피부조직검사: 소신경섬유 평가의 유용한 방법

손은희,Sohn, Eun Hee 대한임상신경생리학회 2015 Annals of Clinical Neurophysiology Vol.17 No.2

Skin biopsy with investigation of small nerve fiber in human epidermis and dermis has been proven to be a useful method for demonstration of small fiber neuropathy. Quantification of intraepidermal nerve fiber density using anti-Protein Gene Product 9.5 (PGP 9.5) antibody is standardized method to diagnose the small fiber neuropathy. Skin biopsy method also makes it possible to differentiate the type of nerve fibers by using different antibodies. Quantification of dermal structures with different type of nerve fibers could be used to invest pathophysiologic mechanism of diseased state.

학술연구 : 증시 상장 후 창립 CEO의 존재가 기업 실패에 미치는 영향: 상황이론적 접근을 중심으로

손은희 ( Eun Hee Sohn ),송재용 ( Jae Yong Song ) 한국중소기업학회 2010 기업가정신과 벤처연구 Vol.13 No.3

퍼지 시계열 모형 연구

손건태(Keon Tae Sohn),김성덕(Sung Duk Kim),손은희(Eun Hee Shon) 한국자료분석학회 2001 Journal of the Korean Data Analysis Society Vol.3 No.2

본 논문은 대칭 삼각퍼지수를 계수로 갖는 퍼지시계열모형을 확장한 일반적인 삼각퍼지수를 계수로 갖는 퍼지시계열모형을 제안하고 모의실험에 의한 자료들에 대하여 추정 결과를 비교하여 일반적인 삼각퍼지수를 계수로 하는 퍼지시계열 모형이 유용함을 보인 것이다. In this paper fuzzy time series models with general triangular fuzzy numbers as coefficients are proposed. The proposed models are compared with fuzzy time series models with symmetric triangular fuzzy numbers as coefficients. The estimates of parameters, triangular fuzzy numbers, can be obtained by nonlinear programming. As results, the proposed models are preferable to fuzzy time series models with symmetric triangular fuzzy coefficients.

Lithium 중독의 위험 요인에 대한 후향적 고찰

김상헌(Sang Heon Kim),손은희(Eun Hee Sohn),이준영(Joon Young Lee) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2

Lithium은 1970년도에 양극성 장애의 치료제로 승인을 받은 이후 정신과의 다양한 영역에서 치료제로 이용되고 있다. 하지만 lithium은 혈청 치료 농도의 범위가 매우 좁다는 약점 때문에 중독의 위험성이 높다. 본 연구에서는 2000년 1월부터 2006년 1월까지 경북대학병원 정신과에서 lithium이 포함된 처방을 받아 복용중인 환자들 중 혈청 lithium 농도 검사를 비롯한 기본적인 검사들을 완료한 72명을 대상으로 하여, lithium 중독의 위험 요인들이 중독 환자군과 비중독 환자군 간에 유의한 차이가 있는 지와 이 요인들이 lithium 중독환자군 내에서 혈액투석치료군과 비혈액투석치료군 사이에서도 차이가 존재하는지를 살펴보았다. 결과는 다음과 같다. 1) Lithium 중독 환자군과 비중독 환자군 간의 lithium 중독 위험 요인의 비교에서 혈청 lithium 수치, 신장 기능의 이상 유무, Gadallah의 증상 중증도 분류에서는 통계적으로 유의한 차이가 있었다. 2) 혈액투석치료군과 비혈액투석치료군 간의 lithium 중독 위험 요인의 비교에서는 혈청 lithium 농도, Gadallah의 증상 중증도 분류에서 통계적으로 유의한 차이를 보였다. 3) Lithium 중독 위험 요인들 사이의 상관관계 분석에서, 혈청 lithium 농도는 소디움 농도와는 음의 상관관계를 그리고 Gadallah의 중독 증상 단계와는 양의 상관관계를 보였다. 본 연구는 신장 문제가 lithium 중독과 관련성이 높다는 기존의 가설을 지지하였고, 높은 혈청 lithium 농도가 lithium 중독증의 치료 방법의 결정에 영향을 주며, 또한 혈청 lithium 농도가 높을수록 혈액투석법이 선택된다는 것을 밝혔다. 또한 lithium의 농도가 올라갈수록 부작용 Gadallah의 중독 증상 단계가 올라간다는 상관관계를 통해서 임상에서 lithium을 처방할 때 각 lithium 농도에 따른 부작용 증상을 숙지하는 것이 추적관찰 치료 시에 필요하며, 이는 자세한 이학적 검사와 문진을 통하여 미리 치명적인 부작용을 방지할 수 있다는 가능성을 시사한다. 향후 연구에서는 표본의 수를 확대하는 것이 필요하다고 본다. After lithium being approved for the treatment of bipolar affective disorder in 1970, it has been used for many psychiatric symptoms. But lithium has a very narrow therapeutic index which can sometimes be fatal to patients. In this study, retrospective analysis was done to 72 psychiatric patients who had taken lithium and completed serum lithium level test, complete blood cell count, liver function test, thyroid function test and serum renal function test. We compared the difference of lithium intoxication risk factors between lithium intoxication and non-intoxication group. And we also studied the difference of risk factors of lithium intoxication in relation to the treatment of hemodialysis. Current findings are as follows:1) Serum lithium levels, presence of renal problems and Gadallah's toxicity symptom stages were significantly higher in lithium intoxication group than in non-intoxication group. 2) Serum lithium levels and Gadallah's toxicity symptom stages were significantly higher in hemodialysis group than in nonhemodialysis group. 3) Serum lithium levels had negative correlations with serum sodium level and positive correlations with toxicity symptom stages. These results suggest that renal problems were related to lithium intoxication and the higher serum lithium levels and intoxication symptom stage were, the more physicians chose the method of hemodialysis. And we also found that Gadallah's toxicity symptom criteria might be very useful for the assessment of the side effects of lithium and helpful to prevent possible lithium intoxication. Further studies for verification of these facts will be necessary in the future.

