Guinea Pig 에서 가수분해된 Carrageenan 으로 유발된 궤양성 대장염의 병태생리에 관한 연구

송인성(In Sung Song),김나영(Na Young Kim),정현채(Hyun Chae Jung),이효석(Hyo Suk Lee),윤용범(Yong Bum Yoon),김정룡(Chung Yong Kim),김우호(Woo Ho Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.3

N/A Background: Ulcerative colitis is a inflammatory bowel disease, of which characteristics are diarrhea, hematochezia, weight low, and the incidence of this disease is rising tendency in Korea, But the causes or pathophysiology of this disease have not been yet clear and the animal model has not been yet established. This paper is concerned with an experimentalnimal odel of ulcerative colitis wherein the ultimate goal is to study the causes and pathopohysiology of ulcerative colitis. Method: For the animal model, we use guinea pigs to observe whether the carrageenan extracted from the seaweed, causes the lesion to large and small intestine, and whether this lesionis similar to human ulcerative colitis clinically and anatomically. We classified the 82guinea pigs into three groups, the first group (the control group) which consisted of 11guinea pigs were given the tap water as drinking water, the 2nd group of 11 guinea pigs were given the 1.5% native carrageenan (1.5% NCG group) and the 3rd group of 60guinea pigs (1.5% HCG group) were given the 1.5% hydrolyzed carrageenan for 40days. In order to identify the pathophysiology of this lesion, we measured the PG4 and LTB4 at the cecal mucosa where the lesion existed. Xanthine oxidase, superoxide dismutase and catalase activity, all of which are closely related to superoxide radical system, were also measured, Results: 1) During experimental period of 40 days, the weight of 11 guinea pigs of the control group increased by 110g to 180g and the weight of 8guinea pig of the 1,5% native carrageenan group increased by 40g to 100g. However, the twenty eight guinea pigs of the 1.5% hydrolyzed carrageenan group lost 10g to 130g during experimental period. All of the 28guinea pigs of the 1.5% HCG group showed diarrhea and loose stools till the end of experiment, the fifty percent of 8 guinea pigs of the l. 5% NCG group showed loose stool, but none of the control group showed loose stool. All of the control group and the 1.5% NCG group showed negative occult blood when the hematest was taken at the end of experiment, but twenty seven guinea pigs (93.3%) of the 1.5% HCG group were positive and 12guinea pigs (43%) showed grossly hematochezia. By the way, the time of onset of clinical symptom in the 1.5% HCG group was very variable among the guinea pigs from 3weeks to 40days after the beginning of HCG intake. Moreover the guinea pig tended to die within 10days once the symptom developed. 2) There was no abnormal finding from the treiz ligament to the rectum in the control group but half of the 1.5% NCG group showed hemorrhagie erosions at the cecum and the twenty seven of 28 guinea pigs of l. 5% HCG group showed hemorrhagic erosions at the cecum. The two guinea pigs of the 1.5% HCG group showed 0.2×0.8cm and 0.3×1.0cm sized ulcerations grossly. 3) When the cecal mucosa was observed with light microscope, the six of the 8guinea pigs of the 1.5% NCG group showed mucosal atrophy and the four of these 6guinea pigs showed mild degree erosions and infiltration of inflammatory cells, but none of 1.5% NCG group showed metachromasia in the toludine blue stain. In the cecal mucosa of the twenty seven of the 28 guinea pigs of the 1.5% HCG group, multiple mucosal confined ulcerations from the shallow and small ulcerations to deep and broad ulcerations were found, and in the 2 of theae 27guinea pigs, the ulcerations were extended to submucosa though the muscularis mucosae. Inflammatory cells such as polymorphonuclear cells, machrophages, lymphocytes and plasma cells were found on the base and margin of the ulcers. Among these inflammatory cells, the infiltration of mechrophages was prominent and definite metachromasia in the toluidine blue stain was found in the machrophages. 4) The mean PGE2 level of the control group was 292.08pg/mg mucosa, and those of the 1.5% NCG group and the 1.5% HCG 281.25pg/mg mucosa, and 429.87pg/mg mucosa, respectively. The mean PGE2 value of 1.5% HCG group was highest among three

소화성 궤양 환자에서 Helicobacter pylori 의 약제 내성률과 재발현 및 재감염률을 고려한 H . pylori 박멸요법의 수립

송인성(In Sung Song),김나영(Na Young Kim),임채남(Chae Nam Lim),임선희(Sun Hee Lim),이계희(Kye Heui Lee),구명숙(Myung Sook Koo),정현채(Hyun Chae Jung),김정룡(Chung Yong Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.3

