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원용훈,양지현,홍선호,구윤태,이상길,최영욱 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.10
The recently developed water-insoluble tegoprazan (TPZ) belongs to the biopharmaceutical classification system (BCS) class II group was formulated through solid dispersion (SD) technology. SD formulations of TPZ were prepared using hydroxymethylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers via the solvent evaporation method. SDs were characterized by scanning electron microscopy (SEM), powder x-ray diffraction (PXRD), and differential scanning calorimetry (DSC). In addition, the equilibrium solubility of SDs, in vitro dissolution, and in vivo bioavailability (BA) study in rats were performed. PXRD and DSC revealed that TPZ was successfully transformed to amorphous forms in SDs. The equilibrium solubility was enhanced by 15–18-fold, and in vitro dissolution was improved by approximately 2.2-fold. Consequently, the BA of TPZ was increased up to 2.1-fold. In conclusion, the use of SDs of TPZ using HPMC and PVP are considered a potential strategy to improve the therapeutic effect of TPZ via enhanced dissolution and BA.
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오미정,원용훈,박명숙 덕성여자대학교 약학연구소 2006 藥學論文誌 Vol.17 No.-
The 3-allylthio-6-anilinopyridazine(3) was synthesized by allylthiolation and amination in order to discover antitumor candidates. We considered a reaction condition like solvent, catalyst and reaction time in order to find optimal reaction for the preparation of 3-allylthio-6-anilinopyridazine(3). 3-Allylthio-6-chloropyridazine(2) was prepared from the reaction of 3,6-dichloropyridazine(1) with allylmercaptan and sodium hydroxide. The aniline moiety was introduced into 6-position of pyridazine ring of compound 2. The aminations for 3-allylthio-6-anilinopyridazine(3) were performed by refluxing for 3h in n-butanol with NH_(4)Cl(method A), 5h in ethanol with NH_(4)Cl(method B) and 6h in n-butanol with Cu powder(method C). The combination of NH_(4)Cl/n-butanol/3h was found to provide a convenient method for giving 3-allylthio-6-anilinopyridazine in satisfactory yields.
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프로그래밍형 자동화기기를 위한 실시간 메카니즘 제어언어의 설계 및 구현기법
백정현,원용훈 대한전자공학회 1997 電子工學會論文誌, C Vol.c34 No.11
As the trend of the automation is increasing, the usage of the programmable automation equipments like programmable controller(PC), numerical controller(NC), distributed control systems(DCS) and robot controller is greatly expanding in the area of the industrial equipments. But the development of the programing language for the programmable automatic equipment is rarely accomplished. In this paper, we propose design and implementation technique of the real-time mechanism control language by adding time constraint constructs and timing analysis constructs ot conditional statement and iteration statement of a programming language. Moreover, we made it possible to predict plausibility of time constraint constructs of a real time application program at compilation time and developing execution time analysiss technique.
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김선미,권용수,원용훈,정가이,김명조,전완주,양희정 한국생약학회 2016 생약학회지 Vol.47 No.2
Two flavonoid glycosides and three secoiridoide glycosides were isolated from the leaves of Lonicera maackii. On the basis of spectral and physico-chemical data, the structures of isolated compounds were identified as hesperetin-7-O-glucoside (1), luteolin-7-O-b-D-glucopyranoside (2), secologanin dimethylacetal (3), epi-vogeloside (4), and vogeloside (5), respectively. Hesperetin-7-O-glucoside (1) was isolated for the first time from this plant.
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Hee Mang Yang(양희망),Yong Hoon Won(원용훈),Ho Yub Yoon(윤호엽),Chang Hyun Kim(김창현),Yoon Tae Goo(구윤태),In Ho Chang(장인호),Young Wook Choi(최영욱) 한국고분자학회 2020 폴리머 Vol.44 No.6
폴록사머 407(PLX) 하이드로젤은 방광 내 주입을 위한 전달 시스템으로 사용되고 있지만, 젤의 강도가 충분하지 않다는 한계가 있다. 하이드로젤의 점도 및 강도를 조절하기 위해, 다양한 고분자 첨가제를 선별하였다. 점도의 변화는 고분자량 히알루론산(HHA; 33.524 Pa·s) > 히드록시프로필메틸셀룰로스 > 키토산 > 저분자량 HA > 알긴산 > 카보폴(24.332 Pa·s) 순서로 관찰되었다. 고분자 첨가는 PLX 하이드로젤의 열 가역적 특성을 변화시키지 않았으며, 젤화 온도(21.0-25.3 °C) 및 젤화 시간(17.28-28.32초)을 나타내었다. 수용성인 젬시타빈을 탑재한 채로 방광 시뮬레이션 모델을 통해 젤 침식 및 약물 방출을 조사하였다. 4회 반복시험 후 남아있는 양을 관찰하였을 때 HHA 첨가 하이드로젤 및 PLX 하이드로젤이 각각 74.6% 및 57.8%로 나타났으며, 약물 방출은 확산 및 침식으로 제어되었다. 따라서 HHA 첨가 하이드로젤은 방광 내 주입을 위한 유망한 시스템으로 판단된다. Poloxamer 407 (PLX) hydrogel has been used as a drug delivery system for intravesical instillation, but it has a limitation of insufficient gel strength. Here, to modulate the viscosity and strength of hydrogel, various polymers were screened. Their effect on viscosity decreased in the following order: high molecular-weight hyaluronic acid (HHA; 33.524 Pa·s) > hydroxypropyl methylcellulose > chitosan > low-molecular weight HA > sodium alginate > carbopol (24.332 Pa·s). Polymer addition hardly altered the thermo-reversible property of hydrogels; the gelation temperature was 21.0–25.3 ℃ and gelation time was 17.28–28.32 s. With gemcitabine as a water-soluble ingredient, gel erosion and drug release were examined using an in vitro bladder simulation model. After four repeated cycles of filling and emptying, the remaining fraction of HHA-added hydrogel and PLX hydrogel was 74.6% and 57.8%, respectively. Furthermore, drug release was diffusion- and erosion-controlled. Thus, HHA-added hydrogel is a promising system for intravesical instillation.
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