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      • KCI등재

        칸디다혈증 후 지연 발생한 흉벽 농양 1예

        유하나,정창수,정성웅,모인호,송원근,이재갑 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.3

        Recently, the incidence of candida infection has increased. Candida species often show hematogenous spread to the kidney, brain, heart, and eyes. And delayed onset of hematogenous spread is relatively rare. A 53-year-old female patient was admitted with left anterior chest pain with swelling and mild fever. She had been treated successfully with fluconazole for candidemia caused by C. albicans eight month ago. On admission chest CT scan revealed multiple subcutaneous abscesses involving the anterior chest. Percutaneous drainage of the abscess was performed. C. albicans was isolated from drained pus. Treatment with fluconazole did not to improve the abscess; therefore, micafungin and voriconazole were administered as a replacement. The patient recovered after 10-week administration.

      • KCI등재
      • KCI등재

        Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells

        유하나,박준성,이정설,최경선,최철희 대한암학회 2012 Cancer Research and Treatment Vol.44 No.3

        Purpose Current treatment of glioblastoma after surgery consists of a combination of fractionated radiotherapy and temozolomide. However, it is difficult to completely remove glioblastoma because it has uncertain boundaries with surrounding tissues. Moreover, combination therapy is not always successful because glioblastoma has diverse resistances. To overcome these limitations, we examined the combined effects of chemotherapy and knockdown of mitogen-activated protein kinase phosphatase-1 (MKP-1). Materials and Methods We used ten different anti-cancer drugs (cisplatin, cyclophosphoamide, doxorubicin, epirubicin,etoposide, 5-fluorouracil, gemcitabine, irinotecan, mitomycin C, and vincristine) to treat glioblastoma multiforme (GBM) cells. Knockdown of MKP-1 was performed using siRNA and lipofectamine. The basal level of MKP-1 in GBM was analyzed based on cDNA microarray data obtained from the Gene Expression Omnibus (GEO) databases. Results Anti-cancer drug-induced cell death was significantly enhanced by knockdown of MKP-1, and this effect was most prominent in cells treated with irinotecan and etoposide. Treatment with these two drugs led to significantly increased phosphorylation of c-Jun N-terminal kinase (JNK)in a time-dependent manner, while pharmacological inhibition of JNK partially inhibited druginduced cell death. Knockdown of MKP-1 also enhanced drug-induced phosphorylation of JNK. Conclusion Increased MKP-1 expression levels could be the cause of the high resistance to conventional chemotherapeutics in human GBM. Therefore, MKP-1 is an attractive target for overcoming drug resistance in this highly refractory malignancy.

      • KCI등재

        우수 알파인스노보드 선수의 심리적 부상요인

        유하나,최재원,강성구,이경하 중소기업융합학회 2021 융합정보논문지 Vol.11 No.1

        본 연구의 목적은 우수 알파인스노보드 선수들을 대상으로 질적연구방법을 채택하여 그들의 부상요인을 심리적 관점에서 심층적으로 분석해 보고자 한다. 이에 국가대표 및 국가대표 후보팀 경력 등 다양한 입상 경력을 가진 우수 알파인스노보드 선수 4명을 대상으로 심층면담을 실시하였으며 결과는 다음과 같다. 우수 알파인스노보드 선수들의 부 상요인 중 심리적 관점의 요인에서는 ‘특성불안’, ‘성격특성’, ‘주요타자기대’, ‘능력과 기대의 불일치’, ‘부상 트라우마’의 5개 요인으로 도출되었다. 5개 심리적 부상요인은 연구대상자의 원자료를 사례 중심적으로 표현하였으며, 실증적이고 현장 중심적인 면담자료는 미래의 알파인스노보드 선수들 및 코치진들에게 부상에 관련한 심리적 요인들을 심층적으로 분석할 수 있을 것이라고 판단된다. 또한 더 나아가 부상에 대한 예방 및 대책 수립에 관한 근거자료로 활용될 수 있을 것이라 사료되며 이러한 모든 자료는 국내 설상 종목의 운동선수들의 경기력과 운동선수로서 삶의 질에 긍정적인 효과 를 가져다주는 기초자료로 활용될 수 있을 것이다. The purpose of this study is to adopt qualitative research methods for alpine snowboard athlete to analyze their injury factors in depth from a psychological perspective. Therefore, in-depth interviews were conducted on four outstanding Alpine Snowboard athlete, and the results were as follows. Among the factors of the injury of Alpine snowboard athlete, the psychological point of view was derived from five factors: 'Trait Anxiety', 'Personality Characteristic', 'Expectancies of Significant Others, 'Discrepancy between ability and expectation' and 'Trauma Injuries'. The five psychological injury factors have expressed the raw data of the subject in a case-oriented manner, and empirical and field-oriented interview data will enable in-depth analysis of psychological factors related to injury to future Alpine snowboard athlete and coaches. It is expected to be used as a basis for injury prevention and countermeasures. All data can be used as a basis for positive effects on the quality of life of athletes and athletes in winter sports.