N/A Objective : This study was conducted to establish an ideal treatment regimen for H. pylori eradication in three aspects: clinical, microbiological, and reinfection. Methods : Four hundred thirty two patients with H. pylori positive peptic ulcer were randomized to receive two types of triple therapy: one includes colloidal bismuth subcitrate, metronidazole and tetracycline (BMT), and the other includes omeprazole, amoxicillin and clarithromycin (OAC). Results : More than 50% of symptom reduction within 1 week was 94.4% both in OAC and in BMT group. The percentages of side effects were 21.6% and 27.1% in OAC and BMT regimen, respectively. Good compliance with at least 85% intake was 99.0% and 95.2% in OAC and BMT regimen. The eradication rates of H. pylori were 85.9% and 89.1% in OAC and BMT regimen. Resistance rates to metronidazole and clarithromycin were 40.6% and 10.2% by E test, 74.3% and 27.0% by broth microdilution, and 45.3% and 10.9% by disk diffusion method. The eradication rates for H. pylori was 100% and 77.8% by BMT in patients with metronidazole-sensitive and -resistant strains, and 100% and 80.0% by OAC with clarithromycin- sensitive and -resistant strains, without significance by their resistances. The recrudescence rate within 1 year after eradication was 21.2% and 14.2% for OAC and BMT regimen without significant difference. The reinfection rate after 1 year was 4.0% and 5.0% for OAC and BMT regimen. Conclusion : Because the eradication rate of BMT regimen is 89.1% in spite of high metronidazole resistance rate, and there was no statistical difference in the aspects of symptom reduction, side effect, compliance, recrudescence and reinfection rate, BMT regimen is as favorable as OAC to eradicate H. pylori.

임상강좌 : 한국인의 염증성 장질환

송인성 ( In Shung Song ) 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

자동차 머플러용 타공파이프 자동절단장치 개발에 관한 연구

송인성(I.S. Song),김용석(Y.S. Kim),윤두환(D.H. Yoon),양순용(S.Y. Yang) 한국생산제조학회 2010 한국생산제조시스템학회 학술발표대회 논문집 Vol.2010 No.4

상용트럭 AEBS용 레이더 및 비전센서 평가기술 개발

송인성(Insung Song),유시복(Sibok Yu),김문식(Moonsik Kim),김병수(Byungsu Kim) 한국자동차공학회 2012 한국자동차공학회 학술대회 및 전시회 Vol.2012 No.11

HKMC, KATECH, SNU and KATRI has been developing the AEBS for trucks and buses from 2010. The role of KATECH is to develop driving simulator connected HILS for investigating AEBS control parameters, to develop the T-car based test-bed and test method for evaluating the sensor systems used for HKMC AEBS. These test results are used for designing the AEBS. The AEBS uses both 77GHz microwave radar developed for ACC and FVCMS and vision sensor together. The AEBS is basically developed for very heavy trucks such as 25 ton truck named TRAGO. KATECH used a SUV vehicle named SantaFe as a test platform. A mount is designed to meet the installation height of the sensors, and sensor signal was taken from the mounted sensors. Originally, two types of radar was tested, but this paper contains the result of only on type. After installation of sensors, the sensors are calibrated according to the sensor installation directions. The data under consideration was relative distance between subject vehicle and target vehicle, relative speed, detecting angles, detecting range, and etc. The test results show the measuring error of radar and vision sensor for different distances, measuring angles, relative speed, and etc. The test was processed for stationary conditions and driving conditions with 40 km/h and 60 km/h.

언론 기사에 나타난 신(조)어 조사 도구의 설계 및 구현

송인성 ( In-sung Song ),정희석 ( Hee-seok Jeong ),이상곤 ( Sangkon Lee ),이래호 ( Raeho Lee ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.1

신조어 조사용 프로그램은 웹에 실시간으로 등록되는 언론 기사를 수집하는 웹 에이전트를 개발하여 텍스트를 추출하고, 간단한 어휘 분석을 통하여 국어사전에 등록된 표제어와 이미 연구자가 발견한 기존의 신조어를 제외하고 새롭게 생성된 신조어를 추출하는 작업을 하는 도구이다. 인터넷의 언론 사이트에서 규칙적인 URL 패턴을 발견하고 뉴스 기사를 수집한다. HTML 소스 분석을 통하여 언론 기사만을 추출하고 이 기사에서 사전의 표제어와 기존에 조사된 신어를 제외하여 국어 전공자가 신어를 찾아내는 작업을 하는데 사용하는 시스템을 설계하고 구현하였다.