증례 : 감염; 파종성 결핵을 동반한 Good 증후군 1예

정현 ( Hyeon Jung ),손경목 ( Kyung Mok Sohn ),김연숙 ( Yeon Sook Kim ),송창헌 ( Chang Hun Song ),손은희 ( Eun Hee Sohn ) 대한내과학회 2013 대한내과학회지 Vol.85 No.3

Good 증후군은 흉선종과 면역결핍이 동반되는 드문 질환이다. 체액성 및 세포성 면역결핍이 모두 발생하며 주로 반복적인 부비동염이나 폐렴으로 발현하지만 바이러스나 진균, 결핵에 감염되기도 한다. 의심하지 않으면 진단이 늦어지는 경우가 많고 성인에서 발현하는 다른 일차성 면역 결핍증에 비해 예후가 불량하다. 치료는 면역글로불린을 주기적으로 투여한다. 저자들은 흉선종 절제술 시행 15년 후 반복적인 폐렴과 결핵에 의한 뇌수막염, 폐결핵으로 사망한 Good 증후군 증례를 경험하여 국내외 문헌고찰과 함께 보고 하는 바이다. Good`s syndrome is the rare association of immunodeficiency with thymoma, characterized by hypogammaglobulinemia, depleted B-cells, diminished T-cells and inversion of the CD4/CD8 ratio. Thymectomy does not usually improve hypogammaglobulinemia; thus, the patient remains prone to infections. Infections affect primarily the sinopulmonary and gastrointestinal system. Here we present a case of a 71-year-old woman with common manifestations of Good`s syndrome who succumbed to disseminated tuberculosis. Serum immunoglobulin levels should be measured for patients with thymoma and susceptibility to infection. (Korean J Med 2013;85:329-333)

인지 기능에 미치는 대뇌 백질 변성의 영향 및 원인분석

손은희,이애영,유성동,권도형,김태우,김재문 대한신경과학회 2001 대한신경과학회지 Vol.19 No.5

대뇌 백질변성의 임상적 의미와 위험인자 분석

이애영,손은희,김태우 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: Cerebral white matter changes can be observed frequently in Alzheimer′s disease or healthy elderly as well as vascular dementia the clinical significance and injury mechanism of cerebral white matter changes have not been clarified Objectives: To evaluate the significance of cerebral white matter changes in elderly patients Methods: We assessed cognitive function and radiological features in patients with white matter changes to evaluate the effect of cerebral white matter changes and cortical central brain atrophy on cognition Grading of white matter changes was measured by the Scheltens scale The cortical atrophy was graded with visual inspection by two independent neurologists and the central atrophy was assessed with ventricular indices The cognitive status was evaluated with Mini-Mental state examination and the modified Mini-mental State examination Results: Identified risk factors for white matter changes were older age, hypertension, and female gender The degree of cerebral white matter changes was significantly associated with cognitive disturbances and their main effect on cognition was fluency and attention deficits There was no difference in the severity of cortical atrophy between the two groups Visual rating for cortical atrophy and measurement of ventricular indices showed good intra-and -observer reliability Conclusion: Our results support the hypothesis that cerebral white matter changes contribute to cognitive disturbances, especially frontal lobe dysfunctions in elderly irrespective of cortical brain atrophy.