      • KCI등재

        코로나19 이후 세이프베케이션(Safe Vacation)이 반영된 AI호텔 공간에 관한 연구

        유하나,류숙희,장석훈 한국공간디자인학회 2023 한국공간디자인학회논문집 Vol.18 No.3

        (Background and Purpose) Due to the global spread of COVID-19, in 2020 the World Health Organization declared a global pandemic at the highest stage. Countries around the world banned or restricted entry by foreigners and the movement of their own citizens to prevent the spread of the virus, and the tourism industry was greatly affected. COVID-19 not only reduced tourism demand but also affected people's tourism patterns, with short-distance travel being preferred over long-distance travel, and domestic travel over international travel. In particular, “cleanliness” became the top priority when deciding on tourist destinations and accommodation, and people preferred tourism activities that considered social distancing. In addition, with the introduction of non-face-to-face technology and VR/AR in the tourism sector, the digital transformation of the tourism industry is expected to accelerate. Due to the spread of COVID-19, services based on artificial intelligence (AI) are rapidly expanding in hotels. Accordingly, this paper proposes an AI hotel spatial design to be implemented in the post-COVID-19 era by substituting specific strategies that should be implemented in hotels after COVID-19 due to the characteristics of various spaces. (Method) In this study, AI hotel spatial design was examined through case studies of hotels using AI technology. Based on data collected through news, newspapers, advertisements, and so on, domestic and overseas hotels that combine AI technology with a certain representativeness and hotel spatial design were selected as examples. (Results) The analysis revealed that AI is used for face-to-face services in hotels, where human services are important. Advances in AI have enabled these technologies to handle basic customer interactions. Second, the introduction of AI services can improve management efficiency and productivity. AI services can save human resources and energy and increase management efficiency by scientifically managing hotel rooms, elevators, and public spaces. Third, sensory stimulation and emotional experiences are possible. In traditional hotel spaces, the population movement rate is too high and problems such as emotionalization with service staff often occur; however, AI can reduce work mistakes. AI can obtain information about guests, understand their language, provide new sensory stimulation and emotional experiences, overcome the limitations of AI services, and effectively improve service quality. (Conclusions) The use and development of AI technology for hotel spatial design should not simply replace manpower using machines, but should realize the in-depth convergence and development of “AI + hotel spatial design,” and future researchers should discuss this aspect. Personally, I hope to do more in-depth research on this topic.

      • KCI등재

        오타고 운동과 요가 운동이 여성 노인의 보행, 우울 및 낙상 효능감에 미치는 효과 비교

        유하나,정은정,이병희 대구대학교 특수교육재활과학연구소 2012 특수교육재활과학연구 Vol.51 No.2

        The purpose of this study was to identify the effects of Otago exercise and Yoga exercise on gait, depression and fall efficacy of elderly women. Elderly women(n =21) were selected according to the conditions of the study and then divided into two groups: Otago exercise group(n =11) and Yoga exercise group(n=10). Otago exercise group received Otago exercise including strengthening, balance training for 60 minutes per day, 3 times per week over a 12 weeks. Yoga exercise group received hatha yoga exercise for the same time. Gait, depression and fall efficacy were measured to confirm the effects of intervention. After intervention, Otago group was significantly increased gait velocity(p =.000), cadence (p =.000), left step length(p =.002), stride length(left: p =.002, right: p =.007) and fall efficacy(p =.040). Yogagroup was sighnificantly increase gait velocity(p =.003), cadence(p =.027) and left step length(p =.048). The only significant difference found between the Otago group and Yoga group was in depression(p =.017). In conclusion, Otago exercise improves gait and fall efficacy of elderly women and Yoga exercise improves temporal gait function(gait velocity, cadence). These results suggest that the Otago exercise be more effective exercise on gait function and fall efficacy than the Yoga exercise in elderly women. 본 연구의 목적은 오타고 운동과 요가운동이 여성노인의 보행능력, 우울 및 낙상 효능감에 미치는 효과를 비교하고자 실시하였다. 서울 N지역에서 모집된 여성 노인 21명을 대상으로 무작위로 오타고 운동 11명과 요가 운동군 10명의 두 그룹으로 나누어 진행하였다. 오타고 운동군은 근력 강화 및 균형 훈련으로 구성하여 주 3회, 40분간 대상자의 수준에 맞춰 단계별로 실시하고 몸 풀기 운동과 마무리 운동을 10분씩 적용(총 60분)하였으며 요가운동군은 유연성 향상 및 스트레칭 효과가 있는 하타 요가를 선택하여 12주, 주당 3회, 회당 60분씩 실시하였다. 그 결과 오타고 운동군은 보행속도, 분속수, 왼쪽 보장, 양쪽 활보장 및 낙상 효능감에서 유의하게 향상되었고(p < .05), 요가 운동군은 보행속도, 분속수 왼쪽 보장에서 유의한 차이를 보였다(p < .05). 본 연구를 통하여 오타고 운동이 여성 노인의 보행 능력 및 낙상효능감에 효과가 있음을 확인하였고, 요가 운동은 보행변수 중 시간적 보행능력에서 효과가 있었음을 확인하였다. 앞으로 오타고 운동이 보행능력과 낙상예방의 효과를 보기 위 한 운동으로서 임상 및 노인시설에서 물리치료의 훈련 방법으로 적극 활용되어지길 기대하며, 더불어 요가운동도 우울과 같은 심리적인 요인뿐만 아니라 보행속도와 같은 시간적 보행 능력의 효과에 대한 재활 기초자료로 제공될 것이라 생각한다.

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