현대국어 호출어 ‘이+보-’류의 발달과 사용 양상의 변화

송인성 ( Song¸ In-seong ) 고려대학교 민족문화연구원 2020 民族文化硏究 Vol.89 No.-

이 연구는 현대국어에서 호출어로 사용되고 있는 ‘이+보-’류의 발달 과정을 살펴보고, 구어 자료를 바탕으로 20세기 초부터 현재까지 호출어 ‘이+보-’류의 사용 양상의 변화를 발화 목적과 발화 상황 측면에서 파악하였다. 호출어는 호칭어, 지칭어와 함께 일상에서 자주 사용하는 언어 표현으로 현대국어에서 다양한 언어 형식으로 사용된다. 호출어 ‘이+보-’류는 ‘여+보-’류가 ‘여기(를) 보-’에서 발달한 것과 같이 ‘이로 가리키는 대상을 보다’의 의미를 지닌 ‘이(를) 보-’에서 발달하여 현재 축약형인 ‘이봐’, ‘이봐요’의 형태가 주로 사용되고 변화형인 ‘이것/거 보-’도 호출어로 쓰이고 있다. 이 두 형태는 청자 대우법의 어미의 결합에 따라 다양한 형태가 나타난다. 호출어 ‘이+보-’류는 요청, 제안, 질문, 명령, 진술, 걱정, 문제 제기, 경고 등의 여러 발화 목적 및 상황에서 쓰이는데, 근래로 올수록 문제 제기, 경고 등의 상황에서 사용이 증가한다. 반면에 요청, 제안, 질문 등을 하는 상황에서의 사용은 1970년-1980년대를 기준으로 감소하는 추세를 보인다. 이 현상을 통해, 호출어 ‘이+보-’류에 문제 제기나 경고 등의 의미와 기능이 이전보다 강화되고 요청, 제안, 질문 등의 상황에서 사용 감소로 인해 전체적인 면에서는 ‘이+보-’류의 사용 범위가 축소되고 있음을 확인하였다. 이는 최근 들어 호출어 ‘저기(요)’가 요청, 제안, 질문 등의 발화 목적 및 상황에서 빈번하게 사용되는 것과 관련이 있는 것으로 해석된다. The purpose of this study is to examine the development process of the ‘I+bo-’ class, which is used as a summonses, and to clarify the changes in the usage of the ‘I+bo-’ class in the modern Korean. Summonses is a frequently used language, and there are various types in modern Korean. The ‘I+bo-’ class is predicted to have developed from ‘I (leul) bo-’ just as the ‘Yeo+bo-’ class developed in ‘Yeogi (leul) bo-’. Currently, the abbreviated forms of ‘I-bwa-’ and ‘I-bwayo-’ are mainly used, and the transformed forms ‘I-geos/geo bo-’ is also used as summonses. These two forms appear in several forms depending on the binding pattern of Hearer-honorification endings. ‘I+bo-’ is used in various discourse situations, and in recent years, the use of ‘I+bo-’ in discourse situations such as protests and warnings has increased. On the other hand, the use of requests, suggestions, questions, etc., showed a decreasing trend from the 1970s to 1980s. Based on this, it can be seen that the meaning of protest and warning is strengthened in the ‘I+bo-’, and the entire scope of use of ‘I+bo-’ is shrinking through the reduction of use in situations such as requests and suggestions. This is considered to be related to the recent use of the ‘Jeogi (yo)’ frequently in discourse situations such as requests, suggestions, and questions.

