임신 중 중증 천식지속상태 환자에서 체외막산소화장치 적용 1예

옥혜성,강래형,여혜주,윤성훈,조우현,전두수,김윤성,이승은 대한 소아알레르기 호흡기학회 2020 Allergy Asthma & Respiratory Disease Vol.8 No.2

Refractory status asthmaticus represents the most severe clinical presentations of asthma, and it is typically associated with the presence of hypoxemia, hypercapnia, lactic acidosis, dynamic hyperventilation and altered state of consciousness. Several case reports have demonstrated extracorporeal membrane oxygenation (ECMO) as an alternative treatment method for patients with status asthmaticus that failed to respond to maximal conventional therapy. We experienced a case of pregnant woman with severe asthma attack not relieved by conventional treatment, in whom early administration of ECMO resulted in a good outcome. A 23-year-old woman at, 11 weeks of pregnancy, was admitted with acute asthma attack. Despite maximal rescue therapies with mechanical ventilation, her condition gradually deteriorated. Venovenous ECMO was initiated 4 hours from intubation and gas exchange with lung mechanics was rapidly recovered within hours. She was extubated 45 hours after initiation of ECMO and had successful weaning from ECMO 2 days after extubation. The patient had no complication and gave birth to a healthy baby at 37 weeks of gestation. This is the first case report in Korea on the successful use of ECMO in a pregnant woman with severe respiratory insufficiency due to status asthmaticus, who failed to respond to mechanical ventilation and maximum pharmacological treatment. Early ECMO application is a useful treatment option for patients with refractory status asthmaticus refractory to conventional therapy.

패혈증 비브리오균에 의한 위장관염에 이은 급성 화농성 척추염

옥혜성 ( Hea Sung Ok ),김병기 ( Byeong Ki Kim ),김기훈 ( Ki Hoon Kim ),박만제 ( Man Je Park ),이현수 ( Hyoun Soo Lee ),위유미 ( Yu Mi Wi ),강철인 ( Cheol In Kang ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

Vibrio vulnificus is a halophilic gram-negative bacillus capable of causing severe to life-threatening infections in high-risk populations. Osteomyelitis caused by V. vulnificus is extremely rare, and a previously reported case had been associated with an adjacent soft-tissue infection. Herein we report the first case of vertebral osteomyelitis resulting from hematogenous spread of V. vulnificus gastroenteritis. The patient was successfully treated with a combination of cefotaxime and ciprofloxacin. (Korean J Med2014;86:519-522)

스타 인재의 비율과 증권사 재무성과의 관계에 대한 연구 - 국내 증권사의 애널리스트를 중심으로 -

옥지호,안혜성 대한경영정보학회 2015 경영과 정보연구 Vol.34 No.3

외부 환경의 불확실성이 점점 더 높아지는 가운데 조직의 경쟁우위를 달성하기 위한 방안으로 우수한인적자원의 확보 및 보유가 점차 중요시되고 있다. 특히, 동료 직원들에 비해 몇 배나 높은 탁월한 성과를 창출할 수 있는 ‘스타 인재’는 지식과 정보가 중시되는 지식기반산업에서 점차 그 중요성이 강조되고있어 이에 관련된 학계와 산업계의 관심이 증대되고 있다. 하지만 이처럼 스타 인재에 대한 관심이 증가하고 있음에도 불구하고 스타 인재의 보유가 조직성과에 미치는 영향을 실증적으로 분석한 선행연구는부족한 편이다. 특히 스타 인재의 보유가 조직 내외부에 미치는 긍정적⋅부정적 영향력을 고려할 때, 조직 내 스타 인재의 비율(ratio of star employee)과 조직성과의 관계는 단순 선형 관계(simple linear relationship)의 가능성 뿐 아니라 비선형의 곡선형 관계(curvilinear relationship)가 존재할 가능성도 가지고 있다. 이에 본 연구에서는 스타 인재에 관한 선행 연구를 토대로, 스타 인재의 비율이 증가함에 따라 한계효과가 증가하는 체증관계(U자형 곡선)와 한계효과가 감소하는 체감관계(역U자형 곡선)의 두 가지 대립가설을 설정한 후 국내 34개 상장증권사의 2008~2013년 134개 관측수를 대상으로 실증분석을 진행하였다. 국내 경제전문지가 선정한 ‘베스트 애널리스트’(스타 인재)의 비율이 증권사의 재무성과에 미치는 영향을 불균형 패널모형으로 검증한 결과, 스타 인재의 비율이 증가할수록 조직성과는 증가하지만, 그 한계효과는 점차 감소하는 체감형 비선형 관계가 검증되었다. 이러한 연구결과는 지식기반 산업에서도 스타 인재를 활용하는 것이 중요함을 시사함과 동시에, 스타 인재에 대한 과도한 의존은 경계할 필요성이 있음을 시사한다. Amidst the growing uncertainty in external environments, securing and retaining superior human resources is becoming emphasized as a key means for organizations to achieve competitive advantages. Particularly, star employees─human resources that are characterized by their ability to create extraordinary performance relative to other peers─are increasingly gaining attention in both academia and industry because of its importance in knowledge-based industries. However, despite the prevailing recognition for star employees, few previous literature have attempted to empirically test the direct relationship between the ratio of star employees in an organization and organizational performance. Considering both the potential for positive and negative influence of star employees on organizations, the relationship between the ratio of star employees and organizational performance can not only be a simple linear relationship but can also exist in a curvilinear form. Building on the existing literature on star employees, this paper establishes competing hypotheses for the two possibilities of curvilinear relationship; as the ratio of star employees increases, marginal effects can either increase (i.e., U-shaped curvilinear relationship) or decrease (i.e., inverted U-shaped curvilinear relationship). Employing an unbalanced panel data of 35 Korean brokerage firms between years 2008 and 2013 with 134 observations, the relationship between the ratio of best analysts (i.e. star employees) as selected by Maeil Business Newspaper and financial performance (i.e. organizational performance) of corresponding brokerage firms is examined. Empirical results indicate that while organizational performance increases as the ratio of star employees increases, its positive effect diminishes over time which provides support for the curvilinear relationship with decreasing marginal effects. Our research findings imply that star employees create value in knowledge-based industries; at the same time, implications are given as results calls for caution for excessive dependence on star employees beyond a certain level.

