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메타콜린 기관지유발검사 시행방법: 대한천식알레르기학회 의견서
손경희 ( Kyoung-hee Sohn ),김환수 ( Hwan Soo Kim ),김병근 ( Byung-keun Kim ),김주희 ( Joo-hee Kim ),이상민 ( Sang Min Lee ),이재현 ( Jae-hyun Lee ),우성일 ( Sung-il Woo ),김철홍 ( Cheol Hong Kim ),정재원 ( Jae Won Jung ),김세훈 ( 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.2
메타콜린 기관지유발검사는 천식의 감별 진단 및 기관지과민증을 측정하기 위해 널리 시행되어온 검사이다. 정확한 진단을 위해 표준화된 프로토콜로 검사가 이루어져야 하나, 최근 검사 장비의 변경 및 2017년 ERS가이드라인에서 프로토콜이 변경되었음에도 불구하고, 진료 일선에서는 과거 프로토콜이 여전히 사용되고 있다. 현재 국내에서 사용 가능한 APS 장비에서는 기존 KoKo dosimeter에서 사용되던 프로토콜을 적용할 수 없으므로 더 간소화되고 고도화된 프로토콜을 제안한다. 학회는 본 전문가 의견서를 통해 새로운 메타콜린 기관지유발검사 프로토콜을 제시하였으며, 개정된 프로토콜의 타당성과 정확성에 대해서는 향후 전향적인 다기관연구가 필요하다. The Korean Academy of Asthma, Allergy, and Clinical Immunology task force report aims to provide new protocols for methacholine challenge test (MCT). Although new devices have different delivery system compared to old ones, previous protocols are still used, which cannot guarantee adequate diagnoses of asthma. Another important issue is the recent recommendation in European Respiratory Society (ERS) technical standard guideline to use a delivered methacholine dose that causes a 20% decrease in forced expiratory volume in 1 second (FEV<sub>1</sub>) (PD<sub>20</sub>). Although the previous protocol based on the methacholine concentration causing a 20% decrease in FEV<sub>1</sub> (PC<sub>20</sub>) has been used globally, several studies have reported that PD<sub>20</sub> is more reliable and applicable for new protocols of MCT. Indeed, a tidal breathing inhalation protocol using a breath-actuated or continuous nebulizer is recommended. Herein, we recommend 3 protocols for the MCT using new devices and provide a brief summary of the change in strategy based on the updated ERS guideline. (Allergy Asthma Respir Dis 2023;11:56-62)
손경희 ( Kyoung Hee Sohn ),김주영 ( Ju Young Kim ),이서영 ( Suh Young Lee ),이승은 ( Seung Eun Lee ),강혜련 ( Hye Ryun Kang ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.4
Background: Vitamin K1 (phytonadione), a fat-soluble vitamin, has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults. Case History: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy. Results: The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid, and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site. Conclusion: We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성
우미희(Mi Hee Woo),이응석(Eung-Seok Lee),최란(Lan Choi),손경희(Kyung-Hee Sohn),김인규(In-Kyu Kim),황보경(Kyoung Hwangbo),이은영(Eunyoung Lee),손종근(Jong-Keun Son),나영화(Younghwa Na),장인혜(Inhye Chang) 大韓藥學會 2002 大韓藥學會 總會 및 學術大會 Vol.2002 No.2
As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.