원주 지역어의 세대 간 단모음 실현 양상

송인성 ( Song¸ In-seong ) 고려대학교 민족문화연구원 2021 民族文化硏究 Vol.92 No.-

이 연구는 원주 지역 출신 70대와 20대 남녀 화자의 음성 자료를 구축하고 모음의 포먼트 분석과 모음 간의 거리를 측정하여 세대별 단모음의 특징을 파악하였다. 분석 결과, 원주 지역어 단모음은 세대 간 차이가 관찰되었다. 먼저 전설 모음에서 /ㅟ/와 /ㅚ/의 경우 70대 화자는 이를 대부분 단모음으로 발음하였지만 20대 화자는 이를 대부분 이중모음으로 발음하였다. /ㅔ/와 /ㅐ/의 경우 70대 남녀 화자는 이 두 모음을 변별하여 발음하는 것으로 나타났는데 70대 남성 화자는 혀의 고저와 전후를 나타내는 F1, F2에서 유의미한 차이를 보였고 70대 여성 화자는 F1에서 유의미한 차이가 나타났다. 반면에 20대 남녀 화자는 /ㅔ/와 /ㅐ/를 변별하여 발음하지 않았다. F1과 F2에서 유의미한 차이가 나타나지 않았고 두 모음이 모음 공간에서 중첩되어 실현되었다. 다음으로 후설 모음의 실현 양상을 살펴보면 /ㅡ/의 경우 F2에서 세대 간의 유의미한 차이가 관찰되었으나, /ㅣ/-/ㅡ/와 /ㅡ/-/ㅜ/의 두 모음 사이의 거리를 측정하여 비교한 결과 70대와 20대 화자 모두 /ㅡ/가 전설 모음인 /ㅣ/보다 후설 모음인 /ㅜ/에 가깝게 실현되었다. /ㅓ/의 경우 F1, F2 모두 성별, 세대 간 유의미한 차이가 나타나지 않았다. 마지막으로 /ㅜ/와 /ㅗ/의 경우 70대 남녀 화자는 F1, F2에서 유의미한 차이가 나타나지 않았지만 20대 남녀 화자는 혀의 전후인 F2에서 유의미한 차이가 나타났고, /ㅜ/와 /ㅗ/의 거리 차이를 통해서도 세대 간 차이를 확인할 수 있었다. 이 연구는 지금까지 방언학과 음성학 연구에서 관심이 부족하였던 원주 지역어를 대상으로 음향음성학적인 방법론을 통해 70대와 20대 화자의 단모음 특징과 세대 간 차이를 객관적으로 살펴본 것에 의의가 있다. The purpose of this study was to examine the acoustic characteristics of the monophthongs in the Won-ju dialect. For this purpose, voice data of male and female speakers in 70s and 20s from the Won-ju dialect were collected. And Characteristics of monophthongs were analyzed by analyzing the formants(F1, F2) of vowels and measuring the distance between vowels. As a results, a generational difference was observed in vowels of the Won-ju dialect. Male and female speakers 70s mainly pronounced /ㅟ/ and /ㅚ/ as monophthongs, but male and female speakers 20s mainly pronounced /ㅟ/ and /ㅚ/ as diphthongs. Male and female speakers 70s pronounced /ㅔ/ and ㅐ/ distinctly, but male and female speakers 20s did not differentiate between these two vowels. A significant difference between generations was observed in F2 in the articulation position of /ㅡ/, but both 70s and 20s pronounced the /ㅡ/ vowel in back. /ㅓ/ did not show any particular difference between generations. Finally, /ㅜ/ and /ㅗ/ showed a significant difference in F2 between male and female speakers in 20s.

자작형 전기자동차의 회생제동 효율에 관한 연구

송인성(Insung Song),정찬세(Chanse Jung),김학선(Hacksun Kim),양순용(Soonyong Yang) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11

Our nation relies on imports for most of the energy has been. The amount of the total energy‘s proportion of oil is far more than half the situation. It is this dependence on oil from other countries, less than half that, given the country’s dependence on oil is very high. In addition, concern about environmental issues increases with Green-cars, has been increasing concern about the recent improvements in battery technology and power electronics technology due to the development of electric vehicles as a Green-cars has become influential. The biggest drawback of electric cars, but the battery’s energy density is much lower than the internal combustion engine vehicle fuel that is used. This one-time charge of electric vehicles driving distance is shorter than the internal combustion engine vehicle. To overcome this, efforts to develop better battery technology is continuing, but the storage of chemical energy is the theoretical limit. Therefore, given the driving distance as the battery energy in order to maximize operating efficiency, the ongoing study on the increase which A way that regenerative braking can be mentioned. Regenerative braking and the biggest advantage you get by Battery SOC due to increased fuel economy is a synergistic effect can be obtained.

아두이노를 이용한 스마트 도어클로저

송인성(I. S. Song),김태구(T. G. Kim),박영민(Y. M. Park),김진현(J. H. Kim),박민규(M. G Park),곽상곤(S. G. Gwak),김지민(J. M. Kim) 한국기계가공학회 2019 한국기계가공학회 춘추계학술대회 논문집 Vol.2019 No.4