간헐적 수요예측을 위한 수정된 Croston 방법

하정훈,옥창수,전홍배,석혜성 한국경영과학회 2015 한국경영과학회 학술대회논문집 Vol.2015 No.4

간헐적 수요예측을 위한 수정된 Croston 방법

하정훈,옥창수,전홍배,석혜성 대한산업공학회 2015 대한산업공학회 춘계학술대회논문집 Vol.2015 No.4

P-81 Therapeutic efficacy comparison of second-generation EGFR-TKI (afatinib) and first-generation EGFR-TKIs (gefitinib/erlotinib) in Advanced EGFR-positive Non-Small-cell Lung Cancer in the real world

강래형,윤성훈,서현택,옥혜성,변기섭,전두수 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Objective: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are routinely used to treat non small cell lung cancer (NSCLC) in patients with activating mutations of the EGFR gene. The aim of the study was to compare the efficacies of second-generation EGFR-TKI (afatinib) and first-generation EGFR-TKIs (gefitinib/erlotinib) in the real world. Method: A retrospective analysis of 93 NSCLC patients treated with second-generation EGFR-TKI (afatinib, n=53) and first-generation EGFR-TKIs (gefitinib/erlotinib, n=42) was performed. EGFR mutations were analyzed using PNA clamp. We assessed the response of tumor and progression-free survival with the type of EGFR gene mutation. Result: Second-generation EGFR-TKI (afatinib) versus First-generation EGFR-TKIs (gefitinib/erlotinib) showed that the objective response rates were 73% versus 63% (p=0.962) and median progression-free survival (PFS) was 11 versus 13.6 months (p= 0.385). Discontinuation rate due to drug-related adverse events was 7 patient (16%) versus 4 patient (8%). The type of EGFR mutation had no impact on median PFS and response rate. Demographic and clinical factors had no impact on PFS or response rate in patients treated with EGFR TKIs. Conclusion: Second-generation EGFR-TKI (afatinib) and first-generation EGFR-TKIs (gefitinib/erlotinib) showed similar efficacies based on treatment response, median PFS (regardless of the type of EGFR gene mutation).

Performance of interferon- release assay in the diagnosis of tuberculous pericarditis: a meta-analysis

서현택,김윤성,강래형,옥혜성,변기섭,윤성훈,여혜주,이승은 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Background: Recently, there have been several articles investigated the diagnostic value of IGRA in the diagnosis of tuberculous pericarditis. IGRA has been reported that a high sensitivity and specificity in these articles. Thus, we conducted the present meta-analysis to comprehensively evaluate the overall diagnostic accuracy of IGRA upon tuberculous pericarditis. Methods: We conducted electronic English-language literature searches of MEDLINE via PubMed, Embase and Cochrane Library database from the earliest available date of indexing through May 31, 2017. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves parameters. Results: Across 8 studies (591 patients), the pooled sensitivity for IGRA methods was 0.92 (95% CI; 0.87-0.95) without heterogeneity (χ2=14.31 , p=0.05) and a pooled specificity of 0.88 (95% CI; 0.75-0.94) with heterogeneity (χ2=9.71, p= 0.21). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 17.5 (95% CI; 9.9-30.9) and negative likelihood ratio (LR-) of 0.08 (95% CI; 0.05-0.14). The pooled DOR was 214 (95% CI; 105-436). Conclusion: IGRA demonstrated good sensitivity and specificity for diagnosis of TB pericarditis. At present, the literature regarding remains the use of IGRA for diagnosis of TB pericarditis still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of IGRA prediction of TB pericarditis.

KCNH2 변이가 확인된 2형 선천성 QT 간격 연장 증후군 1예

김병기,김기훈,박만제,옥혜성,이현수,오주현,강구현 조선대학교 의학연구소 2013 The Medical Journal of Chosun University Vol.38 No.2

A 41-year-old woman arrived at our emergency department with semicomatous mentality due to aborted cardiac arrest from ventricular fibrillation, which occurred during resting state. Prolonged QT interval in condition of hypokalemia and hypomagnesemia was observed on initial electrocardiography. However, even after normalization of serum potassium, magnesium and mentality, QT prolongation was sustained. In addition, genetic analysis showed KCNH2 mutation which was consistent with type 2 congenital long QT syndrome (LQTS). In this case, the patient was treated with an implantable cardioverter defibrillator and genotype specific medical therapy with potassium channel opener.

아동이 지각한 어머니의 언어통제 유형과 아동의 사회적 행동특성간의 관계

권준희,김미양,김현경(A),변경옥,신윤승,신혜영,양혜성 연세대학교 생활과학대학 1992 婦學 Vol.25 No.-