pre-service teachers. Students in the fifth and sixth grades were studied the most, followed by fourth, third, second, and first graders. In terms of methodology, quantitative research was used most often, followed by literature research, qualitative research and mixed methods research. Among the most discussed research topics – when listed in the order of frequency – were theory and contents analysis, program development and application, effect analysis and trend analysis these topics appear more or less in similar frequency. In terms of the possible approaches to invention education, researchers were most interested in teaching invention in living, followed by teaching focused on invention production, problem solving and the use of children’s stories. Concerning how the effectiveness of invention education should be analyzed, creativity was the most used criteria of evaluation, followed by attitudes toward invention and interest levels. Based on these results, this study further discusses potential directions for future investigation sand suggests the possible orientations that might be taken in Early Childhood Education. 본 연구는 초등학교 대상의 발명교육 연구 현황을 분석함으로써 유아교육에서의 방향을 탐색하는 것을 목적으로 하고 있다. 연구를 위해 2000년부터 2015년까지 발표된 국내 학술지 논문 81편을 대상으로 분석하였다. 연구 결과 연구 시기는 2014년(19편), 2013년(13편), 2009년(11편) 순으로 발표되었고, 연구 대상은 일반학생, 영재학생, 교사, 예비교사 순으로 수행되었으며, 연구 대상 학년은 5학년과 6학년이 가장 많았으며, 4학년, 3학년, 2학년과 1학년 순이었다. 연구 방법은 양적연구, 문헌연구, 질적연구, 혼합연구 순이었고, 연구 내용은 이론 및 내용분석, 프로그램 개발 및 적용, 효과분석, 실태 및 인식 순으로 수행되었고 대체로 비숫한 비율로 연구되고 있었다. 발명교육 접근법은 생활발명중심, 발명제작중심, 문제해결중심, 동화활용 중심 순으로 연구되었으며, 발명교육효과성은 창의성 분야가 가장 많았고, 발명태도와 발명 흥미도 순이었다. 연구 결과를 토대로 추후 연구의 방향성을 논의하고 유아교육에서의 방향을 탐색하여 제시하였다.

성인의 기관지결핵의 방사선학적 고찰

이경연 대한영상의학회 1988 대한영상의학회지 Vol.24 No.2

Tuberculous involvement of the tracheobronchial tree usually coexists with active pulmonary parenchymal or intrathoracic lymph node infection and very rarely has veen showed normal chest roentgenogram. This paper described 30 cases of endobronchial tuberculosis confirmed by bronchoscopy and biopsy in correlation to broncbographic finding on the patients from jan 1983 to Nov 1986 in Department of Radiology National Medical Center. The results were as follows; 1. Sex distribution of endobronchial tuberculosis showed 8 cases (26.7%) in male 22 cases (73.3%) in female and the higheset incidence in the third decade. 2. The radiologic findings of initial plain chest showed lobar or segmental collapse 16 cases (53.3%) minimal pulmonary tuberculosis 7 cases (23.3%) moderately advanced pulmonary tuberculosis 4 cases (13,3%) far advanced pulmonary tuberculosis 2 cases (6.7%) and normal finding 1 case (3.3%) 3. 25 cases of 28 bronchogram showed bronchial obstruction The left side was affected slightly more than the right (14:11) 4. The obstruction site of bronchus showed complete obstruction in11 cases among them sharp cut off in 2 rat tail narrowing in 1 symmetrical V-shaped narrowing in 8 and incomplete obstruction in 14 cases among them thumbprinting indentation in 2 circumferential symmetrical narrowing in 12. 5. 10 cases of 25 obstruction showed an associated bronchiectatic change of distal or adjacent to the lesion sote among them tubular in 3 saccular in 2 cystic in 5 cases

Neurologic Manifestations of Enterovirus 71 Infection in Korea

이경연,이명숙,김동빈 대한의학회 2016 Journal of Korean medical science Vol.31 No.4

Enterovirus 71 frequently involves the central nervous system and may present with a variety of neurologic manifestations. Here, we aimed to describe the clinical features, magnetic resonance imaging (MRI) findings, and cerebrospinal fluid (CSF) profiles of patients presenting with neurologic complications of enterovirus 71 infection. We retrospectively reviewed the records of 31 pediatric patients hospitalized with acute neurologic manifestations accompanied by confirmed enterovirus 71 infection at Ulsan University Hospital between 2010 and 2014. The patients’ mean age was 2.9 ± 5.5 years (range, 18 days to 12 years), and 80.6% of patients were less than 4 years old. Based on their clinical features, the patients were classified into 4 clinical groups: brainstem encephalitis (n = 21), meningitis (n = 7), encephalitis (n = 2), and acute flaccid paralysis (n = 1). The common neurologic symptoms included myoclonus (58.1%), lethargy (54.8%), irritability (54.8%), vomiting (48.4%), ataxia (38.7%), and tremor (35.5%). Twenty-five patients underwent an MRI scan; of these, 14 (56.0%) revealed the characteristic increased T2 signal intensity in the posterior region of the brainstem and bilateral cerebellar dentate nuclei. Twenty-six of 30 patients (86.7%) showed CSF pleocytosis. Thirty patients (96.8%) recovered completely without any neurologic deficits; one patient (3.2%) died due to pulmonary hemorrhage and shock. In the present study, brainstem encephalitis was the most common neurologic manifestation of enterovirus 71 infection. The characteristic clinical symptoms such as myoclonus, ataxia, and tremor in conjunction with CSF pleocytosis and brainstem lesions on MR images are pathognomonic for diagnosis of neurologic involvement by enterovirus 71 infection.