피질하혈관성 치매와 알쯔하이머병에서 뇌량 용적의 변화 비교

이애영,손은희,유성동 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background : The clinical significance of callosal atrophy in demented patients has not been elucidated. We performed this study to compare the total and regional difference of corpus callosum according to demenua subtypes and analyzed the relationship with the white matter changes. Methods : Twenty-eight patients with Alzheimer's disease (NINCDS-ADRDA criteria), 17 patients with vascular dementia (NINDS-AIREN criteria), and 14 healthy controls were included. The total area of corpus callosum and three distinct subdivision were measured by manual tracing with Paintshop Pro 6.02 software. The degree of white matter changes were graded by the Scheltens' scale. The MMSE and Modified Mini-Mental Stats (3MS) Examination were used for cognitive function test Results : Total callosal area was much smaller in vascular dementia compared with those of Alzheimer's disease and control. The degree of white matter change correlated siginficantiy with the callosal atrophy in vascular dementia Callosal atrophy was proportional to the cognitive decline. Conclusion : We suggest that callosal atrophy in patients with subcortical vascular dementia may be a neuroradiological clue for the coginitive decline and reflects the cerebral white matter injury.

알쯔하이머병 환자의 혈소판 아밀로이드 전구단백질 이상

이애영,조은경,김건익,김선국,손은희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Background:Although Alzheimer's disease (AD) is a progressive neurodegenerative disorder without any truly effective pharmacological treatment at present, early accurate diagnosis is important for the delaying of disease progression and proper management It would be desirable to have a peripheral biological marker to identify patients affected by AD Amyloid β-peptide originates from a larger precursor, the amyloid precursor protein (APP). which can be seen in the platelet of its equivalent to those found in brain. To investigate if there is a correlation between level of platelet APP isoform and AD, we evaluate a cohort of subjects including patients affected by sporadic AD, vascular dementia, and controls Subjects & Methods :Thirty-five patients with sporadic AD diagnosed according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Relatec Disorders criteria (NINCDS-ADRDA) and 26 vascular dementia patients diagnosed by the Diagnosis and Statistical Manual of Mental Disorders, Fouth Edition (DSM-Ⅳ) criteria and 12 controls were included Blood sample were drawn from fasting state and collected into 3 mL of 3.8% sodium citrate. Platelets were collected by centrifugation at 500 g for 20 minutes and washed. and the platelet pellet was stored at -80℃ until used APP was assessed by western blot analysis and quantified by densitometry using Image Analyzer Results:In platelets densitometer as well as the result of Western blot was higher compared with those of patients with non-Alzheimer dementia and controls We observed statistically significant reductions in the ratio of 120 kDa to 130 kDa APP to 110 kDa APP (APPr) for patients with probable AD compared with control subjects and patients with vascular dementia APPr levels in AD correlated with the severity of dementia measured by CDR. Accuracy levels measured by Receiver Operating Curve analysis showed that a cut-off level of 0.45 resulted in a sensitivity of 71% and a specificity of 74%, with an area under the curve of 0 793 Conclusion:Platelet APPr allowed to differentiate AD from normal aging and vascular dementia with high sensitivity and specificity These findings suggest that platelet APPr may be a helpful peripheral marker for diagnosis and clinical progression of Alzheimer disease.

카드뮴 및 Adriamycin 저항성 CHO 세포의 Telomeric Band 의 변화

정해원,정경인,손은희 한국유전학회 1997 Genes & Genomics Vol.19 No.3

To investigate the properties and functions of telomere in cells resistant to cadmium and adriamycin, changes of telomeric band number were studied using fluorescence in situ hybridization (FISH) technique. To determine the amplification of telomeric signal, we counted total number of telomeric bands, number of marker chromosomes and number of double minutes (DMs) in cadmium resistant and adriamycin resistant cell groups. Cell lines exposed to cadmium showed higher ITB scores than controls. Cell line with longest exposure to cadmium had the highest ITBs. Adriamycin resistant cell lines showed lower ITB scores than controls. Number of marker chromosomes in cadmium resistant cell lines was similar to that in control cells whereas that in adriamycin resistant cell lines was decreased. Total number of DMs with presence of telomere signal was increased in cadmium resistant CHO cells, whereas no increase was found in adriamycin resistant cells. Our results suggest that there might be different mechanisms in the acquisition of resistance to different agents.